检索结果-南通市图书馆

Impact of hypothermia on the biomechanical effect of epithelium-off corneal cross-linking

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Eye and Vision 2021年第3期8卷 31-35页

作者： Hormoz Abdshahzadeh Reyhaneh Abrishamchi Emilio A.Torres-Netto Sabine kling Nikki L.Hafezi Mark Hillen Farhad Hafezi Ocular Cell Biology Group Center for Applied Biotechnology and Molecular MedicineUniversity of ZurichWinterthurerstrasse 1908057 ZurichSwitzerland ELZA Institute Dietikon/ZurichSwitzerland Department of Ophthalmology Paulista School of MedicineFederal University of Sao PauloSao PauloBrazil Faculty of Medicine University of GenevaGenevaSwitzerland OPTIC-team Computer Vision LaboratoryETH ZurichZurichSwitzerland Department of Ophthalmology University of WenzhouWenzhouChina USC Roski Eye Institute USC Los AngelesLos AngelesCAUSA

Background:The corneal cross-linking(CXL)photochemical reaction is essentially dependent on oxygen and hypothermia,which usually leads to higher dissolved oxygen levels in tissues,with potentially greater oxygen availability for ***,we evaluate whether a reduction of corneal temperature during CXL may increase oxygen availability and therefore enhance the CXL biomechanical stiffening effect in ex vivo porcine ***:One hundred and twelve porcine corneas had their epithelium manually debrided before being soaked with 0.1%hypo-osmolaric *** corneas were equally assigned to one of four *** 2 and 4 underwent accelerated epithelium-off CXL using 9 mW/cm^(2) irradiance for 10 min,performed either in a cold room temperature(group 2,4℃)or at standard room temperature(group 4,24℃).Groups 1 and 3 served as non-crosslinked,temperature-matched *** a stress-strain extensometer,the elastic moduli of 5-mm wide corneal strips were analyzed as an indicator of corneal ***:Accelerated epithelium-off CXL led to significant increases in the elastic modulus between 1 and 5%of strain when compared to non-cross-linked controls(P<0.05),both at 4℃(1.40±0.22 vs 1.23±0.18 N/mm)and 24℃(1.42±0.15 vs 1.19±0.11 N/mm).However,no significant difference was found between control groups(P=0.846)or between groups in which CXL was performed at low or standard room temperature(P=0.969).Conclusions:Although initial oxygen availability should be increased under hypothermic conditions,it does not appear to play a significant role in the biomechanical strengthening effect of epithelium-off CXL accelerated protocols in ex vivo porcine corneas.

关键词： Corneal cross-linking CXL Keratoconus Temperature Oxygen diffusion Hypothermia

维普期刊数据库

Recent trends in liver transplantation for alcoholic liver disease in the United States

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2017年第36期9卷 1315-1321页

作者： Catherine E kling James D Perkins Robert L Carithers Dennis M Donovan Lena Sibulesky Division of Transplant Surgery Department of Surgery University of Washington Division of Gastroenterology and Hepatology Department of Medicine University of Washington Department of Psychiatry and Behavioral Sciences University of Washington

AIM To examine temporal changes in the indications for liver transplantation(LT) and characteristics of patients transplanted for alcoholic liver disease(ALD).METHODS We performed a retrospective cohort analysis of trends in the indication for LT using the United Network for Organ Sharing(UNOS) database between 2002 and 2015. Patients were grouped by etiology of the liver disease and characteristics were compared using χ~2 and t-tests. Time series analysis was used identifying any year with a significant change in the number of transplants per year for ALD, and before and after eras were modeled using a general linear model. Subgroup analysis of recipients with ALD was performed by age group, gender, UNOS region and etiology(alcoholic cirrhosis, alcoholic hepatitis and hepatitis C-alcoholic cirrhosis dual listing).RESULTS Of 74216 liver transplant recipients, ALD(n = 9400, 12.7%) was the third leading indication for transplant after hepatitis C and hepatocellular carcinoma. Transplants for ALD, increased from 12.8%(553) in 2002 to 16.5%(1020) in 2015. Time series analysis indicated a significant increase in the number of transplants per year for ALD in 2013(P = 0.03). There were a stable number of transplants per year between 2002 and 2012(linear coefficient 3, 95%CI:-4.6, 11.2) an increase of 177 per year between 2013 and 2015(95%CI: 119, 234). This increase was significant for all age groups except those 71-83 years old, was observed for both genders, and was incompletely explained by a decrease in transplants for hepatitis C and ALD dual listing. All UNOS regions except region 9 saw an increase in the mean number of transplants per year when comparing eras, and this increase was significant in regions 2, 3, 4, 5, 6, 8, 10 and *** There has been a dramatic increase in the number of transplants for ALD starting in 2013.

