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Contemporary perspective on endogenous myocardial regeneration

World Journal of Stem Cells 2015年第5期7卷 793-805页

作者： Dejan Milasinovic werner mohl Department of Cardiology Clinical Centre of Serbia Department of Cardiac Surgery Medical University of Vienna

Considering the complex nature of the adult heart, it is no wonder that innate regenerative processes, while maintaining adequate cardiac function, fall short in myocardial jeopardy. In spite of these enchaininglimitations, cardiac rejuvenation occurs as well as restricted regeneration. In this review, the background as well as potential mechanisms of endogenous myocardial regeneration are summarized. We present and analyze the available evidence in three subsequent steps. First, we examine the experimental research data that provide insights into the mechanisms and origins of the replicating cardiac myocytes, including cell populations referred to as cardiac progenitor cells(i.e., c-kit+ cells). Second, we describe the role of clinical settings such as acute or chronic myocardial ischemia, as initiators of pathways of endogenous myocardial regeneration. Third, the hitherto conducted clinical studies that examined different approaches of initiating endogenous myocardial regeneration in failing human hearts are analyzed. In conclusion, we present the evidence in support of the notion that regaining cardiac function beyond cellular replacement of dysfunctional myocardium via initiation of innate regenerative pathways could create a new perspective and a paradigm change in heart failure therapeutics. Reinitiating cardiac morphogenesis by reintroducing developmental pathways in the adult failing heart might provide a feasible way of tissue regeneration. Based on our hypothesis "embryonic recall", we present first supporting evidence on regenerative impulses in the myocardium, as induced by developmental processes.

关键词： Cardiac regeneration Cardiac development Embryonic recall Pressure-controlled intermittentcoronary sinus occlusion Heart failure Myocardialinfarction

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Right Ventricular Myxoma Causing Right Ventricular Outflow Tract Obstruction: A Case Report

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Open Journal of Clinical Diagnostics 2015年第3期5卷 121-124页

作者： Xuemei Jiang Yang Wang werner mohl Zhongyi Si Department of Cardiac Surgery The First Hospital of Liaoning Medical University Jinzhou China Department of Cardiac Surgery AKH Medical University of Vienna Vienna Austria Department of Cardiac and Vascular Surgery Panjin Central Hospital Panjin China

A 63-year-old patient presented with dyspnea and chest distress. A computerized tomography and echocardiogram showed a cardiac mass in the right ventricle, which caused obstruction of the right ventricular outflow tract. Coronary angiography revealed a dense meshwork of the abnomorly capillary vessels originating from right coronary artery. The mass was completely excised under cardiopulmonary bypass. The mass attached right ventricle lateral wall and posterior triscupid leaflet. Histology was typical myomatous tissue.

关键词： Myxoma Cardiac Tumor Right Ventricular Outflow Tract

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Soil microbial ecology through the lens of metatranscriptomics

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Soil Ecology Letters 2024年第3期6卷 1-15页

作者： Jingjing Peng Xi Zhou Christopher Rensing werner Liesack Yong-Guan Zhu State Key Laboratory of Nutrient Use and Management College of Resources and Environmental SciencesNational Academy of Agriculture Green DevelopmentKey Laboratory of Plant-Soil InteractionsMinistry of EducationChina Agricultural UniversityBeijing 100193China Institute of Environmental Microbiology College of Resource and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002China Max Planck Institute for Terrestrial Microbiology Marburg 35043Germany State Key Laboratory of Urban and Regional Ecology Research Centre for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Key Laboratory of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China

Metatranscriptomics is a cutting-edge technology for exploring the gene expression by,and functional activities of,the microbial community across diverse ecosystems at a given time,thereby shedding light on their metabolic responses to the prevailing environmental *** double-RNA approach involves the simultaneous analysis of rRNA and mRNA,also termed structural and functional *** contrast,mRNA-centered metatranscriptomics is fully focused on elucidating community-wide gene expression profiles,but requires either deep sequencing or effective rRNA *** this review,we critically assess the challenges associated with various experimental and bioinformatic strategies that can be applied in soil microbial ecology through the lens of functional *** particular,we demonstrate how recent methodological advancements in soil metatranscriptomics catalyze the development and expansion of emerging research fields,such as rhizobiomes,antibiotic resistomes,methanomes,and *** review provides a framework that will help to design advanced metatranscriptomic research in elucidating the functional roles and activities of microbiomes in soil ecosystems.

