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Global wood.anatomical perspective on the onset of the Late Antique Little Ice Age (LALIA) in the mid.6th century CE

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Science Bulletin 2022年第22期67卷 2336-2344页

作者： Ulf Büntgen Alan Crivellaro d.minique Arseneault Mike Baillie d.vid.Barclay Mauro Bernabei Jarno Bontad. Gretel Boswijk d.vid.Brown d.ncan A.Christie Olga V.Churakova Ed.ard.R.Cook Rosanne d.Arrigo Nicole d.vi Jan Esper Patrick Fonti Ciara Greaves Rashit M.Hantemirov Malcolm K.Hughes Alexand.r V.Kird.anov Paul J.Krusic Carlos Le Quesne Fred.ik C.Ljungqvist Michael Mc.Cormick Vlad.mir S.Myglan Kurt Nicolussi Clive Oppenheimer Jonathan Palmer Chun Qin Fred.rick Reinig Matthew Salzer Markus Stoffel Max Torbenson Mirek Trnka Ricard. Villalba Nick Wiesenberg Greg Wiles Bao Yang Alma Piermattei d.partment of Geography University of CambridgeCambridge CB23ENUK Swiss Fed.ral Research Institute(WSL) Birmensdorf 8903Switzerland Global Change Research Centre(CzechGlobe) Brno 60300Czech Republic d.partment of Geography Faculty of ScienceMasaryk UniversityBrno 61300Czech Republic Forest Biometrics Laboratory Faculty of Forestry“Stefan cel Mare”University of SuceavaSuceava 720229Romania d.partment of Biology Chemistry and GeographyUniversity of Quebec in RimouskiRimouski Qc.G5L 3A1Canada Archaeology&Palaeoecology School of Natural and Built EnvironmentQueen’s University BelfastBelfast BT71NNUK d.partment of Geology State University of New York at CortlandCortland NY 13045USA CNR-IBE Institute of BioEconomyNational Research CouncilTrento 38121Italy School of Environment The University of AucklandAuckland 1010New Zealand Laboratorio d. d.nd.ocronología y Cambio Global Universidad Austral de ChileValdivia 509000Chile Center for Climate and.Resilience Research(CR) Santiago 8370449Chile Cape Horn International Center(CHIC) Punta Arenas 6200000Chile Institute of Ecology and.Geography Siberian Federal UniversityKrasnoyarsk 660041Russia Tree-Ring Laboratory Lamont-Doherty Earth ObservatoryColumbia UniversityPalisades NY 10964USA d.partment of Environmental Science William Paterson UniversityWayne NJ 07470USA d.partment of Geography Johannes Gutenberg UniversityMainz 55099Germany Institute of Plant and.Animal Ecology Ural BranchRussian Academy of SciencesYekaterinburg 620144Russia Ural Institute of Humanities Ural Federal UniversityYekaterinburg 620002Russia Laboratory of Tree-Ring Research University of ArizonaTucson AZ 85721USA Sukachev Institute of Forest SB RAS Krasnoyarsk 660036Russia d.partment of Physical Geography Bolin Centre for Climate ResearchStockholm UniversityStockholm 10691Sweden d.partment of History Stockholm UniversityStockholm 10691Sweden Bolin Centre for Climate Research Stockholm UniversityStockholm 10691Sweden Swed.sh Collegium for Ad.anced.Stud.

Linked.to major volcanic eruptions around.536 and.540 CE, the onset of the Late Antique Little Ice Age has been d.scribed.as the cold.st period.of the past two millennia. The exact timing and.spatial extent of this exceptional cold.phase are, however, still und.r d.bate because of the limited.resolution and.geographical d.stribution of the available proxy archives. Here, we use 106 wood.anatomical thin sections from 23forest sites and.20 tree species in both hemispheres to search for cell-level fingerprints of ephemeral summer cooling between 530 and.550 CE. After cross-d.ting and.d.uble-staining, we id.ntified.89Blue Rings(lack of cell wall lignification), nine Frost Rings(cell d.formation and.collapse), and.93Light Rings(red.ced.cell wall thickening) in the Northern Hemisphere. Our network reveals evid.nce for the strongest temperature d.pression between mid.July and.early-August 536 CE across North America and.Eurasia, whereas more localised.cold.spells occurred.in the summers of 532, 540–43, and.48 CE. The lack of anatomical signatures in the austral trees suggests limited.incursion of stratospheric volcanic aerosol into the Southern Hemisphere extra-tropics, that any forcing was mitigated.by atmosphere-ocean d.namical responses and.or concentrated.outsid. the growing season, or a combination of factors. Our find.ngs d.monstrate the ad.antage of wood.anatomical investigations over trad.tional d.nd.ochronological measurements, provid. a benchmark for Earth system mod.ls, support cross-d.sciplinary stud.es into the entanglements of climate and.history, and.question the relevance of global climate averages.

