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Three Cases Infected with Avian Influenza A(H5N6)Virus-Chongqing Municipality,China,January-September,2021

China CDC weekly 2022年第1期4卷 11-16页

作者： Kun Su Zhen Yu Yu Lan Ju Wang Shuang Chen Li Qi Yaokai Chen Yun Tang Yu Xiong Zhangping Tan Mingyue Wang Sheng Ye Dayan Wang Hua Ling william jliu Xiaoni Zhong Qin Li Wenge Tang Chongqing Municipal Center for Disease Control and Prevention ChongqingChina College of Public Health and Management Chongqing Medical UniversityChongqingChina Chongqing Public Health Medical Center ChongqingChina Chongqing Municipal Key Laboratory for High Pathogenic Microbes ChongqingChina NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?The World Health Organization(WHO)has reported a total of 48 cases by October 15,*** continuous genomic reassortments of H5N6 and other subtype avian influenza viruses(AIVs)pose a long-term threat to public health and the poultry *** is added by this report?Three new cases of H5N6 that occurred from January to September 2021 in Chongqing Municipality,China were reported in this *** information of the three cases showed raising poultry and visiting live poultry market contributed to these infections,and there was no evidence of human-to-human transmission of H5N6 currently but a potential spatial *** increase of H5N6 cases was recorded in the *** are the implications for public health practice?In case of unexplained pneumonia or severe respiratory infection,the patients’epidemiological history of contact with poultry or live poultry markets(LPMs)may be an important interrogation to help *** and long-term surveillance of avian influenza viruses in LPMs is essential.

关键词： Chongqing poultry H5N6

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Avian influenza viruses suppress innate immunity by inducingtrans-transcriptional readthrough via SSU72

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Cellular & Molecular Immunology 2022年第6期19卷 702-714页

作者： Yan Zhao Fengming Huang Zhen Zou Yuhai Bi Yang Yang Cong Zhang Qiang Liu Daozhen Shang Yiwu Yan Xiangwu Ju Song Mei Peng Xie Xiao Li Mingyao Tian Shuguang Tan Huijun Lu Zongsheng Han Kangtai Liu Yuqing Zhang Junbo Liang Zhu Liang Qingchao Zhang Jiahui Chang william jliu Cong Feng Tanshi Li Michael Q.Zhang Xiaoyue Wang George FGao Yingxia Liu Ningyi Jin Chengyu Jiang State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of BiochemistryPeking Union Medical CollegeBeijing 100005China Shenzhen Key Laboratory of Pathogen and Immunity State Key Discipline of Infectious DiseaseSecond Hospital Affiliated with Southern University of Science and TechnologyShenzhen Third People’s HospitalShenzhenGuangdong 518112China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China School of Life Science University of Science and Technology of ChinaHefeiAnhui 230027China Department of Automation Tsinghua UniversityBeijing 100084China Genetic Engineering Laboratory Institute of Military VeterinaryAcademy of Military Medical SciencesChangchunJilin 130062China State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy West China HospitalSichuan UniversityChengduSichuan 610000China State Key Laboratory of Medical Molecular Biology Department of Biochemistry and Center for BioinformaticsInstitute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China National Institute for Viral Disease Control and Prevention Chinese Centers for Disease Control and PreventionBeijing 102206China Department of Emergency General Hospital of the PLAHaidian DistrictBeijing 100853China Department of Biological Sciences and Center for Systems Biology The University of Texas at DallasRichardsonTXUSA