关键词： Alcoholic liver disease Liver transplantation Cirrhosis Epidemiology Hepatitis C

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

美国的信息劳动力与信息劳动力市场

国外情报科学 1994年第3期12卷 7-10,27页

作者： kling.,R 楚艳丽

Changing landscape of hepatitis C virus-positive donors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2017年第20期9卷 905-906页

作者： Catherine E kling Ajit P Limaye Lena Sibulesky Division of Transplant Surgery Department of Surgery University of Washington Division of Allergy and Infectious Disease Department of Medicine University of Washington

With the introduction of the new highly effective antiviral therapies, there has been a dramatic increase in the use of the hepatitis C virus(HCV)-positive livers in HCV-positive recipients. In the majority of studies, HCV positivity was defined as a donor testing HCV Ab positive. In 2015, all Organ Procurement Organizations were mandated to perform and report HCV Nucleic Acid Amplification Testing(NAT) results on all deceased and living donors. Studies are not yet available on how organs are being utilized based on NAT status and whether NAT status affects recipient outcomes. Further studies are needed to maximize the use of these organs.

关键词： Heptitis C organ utilization Hepatitis C virus aviremic Liver transplantation Hepatitis C positive recipients

A Comparison of Value Elicitation Question Formats in Multiple-Good Contingent Valuation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Economics in China-Selected Publications from Chinese Universities 2014年第1期9卷 85-108页

作者： Chih-Chen Liu Joseph A. Herriges C. L. kling Silvia Secchi Joan I. Nassauer Daniel J. Phaneuf Department of Applied Economics National University of Kaohsiung Kaohsiung 81148Taiwan China Department of Economics Iowa State University Ames IA 50011 USA Department of Agribusiness Economics Southern Illinois University Carbondale IL 62901USA School of Natural Resources and Environment University of Michigan Ann Arbor M148103USA Department of Agricultural and Applied Economics University of Wisconsin Madison WI53706 USA

This paper provides a convergent validity test of two types of multinomial choice questions vis-a-vis a dichotomous choice question by formally testing whether these stated preference elicitation question formats provide comparable welfare estimates. In particular, a dichotomous choice question, a traditional multinomial choice question, and a modified multinomial choice question suggested by Carson and Groves （2007） were applied in split samples to assess the influence of the informational and incentive properties on the respondents＇ annual willingness to accept compensation for adopting costly conservation practices in agriculture that benefit the environment. Our findings suggest that the two multinomial choice question formats elicit a similar mean willingness to accept distributions, but they are both different from a standarddichotomous choice question. Further, the willingness to accept distributions derived from the multinomial choice question formats are more dispersed than those from the dichotomous choice question.

关键词： stated preference choice experiment dichotomous choice,incentive compatibility multinomial choice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

台式计算机化是一个连续的过程

计算机工程与应用 1991年第5期27卷 110-120页

作者： M.Zmuidzinas R.kling J.George 祁伟国家教委信息中心

本文首次对工作小组计算机化的连续过程进行纵向的、定量的分析。我们认为计算机化应被定义成连续的过程,而不象通常认为的静态过程。我们还认为计算机化也不象许多技术杂志上所描述的那种动态的变化。把计算机化看作是连续过程也隐含... 详细信息

本文首次对工作小组计算机化的连续过程进行纵向的、定量的分析。我们认为计算机化应被定义成连续的过程,而不象通常认为的静态过程。我们还认为计算机化也不象许多技术杂志上所描述的那种动态的变化。把计算机化看作是连续过程也隐含了在计算机化的小组中工作是如何变化的、以及我们如何研究工作的变化。为获取动态的信息和区分稳定和偶然的因素,在配置设备之后的较长时间内观察工作的变化并进行重复的观察是需要的。我们将介绍我们的研究成果,这些成果是对二年来在39个工作小组中,计算机化所起的作用的调查基础上取得的。在1999和1989年中,我们通过调查和访问收集了有关的数据。我们把计算机化过程分为四个要素:设备、基础条件、计算的社会组织和控制方式。对每个要素我们将提供有关的数据。在88到89年间,技术因素变得更复杂了(例如:设备种类,配备及使用的广度),社会因素(如:计算的基础条件)没有多大的变化。工作变化的初步分析表明,工作小组的工作更繁忙了。

