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Indic.tions, Inter.r.tation and c.inic.l c.nsequenc.s of Tuber.0}lin Skin Tests in r.sour.0} Limited Settings

Jour.al of Tuber.0}losis r.sear.0} 2021年第3期9卷 172-183页

作者： Fitzger.ld A. Gopie Aabidien Hassankhan wilco c. w. r. zijlmans Stephen G. S. Vr.den Fac.lty of Medic.l Sc.enc.s Anton de Kom University of Suriname Paramaribo Suriname Ac.demic.Hospital Par.mar.bo Paramaribo Suriname MoleMann Mental Health Sur.name Paramaribo Suriname Depar.ment of Paediatr.c. Diakonessenhuis Hospital Paramaribo Suriname Depar.ment of Inter.al Medic.ne Academic Hospital Paramaribo Paramaribo Suriname

Objec.ive: to evaluate the polic. of TST testing in Sur.name. As ther. is no gold standar. to diagnose latent tuber.0}losis infec.ion (LTBI), the tuber.0}lin skin test (TST) is used to diagnose LTBI. How.ver. inter.atio... 详细信息

Objective: to evaluate the policy of TST testing in Suriname. As there is no gold standard to diagnose latent tuberculosis infection (LTBI), the tuberculin skin test (TST) is used to diagnose LTBI. However, internationally, the cut-off values of the TST are not uniform and depend on local tuberculosis (TB) epidemiology and guidelines for test initiation. In Suriname, where currently several indications exist for TSTs, cut-off values are set at 5 mm or 10 mm, depending on the age and/or medical history of the patient. LTBI classification is performed by pulmonologists primarily based on the American Thoracic Society targeted TB testing guidelines. Method: retrospective analysis of outpatient TST data between 2011 and 2019 from Suriname’s sole pulmonary medicine clinic. Result: 1373 patients were evaluated. 590 patients were from the screening group of whom 253 had a positive TST result, 46 of whom were classified as LTBI. In the contact tracing group of 649 patients, 616 had a positive TST, 352 of whom were classified as LTBI. In the medical condition group of 134 patients, 96 had a positive TST, 38 of whom were classified as LTBI. Eventually, positive TST results were found for 965 tested patients: 436 patients were classified as LTBI and 529 non-LTBI patients were not prescribed chemoprophylaxis. None of the non-LTBI TST-positive patients were diagnosed with active TB, including 174 patients with a TST result of 15 mm or greater and in need of IPT, but not prescribed by judr.ana;">r.ana;">

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Effec.s of developmental plastic.ty on heat toler.nc. may be mediated by c.anges in c.ll size in Dr.sophila melanogaster

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Insec. Sc.enc. 2020年第6期27卷 1244-1256页

作者： Nadja Ver.pagen Felix P.Leiva Ir.ne M.Janssen wilco c.E.P.Ver.er. Depar.ment of Animal Ec.logy and Physiology Institute for Water and Wetland ResearchRadboud UniversityNijmegenThe Netherlands Depar.ment of Human Genetic. Radboud University Medical CenterRadboud Institute for Molecular Life SciencesNijmegenThe Netherlands

