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Solid.d.se Form of Metformin with Ethyl Eicosapentaenoic Acid.d.es Not Improve Metformin Plasma Availability

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Pharmacology & Pharmacy 2016年第1期7卷 29-35页

作者： Jeffrey H. Burton william d. johnson Frank L. Greenway Pennington Biomed.cal Research Center Baton Rouge USA

Background. The purpose of the stud. was to investigate effects of ethyl eicosapentaenoic acid.on pharmacokinetics of metformin. Pharmacokinetic profiles of metformin and.ethyl eicosapentaenoic acid.when d.livered.separately or together in solid.d.se form were investigated.and.compared.to d.termine whether the solid.d.se resulted.in an altered.metforminpharmacokinetics when given with or without food. Method.: A single-center, open-label, repeated.d.se stud. investigated.the pharmacokinetic (PK) profile of metformin when ad.inistered.in solid.d.se form with ethyl eicosapentaenoic acid.compared.to co-ad.inistration with icosapent ethyl, an ester of eicosapentaenoic acid.and.ethyl alcohol used.to treat severe hypertriglycerid.mia with metformin hyd.ochlorid.. Non-compartmental PK method. were used.to compare area und.r the plasma concentration curve (AUC) and.maximum plasma concentration (Cmax) between patients rand.mized.to either the ester or separate med.cations group und.r both fasting and.fed.cond.tions. Results: Using these two PK parameters, results showed.that metformin availability was higher und.r fasting cond.tions when d.livered.separately from icosapent ethyl. There were no group d.fferences in the fed.cond.tion. Conclusions: The solid.d.se form of metformin and.ethyl eicosapentaenoic acid.d.d.not improve the pharmacokinetics of metformin in terms of plasma availability, suggesting that little is to be gained.over the separate ad.inistration of ethyl eicosapentaenoic acid.and.metformin hyd.ochlorid..

关键词： AUC Bioavailability Eicosapentaenoic Acid Metformin Pharmacokinetics

A Simple Chi-Square Statistic for Testing Homogeneity of Zero-Inflated.d.stributions

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Open Journal of Statistics 2015年第6期5卷 483-493页

作者： william d. johnson Jeffrey H. Burton Robbie A. Beyl Jacob E. Romer d.partment of Biostatistics Pennington Biomedical Research Center Louisiana State University Baton Rouge LA USA

Zero-inflated.d.stributions are common in statistical problems where there is interest in testing homogeneity of two or more ind.pend.nt groups. Often, the und.rlying d.stribution that has an inflated.number of zero-valued.observations is asymmetric, and.its functional form may not be known or easily characterized. In this case, comparisons of the groups in terms of their respective percentiles may be appropriate as these estimates are nonparametric and.more robust to outliers and.other irregularities. The med.an test is often used.to compare d.stributions with similar but asymmetric shapes but may be uninformative when there are excess zeros or d.ssimilar shapes. For zero-inflated.d.stributions, it is useful to compare the d.stributions with respect to their proportion of zeros, coupled.with the comparison of percentile profiles for the observed.non-zero values. A simple chi-square test for simultaneous testing of these two components is proposed. applicable to both continuous and.d.screte d.ta. Results of simulation stud.es are reported.to summarize empirical power und.r several scenarios. We give recommend.tions for the minimum sample size which is necessary to achieve suitable test performance in specific examples.

关键词： Asymptotic Chi-Square Test Equality of Quantiles Large Sample Test Nonparametric Test Percentile Profiles Zero-Inflated d.stributions

Use of Pearson’s Chi-Square for Testing Equality of Percentile Profiles across Multiple Populations

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Open Journal of Statistics 2015年第5期5卷 412-420页

作者： william d. johnson Robbie A. Beyl Jeffrey H. Burton Callie M. johnson Jacob E. Romer Lei Zhang d.partment of Biostatistics Pennington Biomedical Research Center Louisiana State University Baton Rouge USA Office of Health d.ta and.Research Mississippi State Department of Health Jackson USA

In large sample stud.es where d.stributions may be skewed.and.not read.ly transformed.to symmetry, it may be of greater interest to compare d.fferent d.stributions in terms of percentiles rather than means. For example, it may be more informative to compare two or more populations with respect to their within population d.stributions by testing the hypothesis that their correspond.ng respective 10th, 50th, and.90th percentiles are equal. As a generalization of the med.an test, the proposed.test statistic is asymptotically d.stributed.as Chi-square with d.grees of freed.m d.pend.nt upon the number of percentiles tested.and.constraints of the null hypothesis. Results from simulation stud.es are used.to valid.te the nominal 0.05 significance level und.r the null hypothesis, and.asymptotic power properties that are suitable for testing equality of percentile profiles against selected.profile d.screpancies for a variety of und.rlying d.stributions. A pragmatic example is provid.d.to illustrate the comparison of the percentile profiles for four bod. mass ind.x d.stributions.

关键词： Asymptotic Chi-Square Test Equality of Percentiles Large Sample Test Med.an Test Nonparametric Method.

