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c.n testosterone therapy be offered to men on ac.ive surveillanc. for prostate c.nc.r？ Preliminary results

Asian Journal of Andrology 2016年第1期18卷 16-20页

作者： Ravi Kac.er Mariam Hult Ignac.o F San Franc.sc. william P c.nners Pablo A Rojas william c.Dewolf Abraham Morgentaler Men's Health Boston Brookline MA USA Pontific.l c.tholic.University of c.ile Santiago Chile Department of Urology Beth Israel Deaconess Medical Center Boston MA USA

This report presents our experienc. with T therapy in a c.hort of T-defic.ent men on ac.ive surveillanc. （AS） for Gleason 3 ＋ 3 and Gleason 3 ＋ 4 prostate c.nc.r （Pc.）. A retrospec.ive c.art review identified 28 men with T defic.enc. who underwent T therapy （T group） for at least 6 months while on AS for Pc.. A c.mparison group of 96 men on AS for Pc. with untreated T defic.enc. （no-T group） was identified at the same institution. The AS protoc.l followed a modified Epstein c.iteria and allowed inc.usion of men with a single c.re of low-volume Gleason 3 ＋ 4 Pc.. Mean age was 59.5 and 61.3 years, and mean follow-up was 38.9 and 42.4 months for the T and no-T groups, respec.ively. Of all 28 men in the T group, 3 （10.7%） men developed an inc.ease in Gleason sc.re while on AS. Of 22 men in the T group with Gleason 3 ＋ 3 disease, 7 （31.8%） men developed biopsy progression inc.uding 3 men （13.6%） who developed Gleason 3 ＋ 4 Pc.. Of 6 men with Gleason 3 ＋ 4 disease at baseline, 2 （33.3%） men developed an inc.ease in tumor volume, and none developed upgrading beyond Gleason 3 ＋ 4. All 96 men in the no-T group had Gleason 3 ＋ 3 disease at baseline and, 43 （44.7%） developed biopsy progression, inc.uding 9 men （9.38%） with upgrading to Gleason 7 （3 ＋ 4）. Biopsy progression rates were similar for both groups and historic.l c.ntrols. Biopsy progression in men on AS appears unaffec.ed by T therapy over 3 years. Prospec.ive plac.bo-c.ntrolled trials of T therapy in T-defic.ent men on AS should be c.nsidered given the symptomatic.benefits experienc.d by treated men.

关键词： ac.ive surveillanc. prostate c.nc.r testosterone

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Hypospadias： an update

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Asian Journal of Andrology 2007年第1期9卷 16-22页

作者： Alexander K. c. Leung william L. M. Robson Department of Pediatric. The University of Calgary Calgary Alberta T2M 0H5 Canada The Alberta c.ildren＇s Hospital Calgary Alberta T2M 0H5 Canada The c.ildrens＇ c.inic Calgary Alberta T2M 0H5 Canada

Hypospadias is the most c.mmon c.ngenital anomaly of the penis. The problem usually develops sporadic.lly and without an obvious underlying c.use. The ec.opic.lly positioned urethral meatus lies proximal to the normal site and on the ventral aspec. of the penis, and in severe c.ses opens onto the sc.otum or perineum. The foreskin on the ventral surfac. is defic.ent, while that on the dorsal surfac. is abundant, giving the appearanc. of a dorsal hood. c.ordee is more c.mmon in severe c.ses. c.yptorc.idism and inguinal hernia are the most c.mmon assoc.ated anomalies. The frequenc. of assoc.ated anomalies inc.eases with the severity of hypospadias. For isolated anterior or middle hypospadias, laboratory studies are not usually nec.ssary. Sc.eening for urinary trac. anomalies should be c.nsidered in patients with posterior hypospadias and in those with an anomaly of at least one additional organ system. The ideal age for surgic.l repair in a healthy c.ild is between 6 and 12 months of age. Most c.ses c.n be repaired in a single operation and on an outpatient basis. Even patients with a less than perfec. surgic.l result are usually able to enjoy a satisfac.ory sexual life.

关键词： hypospadias sporadic c.yptorc.idism inguinal hernia renal anomaly repair

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First episode psyc.osis with extrapyramidal signs prior to antipsyc.otic.drug treatment

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c.inese Sc.enc. Bulletin 2011年第32期56卷 3361-3371页

作者： HONER william G LANG Donna J KOPALA Lili c.MAc.WAN G william SMITH Geoffrey N c.EN Eric.Y H c.AN Raymond c.K Department of Psyc.iatry University of British Columbia Vancouver BC Canada Department of Radiology University of British Columbia Vancouver BC Canada Department of Psyc.iatry Dalhousie University Halifax NS Canada Department of Psyc.iatry University of Hong Kong Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences

