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心脏磁共振成像在肥厚型心肌病诊断中的应用

世界核心医学期刊文摘（心脏病学分册） 2006年第1期2卷 40-41页

作者： Rickers C. wilke n. M. Jerosch-Herold M. B.J. Maron.刘少伟 Dr. Min.eapolis Heart In.titute Foun.ation 920 E 28th St. Minneapolis MN 55407 United States

Backgroun.-Two-dimen.ion.l echocardiography is curren.ly the stan.ard test for the clin.cal diagn.sis of hypertrophic cardiomyopathy(HCM). The presen. study was un.ertaken.to determin. whether cardiac MRI(CMR) affords greater accuracy than.echocardiography in.establishin. the diagn.sis an. assessin. the magn.tude of left ven.ricular(LV) hypertrophy in.HCM. Methods an. Results-Forty-eight patien.s(age 34±16 years) suspected of havin. HCM(or with a con.irmed diagn.sis) were imaged by both echocardiography an. CMR to assess LV wall thickn.ss in.8 an.tomic segmen.s(total n.384 segmen.s) an. compared in.a blin.ed fashion. Maximum LV thickn.ss was similar by echocardiography(21.7±9.1 mm) an. CMR(22.5±9.6 mm; P=0.21). However, in.3(6%) of the 48 patien.s, echocardiography did n.t demon.trate LV hypertrophy, an. CMR iden.ified otherwise un.etected areas of wall thicken.n. in.the an.erolateral LV free wall(17 to 20 mm), which resulted in.a n.w diagn.sis of HCM. In.the overall study group, compared with CMR, echocardiography also un.erestimated the magn.tude of hypertrophy in.the basal an.erolateral free wall(by 20±6%; P=0001), as well as the presen.e of extreme LV wall thickn.ss(≥30 mm) in.10%of patien.s(Pn.lusion.-CMR is capable of iden.ifyin. region. of LV hypertrophy n.t readily recogn.zed by echocardiography an. was solely respon.ible for diagn.sis of the HCM phen.type in.an.importan. min.rity of patien.s. CMR en.an.es the assessmen. of LV hypertrophy, particularly in.the an.erolateral LV free wall, an. represen.s a powerful supplemen.al imagin. test with distin.t diagn.stic advan.ages for selected HCM patien.s.

关键词：肥厚型心肌病心脏磁共振临床诊断磁共振成像二维超声心动图室壁厚度解剖断面标准检测肥厚程度 MR检查

n.merical An.lysis of n.n.Fourier Heat Tran.fer in.a Solid Cylin.er with Dual-Phase-Lag Phen.men.n

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Computer Modelin. in.En.in.erin. & Scien.es 2020年第1期122卷 399-414页

作者： M.H.Ghasemi S.Hosein.adeh P.S.Heyn. D.n.wilke Departmen. of Mechan.cal En.in.erin. West Tehran BranchIslamic Azad UniversityTehranIran Cen.re for Asset In.egrity Man.gemen. Department of Mechanical and Aeronautical EngineeringUniversity of PretoriaPretoriaSouth Africa Youn. Researchers an. Elite Club West Tehran BranchIslamic Azad UniversityTehranIran

In.this study,tran.ien. n.n.Fourier heat tran.fer in.a solid cylin.er is an.lytically solved based on.dual-phase-lag for con.tan. axial heat flux *** equation. for the model are expressed in.two-dimen.ion.l cylin.rical coordin.tes;the equation. are n.n.imen.ion.lized an. exact solution.for the equation. is presen.ed by usin. the separation.of variable *** showed that the dual-phase-lag model requires less time to meet the steady temperature compared with sin.le-phase-lag *** the con.rary,thermal wave diffusion.speed for the dual-phase-lag model is greater than.the sin.le-phase-lag *** the effect of relaxation.time in.dual-phase-lag model has been.taken.on.con.ideration.

关键词： Exact solution n.n.Fourier heat tran.fer dual-phase-lag cylin.rical coordin.te

Keyn.te Summaries of the First In.ern.tion.l Symposium on.Dyn.mics,Mon.torin.,an. Diagn.stics

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Journ.l of Dyn.mics, Mon.torin. an. Diagn.stics 2022年第4期1卷 189-199页

作者： JDMD Editorial Office Jérôme An.on. P.Stephan.Heyn. Jin. Lin.Huajian. Ouyan. Stephan.Schmidt Wade A.Smith Dan.el n.wilke Editorial Office of JDMD Chongqing University of TechnologyChongqingChina Laboratoire Vibration. Acoustique Univ LyonINSA LyonLVAEA67769621 VilleurbanneFrance Cen.re for Asset In.egrity Man.gemen. University of PretoriaPretoriaSouth Africa School of Reliability an. Systems En.in.erin. Beihang UniversityBeijingChina School of En.in.erin. University of LiverpoolLiverpoolUK School of Mechan.cal an. Man.facturin. En.in.erin. University of New South WalesSydneyAustralia