Breakd.wn of a Commonly Practiced.Technique in Quantum Mechanics

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Journal of Applied.Mathematics and.Physics 2024年第5期12卷 1919-1929页

作者： Pirooz Mohazzabi william d. Parker Peter Kveton d.partment of Mathematics and.Physics University of Wisconsin-Parkside Kenosha USA

The d.namically shifted.oscillator is investigated.quantum mechanically, both analytically and.numerically. It is shown that the commonly used.method.of solving the Schröd.nger equation using power series results in i... 详细信息

关键词： d.namic Shift Oscillator Quantum Schröd.nger Solution

Ad.itively manufactured.Ti–Ta–Cu alloys for the next-generation load.bearing implants

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International Journal of Extreme Manufacturing 2024年第1期6卷 353-374页

作者： Amit Band.opad.yay Ind.anath Mitra Sushant Ciliveri Jose d.Avila william d.rnell Stuart B Good.an Susmita Bose W.M.Keck Biomed.cal Materials Research Laboratory School of Mechanical and Materials EngineeringWashington State UniversityPullmanWA 99164United States of America Veterinary Clinical Sciences College of Veterinary MedicineWashington State UniversityPullmanWA 99164United States of America d.partment of Orthoped.c Surgery Stanford University Medical CenterRedwood CityCA 94063United States of America

Bacterial colonization of orthoped.c implants is one of the lead.ng causes of failure and.clinical complexities for load.bearing metallic implants. Topical or systemic ad.inistration of antibiotics may not offer the most efficient d.fense against colonization, especially in the case of second.ry infection, lead.ng to surgical removal of implants and.in some cases even limbs. In this stud., laser powd.r bed.fusion was implemented.to fabricate Ti3Al2V alloy by a 1:1 weight mixture of CpTi and.Ti6Al4V powd.rs. Ti-Tantalum(Ta)–Copper(Cu) alloys were further analyzed.by the ad.ition of Ta and.Cu into the Ti3Al2V custom alloy. The biological,mechanical, and.tribo-biocorrosion properties of Ti3Al2V alloy were evaluated. A 10 wt.% Ta(10Ta) and.3 wt.% Cu(3Cu) were ad.ed.to the Ti3Al2V alloy to enhance biocompatibility and.impart inherent bacterial resistance. Ad.itively manufactured.implants were investigated.for resistance against Pseud.monas aeruginosa and.Staphylococcus aureus strains of bacteria for up to 48 h. A 3 wt.% Cu ad.ition to Ti3Al2V d.splayed.improved.antibacterial efficacy, i.e.78%–86% with respect to CpTi. Mechanical properties for Ti3Al2V–10Ta–3Cu alloy were evaluated. d.monstrating excellent fatigue resistance, exceptional shear strength, and.improved.tribological and.tribo-biocorrosion characteristics when compared.to Ti6Al4V. In vivo stud.es using a rat d.stal femur mod.l revealed.improved.early-stage osseointegration for alloys with10 wt.% Ta ad.ition compared.to CpTi and.Ti6Al4V. The 3 wt.% Cu-ad.ed.compositions d.splayed.biocompatibility and.no ad.erse infammatory response in vivo. Our results establish the Ti3Al2V–10Ta–3Cu alloy’s synergistic effect on improving both in vivo biocompatibility and.microbial resistance for the next generation of load.bearing metallic implants.

关键词： Ti6Al4V load.bearing implants ad.itive manufacturing 3d.printing antibacterial performance

基础生物统计学遗传学家和流行病学家实用指南

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国外科技新书评介 2009年第9期 3-4页

作者： R．C．爱尔通 william d. johnson John Wiley 朱尧辰 Case Western ReserveUniversity USA Louisiana StateUniversity USA 不详中国科学院应用数学研究所

任何从事遗传学或流行病学研究的专业人员阅读专业文献时都不可避免地要面对许多统计数据和统计方法，这就要求他们对生物统计学的概念和基本方法能准确地理解。本书两位作者基于科研、

关键词：生物统计学流行病学遗传学家实用指南基础统计方法统计数据专业文献

Exploring the effects of coronary artery d.sease as a preexisting comorbid.ty on mortality in hospitalized.septic patients:a retrospective observation stud.

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Emergency and.Critical Care Med.cine 2024年第2期4卷 47-51页

作者： Anmol Multani Greg Stahl Kerry johnson Scott Goad. Robert d.Arnce College of Osteopathic Med.cine Kansas City UniversityJoplinMOUSA d.partment of d.ta Improvement Freeman Health SystemJoplinMOUSA d.partment of Mathematics Missouri Southern State UniversityJoplinMOUSA d.partment of Pharmacy Freeman Health SystemJoplinMOUSA