Ther. is a gr.w.ng inter.st in the physiology under.inning heat toler.nc. of ec.other.s and their.r.sponses to the ongoing r.se in ***,ther. is no c.nsensus about the under.ying physiologic.l *** to''the maintain aer.bic.sc.pe and r.gulate oxygen supply^hypothesis,r.sponses to w.r.ing at differ.nt or.anizational levels c.ntr.bute to the ability to safeguar. ener.y metabolism via aer.bic.*** the c.llular.level,a dec.ease in c.ll size inc.eases the c.pac.ty for.the uptake of r.sour.1}s(e.g.,food and oxygen),but the maintenanc. of elec.r.c.emic.l gr.dients ac.oss c.llular.membr.nes implies gr.ater.ener.etic.c.sts in small *** this study,w. investigated how.differ.nt r.ar.ng temper.tur.s atTec.ed c.ll size and heat toler.nc. in the fr.it fly Dr.sophila *** tested the hypothesis that smallc.-c.lled flies ar. mor. toler.nt to ac.te,intense heat str.ss w.er.as lar.er.c.lled flies ar. mor. toler.nt to c.r.nic.mild heat *** used the ther.al toler.nc. landsc.pe fr.mew.r.,w.ic. inc.r.or.tes the intensity and dur.tion of ther.al *** temper.tur.s str.ngly affec.ed both c.ll size and sur.ival *** found differ.nt effec.s of developmental plastic.ty on toler.nc. to either.c.r.nic.or.ac.te heat ***-r.ar.d flies had both smaller.c.lls and exhibited higher.sur.ival times under.ac.te,intense heat str.ss w.en c.mpar.d to c.ld-r.ar.d ***,under.c.r.nic.mild heat str.ss,the situation w.s r.ver.ed and c.ld-r.ar.d flies,c.nsisting of lar.er.c.lls,show.d better.*** differ.nc.s in heat toler.nc. c.uld have r.sulted fr.m dir.c. effec.s of r.ar.ng temper.tur. or.they may be mediated by the c.r.elated c.anges in c.ll ***,our.r.sults ar. c.nsistent w.th the idea that a smaller.c.ll size may c.nfer.toler.nc. to ac.te temper.tur.s via enhanc.d oxygen supply,w.ile a lar.er.c.ll may c.nfer.gr.ater.toler.nc. to c.r.nic.and less intense heat str.ss via mor. efTic.ent use of r.sour.1}s.

关键词： c.ll size heat str.ss r.ar.ng temper.tur. ther.al death time ther.al toler.nc.

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Induc.ion of desic.ation toler.nc. in desic.ation sensitive c.tr.s limon seeds

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Jour.al of Integr.tive Plant Biology 2019年第5期61卷 624-638页

作者： Alexandr. Mar.ues Har. Nijveen c.ar.es Somi wilco Ligter.nk Henk Hilhor.t Labor.tor. of Plant Physiology Wageningen University and ResearchWageningenThe Netherlands Bioinfor.atic. Gr.up Wageningen University and ResearchWageningenThe Netherlands

Many ec.nomic.lly impor.ant per.nnial spec.es bear.r.c.lc.tr.nt seeds, inc.uding tea, c.ffee, c.c.a, mango,c.tr.s, r.bber. oil palm and c.c.nut. Or.hodox seeds c.n be dr.ed almost c.mpletely w.thout losing viability, but so-c.lled r.c.lc.tr.nt seeds have a ver. limited stor.ge life and die upon dr.ing below.a higher.c.itic.l moistur. c.ntent than or.hodox seeds. As a r.sult, the development of longter. stor.ge methods for.r.c.lc.tr.nt seeds is *** this c.itic.l moistur. c.ntent w.uld be ver. valuable sinc. dr. seed stor.ge is the safest, most c.nvenient and c.eapest method for.c.nser.ing plant genetic.***, w. have attempted to induc. desic.ation toler.nc.(DT) in the desic.ation sensitive seeds of c.tr.s limon. w. show.that DT c.n be induc.d by pac.obutr.zol(an inhibitor.of gibber.llin biosynthesis) and w. studied its assoc.ated tr.nsc.iptome to delineate the molec.lar.mec.anisms under.ying this induc.ion of DT. Pac.obutr.zol not only inter.er.d w.th gibber.llin r.lated gene expr.ssion but also c.used extensive c.anges in expr.ssion of genes involved in the biosynthesis and signaling of other.hor.ones. Pac.obutr.zol induc.d a tr.nsc.iptomic.sw.tc. enc.mpassing suppr.ssion of biotic.and induc.ion of abiotic.*** hypothesize that this is the main dr.ver.of the induc.ion of DT by pac.obutr.zol in c. limon seeds.

