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An inexpensive underwater mine countermeasures simulator with real-time 3D after action review

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Defence Technology（防务技术） 2016年第5期12卷 367-379页

作者： Robert STONE Timothy SNELL Neil cooke human Interface Technologies Team University of Birmingham UK University of Birmingham UK

This paper presents the results of a concept capability demonstration pilot study, the aim of which was to investigate how inexpensive gaming software and hardware technologies could be exploited in the development and evaluation of a simulator prototype for training Royal Navy mine clearance divers, specifically focusing on the detection and accurate reporting of the location and condition of underwater ordnance. The simulator was constructed using the Blender open source 3D modelling toolkit and game engine, and featured not only an interactive 3D editor for underwater scenario generation by instructors, but also a real-time, 3D After Action Review(AAR) system for formative assessment and *** simulated scenarios and AAR architecture were based on early human factors observations and briefings conducted at the UK's Defence Diving School(DDS), an organisation that provides basic military diving training for all Royal Navy and Army(Royal Engineers) divers. An experimental pilot study was undertaken to determine whether or not basic navigational and mine detection components of diver performance could be improved as a result of exposing participants to the AAR system, delivered between simulated diving scenarios. The results suggest that the provision of AAR was accompanied by significant performance improvements in the positive identification of simulated underwater ordnance(in contrast to non-ordnance objects) and on participants' description of their location, their immediate in-water or seabed context and their structural condition. Only marginal improvements were found with participants' navigational performance in terms of their deviation accuracies from a pre-programmed expert search path. Overall, this project contributes to the growing corpus of evidence supporting the development of simulators that demonstrate the value of exploiting open source gaming software and the significance of adopting established games design techniques in delivering highly

关键词： Simulation Virtual reality Diver training Ordnance disposal Mine clearance

GLOBAL GOVERNANCE: ChINA’S CONTRIBUTION ThROUGh ThE ShANGhAI COOPERATION ORGANISATION

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International Understanding 2018年第4期 26-29页

作者： George I.h.cooke Bandaranaike Centre for International Studies

Global Governance:where are we? Symbiotic associations among states and peoples have occurred over centuries whilst a semblance of collective governance on an international scale in varied forms and manifestations has... 详细信息

关键词： GLOBAL GOVERNANCE ChINA

用显微镜观察皮革的松面及其对皮革机械性能的影响

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北京皮革（中外鞋讯）（下） 2010年第11期 91-94页

作者： ChENG-Kun Liu P. Latona Joseph Lee Peter h.cooke 李魏（编译）戴红（校） US.Department of Agriculture Agriculture Eesearch Service EAstern Eegional Research Center 600 East Mermaid LAne Wyndmoor PA 19038-8598 四川大学生物质和皮革工程系四川成都610065

对皮革结构和皮革产品来说，松面是一个非常棘手的问题。制革工人尤其关注松面，他们会想尽一切办法，通过添加不同的化学物质来解决松面的问题。然而，人们对松面的纤维结构和松面对皮革机械性能的影响还不是很清楚。这篇论文采用显微... 详细信息

对皮革结构和皮革产品来说，松面是一个非常棘手的问题。制革工人尤其关注松面，他们会想尽一切办法，通过添加不同的化学物质来解决松面的问题。然而，人们对松面的纤维结构和松面对皮革机械性能的影响还不是很清楚。这篇论文采用显微镜观察松面革的纤维结构，并且研究松面对抗张强度、抗冲击性等机械性能的影响，从而更好的了解松面。显微镜观察显示，在空松革的间隙层与真皮层之间有可见的缝隙。此外，粒面层显示为片层结构，而在正常皮革中，粒面层是紧紧粘在一起的，而且其纤维束看起来要比空松革的纤维束小得多。机械性能研究显示，松面会导致皮革的韧性降低，然而测量也显示其抗张强度和伸长率也有微小变化。并且，粘弹性研究表明在应力松弛曲线上，空松革与紧实革非常相似，两种革都显示出在最初的几秒钟内应力迅速减小，然后是缓慢的衰减。然而，空松革的初始应力比紧实革大，也表明其坚实性比紧实革大。这篇研究对松面进行了更加深入的了解，进而促使人们研究一些方法来解决松面问题，例如对皮革进行填充。

关键词：显微镜观察皮革产品机械性能松面纤维结构抗张强度化学物质抗冲击性

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电弧炉采用RCB吹氧技术冶炼不锈钢

钢铁 2004年第8期39卷 64-66页

作者： P.Moxon M.Abel h.Knapp R.cooke 奥钢联福克斯公司 CORUS钢铁工程公司

吹氧技术自20世纪50年代起引入电弧炉炼钢工艺以来,促进了电弧炉性能的持续提高。奥钢联福克斯应用组合式精炼烧嘴(RCB)的吹氧技术,在降低消耗指标、提高设备可靠性和改善控制等方面取得了重要进展。2002年1月,在CORUS钢铁工程公司的电... 详细信息