关键词： metatranscriptomics mRNA MAGs rhizobiont resistome virome

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Spatiotemporal mapping of(ultra‐)mafic magmatic mine areas:Implications of economic and political realities in China

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Deep Underground Science and Engineering 2024年第1期3卷 91-102页

作者： Heling Li Liang Tang Tim T.werner Zhengmeng Hou Fan Meng Jingjing Li College of Earth Sciences Chengdu University of TechnologyChengduChina Institute of Subsurface Energy Systems Clausthal University of TechnologyClausthal ZellerfeldGermany School of Geography Earth and Atmospheric SciencesFaculty of ScienceThe University of MelbourneMelbourneVictoriaAustralia

The spatiotemporal extension/expansion of mine areas is affected by multiple *** far,very little has been done to examine the interaction between mine areas and political or economic ***(ultra‐)mafic magmatic mines in China played a specific role in supporting national development and providing an ideal research subject for monitoring their *** this study,remote sensing and mining‐related GIS data were used to identify and analyze 1233(ultra‐)mafic magmatic mine area polygons in China,which covered approximately 322.96 km2 of land and included a V–Ti–Fe mine,a copper–nickel mine,a chromite mine,an asbestos mine,and a diamond *** was found that(1)the areal expansion of mines is significantly related to the mine types,perimeter,topography,and population density.(2)The mine area variation also reflects market and policy *** temporal expansion of the mine area from 2010 to 2020 followed an S‐shaped pattern(with the turning point occurring in 2014),closely related to iron overcapacity and tightened mining policies.(3)The complexity(D)of the mine area may reflect mine design and excavation *** be specific,lower D indicates early‐stage or artisanal/small‐scale mining,whereas higher D represents large‐scale *** study demonstrates that the detailed mapping of mine land can serve as an indicator to implement miningrelated market and policy ***(ultra‐)mafic mines area data set can be accessed at https://***/record/7636616#.Y-p0uXaZOa0.

关键词： complexity mine area mining and socioeconomic interaction spatiotemporal distribution (ultra‐)mafic magmatic mine

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Cretaceous Large Igneous Provinces (LIPs) Affect Sedimentary Processing: Jordan, Arabian Plate;NW Germany, Central Europe

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Open Journal of Geology 2024年第6期14卷 671-704页

作者： werner Schneider Elias Salameh (Retired) Department of Geology Faculty of Science Braunschweig Technical University Braunschweig Germany Department of Geology Faculty of Science University of Jordan Amman Jordan

Both the NE Gondwana Platform (Jordan) and the Carpathian/NW Europe Seaway towards the N Atlantic expose comparable sequence analytical patterns as i.e. the Maximum Flooding Surface (MSF), relating to the Arabian Shelf, throughout one of the warmest Phanerozoic Epochs. Supervolcanic Large Igneous Provinces (LIPs), (explosive island arc andesitic volcanism), Mid-Oceanic Rift Basalts (MORB), (S/N Atlantic, Arctic) and kimberlitic volcanism (W Gondwana) provided striking conditions for an immense influence (tuff, degassing, T) on the sedimentary processing throughout the Cretaceous, mainly verified by K-montmorillonite , dozens of tuff beds (predominantly in NW Germany), zeolite, cristobalite, extremely high chert occurrences as well as the reconfirming of the global anoxic event around the Cenomanian/Turonian b. (94 Ma) by a positive ∂13C-maximum (~0.5%). Thus the lithofacies spectrum (carbonate rocks, chalk, chert, porcellanite, shale) was affected by pH, Eh, T, photosynthesis, and greenhouse gases—change during varying positive/negative climate forcing. While acid sturzrain events caused the transformation of arkosic/subarkosic sediments of the hinterlands to quartz arenite cycles deposited on the Jordanian Platform during early Cretaceous, the other patterns mentioned, led to a rapid change of lithofacies through Late Cretaceous. The southward directed Neotethys transgression can be reconstructed during the Early Cretaceous by glauconite-aged tidalites that give hint on transpressional tectonics during the Upper Cenomanian east of the Dead Sea. The Cretaceous/Paleogene (K-Pg) transitional zone evidences a zone of several cumulative events (island arc-volcanism) and the Chicxulub impact, indicated by at least two extinctions phases. The southward obduction of the Palmyrides, Syria and related transtensional/transpressional strike slip tectonics (partially pull-apart structures) left a fast facies change on the Jordanian Platform.