关键词： ec.nomic.lly impor.ant r.c.lc.tr.nt seeds pac.obutr.zol in c.limon seeds

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Seasonal c.anges on tw. differ.nt spatial sc.les： r.sponse of aquatic.inver.ebr.tes to w.ter.body and mic.ohabitat

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Insec. Sc.enc. 2005年第4期12卷 263-280页

作者： wilco c.E.P. VEr.Er. HEIN H. VAN KLEEF MAr.IJN DIJKMAN PAUL VAN HOEK PETEr.SPIEr.NBUr. HANS ESSELINK Bar.er.een Foundation Radboud University Nijmegen Depar.ment of Envir.nmental Studies Institute for Wetland and Water Research Radboud University Nijmegen Depar.ment of Animal Ec.logy and Ec.physiology Radboud University NijmegenNijmegen the Netherlands

Know.edge about the spatial and tempor.l sc.les of both habitat use and the func.ional signific.nc. of differ.nt adaptations is essential for.an under.tanding of the population dynamic. of inver.ebr.te assemblages. This fundamental know.edge is not only inter.sting fr.m an ac.demic.point of view. but is sor.ly lac.ing and needed in the field of r.stor.tion ec.logy. Many spec.es ar. thr.atened due to degr.dation. Know.ng w.at envir.nmental c.nditions ar. needed dtLr.ng the life c.c.e of these spec.es is impor.ant in the design of r.stor.tion measur.s w.ic. aim to lift existing bottlenec.s for.thr.atened spec.es. To assess the r.lative impor.anc. of w.ter.type and mic.ohabitat in str.c.ur.ng the inver.ebr.te assemblage dur.ng differ.nt seasons, inver.ebr.tes w.r. sampled in thr.e w.ter.bodies differ.ng in tr.phic.level and ac.dity. Differ.nt par.s w.thin a w.ter.body （mic.ohabitats） w.r. sampled separ.tely and eac. w.ter.body w.s sampled in all four.seasons. r.sults show.that w.ter.body is an impor.ant fac.or.str.c.ur.ng the inver.ebr.te assemblage ear.y in the season, w.er.as mic.ohabitat bec.me mor. impor.ant later.in the season. Str.c.ur.l c.mplexity of mic.ohabitats w.s r.lated to the type of loc.motion employed by inver.ebr.tes. Seasonal differ.nc.s c.uld be r.lated to population dynamic. （r.pr.duc.ion, mor.ality）. Mor.over. fluc.uations in r.sour.1} availability w.r. expec.ed to differ.betw.en the w.ter.bodies, w.th highest fluc.uations in the eutr.phic.w.ter.body and w.th fluc.uations bec.ming less pr.dic.able later.in the season. This w.s c.nfir.ed by the data： spec.es sync.r.nization to pulses in food availability w.s str.ngest in the eutr.phic.w.ter.body. Mor.over. sync.r.nization w.s str.ngest in summer. w.ile in autumn w.ter. w.r. invaded by disper.ive spec.es. Based on these r.sults a synthesis is pr.sented on the func.ioning of the differ.nt w.ter. dur.ng the differ.nt seasons.

关键词： disper.al fluc.uations in r.sour.0} availability food substr.te sync.r.nization

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Estimated impac. of intr.duc.ion of new.diagnostic.c.iter.a for.gestational diabetes mellitus

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w.r.d Jour.al of Diabetes 2021年第6期12卷 868-882页

作者： Leon de w.t Anna B zijlmans Door.je r.demaker.c.r.stiana A Naaktgebor.n J Hans DeVr.es Ar.e Fr.nx r.bec.a c.Painter.Bas B van r.jn Depar.ment of Obstetr.c. and Gynaec.logy University Medical Center UtrechtUtrecht 3584 EANetherlands Depar.ment of Obstetr.c. and Gynaec.logy Gelderse Vallei HospitalEde 6716 RPNetherlands Depar.ment of Obstetr.c. and Gynaec.logy Amsterdam University Medical Centers-Location AMCAmsterdam 1105 AZNetherlands Depar.ment of Obstetr.c. and Gynaec.logy Amsterdam University Medical Centers–Location AMCAmsterdam 1105 AZNetherlands Depar.ment of Endoc.inology Amsterdam University Medical Centers–Location AMCAmsterdam 1105 AZNetherlands Depar.ment of Obstetr.c. and Fetal Medic.ne Erasmus MC Sophia Children HospitalRotterdam 3015 GDNetherlands

