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Current strategies for targeting the activity of androgen receptor variants

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Asian Journal of Urology 2019年第1期6卷 42-49页

作者： Cameron M.Armstrong allen C.Gao Department of Urology University of CaliforniaDavisSacramentoCAUSA Comprehensive Cancer Center University of CaliforniaDavisSacramentoCAUSA VA Northern California Health Care System SacramentoCAUSA

Current therapies for advanced prostate cancer,such as enzalutamide and abiraterone,focus on inhibiting androgen receptor(AR)activity and reducing downstream signaling pathways to inhibit tumor ***,cancer cells are very adaptable and,over time,these cells develop mechanisms by which they can circumvent *** of the many mechanisms that have been discovered is the generation of AR *** variants are generated through alternative splicing of the full length AR and often lack the ligand binding *** leads to forms of the AR that are constitutively active that continue to promote prostate cancer cell growth even in the absence of *** high prevalence of AR variants and their role in disease progression have prompted a number of studies investigating ways to inhibited AR variant expression and *** these are the antihelminthic drug,niclosamide,which selectively promotes degradation of AR variants over full length AR and re-sensitizes anti-androgen resistant prostate cancer cells to treatment with enzalutamide and *** AR variant targeting mechanisms include interfering with AR variant co-activators and the development of drugs that bind to the DNA or N-terminal AR domains,which are retained in most AR *** clinical efficacy of treating prostate cancer by targeting AR variants is under investigation in several clinical *** this review,we provide an overview of the most relevant AR variants and discuss current AR variant targeting strategies.

关键词： Prostate cancer Androgen receptor variants Drug resistance

Festschrift in Honor of *** McKay——On occasion of his retirement from Department of Chemical and Biomolecular Engineering,the Hong Kong University of Science and Technology

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Chinese Journal of Chemical Engineering 2012年第3期20卷 I0003-I0004页

作者： Koon Fung LAM Stephen allen The Hong Kong University of Science and Technology

Professor Gordon McKay has a long,exciting and distinguished professional career as a chemical *** his early days in industry through to his most recent appointment as professor and Acting Head of Department of Chemical and Biomolecular Engineering at the Hong Kong University of Science and Technology(HKUST),he has made a substantial contribution to the profession.

关键词：香港科技大学生物分子工程化学工程工程学院论文集麦退休术部

Infection control a practical guide for health care facilities George allen ; Cathy Frye, contributing editor

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Adaptive pathways and emerging strategies overcoming treatment resistance in castration resistant prostate cancer

2013年

作者： George allen Cathy Frye

ISBN: (纸本)0735563209;9780735563209

Introduction -- Infection control program infrastructure -- Surveillance and prevention -- Patient care -- Personnel and employee health -- Practice settings -- Visitation guidelines -- Environment -- Overview of facilities management -- Infectious diseases and emerging pathogens -- Accreditation and regulatory compliance.

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Asian Journal of Urology 2016年第4期3卷 185-194页

The therapies available for prostate cancer patients whom progress from hormonesensitive to castration resistant prostate cancer include both systemic drugs,including docetaxel and cabazitaxel,and drugs that inhibit androgen signaling such as enzalutamide and ***,it is estimated that up to 30%of patients have primary resistance to these treatments and over time even those who initially respond to therapy will eventually develop resistance and their disease will continue to progress regardless of the presence of the *** the mechanisms involved in the development of resistance to these therapies has been the area of intense study and several adaptive pathways have been *** receptor(AR)mutations,expression of AR-V7(or other constitutively active androgen receptor variants),intracrine androgen production and overexpression of androgen synthesis enzymes such as Aldo-Keto Reductase Family 1,Member C3(AKR1C3)are among the many mechanisms associated with resistance to *** regards to the taxanes,one of the key contributors to drug resistance is increased drug efflux through ATP Binding Cassette Subfamily B Member 1(ABCB1).Targeting these resistance mechanisms using different strategies has led to various levels of success in overcoming resistance to current *** instance,targeting AR-V7 with niclosamide or AKR1C3 with indomethacin can improve enzalutamide and abiraterone ***1 transport activity can be inhibited by the dietary constituent apigenin and antiandrogens such as bicalutamide which in turn improves response to docetaxel.A more thorough understanding of how drug resistance develops will lead to improved treatment *** review will cover the current knowledge of resistance mechanisms to castration resistant prostate cancer therapies and methods that have been identified which may improve treatment response.

