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世界核心医学期刊文摘（妇产科学分册） 2005年第4期1卷 5-6页

作者： whitington p.f. Hibbard J.U. 高雪莲 Department of pediatrics Feinberg Sch. of Med. of NW Univ. Children’s Memorial Hospital 2300 Children’s Plaza Box 57 Chicago IL 60614 United States

Background Neonatal haemochromatosis is a rare disease of gestation that results in severe fetal liver injury. We hypothesised an alloimmune aetiology for the disorder on the basis of its high recurrence rate in sibships. In this study, we assessed the effectiveness in preventing or changing the severity of recurrent neonatal haemochromatosis of administering during pregnancy highdose intravenous immunoglobulin (IVIG) derived from pooled serum of multiple donors. Methods Women whose most recent pregnancy ended in documented neonatal haemochromatosis were treated with IVIG, 1 g/kg bodyweight, weekly from the 18th week until the end of gestation in their subsequent pregnancy. The outcomes of treated pregnancies were compared with those of randomly selected previous affected pregnancies for each woman, which were used as historical controls. findings 15 women were treated through 16 pregnancies. All pregnancies progressed uneventfully and resulted in live babies with normal physical examinations and birthweights that were appropriate for gestational age. 12 babies had evidence of liver involvement with neonatal haemochromatosis: 11 had higher than normal concentrations of serum αfetoprotein and ferritin or serum αfetoprotein alone, including four with coagulopathy (international normalised ratio >1.5), and one had coagulopathy alone. All babies survived with medical or no treatment and were healthy at followup within the past 6 months. In analysis on a permother basis comparing outcomes of treated gestations with those of randomly selected previous affected gestations, gestational IVIG therapy was associated with better infant survival (15 good outcomes vs two in previous pregnancies; p=0.0009). Interpretation Treatment with highdose IVIG during gestation appears to have modified recurrent neonatal haemochromatosis so that it was not lethal to the fetus or neonate. These results further support an alloimmune mechanism for recurrent neonatal haemochromatosis.

关键词：妊娠期妇女免疫球蛋白妊娠疾病同胞群高复发率血清甲胎蛋白终止妊娠血色素沉着病免疫性疾病同种免疫

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维普期刊数据库

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妊娠期间大剂量应用免疫球蛋白对复发性新生儿血色病的作用

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世界核心医学期刊文摘（胃肠病学分册） 2005年第4期1卷 10-10页

作者： whitington p.f. Hibbard J.U. 郝筱倩 Department of pediatrics Feinberg Sch.of Med. of NW Univ. Children’s Memorial Hospital 2300 Children’s Plaza Box 57 Chicago IL 60614United StatesDr.

Background Neonatal haemochromatosis is a rare disease of gestation that results in severe fetal liver injury. We hypothesised an alloimmune aetiology for the disorder on the basis of its high recurrence rate in sibships. In this study, we assessed the effectiveness in preventing or changing the severity of recurrent neonatal haemochromatosis of administering during pregnancy high-dose intraven ous immunoglobulin (IVIG) derived from pooled serum of multiple donors. Methods Women whose most recent pregnancy ended in documented neonatal haemochromatosis were treated with IVIG, 1 g/kg bodyweight, weekly from the 18th week until the end of gestation in their subsequent pregnancy. The outcomes of treated pregnancies were compared with those of randomly selected previous affected pregnancies for each woman, which were used as historical controls. findings 15 women were treated through 16 pregnancies. All pregnancies progressed uneventfully and resulted in live babies with normal physical examinations and birthweights that were a ppropriate for gestational age. 12 babies had evidence of liver involvement with neonatal haemochromatosis: 11 had higher than normal concentrations of serum α-fetoprotein and ferritin or serum α-fetoprotein alone, including four with coagulopathy (international normalised ratio >1.5), and one had coagulopathy alone. All babies survived with medical or no treatment and were healthy at follow-up within the past 6 months. In analysis on a per-mother basis comparing outcomes of treated gestations with those of randomly selected previous affected gesta tions, gestational IVIG therapy was associated with better infant survival (15 good outcomesvs two in previous pregnancies; p=0.0009). Interpretation Treatment with high dose IVIG during gestation appears to have modified recurrent neonat al haemochromatosis so that it was not lethal to the fetus or neonate. These res ults further support an alloimmune mechanism for recurrent neonatal haemochromat osis.

关键词：新生儿血色病免疫球蛋白剂量应用病态妊娠静脉输注血清甲胎蛋白同种免疫凝血病严重肝损伤妊娠结果

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英国的五月节

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英语沙龙(时尚版) 1999年第5期 12-13页

作者： Anna whitington 如云

5月1日是一个银行休假日——英国每年的第一个公共节假日,因此深受人们的欢迎。大多数人都认为5月1日是一个特殊的日子:它标志着夏季的来临,白天逐渐变长,天气开始变暖。但是事实上我们不一定总能如愿。5月里也会有令人失望却也是预料... 详细信息

5月1日是一个银行休假日——英国每年的第一个公共节假日,因此深受人们的欢迎。大多数人都认为5月1日是一个特殊的日子:它标志着夏季的来临,白天逐渐变长,天气开始变暖。但是事实上我们不一定总能如愿。5月里也会有令人失望却也是预料之中的寒风,晚上还会有霜降。冬天即将过去。大部分人都知道,以前几乎人人都从事农业

关键词：凯尔特人庆祝活动

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盖伊·福克斯之夜—11月5日

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英语沙龙(时尚版) 1998年第11期 6-7页

作者： Anna whitington 谭务凤

在英格兰.人们仍于每年11月5日庆祝盖伊·福克斯之夜。然而50年前,庆祝活动远比现在热闹。盖伊·福克斯之夜与其他节日相比有几点不同。尽管节日是在秋季,它却不是季节性节日,而是政治性节日。最初庆祝这一节日是为了维护对宗教和国家... 详细信息

在英格兰.人们仍于每年11月5日庆祝盖伊·福克斯之夜。然而50年前,庆祝活动远比现在热闹。盖伊·福克斯之夜与其他节日相比有几点不同。尽管节日是在秋季,它却不是季节性节日,而是政治性节日。最初庆祝这一节日是为了维护对宗教和国家的忠诚。

关键词：福克斯

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