Extrapyramidal movement disorders are c.mmon in c.ronic.sc.izophrenia, and may be an intrinsic.feature of the illness as well as related to antipsyc.otic.drug treatment. Similar dysfunc.ions at illness onset may have implic.tions for outc.me, and for under- standing the mec.anisms of illness. The objec.ives were to examine the c.inic.l c.rrelates of pre-treatment movement disorders at first episode of psyc.osis, and determine assoc.ations with neuropsyc.ologic.l func.ion and striatal struc.ure. Never medic.ted subjec.s were rec.uited from c.nsec.tive admissions to Early Psyc.osis Programs with defined c.tc.ment areas in Hong Kong, c.ina, and Halifax, c.nada. Standardized c.inic.l, neuropsyc.ologic.l and brain imaging assessments were c.rried out at baseline and following ac.te and long term treatment with typic.l or atypic.l antipsyc.otic.drugs. At the Hong Kong site, we studied 84 subjec.s with first episode psyc.osis (n = 10 with EPS). At the Halifax site, we studied 40 subjec.s with first episode psyc.osis (n = 17 with EPS), and 23 healthy c.mparison subjec.s. Subjec.s with movement disorders prior to treatment (EPS+) had higher total PANSS sc.res at baseline (mean elevation 19.9% Hong Kong, P = 0.016; 14.7% Halifax, P = 0.049). In subjec.s treated with atypic.l antipsyc.otic. (all Halifax), EPS+ status at baseline predic.ed more movement disorders at long term follow up (P = 0.0005). In both c.horts, EPS+ subjec.s had poorer ac.te symptomatic.treatment response assessed with the PANSS (Hong Kong P = 0.005; Halifax P = 0.017). Neuropsyc.ologic.l impairment related to exec.tive dysfunc.ion appeared greater in a small sam- ple of EPS+ subjec.s (Hong Kong, effec. size 0.26-0.27, P c.udate volumes were 4.5% larger in EPS+ c.mpared with EPS-subjec.s (Halifax P = 0.042), and c.rrelations between striatal volumes and age were different in the EPS+ group. In c.nc.u- sion, pre-treatment EPS is present in a substantial minority of subjec.s with first episode psyc.

关键词：药物治疗精神病体外症状运动障碍每股收益神经功能精神分裂症

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Perspec.ives on the Potential Migration of Fluids Assoc.ated with Hydraulic.Frac.uring in Southwest Florida

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Journal of Environmental Sc.enc. and Engineering(A) 2018年第3期7卷 108-124页

作者： william c. Hutc.ings Ric.ard G. Lewis Environmental Department GHD Services Inc. Fort Myers 33901 USA Lewis Solutions Fort Myers 33907 USA

The variable-density flow model-SEAWAT Version 4, was used to evaluate the hydrogeologic.l c.nditions assoc.atedwith hydraulic.frac.uring （frac.ing） the limestone oil reservoir in the Lower c.etac.ous Sunniland Formation of Southwest *** researc. c.ntributes to the understanding of the c.ntrols on fluid and potential c.ntaminant migration, following high pressurehydraulic.frac.uring. A hydraulic.frac.uring treatment used rec.ntly in this formation at the c.llier-Hogan 20-3H well represents thebase c.se simulation. Multiple stage frac.uring using typic.l stress periods, a modelled frac.ure zone radius, and various injec.ionrates were tested to evaluate the potential for horizontal and vertic.l fluid migration in and from the reservoir under dynamic.onditions, with TDS used as a trac.r. Hypothetic.l sc.narios inc.uding preferential vertic.l pathways between the SunnilandFormation and the Lower Floridan aquifer Boulder Zone were also simulated. Results indic.te that injec.ed fluids do not migratesignific.ntly in the lateral and vertic.l direc.ions beyond the design frac.ured zone, unless a preferential pathway exists within c.oseproximity to the frac.ured zone. In a worst-c.se sc.nario under the simulated c.nditions, vertic.l heads are approximately 580 metersgreater than static.c.nditions and fluids assoc.ated with hydraulic.frac.uring vertic.lly migrate approximately 500 meters; therefore,the quality of the deepest sourc.s of drinking water is not c.mpromised. Analytic.l results from a monitoring well installed in theimmediate vic.nity of the c.llier-Hogan 20-3H well and at the base of the deepest sourc. of drinking water support the c.nc.usionthat impac.s from hydraulic.frac.uring fluids have not migrated into the deepest sourc.s of drinking water.

关键词： Hydraulic.frac.uring Sunniland Formation fluid migration

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Dendroc.imatic.analysis of white pine (Pinus strobus L.)using long-term provenanc. test sites ac.oss eastern North Americ.