关键词： Prostate cancer Castration resistant prostate cancer Enzalutamide Abiraterone Docetaxel Drug resistance

The effect of adjunct caudal block on postoperative analgesia in robot-assisted laparoscopic radical prostatectomy: A prospective randomized controlled, single blinded pilot study in a tertiary centre

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Asian Journal of Urology 2018年第2期5卷 122-126页

作者： Kenneth Chen allen Sim Alex Ford Kan Department of Urology Singapore General HospitalSingapore Department of Anaesthesiology Singapore General HospitalSingapore

Objective:Caudal block provides satisfactory postoperative pain relief in lower abdominal *** pilot study explores its safety and effect on postoperative pain control in patients who underwent robot-assisted laparoscopic radical prostatectomy(RARP).Methods:From 2013 to 2014,40 consecutive patients were randomized into two groups d one received caudal block using ropivacaine immediately after operation,the other received standard *** outcome measure was pain score based on 11-point Likert scale(0e10)recorded at recovery room,and at 6,12,24,48,and 72 h after *** analgesic requirements,opioid-related adverse events and time to passage of flatus were ***:Mean age of the two groups was similar(60.4 vs.62.3 years,p Z 0.33),as was American Society of Anaesthesiologists(ASA)class,body mass index(BMI)and operation *** significant difference in median pain scores was reported in recovery room(2 vs.3,p Z 0.34),and at 6 h(2 vs.2,p Z 0.94),12 h(0 vs.0,p Z 0.62),24 h(1 vs.0,p Z 0.58),48 h(1 vs.0,p Z 0.36)and 72 h(0 vs.0,p Z 0.78)postoperatively between control and caudal block groups,*** was a higher mean opioid usage in the caudal block group which was not statistically *** this was statistically insignificant while no significant difference in mean paracetamol usage was observed *** time to passage of flatus was similar(2.0 vs.2.0 days,p Z 0.97).There was one case of superficial wound infection and no opioid-related adverse events *** stay was similar in both groups(2.5 vs.2.5 days,p Z 0.96).

关键词： Caudal block Robotic radical prostatectomy Post-operative pain Analgesia Opioid

Agronomy, Nutritional Value, and Medicinal Application of Faba Bean(Vicia faba L.)

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Horticultural Plant Journal 2019年第4期5卷 170-182页

作者： Fatemeh Etemadi Masoud Hashemi allen V.Barker Omid Reza Zandvakili Xiaobing Liu Stockbridge School of Agriculture University of Massachusetts AmherstMA01003USA Northeast Institute of Geography and Agroecology Chinese Academy of SciencesHarbin150081China

Faba bean(Vicia faba L.) is a cool season grain legume crop with the potential to be grown as multi-purpose crop in areas with short growing season. Faba bean is grown in many regions in the world due to its high nutritional value, medicinal effect, and effective biological nitrogen fixation. Diverse ecosystem benefits are expected from integrating faba bean in cropping systems. This paper specifically reviews the published work covering agronomic practices, nutritional values, medicinal benefits, and faba bean’s capacity for nitrogen fixation.

关键词： Biomass Faba bean L-Dopa Nitrogen fixation Nutrient

Commentary on impact of pulmonary function on robotic pulmonary resection

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Laparoscopic, Endoscopic and Robotic Surgery 2021年第3期4卷 93-94页

作者： Anthony Le Matheus Carelli allen Guo Christopher Cao Department of Cardiothoracic Surgery Royal Prince Alfred HospitalSydney UniversitySydneyAustralia The Baird Institute for Applied Heart and Lung Surgical Research SydneyAustralia Chris O'Brien Lifehouse SydneyAustralia