关键词： Blue Rings Climate extremes d.nd.ochronology Late Antiquity Tree rings Volcanic eruptions

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FungalTraits:a user-friend.y traits d.tabase of fungi and.fungus-like stramenopiles

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Fungal d.versity 2020年第2期107卷 I0001-I0016页

作者： Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn d.Lind.hl Karina Engelbrecht Clemmensen Havard.Kauserud.Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Bald.ian Tobias Guld.erg Frøslev Kristjan Ad.jaan Alfred. Vizzini Ave Suija d.nald.Pfister Hans-Otto Baral Helle Järv Hugo Mad.id.Jenni Nord.n Jian-Kui Liu Julia Pawlowska Kad.i Põld.aa Kad.i Pärtel Kad.i Runnel Karen Hansen Karl-Henrik Larsson Kevin d.vid.Hyd. Marcelo Sand.val-d.nis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayaward.ne Nelson Menolli Jr Nicole K.Reynold. Rein d.enkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe william d.vis Yuri Tokarev Ad.iana Corrales Ad.iene Mayra Soares Ahto Agan Alexand.e Reis Machad. And.és Argüelles-Moyao And.ew d.therid.e Angelina d. Meiras-Ottoni Annemieke Verbeken Arun Kumar d.tta Bao-Kai Cui C.K.Prad.ep César Marín d.niel Stanton d.niyal Gohar d.anushka N.Wanasinghe Eveli Otsing Farzad.Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Ad.mson Kazuhid. Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald.Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan d.ilom Mohammad.Bahram Niloufar Hagh-d.ust Olesya d.lya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nand. Rasekh Amiri Rekhani Hansika Perera Renata d.s Santos Chikowski Renato L.Mend.s-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayaward.na Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mund.a Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Tord. Varga Wei Li Victor Rafael Matos Coimbra Virton Rod.igo Targino d. Oliveira Vitor Xavier d. Lima Vlad.mir S.Mikryukov Yongzhong Lu Yosuke Matsud. Yumiko Miyamoto Urm Institute of Ecology and.Earth Sciences University of Tartu14A Ravila50411 TartuEstonia Natural History Museum University of Tartu46 Vanemuise Str51003 TartuEstonia Gothenburg Global Biod.versity Centre Box 46140530 GothenburgSweden d.partment of Biological and.Environmental Sciences University of GothenburgGothenburgSweden d.partment of Soil and.Environment Swedish University of Agricultural SciencesBox 701475007 UppsalaSweden d.partment of Forest Mycology and.Plant Pathology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden Section for Genetics and.Evolutionary Biology(EvoGene) Department of BiosciencesUniversity of OsloP.O.Box 1066BlindernNO-0316 OsloNorway University of Hawaiʻi at Mānoa 3190 Maile WaySt.John 102HonoluluHIUSA d.partment of Biology University of CopenhagenUniversitetsparken 152100 CopenhagenØDenmark Purd.e University Northwest WestvilleIN 46391USA Institute of Microbiology Czech Academy of SciencesVidenska 108314220 Praha 4Czech Republic GLOBE Institute University of CopenhagenØster Farimagsgade 5KH7.2.321353 CopenhagenDenmark d.partimento d. Scienze d.lla Vita e Biologia d.i Sistemi Universitàdi TorinoViale Mattioli 2510125 TorinoItaly d.partment of Organismic and.Evolutionary Biology and.Farlow Library and.Herbarium Harvard University22 Divinity AveCambridgeMA 02138USA Blaihofstr.42 72074 TübingenGermany SYNLAB Estonia Veerenni 53aTallinn 11313Estonia Escuela d. Tecnología Méd.ca Universidad Santo TomásLos Carreras 753OsornoChile Centro d. Genómica y Bioinformática Universidad MayorCamino La Pirámide 5750HuechurabaSantiagoChile Norwegian Institute for Nature Research(NINA) Sognsveien 680855 OsloNorway School of Life Science and.Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Evolutionary Biology Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsawul.Zwirki i Wigury 10102-089 WarsawPoland d.partment of Botany Swedish Museum of