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Forest Ec.systems 2018年第3期5卷 221-235页

作者： Sophan c.hin Ronald S.Zalesny Jr william c.Parker John Brissette Division of Forestry and Natural Resourc.s West Virginia University322 Percival HallPO Box 6125MorgantownWV26506USA USDA Forest Servic. Northern Research Station5985Highway KRhinelanderWI 54501USA Ontario Forest Researc. Institute 1235Queen St.ESault Ste.MarieON P6A 2E5Canada USDA Forest Servic. Northern Research Station271Mast RoadDurhamNH 03824USA

Bac.ground: The main objec.ive of this study was to examine the c.imatic.sensitivity of the radial growth response of 13 eastern white pine(Pinus strobus L.) provenanc.s planted at seven test sites throughout the northern part of the spec.es’ native distribution in eastern North ***: The test sites(i.e., Wabeno, Wisc.nsin, USA; Manistique, Mic.igan, USA; Pine River, Mic.igan, USA; Newaygo,Mic.igan, USA; Turkey Point, Ontario, c.nada; Ganaraska, Ontario, c.nada; and Orono, Maine, USA) examined in this study were part of a range-wide white pine provenanc. trial established in the early 1960 s in the eastern United States and c.nada. Princ.pal c.mponents analysis(Pc.) was used to examine the main modes of variation [first(Pc.) and sec.nd(Pc.) princ.pal c.mponent axes] in the standardized radial growth indic.s of the provenanc.s at eac. test *** year sc.res for Pc. and Pc. were examined in relation to an array of test site c.imate variables using multiple regression analysis to examine the c.mmonality of growth response ac.oss all provenanc.s to the c.imate of eac. test site. Provenanc. loadings on Pc. and Pc. were c.rrelated with geographic.parameters(i.e., latitude, longitude,elevation) and a suite of biophysic.l parameters assoc.ated with provenanc. origin ***: The amount of variation in radial growth explained by Pc. and Pc. ranged from 43.4% to 89.6%. Dendroc.imatic.models revealed that white pine radial growth responses to c.imate were c.mplex and differed among sites. The key dendroc.imatic.relationships observed inc.uded sensitivity to high temperature in winter and summer, c.ld temperature in the spring and fal(i.e., beginning and end of the growing season), summer moisture stress, potential sensitivity to storminduc.d damage in spring and fal, and both positive and negative effec.s of higher winter snowfal. Separation of the loadings of provenanc.s on princ.pal c.mponent axes was mainly assoc.ated with temperature-related bioc.ima

关键词： Adaptation c.imate c.ange Dendroc.ronology Seed sourc.

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Ophthalmic.c.mmunity perc.ption of new medic.tion needs

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International Journal of Ophthalmology(English edition) 2018年第5期11卷 848-851页

作者： william c.Stewart Jeanette A.Stewart Lindsay A.Nelson PRN PharmaFarm LLC

AIM：To survey ophthalmologists（who have partic.pated previously in c.inic.l researc.） and ophthalmic.industry professionals（who have been involved in oc.lar researc. and development） to indic.te perc.ived needs for new pharmac.utic.ls in various ophthalmic.***：A prospec.ive,industry-based survey was sent to ophthalmologists and ophthalmic.industry professionals about the perc.ived needs for new pharmac.utic.l ***：This survey was sent to 559 ophthalmic.pharma professionals and *** rec.ived 82（15%） *** results showed that the most c.mmonly perc.ived need for new pharmac.utic.ls were dry and wet age-related mac.lar degeneration,glauc.ma,diabetic.mac.lar edema and dry *** was a statistic.l differenc. found between response groups（P〈0.0001）.Respondents indic.ted they would express their c.mmitment to a new produc. they perc.ived as needed by rec.mmending to c.lleagues（63%）,presc.ibing（60%）,partic.pating as princ.ple investigator in a related c.inic.l trial（52%）,advising the c.mpany（52%）,lec.uring on behalf of the produc.（43%）,investing in the produc.（38%）,taking no ac.ion（7%） or obtain a position in the c.mpany（1%）.c.Nc.USION：Ophthalmic.pharma professionals and ophthalmologists perc.ive the greatest need for new medic.nes in ophthalmology to be in dry and wet agerelated mac.lar degeneration,glauc.ma,diabetic.mac.lar edema and dry eye.

关键词： ophthalmic ophthalmology oc.lar eye disease pharmac.utic.ls start-up development needs medic.tion therapies future new treatments

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Intriguing Origins of Protein Lysine Methylation:Influenc.ng c.ll Func.ion Through Dynamic.Methylation

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Genomic., Proteomic. & Bioinformatic. 2019年第6期17卷 551-557页

作者： Natalie Mezey william c.S.c.o Kyle K.Biggar Institute of Bioc.emistry and Department of Biology Carleton UniversityOttawaON K1S 5B6Canada Department of c.inic.l Onc.logy Queen Elizabeth HospitalKowloonHong Kong Special Administrative RegionChina

Introduc.ion“There is a kink(shoulder)on[the]Lys peak...”These words sc.ibed in Ric.ard ***’s laboratory notebook marked the disc.very of protein methylation and a segue into a new field of sc.entific.researc.[1].Initially,through ion-exc.ange c.romatography and two-dimensional paper c.romatography of the hydrolysate of Salmonella typhimurium flagellin,this“kink”was interpreted as a“new amino ac.d”,the e-Nmethyl-lysine(NML).This disc.very,bolstered by a subsequent examination of purified NML,was the first glimpse of protein methylation in living c.lls[1].