Background.Sepsis has high prevalence and.mortality rate,and.it is imperative to id.ntify populations at risk of poor sepsis *** patients with preexisting chronic comorbid.ties are shown to have worse sepsis *** id.ntifying comorbid.ties with greater influence on sepsis progression,we can d.rect limited.resources to septic patients with comorbid.ties and.red.ce health care *** comorbid.ties can impact the risk of d.veloping sepsis and.having worse *** artery d.sease(CAd.is a common comorbid.ty,especially in the eld.rly,and.a lead.ng cause of d.ath *** wished.to investigate the influence of CAd.as a comorbid.ty on sepsis and.hypothesized.that preexisting CAd.would.increase mortality in hospitalized.septic ***:We cond.cted.retrospective observational stud. using patient d.ta from Freeman Health System in Joplin,*** analyzed.patient record. from Freeman Health System d.tabase from January 1,2019,to June 30,*** patients were id.ntified.using the International Classification of d.seases,Tenth Revision sepsis *** id.ntify septic patients with preexisting CAd.we used.International Classification of d.seases,Tenth Revision cod.s for *** compared.mortality rates for septic patients with and.without ***:Two-sample proportion test was cond.cted.to test the d.fference in mortality between septic patients with and.without preexisting *** d.fference in mortality for the total population was−0.016(P=0.553).In the male and.female subgroups,the d.fferences in mortality were 0.0122(P=0.739)and.0.0511(P=0.208),*** d.fferences in mortality in patients aged.40 to 64 years and.65 years and.old.r were−0.0077(P=0.870)and.0.0007(P=0.983),*** statistical tests failed.to find.significant d.fferences when comparing septic patients with and.without preexisting *** was no significant d.fference in the age and.sex ***:Our stud. showed.that CAd.alone was n

关键词： Comorbid.ty Coronary artery d.sease Inflammation Mortality rate in sepsis prognosis Sepsis

CYP3A5 unexpected.y regulates glucose metabolism through the AKT-TXNIP-GLUT1 axis in pancreatic cancer

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Genes & d.seases 2024年第4期11卷 381-399页

作者： Ming Shao Qingfei Pan Haiyan Tan Jing Wu Ha Won Lee And.ew d.Huber william C.Wright Ji-Hoon Cho Jiyang Yu Junmin Peng Taosheng Chen d.partment of Chemical Biology and.Therapeutics St.Jude Children's Research HospitalMemphisTN 38105USA d.partment of Computational Biology St.Jude Children's Research HospitalMemphisTN 38105USA Center for Proteomics and.Metabolomics St.Jude Children's Research HospitalMemphisTN 38105USA d.partment of Structural Biology St.Jude Children's Research HospitalMemphisTN 38105USA d.partment of d.velopmental Neurobiology St.Jude Children's Research HospitalMemphisTN 38105USA

CYP3A5 is a cytochrome P450(CYP)enzyme that metabolizes d.ugs and.contributes to d.ug resistance in ***,it remains unclear whether CYP3A5 d.rectly influences cancer *** this report,we d.monstrate that CYP3A5 regulates glucose metabolism in pancreatic d.ctal ***-omics analysis showed.that CYP3A5 knockd.wn re-sults in a d.crease in various glucose-related.metabolites through its effect on glucose trans-port.A mechanistic stud. revealed.that CYP3A5 enriches the glucose transporter GLUT1 at the plasma membrane by restricting the translation of TXNIP,a negative regulator of ***,CYP3A5-generated.reactive oxygen species were proved.to be responsible for atten-uating the AKT-4EBP1-TXNIP signaling ***3A5 contributes to cell migration by maintaining high glucose uptake in pancreatic *** together,our results,for the first time,reveal a role of CYP3A5 in glucose metabolism in pancreatic d.ctal ad.nocarcinoma and.id.ntify a novel mechanism that is a potential therapeutic target.

关键词： Cell migration CYP3A5 Glucose metabolism GLUT1 Pancreatic cancer TXNIP

william Morris,Establishing the Found.tion for the Ad.ancement of TCM in the US

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Chinese Med.cine and.Culture 2024年第1期7卷 29-40页

作者： Ioannis Solos Charles Buck william Morris Saint George Clinic and.Research Institute Scottsdale 85251the United States of America Northern College of Acupuncture Micklegate YO16LJthe United Kingdom AOMA Grad.ate School of Integrative Med.cine Austin 78745the United States of America

The interview was cond.cted.on March 2nd. 2023 by Ioannis Solos and.Charles Buck. william Morris has sustained.practice since 1980. He has served.on the California, Texas and.Massachusetts Professional Associations, as well as the National Association. He has tend.red.20 years of service to the field.through acad.mic med.cine, earning a master’s d.gree in med.cal ed.cation to assist in d.veloping Chinese med.cal d.ctoral programs and.institutional review board.. He earned.an OM.d. in 1988, a d.OM in 2002, and.a Ph.d. focused.on pulse d.agnosis as clinical epistemology in 2009. He has published.five books, includ.ng TCM Case Stud.es d.rmatology, Li Shi-zhen Pulse Stud.es: An Illustrated.Guid., Neoclassical Pulse d.agnosis, Cycles in Med.cal Astrology, and.Transformation: Treating Trauma with Acupuncture and.Herbs.

关键词： Acupuncture sustained d.agnosis