吹氧技术自20世纪50年代起引入电弧炉炼钢工艺以来,促进了电弧炉性能的持续提高。奥钢联福克斯应用组合式精炼烧嘴(RCB)的吹氧技术,在降低消耗指标、提高设备可靠性和改善控制等方面取得了重要进展。2002年1月,在CORUS钢铁工程公司的电弧炉炼钢厂进行了一系列试验,采用组合式精炼烧嘴(RCB)以及喷碳枪进行碳钢、合金钢、特别是不锈钢的冶炼。这是西半球首次在电弧炉上成功应用氧气射流技术冶炼不锈钢。

关键词：电弧炉吹氧组合式精炼烧嘴不锈钢

Voxel-based magnetic resonance imaging investigation of poor and preserved clinical insight in people with schizophrenia

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World Journal of Psychiatry 2016年第3期6卷 311-321页

作者： Adegboyega Sapara Dominic h Ffytche Michael A cooke Steven CR williams Veena Kumari Department of Psychology Institute of PsychiatryPsychology and NeuroscienceKing’s College London Department of Old Age Psychiatry and Neuroimaging Sciences Institute of PsychiatryPsychology and NeuroscienceKing’s College London Department of Neuroimaging Sciences Institute of PsychiatryPsychology and NeuroscienceKing’s College London NIhR Biomedical Research Centre for Mental health South London and Maudsley NHS Foundation Trust

AIM To define regional grey-matter abnormalities in schizophrenia patients with poor insight(Insight-),relative to patients with preserved clinical insight(Insight+),and healthy *** Forty stable schizophrenia outpatients(20 Insight-and 20 Insight+) and 20 healthy controls underwent whole brain magnetic resonance imaging(MRI).Insight in all patients was assessed using the Birchwood Insight Scale(BIS;a self-report measure).The two patient groups were preselected to match on most clinical and demographic parameters but,by design,they had markedly distinct BIS ***-based morphometry employed in SPM8 was used to examine group differences in grey matter volumes across the whole *** The three participant groups were comparable in age [F(2,57) = 0.34,P = 0.71] and the patient groups did not differ in age at illness onset [t(38) = 0.87,P = 0.39].Insight-and Insight+ patient groups also did not differ in symptoms on the Positive and Negative Syndromes scale(PANSS):Positive symptoms [t(38) = 0.58,P = 0.57],negative symptoms [t(38) = 0.61,P = 0.55],general psychopathology [t(38) = 1.30,P = 0.20] and total PANSS scores [t(38) = 0.21,P = 0.84].The two patient groups,as expected,varied significantly in the level of BIS-assessed insight [t(38) = 12.11,P hippocampal,occipital and cerebellar grey matter volumes in Insightpatients,relative to Insight+ patients and healthy controls(for all clusters,family-wise error corrected P ht+ patient and healthy controls did not differ significantly(P > 0.20) from each *** Our findings demonstrate a clear association between poor clinical insight and smaller fronto-temporal,occipital and cerebellar grey matter volumes in stable long-term schizophrenia patients.

关键词： Psychosis Insight Grey matter volumes Fronto-temporal Neural networks Birchwood insight scale

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在酵母中克隆:哺乳动物基因组的克隆模式

国外医学.遗传学分册 1988年第4期11卷 193-195页

作者： cooke h 顾毅中

在原核系统中克隆DNA片段的技术使我们对基因结构和功能的了解有了一个飞跃。现在这一技术在互不相关的生物学分支如分类学和神经生物学中均已成为一个主要的研究工具。它导致了价值几百万美元的工业生产,并使我们对重大问题(立刻联想... 详细信息

在原核系统中克隆DNA片段的技术使我们对基因结构和功能的了解有了一个飞跃。现在这一技术在互不相关的生物学分支如分类学和神经生物学中均已成为一个主要的研究工具。它导致了价值几百万美元的工业生产,并使我们对重大问题(立刻联想起爱滋病)能以某种方式和在15年前不可能的速度加以研究。但目前采用的方法在细胞遗传学或遗传学分析水平和分子克隆水平中还存在一个间隙(gaP),特别在研究对象是

关键词：人工染色体 DNA 酵母基因组染色体组哺乳动物

MACMIC Reveals A Dual Role of CTCF in Epigenetic Regulation of Cell Identity Genes

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Genomics, Proteomics & Bioinformatics 2021年第1期19卷 140-153页

作者： Guangyu Wang Bo Xia Man Zhou Jie Lv Dongyu Zhao Yanqiang Li Yiwen Bu Xin Wang John P.cooke Qi Cao Min Gyu Lee Lili Zhang Kaifu Chen Center for Bioinformatics and Computational Biology Department of Cardiovascular SciencesInstitute for Academic MedicineHouston Methodist Research InstituteHoustonTX 77030USA Center for Cardiovascular Regeneration Department of Cardiovascular SciencesInstitute for Academic MedicineHouston Methodist Research InstituteHoustonTX 77030USA Department of Cardiothoracic Surgeries Weill Cornell Medical CollegeCornell UniversityNew YorkNY 10065USA houston Methodist Institute for Academic Medicine Houston Methodist Research InstituteHoustonTX 77030USA Basic and Translational Research Division Department of CardiologyBoston Children’s HospitalBostonMA 02115USA Department of Pediatrics Harvard Medical SchoolBostonMA 02115USA Department of Urology Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA Robert h.Lurie Comprehensive Cancer Center Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA 不详