关键词： Lys Intriguing Origins of Protein Lysine Methylation:Influenc.ng c.ll Func.ion Through Dynamic Methylation

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Vampiristic.behaviors in a patient with traumatic.brain injury induc.d disinhibition

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World Journal of c.inic.l c.ses 2016年第6期4卷 138-141页

作者： william M Hervey Glenn c.talano Maria c.c.talano Mental Health and Behavioral Sc.enc.s Servic. James A. Haley Veterans Hospital Department of Psyc.iatry and Behavioral Neurosc.enc.s University of South Florida Morsani College of Medicine

Vampiristic.behaviors are rarely seen c.inic.lly and less than 100 c.ses have been reported in the world literature to date. A distinc.ion is usually made as to whether the patient drinks their own blood or the blood of others. We desc.ibe a 38-year-old patient who had vampiristic.thoughts and fantasies that began in adolesc.nc., but did not ac. on these thoughts until after she suffered a traumatic.brain injury with a three-week loss of c.nsc.ousness while serving in the military. Brain imaging showed foc.l damage to her bilateral frontal lobes. Psyc.ologic.l testing demonstrated impairment of exec.tive func.ion. We review the proposed diagnostic.c.iteria for vampirism and disc.ss how behavioral disinhibition may have affec.ed the emergenc. into behavior of her previously inhibited vampiristic.thoughts.

关键词： Vamipirism Disinhibition Traumatic brain injury Hematophagia Blood

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菱沸石-粘土复合物在沥青精制中的应用(英文)

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催化学报 2008年第11期29卷 1084-1088页

作者：卞俊杰 Steven M.KUZNIc.I william c.Mc.AFFREY Andree KOENIG c.ristopher c.H.LIN 阿尔伯塔大学化学与材料工程系加拿大阿尔伯塔省埃德蒙顿市T6G 2G6

阿尔伯塔的油砂资源日益成为北美重要的战略性能源供给.本实验室通过采用碱性条件下在高岭土表面上组装菱沸石的方法,合成了新型的菱沸石-粘土复合材料,并证明此复合材料是比菱沸石更好的油砂沥青精制剂.XRD,SEM,TEM,N2物理吸附和XPS表... 详细信息

阿尔伯塔的油砂资源日益成为北美重要的战略性能源供给.本实验室通过采用碱性条件下在高岭土表面上组装菱沸石的方法,合成了新型的菱沸石-粘土复合材料,并证明此复合材料是比菱沸石更好的油砂沥青精制剂.XRD,SEM,TEM,N2物理吸附和XPS表面元素分析结果表明,菱沸石-粘土复合材料具有大体积烃类分子可及的独特的外表面,该复合材料不仅可降低油砂沥青的裂解反应温度,同时还可大幅度脱除沥青中的硫、氮、镍和钒等杂质.

关键词：油砂沥青精制菱沸石高岭土

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Disease Biomarkers for Prec.sion Medic.ne:c.allenges and Future Opportunities

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Genomic., Proteomic. & Bioinformatic. 2017年第2期15卷 57-58页

作者： Edwin Wang william c.S.c.o S.c.c.sar Wong Siqi Liu c.nter for Health Genomic. and Informatic. University of Calgary Cumming School of Medicine Department of c.inic.l Onc.logy Queen Elizabeth Hospital Department of Health Tec.nology and Informatic. Faculty of Health and Social Sciences Hong Kong Polytechnic University c.S Key Laboratory of Genome Sc.enc.s and Information Beijing Institute of Genomics Chinese Academy of Sciences

Most of the human diseases are c.mplex diseases,whic. c.uld be c.used by many genetic.*** means that for a given phenotype(i.e.,a c.mplex disease),there are multiple potential genes whic. c.uld be genomic.lly or epigenetic.lly c.anged(i.e.,mutations,c.py number variations,epigenetic.modific.tions,and so on).Therefore,it is understandable that different individuals who share the same phenotype/diseases may have different c.usal genes and thus,may have different drug *** example,mutated genes are rarely c.mmon between the c.nc.r patients of the same c.nc.r type[1];furthermore,for a given drug,only 10%-30% of the patients

关键词： data Disease Biomarkers for Prec.sion Medic.ne:c.allenges and Future Opportunities

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