关键词：计算机化连续过程计算机应用

小麦育种中杂交亲本选配理论与方法的研究 Ⅰ.标准差距离分组法预测杂种优势

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

北京农业大学学报 1990年第1期16卷 19-25页

作者：张爱民黄铁城张树榛 Ch.I.kling 北京农业大学联邦德国霍恩海姆大学

本文提出了标准差距离分组法并以中国和联邦德国4个不同生态环境,5个不同年份的5套试验资料研究用标准差距离分组法进行小麦杂种优势预测。结果表明:G:组(D^2±1/2s)出现强优势组合最多,为43个,平均杂种优势最高,为60.4%;强优势组合出... 详细信息

本文提出了标准差距离分组法并以中国和联邦德国4个不同生态环境,5个不同年份的5套试验资料研究用标准差距离分组法进行小麦杂种优势预测。结果表明:G:组(D^2±1/2s)出现强优势组合最多,为43个,平均杂种优势最高,为60.4%;强优势组合出现的频率也最高,为57.3%。因而可以选择遗传距离(D^2)大小为(m±1/28)的亲本进行杂交,这样有较大的把握和机会获得强优势组合。为应用遗传距离预测小麦杂种优势提供了一个量化指标。

关键词：小麦杂种优势遗传距离

MyCTC chip:microfluidic-based drug screen with patient-derived tumour cells from liquid biopsies

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2022年第6期8卷 125-135页

作者： Fabienne D.Schwab Manuel C.Scheidmann Lauren L.Ozimski Andrékling Lucas Armbrecht Till Ryser Ilona Krol Karin Strittmatter Bich Doan Nguyen-Sträuli Francis Jacob AndréFedier Viola Heinzelmann-Schwarz Andreas Wicki Petra S.Dittrich Nicola Aceto Department of Biomedicine Cancer Metastasis LaboratoryUniversity of BaselBaselSwitzerland Department of Gynaecologic Oncology University Hospital BaselBaselSwitzerland Department of Biology Swiss Federal Institute of Technology Zurich(ETH Zurich)ZurichSwitzerland Department of Biosystems Science and Engineering Swiss Federal Institute of Technology Zurich(ETH Zurich)BaselSwitzerland Department of Gynaecology University Hospital Zurich and University of ZurichZurichSwitzerland Department of Biomedicine Ovarian Cancer ResearchUniversity Hospital Basel and University of BaselBaselSwitzerland University of Zurich and University Hospital Zurich ZurichSwitzerland

Cancer patients with advanced disease are characterized by intrinsic challenges in predicting drug response patterns,often leading to ineffective *** clinical practice for treatment decision-making is commonly based on primary or secondary tumour biopsies,yet when disease progression accelerates,tissue biopsies are not performed on a regular *** is in this context that liquid biopsies may offer a unique window to uncover key vulnerabilities,providing valuable information about previously underappreciated treatment ***,we present MyCTC chip,a novel microfluidic device enabling the isolation,culture and drug susceptibility testing of cancer cells derived from liquid *** cell capture is achieved through a label-free,antigen-agnostic enrichment method,and it is followed by cultivation in dedicated conditions,allowing on-chip expansion of captured *** growth,cancer cells are then transferred to drug screen chambers located within the same device,where multiple compounds can be tested *** demonstrate MyCTC chip performance by means of spike-in experiments with patientderived breast circulating tumour cells,enabling>95%capture rates,as well as prospective processing of blood from breast cancer patients and ascites fluid from patients with ovarian,tubal and endometrial cancer,where sensitivity to specific chemotherapeutic agents was ***,we provide evidence that MyCTC chip may be used to identify personalized drug response patterns in patients with advanced metastatic disease and with limited treatment opportunities.

关键词： fluid transferred Together

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

为食品工业设备而变的塑料产品

现代制造 2013年第46期 32-33页

作者： RalfSchmitt—kling

很长时间以来，美国食品和药品管理局（FDA）的条例一直作为食品审批最严格的评判标准；但从现在开始情况发生了变化。大约两年半前开始，它被欧盟的新标准所代替。生产食品工业机械设备和装备所需的金属原材料的厂家投入了大量的时间... 详细信息

很长时间以来，美国食品和药品管理局（FDA）的条例一直作为食品审批最严格的评判标准；但从现在开始情况发生了变化。大约两年半前开始，它被欧盟的新标准所代替。生产食品工业机械设备和装备所需的金属原材料的厂家投入了大量的时间和费用来落实这些法规，以满足欧盟规定的要求。

关键词：食品工业塑料产品工业设备评判标准机械设备管理局原材料时间