Innate immunity plays critical antiviral roles. The highly virulent avian influenza viruses (AIVs) H5N1, H7N9, and H5N6 can betterescape host innate immune responses than the less virulent seasonal H1N1 virus. Here, we report a mechanism by whichtranscriptional readthrough (TRT)-mediated suppression of innate immunity occurs post AIV infection. By using cell lines, mouselungs, and patient PBMCs, we showed that genes on the complementary strand (“trans” genes) influenced by TRT were involved inthe disruption of host antiviral responses during AIV infection. The trans-TRT enhanced viral lethality, and TRT abolishmentincreased cell viability and STAT1/2 expression. The viral NS1 protein directly bound to SSU72, and degradation of SSU72 inducedTRT. SSU72 overexpression reduced TRT and alleviated mouse lung injury. Our results suggest that AIVs infection induce TRT byreducing SSU72 expression, thereby impairing host immune responses, a molecular mechanism acting through the NS1-SSU72-trans-TRT-STAT1/2 axis. Thus, restoration of SSU72 expression might be a potential strategy for preventing AIV pandemics.

关键词： AIV infection TRT SSU72 NS1 Immune escape

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Intra-host Ebola viral adaption during human infection

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Biosafety and Health 2019年第1期1卷 14-24页

作者： william jliu Weifeng Shi Wuyang Zhu Cong Jin Shumei Zou Ji Wang Yuehua Ke Xiaofeng Li Mi Liu Tao Hu Hang Fan Yigang Tong Xiang Zhao Wenbin Chen Yuhui Zhao Di Liu Gary Wong Chengchao Chen Chunyu Geng Weiwei Xie Hui Jiang Idrissa Laybor Kamara Abdul Kamara Matt Lebby Brima Kargbo Xiangguo Qiu Yu Wang Xiaofeng Liang Mifang Liang Xiaoping Dong Guizhen Wu George F.Gao Yuelong Shu NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Shandong Universities Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases Taishan Medical UniversityTaian 271000China Institute of Disease Control and Prevention Academy of Military Medical SciencesBeijing 100071China State Key Laboratory of Pathogen and Biosecurity Institute of Microbiology and EpidemiologyAcademy of Military Medical SciencesBeijing 100071China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China BGI-Shenzhen Shenzhen 518083China Sierra Leone Ministry of Health and Sanitation FreetownSierra Leone Special Pathogens Program National Microbiology LaboratoryPublic Health Agency of CanadaWinnipegCanada Chinese Center for Disease Control and Prevention Beijing 102206China Public Health School(Shenzhen) Sun Yat-sen UniversityShenzhen 510006China

The onsite next generation sequencing(NGS)of Ebola virus(EBOV)genomes during the 2013–2016 Ebola epidemic in Western Africa provides an opportunity to trace the origin,transmission,and evolution of this ***,we have diagnosed a cohort of EBOV patients in Sierra Leone in 2015,during the late phase of the *** surviving EBOV patients had a recovery process characterized by decreasing viremia,fever,and biochemical *** genomes sequenced through the longitudinal blood samples of these patients showed dynamic intra-host substitutions of the virus during acute infection,including the previously described short stretches of 13 serial TNC ***,within individual patients,samples collected during the early phase of infection possessed Ts at these nucleotide sites,whereas they were replaced by Cs in samples collected in the later phase,suggesting that these short stretches of TNC mutations could emerge *** addition,up to a total of 35 nucleotide sites spanning the EBOV genome were mutated *** study showed the dynamic intra-host adaptation of EBOV during patient recovery and gave more insight into the complex EBOV-host interactions.

关键词： Ebola virus Intra-host Nucleotide Variation Adaptation Genome sequencing Clinical manifestations Blood biochemistry

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Compression behaviour of Pd39Ni10Cu30P21 bulk metallic glass up to 23.5Gpa

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Beijing Synchrotron Radiation Facility 2001年第2期 159-164,页

作者： LMWang ZJZhan jliu LLSun GLi WKWang BSRF InstituteofHighEnergyPhysicsChineseAcademyofSciencesBeijing100039People’sRepublicofChina CenterforCondensedMatterPhysics InstituteofPhysicsChinsesAcademyofSciencesBeijing100080People’sRep

The compression behaviour of Pd39Ni10Cu30P21 bulk metallic glass is ivestigated at room temperature up to 23.5GPa using in situ high pressure energy dispersive x-ray diffraction with a synchrotron radiation *** induced strucural relaxation of the bulk metallic glass is exhibited within the pressure *** is found that below about 5GPa,the existence of excess free volume contributes to rapid structural relaxation,which gives rise to rapid volumetic *** higher pressure,further relaxation results in structural stiffness.