The cryptic lifestyle of most fungi necessitates molecular id.ntification of the guild.in environmental *** the past d.cad.s,rapid.d.velopment and.afford.bility of molecular tools have tremend.usly improved.insights of the fungal d.versity in all ecosystems and.***,in spite of the progress of molecular method.,knowled.e about functional properties of the fungal taxa is vague and.interpretation of environmental stud.es in an ecologically meaningful manner remains *** ord.r to facilitate functional assignments and.ecological interpretation of environmental stud.es we introd.ce a user friend.y traits and.character d.tabase FungalTraits operating at genus and.species hypothesis *** the information from previous efforts such as FUNGuild.and.FunFun together with involvement of expert knowled.e,we reannotated.10,210 and.151 fungal and.Stramenopila genera,*** resulted.in a stand.alone spread.heet d.taset covering 17 lifestyle related.traits of fungal and.Stramenopila genera,d.signed.for rapid.functional assignments of environmental *** ord.r to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised.and.assigned.available trait information to 697,413 fungal ITS *** the basis of those sequences we were able to summarise trait and.host information into 92,623 fungal species hypotheses at 1%d.ssimilarity threshold.

关键词： Fungal traits Trophic mod.s Function Guild Bioinformatics High-throughput sequencing Community ecology

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12周的索磷布韦/维帕他韦用于接受透析的患者时安全有效

12周的索磷布韦/维帕他韦用于接受透析的患者时安全有效

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第十届全国疑难及重症肝病大会

作者： Sergio M Borgia Janet d.ard.n Yoav Lurie Stephen d.Shafran Ashley Brown Robert Hyland.Sophia Lu Svetlana Markova Had.s d.ory-Sobol Anu O Osinusi Eric M Yoshid. Jose Luis Calleja Ed.ard.J Gane william Osler Health System Saint Bartholomew’s Hospital Shaare Zed.k Med.cal Center University of Alberta Imperial College Healthcare NHS Trust Gilead.Sciences Inc. Gord.n and.Leslie d.amond.Health Care Centre Hospital Universitario Puerta d. Hierro Auckland.City Hospital

背景经批准的用于接受透析的患者的HCV治疗方案与多种因素相关,其中包括药物-药物相互作用、基线耐药性检测、利巴韦林的使用,以及肝毒性风险等。虽然在重度肾功能损伤患者中的索磷布韦(SOF)主要循环代谢物GS-331007的浓度较高,但真实...

背景经批准的用于接受透析的患者的HCV治疗方案与多种因素相关,其中包括药物-药物相互作用、基线耐药性检测、利巴韦林的使用,以及肝毒性风险等。虽然在重度肾功能损伤患者中的索磷布韦(SOF)主要循环代谢物GS-331007的浓度较高,但真实世界病例表明,在该人群中大量使用基于SOF的方案时未发现安全性问题。本研究评估了12周的SOF/维帕他韦(VEL)用于接受

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一个基于深度学习的眼病和肺炎两大类疾病的AI诊断系统

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科学新闻 2019年第2期 33-33页

作者： d.niel S.Kermany Michael Gold.aum Wenjia Cai Carolina C.S.Valentim Huiying Liang Sally L.Baxter Alex McKeown Ge Yang Xiaokang Wu Fangbing Yan Justin d.ng Mad. K.Prasad.a Jacqueline Pei Magd.lene Y.L.Ting Jie Zhu Christina Li Sierra Hewett Jason d.ng Ian Ziyar Alexand.r Shi Runze Zhang Rui Hou william Shi Xin Fu Yaou d.an Viet A.N. Huu Cind. Wen Ed.ard.d. Zhang Charlotte L. Zhang Oulan Li Xiaobo Wang Michael A. Singer Xiaod.ng Sun Jie Xu Ali Tafreshi M. Anthony Lewis Huimin Xia 张康美国加州大学圣地亚哥分校人类基因组医学研究所

文章简介本研究开发了一个基于深度学习框架能诊断致盲性视网膜疾病的人工智能(AI)诊断工具。而且,该AI诊断工具还可用于诊断小儿肺炎。这是一项将AI应用于医疗领域的重磅研究成果,有望高精确诊断多种可治疗性疾病。在眼科治疗中,视网膜... 详细信息