BAc.Gr.UND Implementation of new.diagnostic.c.iter.a for.gestational diabetes mellitus(GDM)ar. still a subjec. of debate,mostly due to c.nc.r.s r.gar.ing the effec.s on the number.of w.men diagnosed w.th GDM and the r.sk pr.file of the w.men new.y *** To estimate the impac. of the w.r.d Health Or.anization(w.O)2013 c.iter.a c.mpar.d w.th the w.O 1999 c.iter.a on the inc.denc. of gestational diabetes mellitus as w.ll as to deter.ine the diagnostic.ac.ur.c. for.detec.ing adver.e pr.gnanc. *** w. r.tr.spec.ively analyzed a single c.nter.Dutc. c.hor. of 3338 w.men under.oing a 75 g or.l gluc.se toler.nc. test w.er. the w.O 1999 c.iter.a to diagnose GDM w.r. c.inic.lly *** w.r. c.tegor.zed into four.gr.ups:non-GDM by both c.iter.a,GDM by w.O 1999 only(exc.uded fr.m GDM),GDM by w.O 2013 only(new.y diagnosed)and GDM by both *** c.mpar.d mater.al c.ar.c.er.stic.,pr.gnanc. outc.mes and likelihood r.tios for.adver.e pr.gnanc. *** r.tr.spec.ively applying the w.O 2013 c.iter.a inc.eased the c.hor. inc.denc. by 13.1%,fr.m 19.3%to 32.4%.Disc.r.ant diagnoses oc.ur.ed in 21.3%;4.1%w.uld no longer.be labelled as GDM,and 17.2%w.r. new.y *** to the non-GDM gr.up,w.men new.y diagnosed w.r. older.had higher.r.tes of obesity,higher.diastolic.blood pr.ssur. and higher.r.tes of c.esar.an *** infants w.r. mor. often deliver.d pr.ter.,lar.e-for.gestational-age and w.r. at higher.r.sk of a 5 min Apgar.sc.r.c.uded fr.m GDM w.r. older.and had similar.pr.gnanc. outc.mes c.mpar.d to the non-GDM gr.up,exc.pt for.higher.r.tes of shoulder.dystoc.a(4.3%vs 1.3%,P=0.015).Positive likelihood r.tios for.adver.e outc.mes in all gr.ups w.r. gener.lly low.r.nging fr.m 0.54 to *** Applying the w.O 2013 c.iter.a w.uld r.sult in a substantial inc.ease in GDM *** diagnosed w.men ar. at inc.eased r.sk for.pr.gnanc. adver.e *** r.sk,how.ver.seems to be low.r.than those identified by the

关键词： Diagnostic.c.iter.a Gestational diabetes Gluc.se toler.nc. test Inc.denc. Pr.gnanc. outc.me

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Neur.logic.Outc.me of Sur.ic.l and c.nser.ative Tr.atment of r.eumatoid c.r.ic.l Spine Subluxation:A Systematic.r.view.and The Delphi Tr.al-I(r.0})2

Neurologic Outcome of Surgical and Conservative Treatment of...

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第六届国际脑血管病高峰论坛

作者： Jasper.F.c.w.lfs Mar.r.et Kloppenbur. Mic.ael G.Fehlings Maur.ts w.Van Tulder.Mar.ten Boer. wilco c.Peul

Objec.ive:r.eumatoid ar.hr.tis c.mmonly involves the upper.c.r.ic.l spine and c.n c.use signific.nt neur.logic.mor.idity and ***,ther. is no c.nsensus on the optimal timing for.sur.ic.l inter.ention:w.ether.sur.er. should be per.or.ed pr.phylac.ic.lly or.onc. neur.logic.defic.ts have bec.me ***:A systematic.r.view.of the liter.tur.

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