检索结果-南通市图书馆

A plant-based diet and hypertension

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2017年第5期14卷 327-330页

作者： Sarah Alexander Robert J Ostfeld Kathleen allen Kim A williams Rush University Medical Center Division of Cardiology Chicago IL USA Montefiore Medical Center Division of Cardiology Bronx NY USA New York University Department of Nutrition & Food Studies NY USA

Hypertension is an insidious, common, and deadly dis-ease, often detected incidentally at a routine doctor＇s visit orworkplace health screening. Worldwide, it is estimated thatone billion people have hypertension and... 详细信息

关键词： Hypertension Vegan Vegetarian Plant-based diet

On environmental threats to male infertility

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2013年第2期15卷 199-200,I0005页

作者： allen J Wilcox Jens Peter E Bonde Epidemiology Branch National Institute of Environmental Health Sciences Durham NC 27709-2233 USA Department of Occupational and Environmental Medicine University Hospital of Copenhagen Copenhagen NV DK-2400 Denmark

The possibility that environmental pollutants damage human fertility is a topic of both public concern and scientific interest. The effect of environmental factors on male fertility （semen parameters） has been a special focus, stimulated in part by the dramatic damage inflicted by the pcstlcide DBCP on testicular function. Extensive searches for testicular toxicants （in particular, the proposed effects of endocrine-disrupting compounds through fetal exposure） have produced little hard evidence of impairment in humans. This scarcity of evidence may reflect the difficultles of studying human fertility. Future fertifity studies should consider the wide spectrum of environmental exposures that plausibly affect reproduction.

关键词： TESTICULAR DYSGENESIS SYNDROME IN-UTERO EXPOSURE SPERM COUNTS SEMEN QUALITY ENDOCRINE DISRUPTION REPRODUCTIVE-TRACT FERTILITY PREGNANCY PHTHALATE SMOKING

Screening antioxidants for the protection of cochlear sensory cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第1期13卷 62-64页

作者： Dong Gu Hur Arwa Kurabi allen F.Ryan Department of Surgery/Otolaryngology School of Medicine University of CaliforniaSan Diego Department of Otorhinolaryngology Gyeongsang National University Changwon Hospital Research Service Veterans Administration Medical Center

Sensory cell damage is a major cause of hearing loss： Sensorineural hearing loss （SNHL） is a common sensory deficit characterized by tissue damage and/or cell death in the cochlea. Moderate and severe SNHL causes deficits in communication, associated with increased isolation from human relationships, and negativly impacts employabflity. Many etiologies have been associated with SNHL： Noise overexposure, certain drugs, inner or middle ear infection or immune-induced inflammation being common. However, the most prevalent form of SNHL is presbycusis or age-related hearing loss, often aggravated by other factors including a history of noise exposure, diabetes or high blood pressure （Wong and Ryan, 2015）. Though systemic steroids are used in the treatment of sudden SNHL, other drugs to prevent or cure hearing loss have not yet been developed. Cochlear sensory cells, known as hair cells （HCs） and neurons have very limited repair capacity. Moreover since these cells do not regenerate, making any loss permanent, prevention of cell damage is critical to protecting hearing.

关键词： HC Screening antioxidants for the protection of cochlear sensory cells

Engineered human pluripotent stem cell-derived natural killer cells with PD-L1 responsive immunological memory for enhanced immunotherapeutic efficacy

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第9期27卷 168-180页

作者： Yun Chang Gyuhyung Jin Weichuan Luo Qian Luo Juhyung Jung Sydney N.Hummel Sandra Torregrosa-allen Bennett D.Elzey Philip S.Low Xiaojun Lance Lian Xiaoping Bao Davidson School of Chemical Engineering Purdue UniversityWest LafayetteIN47907USA Purdue University Institute for Cancer Research West LafayetteIN47907USA Department of Comparative Pathobiology Purdue UniversityWest LafayetteIN 47907USA Department of Chemistry Purdue UniversityWest LafayetteIN47907USA Department of Biomedical Engineering The Huck Institutes of the Life SciencesDepartment of BiologyThe Pennsylvania State UniversityUniversity ParkPA16802USA