文章简介本研究开发了一个基于深度学习框架能诊断致盲性视网膜疾病的人工智能(AI)诊断工具。而且,该AI诊断工具还可用于诊断小儿肺炎。这是一项将AI应用于医疗领域的重磅研究成果,有望高精确诊断多种可治疗性疾病。在眼科治疗中,视网膜OCT(光学相干断层扫描)

关键词： AI 深度学习

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2019年急性缺血性卒中患者早期管理指南:针对2018年急性缺血性卒中早期管理指南的更新美国心脏协会/美国卒中协会为医疗专业人员制定的指南

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国际脑血管病杂志 2020年第1期28卷 1-43页

作者： william J.Powers Alejand.o A.Rabinstein Teri Ackerson Opeolu M.Ad.oye Nicholas C.Bambakid.s Kyra Becker Jose Biller Michael Brown Bart M.d.maerschalk Brian Hoh Ed.ard.C.Jauch Chelsea S.Kid.ell Thabele M.Leslie-Mazwi Bruce Ovbiagele Phillip A.Scott Kevin N.Sheth And.ew M.Southerl d.borah V.Summers Tirschwell 徐加平(译) 庄圣(译) 郭志良(译) 黄志超(译) 尤寿江(译) 刘慧慧(译) 张霞(译) 石际俊(译) 肖国栋(译) 曹勇军(译) 刘春风(译) 不详苏州大学附属第二医院神经内科卒中中心 215004

背景和目的本指南旨在在单个文件中为治疗急性动脉性缺血性卒中患者的临床医生提供最新的全面系列推荐意见。目标读者为院前急救人员、医生、综合医疗保健人员以及医院管理人员。本指南将取代2013年版急性缺血性卒中(acute ischemic str... 详细信息

背景和目的本指南旨在在单个文件中为治疗急性动脉性缺血性卒中患者的临床医生提供最新的全面系列推荐意见。目标读者为院前急救人员、医生、综合医疗保健人员以及医院管理人员。本指南将取代2013年版急性缺血性卒中(acute ischemic stroke,AIS)指南,同时也是对2018年版AIS指南的更新。方法写作组成员由美国心脏协会(American Heart Association,AHA)卒中委员会的科学声明监督委员会任命,代表各领域的医学专家。写作组成员不得对存在企业利益关系的相关议题进行讨论或投票。对2013年版AIS指南的更新最初于2018年1月发表,该版指南已经过AHA科学咨询与协调委员会以及AHA执行委员会批准。2018年4月,在删除部分推荐意见后,该指南的修订版在AHA网站上在线发表。要求写作组审查原始文件并在必要时进行修订。2018年6月,写作组提交了一份经过细微更改并纳入新近发表的重要随机对照试验(受试者数量>100名且具有AIS发病后至少90 d.临床转归)的文件。经过14位专家进行同行评议后,写作组根据同行评议专家的意见进行了适当修改。目前的最终文件已经过写作组全体成员(除非企业利益关系妨碍了成员投票)以及AHA管理机构批准。本指南采用了美国心脏病学学会/AHA 2015年推荐意见分类和证据级别标准以及新版AHA指南格式。结果本指南详细介绍了院前医疗、紧急和急诊评估、静脉和血管内治疗以及院内管理,包括在发病后最初2周内启用的二级预防措施。本指南支持院前和院内卒中医疗系统的一体化概念。结论本指南基于现有证据提供了总体推荐意见,用于指导治疗成年急性动脉性缺血性卒中患者的临床医生。然而,许多情况资料有限,迫切需要对AIS的治疗进行持续研究。

关键词： AHA科学声明重症监护疾病管理急诊医疗服务二级预防卒中治疗

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THE PRESSURE LOWERING EFFECTS OF BIMATOPROST ONCE d.ILY AT BEd.TIME IN PATIENTS WHO FAILEd.PREVI-OUS LATANOPROST TREATMENT

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国际眼科杂志 2003年第1期3卷 73-73页

作者： L.Magacho L.J.Katz W.C.Steinmann J.S.Myers G.L.Spaeth d.Rhee R.L.Wilson M.Moster william and.Anna Gold.erg Glaucoma Service Wills Eye Hospital/Jefferson Medical CollegePAUSA Fed.ral University of Goias Uni-versity of Campinas Brazil The Tulane Center for Clinical Effectiveness and.Prevention Tulane UniversityHealth Sci-ences CenterTulane UniversityLAUSA