关键词： Degassing Explosive Tuff Acid Rain Climate Forcing Photosynthesis Mineral Trans/Neoformation Lithofacies Modified Synsedimentary Tectonics

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Magnificent Frigatebird Optimization: A New Bio-Inspired Metaheuristic Approach for Solving Optimization Problems

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Computers, Materials & Continua 2024年第8期80卷 2721-2741页

作者： Tareq Hamadneh Khalid Kaabneh Ibraheem AbuFalahah Gulnara Bektemyssova Galymzhan Shaikemelev Dauren Umutkulov Sayan Omarov Zeinab Monrazeri Frank werner Mohammad Dehghani Department of Mathematics Al Zaytoonah University of JordanAmman11733Jordan Faculty of Information Technology Al-Ahliyya Amman UniversityAmman19328Jordan Department of Mathematics Faculty of ScienceThe Hashemite UniversityP.O.Box 330127Zarqa13133Jordan Department of Computer Engineering International Information Technology UniversityAlmaty050000Kazakhstan Department of Big Data Analytics and Data Science Software Development Company《QazCode》Almaty050063Kazakhstan Department of Electrical and Electronics Engineering Shiraz University of TechnologyShiraz***Iran Faculty of Mathematics Otto-von-Guericke UniversityP.O.Box 4120Magdeburg39016Germany

This paper introduces a groundbreaking metaheuristic algorithm named Magnificent Frigatebird Optimization(MFO),inspired by the unique behaviors observed in magnificent frigatebirds in their natural *** foundation of MFO is based on the kleptoparasitic behavior of these birds,where they steal prey from other *** this process,a magnificent frigatebird targets a food-carrying seabird,aggressively pecking at it until the seabird drops its *** frigatebird then swiftly dives to capture the abandoned prey before it falls into the *** theoretical framework of MFO is thoroughly detailed and mathematically represented,mimicking the frigatebird’s kleptoparasitic behavior in two distinct phases:exploration and *** the exploration phase,the algorithm searches for new potential solutions across a broad area,akin to the frigatebird scouting for vulnerable *** the exploitation phase,the algorithm fine-tunes the solutions,similar to the frigatebird focusing on a single target to secure its *** evaluate MFO’s performance,the algorithm is tested on twenty-three standard benchmark functions,including unimodal,high-dimensional multimodal,and fixed-dimensional multimodal *** results from these evaluations highlight MFO’s proficiency in balancing exploration and exploitation throughout the optimization *** studies with twelve well-known metaheuristic algo-rithms demonstrate that MFO consistently achieves superior optimization results,outperforming its competitors across various *** addition,the implementation of MFO on four engineering design problems shows the effectiveness of the proposed approach in handling real-world applications,thereby validating its practical utility and robustness.

关键词： Optimization metaheuristic magnificent frigatebirds exploration exploitation

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Robotic complete mesocolic excision for right colon cancer:Learning curve,training,techniques,approach,platforms,and future perspectives

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第2期7卷 53-59页

作者： Guglielmo NiccolòPiozzi Sentilnathan Subramaniam Rauand Duhoky werner Hohenberger Jim S.Khan Department of Colorectal Surgery Portsmouth Hospitals University NHS TrustPortsmouthUK Colorectal Surgery Unit Department of General SurgeryHospital SelayangSelangorMalaysia Faculty of Technology University of PortsmouthPortsmouthUK Department of General Surgery Universitatsklinikum ErlangenErlangenGermany Faculty of Science and Health University of PortsmouthPortsmouthUK

Colon cancer has the fifth highest incidence worldwide and has the sixth highest *** with rectal cancer,colon cancer currently has the worst 5-year overall survival for patients with stage II and III *** mesocolic excision has been developed as a standardized and optimized surgical technique for the excision of colon *** technique has traditionally been performed through an open approach since laparoscopy is generally considered technically *** robotic approach has been slowly implemented for colon cancer,but the newest robotic platforms allow for a safer and optimized approach for right colon *** robotic approaches have been developed and *** expansion of the current robotic platform ecosystem is gradually providing new outputs in the application of the robotic approach to complete mesocolic *** review gains an oversight of existing literature on robotic complete mesocolic excision for right colon cancer(learning curve,training,techniques,approach,platforms,and future perspectives).

关键词： Robotic surgery Complete mesocolic excision Robotic platform Colon cancer Colorectal surgery

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Cytokines-activated nuclear IKKα-FAT10 pathway induces breast cancer tamoxifen-resistance

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Science China(Life Sciences) 2024年第7期67卷 1413-1426页

作者： Xueyan Chen Weilin Wu Ji-Hak Jeong Matjaz Rokavec Rui Wei Shaolong Feng werner Schroth Hiltrud Brauch Shangwei Zhong Jun-Li Luo Department of Oncology Xiangya HospitalCentral South UniversityChangsha 410008China Department of Molecular Medicine The Scripps Research InstituteJupiter 33458USA Dr.Margarete Fischer-Bosch-Institute of Clinical Pharmacology Stuttgart 70376Germany iFIT Cluster of Excellence University of TübingenTübingen 72074Germany The Cancer Research Institute and the Second Affiliated Hospital Henyang Medical SchoolUniversity of South ChinaHengyang 421001China National Health Commission Key Laboratory of Birth Defect Research and Prevention Hunan Provincial Maternal and Child Health Care HospitalChangsha 410008China