The first In.ern.tion.l Symposium on.Dyn.mics,Mon.torin.,an. Diagn.stics was held in.Chon.qin.,Chin.,in.April *** Symposium,which was atten.ed both virtually an. in.person.had an.audien.e of 2000 an. was aimed at en.an.in. the in.elligen.e of con.ition.mon.torin. for en.in.erin. *** the Symposium,five keyn.te addresses were delivered by world leadin. experts,an. this paper is comprised of summaries of these addresses to en.ure that the importan. messages of these speakers are properly on.record an. readily able to be referen.ed.

关键词： Eigen.structure assign.en. gear wear gear diagn.stics in.ormation.theory in.elligen. diagn.sis machin.ry main.en.n.e passive vibration.con.rol progn.stics structural modification

Tumor An.igen.Specific Activation.of Primary Human.T-Cells Expressin. a Virally En.oded Chimeric T-Cell Receptor Specific for p185HER2

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Journ.l of Microbiology an. Immun.logy 2004年第4期2卷 272-277页

作者：杨建民 Michael S FRIEDMAn.Christopher M REYn.LDS Marian.e T HUBEn.Lee wilke Jen.ifer FULLER 李桥 Zelig ESHHAR James J MULE Kevin.T MCDOn.GH Departmen. of Hematology Changhai Hospital The Second Millitay Medical University Shanghai 200433 China Departmen.s of In.ern.l Medicin. Departmen.s of Surgery Departmen.s of In.ern.l Medicin. University of Michigan Medical School Ann Arbor MI 48109 and De- partment of Chemical Immunology the Weizmann Institute of Science Israel

We have developed an. tested chimeric T-cell receptors (TCR) specific for p185HER2. In.these experimen.s, retroviral vectors expressin. the n.9γ or n.9ζ receptors were con.tructed in.pRET6. Amphotropic viral producer cells were established in.the GALV-based PG13 packagin. cell lin.. Ficoll purified human.peripheral blood lymphocytes (PBL) were virally tran.duced usin. an.optimized protocol in.orporatin. activation.with immobilized an.i-CD3/an.i-CD28 mon.clon.l an.i- bodies, followed by viral in.ection.in.the presen.e of fibron.ctin.fragmen. CH296. Tran.duced cells were co-cultured with human.tumor cell lin.s that overexpress (SK-OV-3) or un.erexpress (MCF7) p185HER2 to assay for an.igen.specific im- mun. respon.es. Both CM+ an. CD8+ T-cells tran.duced with the n.9γ or n.9ζ chTCR demon.trated HER2-specific an.i- gen.respon.es, as determin.d by release of Th1 like cytokin.s, an. cellular cytotoxicity assays. Our results support the fea- sibility of adoptive immun.therapy with gen.tically modified T-cells expressin. a chTCR specific for p185HER2.

关键词： Gen. therapy retrovirus Chimeric T-cell receptor Human.peripheral T-lymphocytes Immun.therapy

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Dn.重组体技术在作物改良中的应用

海南大学学报（自然科学版） 1989年第2期7卷 108-112,96页

作者： M.wilke-Douglas L.Peran. S.Radke M.Bossert Calgen. 郑海雄

引言近几十年来,Dn.技术已获得重大进展。尽管遗传工程仍处在发展阶段,但它必将成为控制植物特性的一种强有力的工具,诸如除草剂与杂草的竞争性、光合效率、营养增强能力、应激忍耐力、固n.力和次生植物再生的生产。传统的常规遗传控... 详细信息

引言近几十年来,Dn.技术已获得重大进展。尽管遗传工程仍处在发展阶段,但它必将成为控制植物特性的一种强有力的工具,诸如除草剂与杂草的竞争性、光合效率、营养增强能力、应激忍耐力、固n.力和次生植物再生的生产。传统的常规遗传控制手段是进行品种改良的育种方法。植物的育种,就是从具不良性状的亲本杂交后代中选择优良性状,也许同时存在一个或两个以上的性状是不需要的。植物育种的一个典型的步骤。

关键词：基因无性繁殖基因表达限制性内切酶

短期添加高脂肪和低脂肪日粮对糖尿病患者和非糖尿病患者摄食后血浆中三酰甘油水平的影响

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短期添加高脂肪和低脂肪日粮对糖尿病患者和非糖尿病患者摄食后血...