Numerous studies of relationship between epigenomic features have focused on their strong correlation across the genome,likely because such relationship can be easily identified by many established methods for correlation ***,two features with little correlation may still colocalize at many genomic sites to implement important *** is no bioinformatic tool for researchers to specifically identify such feature ***,we develop a method to identify feature pairs in which two features have maximal colocalization minimal correlation(MACMIC)across the *** MACMIC analysis of 3306 feature pairs in 16 human cell types,we reveal a dual role of CCCTC-binding factor(CTCF)in epigenetic regulation of cell identity *** super-enhancers are associated with activation of target genes,only a subset of super-enhancers colocalized with CTCF regulate cell identity *** super-enhancers colocalized with CTCF,CTCF is required for the active marker h3 K27 ac in cell types requiring the activation,and also required for the repressive marker h3 K27 me3 in other cell types requiring *** work demonstrates the biological utility of the MACMIC analysis and reveals a key role for CTCF in epigenetic regulation of cell *** code for MACMIC is available at https://***/bxia888/MACMIC.

关键词： Mutual information Correlation CCCTC-binding factor h3K27ac h3K27me3

Influence of supraphysiological cortisol manipulation on predator avoidance behaviors and physiological responses to a predation threat in a wild marine teleost fish

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Integrative Zoology 2018年第2期13卷 206-218页

作者： Michael J.LAWRENCE Erika J.ELIASON Jacob W.BROWNSCOMBE Kathleen M.GILMOUR John W.MANDELMAN Lee F.G.GUTOWSKY Steven J.cooke Fish Ecology and Conservation Physiology Laboratory Department of BiologyCarleton UniversityOttawaOntarioCanada Department of Ecology Evolution&Marine BiologyUniversity of CaliforniaSanta BarbaraCaliforniaUSA Department of Biology University of OttawaOttawaOntarioCanada School for the Environment University of New EnglandBiddefordMaineUSA John h.Prescott Marine Laboratory New England AquariumBostonMassachusettsUSA

The stress axis in teleost fish attempts to maintain internal homeostasis in the face of allostatic ***,stress axis induction has been associated with a higher predation rate in *** date,the physiological and behavioral factors associated with this outcome are poorly *** purpose of the present study was to investigate the impact of experimental cortisol elevation on anti-predator behavior and physiological responses to predator *** hypothesized that semi-chronic cortisol elevation would increase susceptibility to predation by increasing stress-induced risk-taking *** test this hypothesis,schoolmaster snapper were given cocoa butter implants without cortisol(sham)or with cortisol(50 mg/kg body weight)and tethered to *** were exposed to either a lemon shark or control conditions for *** use and activity were recorded throughout and fish were terminally sampled for *** implantation,relative to shams,resulted in higher blood glucose and plasma cortisol concentrations with a lower plasma lactate *** exposure,relative to controls,elicited higher blood glucose and lactate concentrations but had no effect on plasma cortisol *** interactions were detected between shark exposure and cortisol treatment for any physiological *** metrics,including shelter use and activity,were unaffected by either cortisol implantation or shark *** responses to cortisol implantation likely resulted from enhanced gluconeogenic activity,whereas alterations under predator exposure may have been the product of catecholamine *** work should address context-specific influences of stress in mediating behavioral responses to predation.

关键词： homeostatic overload lemon shark predation refuging stress axis teleost physiology

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更新世年代学:是长还是短?

地球与环境 1974年第12期 7-12页

作者： h.B.S.cooke ,郑洪汉

彭克和布鲁克纳对阿尔卑斯的经典研究(Penck,1882;Penck and Br(?)ckner,1909)得出了被普遍接受的更新世“四个冰期”的概念。阿尔卑斯冰期贡兹、民德、里斯和武木,甚至在欧洲以外地区也都成为冰期划分的标准。尽管有由埃伯尔(Eberl,19... 详细信息

彭克和布鲁克纳对阿尔卑斯的经典研究(Penck,1882;Penck and Br(?)ckner,1909)得出了被普遍接受的更新世“四个冰期”的概念。阿尔卑斯冰期贡兹、民德、里斯和武木,甚至在欧洲以外地区也都成为冰期划分的标准。尽管有由埃伯尔(Eberl,1930)称为多瑙的,以及更早的谓之比伯(Eiber)的前贡兹冰期存在(Schaefer,1956),但这些术语尚未被广泛采用。

关键词：岩心岩芯动物群动物区系浮游有孔虫克罗默地磁极性事件贡兹冰期火山灰火山碎屑地层里斯冰期古地磁