Endocrine therapy that blocks estrogen signaling is the most effective treatment for patients with estrogen receptor positive(ER+)breast ***,the efficacy of agents such as tamoxifen(Tam)is often compromised by the development of *** we report that cytokines-activated nuclear IKKαconfers Tam resistance to ER+breast cancer by inducing the expression of FAT10,and that the expression of FAT10 and nuclear IKKαin primary ER+human breast cancer was correlated with lymphotoxinβ(LTB)expression and significantly associated with relapse and metastasis in patients treated with adjuvant ***αactivation or enforced FAT10 expression promotes Tam-resistance while loss of IKKαor FAT10 augments Tam *** induction of FAT10 by IKKαis mediated by the transcription factor Pax5,and coordinated via an IKKα-p53-miR-23a circuit in which activation of IKKαattenuates p53-directed repression of ***,our findings establish IKKα-to-FAT10 pathway as a new therapeutic target for the treatment of Tam-resistant ER+breast cancer.

关键词： nuclear IKKα breast cancer Tam-resistance FAT10 Pax5 lymphotoxin nuclear IKKα-FAT0 pathway

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Frilled Lizard Optimization: A Novel Bio-Inspired Optimizer for Solving Engineering Applications

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Computers, Materials & Continua 2024年第6期79卷 3631-3678页

作者： Ibraheem Abu Falahah Osama Al-Baik Saleh Alomari Gulnara Bektemyssova Saikat Gochhait Irina Leonova OmParkash Malik Frank werner Mohammad Dehghani Department of Mathematics Faculty of ScienceThe Hashemite UniversityP.O.Box 330127Zarqa13133Jordan Department of Software Engineering Al-Ahliyya Amman UniversityAmman19328Jordan Faculty of Science and Information Technology Software EngineeringJadara UniversityIrbid21110Jordan Department of Computer Engineering International Information Technology UniversityAlmaty050000Kazakhstan Symbiosis Institute of Digital and Telecom Management Constituent of Symbiosis International Deemed UniversityPune412115India Neuroscience Research Institute Samara State Medical UniversitySamara443001Russia Faculty of Social Sciences Lobachevsky UniversityNizhny Novgorod603950Russia Department of Electrical and Software Engineering University of CalgaryCalgaryAB T2N 1N4Canada Faculty of Mathematics Otto-von-Guericke UniversityP.O.Box 4120Magdeburg39016Germany Department of Electrical and Electronics Engineering Shiraz University of TechnologyShiraz***Iran

This research presents a novel nature-inspired metaheuristic algorithm called Frilled Lizard Optimization(FLO),which emulates the unique hunting behavior of frilled lizards in their natural *** draws its inspiration from the sit-and-wait hunting strategy of these *** algorithm’s core principles are meticulously detailed and mathematically structured into two distinct phases:(i)an exploration phase,which mimics the lizard’s sudden attack on its prey,and(ii)an exploitation phase,which simulates the lizard’s retreat to the treetops after *** assess FLO’s efficacy in addressing optimization problems,its performance is rigorously tested on fifty-two standard benchmark *** functions include unimodal,high-dimensional multimodal,and fixed-dimensional multimodal functions,as well as the challenging CEC 2017 test ***’s performance is benchmarked against twelve established metaheuristic algorithms,providing a comprehensive comparative *** simulation results demonstrate that FLO excels in both exploration and exploitation,effectively balancing these two critical aspects throughout the search *** balanced approach enables FLO to outperform several competing algorithms in numerous test ***,FLO is applied to twenty-two constrained optimization problems from the CEC 2011 test suite and four complex engineering design problems,further validating its robustness and versatility in solving real-world optimization ***,the study highlights FLO’s superior performance and its potential as a powerful tool for tackling a wide range of optimization problems.

关键词： Optimization engineering bio-inspired metaheuristic frilled lizard exploration exploitation

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质子磁荷半径:新疑难?

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Science Bulletin 2024年第4期69卷 419-421页

作者：林勇辉 Hans-werner Hammer Ulf-G.Meiûner Helmholtz Institut für Strahlen-und Kernphysik and Bethe Center for Theoretical Physics Universität BonnBonn D-53115Germany Technische Universität Darmstadt Department of PhysicsInstitut für KernphysikDarmstadt 64289Germany ExtreMe Matter Institute EMMI and Helmholtz Forschungsakademie Hessen für FAIR GSI Helmholtzzentrum für Schwerionenforschung GmbHDarmstadt 64291Germany Institute for Advanced Simulation and Institut für Kernphysik Forschungszentrum JülichJülich D-52425Germany Tbilisi State University Tbilisi 0186Georgia

The electric radius,rE,and the magnetic radius,rM,of the proton are fundamental quantities of low-energy QCD,as they are a measure of the probe-dependent size of the proton.

关键词： radius quantities fundamental

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