Buitrago and colleagues should be commended on an excellent case report on the effective use of the robotic platform for a successful minimally invasive left lower lobectomy for a patient with biopsy proven squamous cell carcinoma.1 Despite a predicted postoperative forced expiratory volume in one second(ppoFEV1)of 23%and a preoperative diffusing capacity for carbon monoxide(DLCO)of 21%,the patient underwent a lobectomy without any intraoperative complications or evidence of disease at 15 months *** node sampling was performed from 5 *** postoperative length of staywas not clearly *** authors made several interesting points about the impact of pulmonary function on postoperative outcomes,the oncological efficacy of lobectomy versus sublobar resections,and merits of roboticassisted thoracoscopic surgery(RATS)versus thoracotomy and conventional video-assisted thoracoscopic surgery(VATS).We would like to discuss these points in further detail based on the available evidence in the current literature.

关键词： Pulmonary function Lung cancer Robot-assisted thoracoscopic surgery Lobectomy

Atrial fibrillation in the elderly: Is ablation ready for prime time ?

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Journal of Geriatric Cardiology 2005年第2期2卷 101-102页

作者： allen J. Solomon George Washington University Hospital

Atrial fibrillation is the most common sustained arrhythmia and results in significant morbidity, especially in the elderly. The prevalence of atrial fibrillation increases dramatically with advancing age to almost 6% in individuals older than 65 years. In fact, 84% of people with atrial fibrillation are over 65 years of age.1 Additionally, the risk of stroke increases with advancing age, such that one-third of strokes in patients over the age of 65 are caused by atrial fibrillation.

关键词： Is ablation ready for prime time Atrial fibrillation in the elderly

Detrital zircon U-Pb-He double dating: A method of quantifying long- and short-term exhumation rates in collisional orogens

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Science China Earth Sciences 2014年第11期57卷 2702-2711页

作者： Christina Yan WANG Ian H.CAMPBELL Peter W.REINERS Charlotte M.allen Key Laboratory of Mineralogy and Metallogeny Guangzhou Institute of Geochemistry Chinese Academy of Sciences Research School of Earth Sciences The Australian National UniversityCanberra ACT 0200 Australia Department of Geosciences University of ArizonaTucson AZ 85721 USA

A U-Pb-He double-dating method is applied to detrital zircons with core-rim structure from the Ganges River in order to de- termine average short and long-term exhumation rates for the Himalayas. Long-term rates are calculated from the U/Pb ages of metamorphic rims of the grains that formed during the Himalayan orogeny and their crystallization temperatures, which are calculated from the Ti-in-zircon thermometer. Short-term rates are calculated from （U-Th）/He ages of the grains with appro- priate closure temperatures. The results show that short-term rates for the Himalayas, which range from 0.70 ± 0.09 to 2.67 ± 0.40 km/Myr and average 1.75 ± 0.59 （1δ） km/Myr, are higher and more varied than the long-term rates, which range from 0.84 ±0.16 to 1.85 ± 0.35 km/Myr and average 1.26 ±0.25 （let） km/Myr. The differences between the long-term and short-term rates can be attributed to continuous exhumation of the host rocks in different mechanisms in continental collision orogen. The U/Pb ages of 44.0 ± 3.7 to 18.3 ±0.5 Ma for the zircon rims indicate a protracted episode of -：25 Myr for regional metamorphism of the host rocks at deeper crust, whereas the （U-Th）/He ages of 42.2 ± 1.8 to 1.3 ± 0.2 Ma for the zircon grains represent a protracted period of -40 Myr for exposure of the host rocks to shallower crustal level. In particular, the oldest （U-Th）/He ages of the zircon grains are close to the oldest U/Pb ages for the rims, indicating that some parcels of the rocks that contain zircons were rapidly exhumed from deep to shallow levels in the stage of collisional orogeny. On the other hand, some parcels of the rocks may have been carried upwards by thrust faults in the post-collisional stage. The parcels could be carried upwards by the thrust faults that steepen as they near the surface, or by transient movement faults so that areas of rapid exhu- mation became areas of slow exhumation and visa versa on a time scale of a few Myr in order to maintain the continuous ex- huma

关键词： zircon U-Pb-He double-dating method Himalayas exhumation rate collisional orogen