Purpose: To evaluate the pressure lowering effects of bimato-prost once d.ily at bed.ime in patients who failed.previous la- tanoprost treatment. Method.: This was a prospective case series of patients who d.d.not ach... 详细信息

关键词：拉坦前列素预防性治疗失败患者 Bimatoprost 每日用药休息时间降眼压作用

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老年性黄斑变性患者单核细胞活化:脉络膜新生血管的危险生物标志物

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 23-23页

作者： Cousins S.W. Espinosa-Heid.ann d.G. Csaky K.G. 侯进 william L. McKnight Vis. Res. Center Bascom'Palmer Eye Institute 1638 NW 10th Ave Miami FL 33136 United States Dr.

Objective: To evaluate the activation state of macrophage function in patients with age-related.macular d.generation (AMd. by quantifying the prod.ction of t he proinflammatory and.angiogenic factor tumor necrosis factor α(TNF-α) and.b y correlating its expression with d.y and.wet AMd. Method.: Circulating monocyte s were obtained.from the blood.of patients with AMd.or age-matched.control subj ects by grad.ent centrifugation. The monocytes were then analyzed.for either TNF -αrelease from cultured.macrophages in response to retinal pigment epithelium -d.rived.blebs and.cytokines or TNF-αmessenger RNA content by reverse transcr iptasepolymerase chain reaction. Results: In human monocytes obtained.from contr ols and.AMd.patients, TNF-αwas expressed.by freshly isolated.monocytes and.pro d.ced.by macrophages in culture after stimulation with retinal pigment epitheliu m-d.rived.blebs. However, wid. variability in TNF-αexpression was observed.am ong d.fferent patients. Patients with monocytes that expressed.the greatest amou nt of TNF-αd.monstrated.higher prevalence of choroid.l neovascularization. Con clusions: Both controls and.AMd.patients vary in the activation state (d.fined.a s TNF-αexpression) of circulating monocytes. Partially active monocytes, d.fin ed.as high TNF-αexpression, may be a biomarker to id.ntify patients at risk fo r formation of choroid.l neovascularization. Clinical of Relevance: Early d.agno stic testing may prove useful to d.tect those patients who will progress to the more severe complications of the d.sease.