Adoptive chimeric antigen receptor(CAR)-engineered natural killer(NK)cells have shown promise in treating various ***,limited immunological memory and access to sufficient numbers of allogenic donor cells have hindered their broader preclinical and clinical ***,we first assess eight different CAR constructs that use an anti-PD-L1 nanobody and/or universal anti-fluorescein(FITC)single-chain variable fragment(scFv)to enhance antigen-specific proliferation and anti-tumor cytotoxicity of NK-92 cells against heterogenous solid *** next genetically engineer human pluripotent stem cells(hPSCs)with optimized CARs and differentiate them into functional dual CAR-NK *** tumor microenvironment responsive anti-PD-L1 CAR effectively promoted hPSC-NK cell proliferation and cytotoxicity through antigen-dependent activation of phosphorylated STAT3(pSTAT3)and pSTAT5 signaling pathways via an intracellular truncated IL-2 receptorβ-chain(ΔIL-2Rβ)and STAT3-binding tyrosine-X-X-glutamine(YXXQ)***-tumor activities of PD-L1-induced memory-like hPSC-NK cells were further boosted by administering a FITC-folate bi-specific adapter that bridges between a programmable anti-FITC CAR and folate receptor alpha-expressing breast tumor ***,our hPSC CAR-NK engineering platform is modular and could constitute a realistic strategy to manufacture off-the-shelf CAR-NK cells with immunological memory-like phenotype for targeted immunotherapy.

关键词： Natural killer cells Human pluripotent stem cells Immunological memory Immunotherapy Chimeric antigen receptor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

助力玻璃工业脱碳：耐火材料解决方案的角色

助力玻璃工业脱碳：耐火材料解决方案的角色

A primer on stochastic epidemic models:Formulation,numerical simulation,and analysis

第25届全国玻璃窑炉技术研讨交流会

作者： Michel Gaubil Mélanie allen LARUT 法国西普耐火材料

除了以最优成本可持续生产高质量玻璃这样的典型挑战外,玻璃行业正面临着新的转变和挑战:碳中和以及循环经济。实现低碳玻璃生产是玻璃行业未来几年的第一个关键挑战。许多政府和公司已经宣布了在未来几十年实现碳中和的明确目标,而玻... 详细信息

除了以最优成本可持续生产高质量玻璃这样的典型挑战外,玻璃行业正面临着新的转变和挑战:碳中和以及循环经济。实现低碳玻璃生产是玻璃行业未来几年的第一个关键挑战。许多政府和公司已经宣布了在未来几十年实现碳中和的明确目标,而玻璃工业也必须发挥它的作用。循环经济是玻璃产业面临的第二大挑战。除了增加对破碎料的使用率,还必须考虑窑炉的整个生命周期,包括其寿命的结束和耐火材料的回收。耐火材料解决方案对玻璃窑炉及其性能是必不可少的一环。因此,其在支持玻璃制造商应对这些新挑战方面发挥着关键作用。

关键词：玻璃工业挂钩砖碳中和

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Infectious Disease Modelling 2017年第2期2卷 128-142页

作者： Linda J.S.allen Department of Mathematics and Statistics Texas Tech UniversityLubbockTX 79409-1042USA

Some mathematical methods for formulation and numerical simulation of stochastic epidemic models are ***,models are formulated for continuous-time Markov chains and stochastic differential *** well-known examples are used for illustration such as an SIR epidemic model and a host-vector malaria *** methods for approximating the probability of a disease outbreak are also discussed.

关键词： Branching process Continuous-time Markov chain Minor outbreak Stochastic differential equation

On the gating of mechanosensitive channels by fluid shear stress

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2016年第6期32卷 1012-1022页

作者： Zhangli Peng On Shun Pak Zhe Feng allen P.Liu Yuan-Nan Young Department of Aerospace and Mechanical Engineering University of Notre Dame Department of Mechanical Engineering Santa Clara University Department of Mechanical Engineering University of Michigan Department of Mathematical Sciences New Jersey Institute of Technology

Mechanosensation is an important process in biological fluid-structure interaction. To understand the biophysics underlying mechanosensation, it is essential to quantify the correlation between membrane deformation, membrane tension, external fluid shear stress, and conformation of mechanosensitive (MS) channels. Smoothed dissipative particle dynamics (SDPD) simulations of vesicle/cell in three types of flow configurations are conducted to calculate the tension in lipid membrane due to fluid shear stress from the surrounding viscous flow. In combination with a simple continuum model for an MS channel, SDPD simulation results suggest that shearing adhered vesicles/cells is more effective to induce membrane tension sufficient to stretch MS channels open than a free shear flow or a constrictive channel flow. In addition, we incorporate the bilayer-cytoskeletal interaction in a two-component model to probe the effects of a cytoskeletal network on the gating of MS channels.