关键词：高压 Pd39Ni10Cu30P21玻璃室温发光行为 X射线衍射同步辐射

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术后硬膜外自控镇痛、连续镇痛及肌肉注射镇痛的对比分析

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甘肃医药 2011年第2期30卷 77-79页

作者：刘发有秦超高台县人民医院麻醉科甘肃张掖734300 高台县人民医院内科甘肃张掖734300

目的:探讨手术后镇痛效果最佳、副作用最小的镇痛方法。方法:回顾分析我院2006年1月-2008年12月择期手术900例术后镇痛患者的临床资料,随机分为3组,术后硬膜外自控镇痛(I组)、硬膜外连续镇痛(II组)及肌肉注射镇痛(III组)。结果:术后VAS... 详细信息

目的:探讨手术后镇痛效果最佳、副作用最小的镇痛方法。方法:回顾分析我院2006年1月-2008年12月择期手术900例术后镇痛患者的临床资料,随机分为3组,术后硬膜外自控镇痛(I组)、硬膜外连续镇痛(II组)及肌肉注射镇痛(III组)。结果:术后VAS评分Ⅰ组明显优于Ⅱ组和Ⅲ组,SS评分12小时以后Ⅱ组优于Ⅰ组,但是Ⅱ组的布比卡因和芬太尼的用量明显多于I组,I组仍优于Ⅲ组。结论:硬膜外自控镇痛具有明显的镇痛优点和连续稳定的镇痛效果,避免波峰及波谷现象,用药量较小,副作用少。

关键词：硬膜外自控镇痛硬膜外连续镇痛肌肉注射镇痛

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褐藻寡糖对翅碱蓬种子萌发及抗盐胁迫能力的影响

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分子植物育种 2023年第8期21卷 2746-2753页

作者：孙林陈春琳钟志海杨剑超刘凯兰翔宇任承钢秦松赵辉刘正一山东科技大学化学与生物工程学院青岛266590 中国科学院烟台海岸带研究所烟台264003 中国农业大学水利与土木工程学院北京100083 烟台市农业科学研究院烟台265500 东营市海洋经济发展研究院东营257000 鲁东大学农学院烟台264025

以耐盐植物翅碱蓬为对象,研究了褐藻寡糖对其种子萌发和耐盐能力的影响。对不同盐浓度溶液处理下的翅碱蓬种子施加褐藻寡糖溶液,结果表明,褐藻寡糖在无盐胁迫时可有效提高翅碱蓬种子的萌发率,由66.67%(空白对照组)提升至78.33%(0.02 mg/... 详细信息

以耐盐植物翅碱蓬为对象,研究了褐藻寡糖对其种子萌发和耐盐能力的影响。对不同盐浓度溶液处理下的翅碱蓬种子施加褐藻寡糖溶液,结果表明,褐藻寡糖在无盐胁迫时可有效提高翅碱蓬种子的萌发率,由66.67%(空白对照组)提升至78.33%(0.02 mg/mL),同时,萌发的幼芽中可溶性糖含量也有较大提升;盐胁迫下,经褐藻寡糖处理的翅碱蓬种子萌发率、芽长均有明显的提升,且幼芽中游离脯氨酸含量也有所增加,且在200 mmol/L及以上盐浓度下效果尤为明显。本研究结果表明,种子在褐藻寡糖的作用下抗盐胁迫能力提高,因此,可初步认为,在高盐环境中褐藻寡糖可促进翅碱蓬幼苗的生长和抗逆能力的提升。

关键词：翅碱蓬(Suaeda heteroptera Kitagawa) 褐藻寡糖抗逆性高盐胁迫

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