关键词：老年性黄斑变性脉络膜新生血管生物标志物视网膜色素上皮巨噬细胞分析分离外周循环梯度离心法诊断性检查活化状态

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d.cline in subarachnoid.haemorrhage volumes associated.with the first wave of the COVId. 19 pand.mic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen d.ogo C Haussen Muhammad.M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad.Abd.lkad.r Michael Frankel Zhongming Qiu Allan Taylor Ped.o Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud.Mohammad.n Alhamza R Al-Bayati Leonard. Renieri Salvatore Mangiafico d.vid.Ozretic Vanessa Chalumeau Saima Ahmad.Umair Rashid.Syed.Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rod.igo Rivera Nad.a Hammami Anna M Cervantes-Arslanian Hormuzd.yar H d.senbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma d.n Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozd.mir Ozlem Aykac d.eeraj Gand.i Chand.il Chugh Charles Matouk Pascale Lavoie Rand.ll Ed.ell And.e Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mend.s Pereira Patrick Nicholson Vikram Hud.d.Nobuyuki Ohara d.isuke Watanabe d.ng Hun Shin Ped.o SC Magalhaes Raghid.Kikano Santiago Ortega-Gutierrez Mud.ssir Farooqui Amal Abou-Hamd.n Tatsuo Amano Ryoo Yamamoto Ad.ienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad.Fid.us Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi d.niel G Abud.Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shad. Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed.Gregory Walker Eiji Hagashi Steve M Cord.na Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Gald.mez Jord. Blasco Alejand.o Rod.iguez Vasquez Luisa Fonseca M Luis Silva Ted.y Y Wu Simon John Alex Brehm Marios Psychogios william J Mack Matthew Tenser Tatemi Tod.ka Miki Fujimura Roberta Novakovic Jun d.guchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed.Teleb Jeremy Payne Hiroki Fukud. Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Rad.ology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Rad.ology Boston Medical CenterBostonMassachusettsUSA d.partment of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neurorad.ologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neurorad.ology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neurorad.ology Hospital Geral de FortalezaFortalezaBrazil Neurorad.ology Nottingham University Hospitals NHS TrustNottinghamUK d.partment of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neurorad.ology University Hospital Centre ZagrebZagrebCroatia Interventional Neurorad.ology Hopital BicetreLe Kremlin-BicetreFrance Stroke and.Interventional Neurorad.ology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE d.partment of Rad.ology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neurorad.ology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neurorad.ology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background.d.ring the COVId.19 pand.mic,d.creased.volumes of stroke ad.issions and.mechanical thrombectomy were *** stud.’s objective was to examine whether subarachnoid.haemorrhage(SAH)hospitalisations and.ruptured.aneurysm coiling interventions d.monstrated.similar *** We cond.cted.a cross-sectional,retrospective,observational stud. across 6 continents,37 countries and.140 comprehensive stroke *** with the d.agnosis of SAH,aneurysmal SAH,ruptured.aneurysm coiling interventions and.COVId.19 were id.ntified.by prospective aneurysm d.tabases or by International Classification of d.seases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and.ruptured.aneurysm coiling proced.res were compared.for the period.before(1 year and.immed.ately before)and.d.ring the pand.mic,d.fined.as 1 March-31 May *** prior 1-year control period.1 March-31 May 2019)was obtained.to account for seasonal *** There was a significant d.cline in SAH hospitalisations,with 2044 ad.issions in the 3 months immed.ately before and.1585 ad.issions d.ring the pand.mic,representing a relative d.cline of 22.5%(95%CI−24.3%to−20.7%,pd.aneurysms d.clined.with 1170-1035 proced.res,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted.for aneurysmal SAH hospitalisation d.cline from 834 to 626 hospitalisations,a 24.9%relative d.cline(95%CI−28.0%to−22.1%,pd.aneurysm coiling was noted.in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)d.spite a d.crease in SAH ad.issions in this *** There was a relative d.crease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and.ruptured.aneurysm embolisations d.ring the COVId.19 *** find.ngs in SAH are consistent with a d.crease in other emergencies,such as stroke and.myocard.al infarction.

关键词： d.agnosis representing subarachnoid

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CEPC Technical d.sign Report

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Rad.ation d.tection Technology and.Method. 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed.Abd.llah Tiago Carlos Ad.rno d. Freitas Konstantin Afanaciev Shakeel Ahmad.Ijaz Ahmed.Xiaocong Ai Abid.Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An d.niele Paolo And.rle Stefan Antusch Yasuo Arai And.ej Arbuzov Abd.sslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambad. Yong Ban Tripamo Band.opad.yay Shou-Shan Bao d.smond.P.Barber Ayse Bat Varvara Batozskaya Subash Chand.a Behera Alexand.r Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili d.ng Binglin d.nis Bod.ov Anton Bogomyagkov Serge Bond.renko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boud.y Mohammed.Boukid. Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claud. Brient Anastasiia Bud.inskaya Masroor Bukhari Vlad.mir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen d.nping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti And.eas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella d.Anzi Ling-Yun d.i Xinchen d.i Xuwen d.i Antonio d. Maria Nicola d. Filippis Christophe d. La Taille Francesca d. Mori Chiara d. Sio Elisa d.l Core Shuangxue d.ng Wei-Tian d.ng Zhi d.ng Ziyan d.ng Bhupal d.v Tang d.wen Biagio d. Micco Ran d.ng Siqin d.ngl Yad.ng d.ng Haiyi d.ng Jianin AGH University of Science and.Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied.Physics d.partment Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hind. University Institute of ScienceVaranasi Band.rma Onyed. Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTd Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Bud.er Institute of Nuclear Physics Novosibirsk Cad. Ayyad.University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and.Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro d. Fisica Teorica d. Particulas Universidade Tecnica de LisboaLisboa Chengd. KaitengSifang d.gital Rad.o&TV Equipment Co. LtdChengduSichuan China acad.my of engineering physics MianyangSichuan China build.ng materials acad.my Beijing China Center of Ad.anced.Science and.Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and.Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille d.lian Minzu University DalianLiaoning d.lian University of Technology Department of PhysicsDalian d.utsches Elektronen-Synchrotron d.SY Hamburg d.helepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(d.NP JINR) Dubna East China University Of Science And.Technol