关键词： Fluid-lipid membrane interaction Viscous flow Mechanosensitive channels Membrane tension

The contribution of fungi to the global economy

在线全文

学校读者我要写书评

暂无评论

Fungal Diversity 2023年第4期121卷 95-137页

作者： allen Grace T.Niego Christopher Lambert Peter Mortimer Naritsada Thongklang Sylvie Rapior Miriam Grosse Hedda Schrey Esteban Charria‑Girón Arttapon Walker Kevin D.Hyde Marc Stadler School of Science Mae Fah Luang UniversityChiang RaiThailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang RaiThailand Iloilo Science and Technology University La Paz5000 IloiloPhilippines Department Microbial Drugs Helmholtz Centre for Infection ResearchInhoffenstrasse 738124 BrunswickGermany Institute of Microbiology Technische Universitat BraunschweigSpielmannstrase 738106 BrunswickGermany Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China Laboratory of Botany Phytochemistry and MycologyFaculty of PharmacyCS 1449115 Avenue Charles Flahault34093 Montpellier Cedex 5France CEFE CNRSUniv MontpellierEPHEIRDCS 1449115 Avenue Charles Flahault34093 Montpellier Cedex 5France Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Institute for Plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225People’s Republic of China

Fungi provide ecological and environmental services to humans, as well as health and nutritional benefits, and are vital to numerousindustries. Fermented food and beverage products from fungi are circulating in the market, generating billions of ***, the highest potential monetary value of fungi is their role in blue carbon trading because of their ability to sequesterlarge amounts of carbon in the soil. There are no conclusive estimates available on the global monetary value of fungi, primarilybecause there are limited data for extrapolation. This study outlines the contribution of fungi to the global economy and providesa first attempt at quantifying the global monetary value of fungi. Our estimate of USD 54.57 trillion provides a starting point thatcan be analysed and improved, highlighting the significance of fungi and providing an appreciation of their value. This paperidentifies the different economically valuable products and services provided by fungi. By giving a monetary value to all importantfungal products, services, and industrial applications underscores their significance in biodiversity and conservation. Furthermore,if the value of fungi is well established, they will be considered in future policies for effective ecosystem management.

关键词： Fungi-based food Medicinal mushrooms Market value Environmental biotechnology

Influences and drivers of woody debris movement in urban watercourses

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2014年第8期57卷 1512-1521页

作者： allen Deonie ARTHUR Scott HAYNES Heather WALLIS Stephen G WALLERSTEIN Nicholas Institute for Infrastructure and Environment Heriot-Watt University

It is recognised that the blockage of culverts by woody debris can result in an increased risk of infrastructure damage and *** date,debris transport analysis has focused on regional fluvial systems and large woody debris,both in flume and field *** the social and economic risk associated with urban flooding,and as urban drainage design shifts away from subsurface piped network reliance,there is an increasing need to understand debris movement in urban *** prediction of urban watercourse small woody debris(SWD)movement,both quantity and risk,has undergone only limited analysis predominantly due to lack of field *** paper describes the development of a methodology to enable the collection of accurate and meaningful SWD residency and transportation data from *** presented research examines the limitations and effective function of PIT tag technology to collect SWD transport data in the field appropriate for risk and prediction *** integrated transponder(PIT)technology provides a method to collect debris transport data within the urban *** this study,the tags are installed within small woody debris and released at known locations into a small urban natural watercourse enabling monitoring of movement and travel *** velocity and detention are collated with solute time of travel,watercourse and point flow characteristics to identify the relationships between these key *** work presented tests three hypotheses:firstly,that the potential for unobstructed or un-detained SWD movement increases with flow velocity and water ***,that SWD travel distance,and the resistance forces along this travel path,influence SWD transport ***,the relationship between SWD and channel dimensions is examined with the aim of advancing representative debris transport prediction modelling.

关键词：城市河道运动木质经济风险驾驶交通分析预测分析旅行时间