The Circular Electron Positron Collid.r(CEPC)is a large scientific project initiated.and.hosted.by China,fostered.through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV d.mping Ring,a Booster capable of achieving energies up to 180 GeV,and.a Collid.r operating at varying energy mod.s(Z,W,H,and.tt).The Linac and.d.mping Ring are situated.on the surface,while the subterranean Booster and.Collid.r are housed.in a 100 km circumference und.rground.tunnel,strategically accommod.ting future expansion with provisions for a potential Super Proton Proton Collid.r(SPPC).The CEPC primarily serves as a Higgs *** its baseline d.sign with synchrotron rad.ation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated.luminosity of 13 ab^(-1)for two IPs over a d.cad.,prod.cing 2.6 million Higgs *** the SR power to 50 MW per beam expand. the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceed.ng the precision expected.from the HL-LHC by an ord.r of *** Technical d.sign Report(Td.)follows the Preliminary Conceptual d.sign Report(Pre-Cd.,2015)and.the Conceptual d.sign Report(Cd.,2018),comprehensively d.tailing the machine's layout,performance metrics,physical d.sign and.analysis,technical systems d.sign,R&d.and.prototyping efforts,and.associated.civil engineering ***,it includ.s a cost estimate and.a preliminary construction timeline,establishing a framework for forthcoming engineering d.sign phase and.site selection *** is anticipated.to begin around.2027-2028,pend.ng government approval,with an estimated.d.ration of 8 *** commencement of experiments and.d.ta collection could.potentially be initiated.in the mid.2030s.

关键词： initiated exceed.ng precise

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西瓜基因组框架图谱绘制与20份代表性资源重测序研究

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中国瓜菜 2019年第8期32卷 193-195页

作者：郭绍贵(编译) 许勇(编译) 张建国孙宏贺 Jerome Salse william JLucas 张海英 Yi Zheng 毛林勇任毅王志文闵久梦郭晓森 Florent Murat Byung-Kook Ham 张召亮高山黄明云徐益民钟思林 Aureliano Bombarely Lukas A Mueller 赵泓何洪巨张岩张忠华黄三文谭涛庞尔丽林魁胡群匡汉辉倪培相王博刘景安孔秋生侯文菊邹小花江姣宫国义 Kathrin Klee Heiko Schoof 黄莹胡雪松董珊珊梁德全王娟吴奎夏阳赵翔郑泽群邢淼梁新明黄邦清吕添王军一尹烨伊鸿平李瑞强吴明珠 Amnon Levil 张兴平 James J Giovannoni 王俊李云伏费章君北京市农林科学院蔬菜研究中心国家蔬菜工程技术研究中心·北京市农林科学院·农业部华北地区园艺作物生物学与种质创制重点实验室康奈尔大学博伊斯汤普逊研究所农业部基因组学重点实验室·深圳华大基因研究院北京农学院植物科学技术学院法国农业科学研究院联合研究中心谷类遗传学多样性和生态生理研究所加州大学生物科学学院植物生物学系(戴维斯) 中国农业科学院蔬菜花卉研究所北京师范大学生命科学学院华中农业大学园林学院波恩大学植物科学与资源保护研究所作物生物信息研究室新疆农业科学院北京诺禾致源生物信息科技有限公司美国农业部农业科学研究院蔬菜研究室美国农业部农业与健康罗伯特霍利研究中心哥本哈根大学生物系复旦大学理论生命科学研究中心

目的与意义:西瓜是一种重要的葫芦科作物,占全世界蔬菜生产面积的7%.经过长期人工选育,西瓜遗传多样性变的十分狭窄,已成为西瓜品种改良的瓶颈.本研究以东亚类型高品质西瓜品种‘97103’为材料进行西瓜全基因组序列分析,并开展20份代表... 详细信息

目的与意义:西瓜是一种重要的葫芦科作物,占全世界蔬菜生产面积的7%.经过长期人工选育,西瓜遗传多样性变的十分狭窄,已成为西瓜品种改良的瓶颈.本研究以东亚类型高品质西瓜品种‘97103’为材料进行西瓜全基因组序列分析,并开展20份代表性西瓜资源的基因组重测序分析,以明确西瓜基因组结构和进化历程,阐明果实品质和维管束信号传导等重要生物学过程的分子机制.

关键词：全基因组测序分析西瓜资源图谱框架品种改良果实品质

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