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Unsaturated bi-heterometal clusters in metal-vacancy sites of 2D MoS2 for efficient hydrogen evolution

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Carbon Energy 2024年第3期6卷 264-275页

作者： Gonglei Shao Jie Xu Shasha Gao zhang zhang Song Liu Xu zhang Zhen Zhou Interdisciplinary Research Center for Sustainable Energy Science and Engineering(IRC4SE2) School of Chemical EngineeringZhengzhou UniversityZhengzhouHenanChina College of Chemistry and Materials Engineering Wenzhou UniversityWenzhouZhejiangChina Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjinChina State Key Laboratory of Chemo/Biosensing and Chemometrics Institute of Chemical Biology and Nanomedicine(ICBN)College of Chemistry and Chemical EngineeringHunan UniversityChangshaHunanChina Institute of New Energy Material Chemistry School of Materials Science and EngineeringNankai UniversityTianjinChina

The valence states and coordination structures of doped heterometal atoms in two-dimensional(2D)nanomaterials lack predictable regulation ***,a robust method is proposed to form unsaturated heteroatom clusters via the metal-vacancy restraint mechanism,which can precisely regulate the bonding and valence state of heterometal atoms doped in 2D molybdenum *** unsaturated valence state of heterometal Pt and Ru cluster atoms form a spatial coordination structure with Pt–S and Ru–O–S as catalytically active *** them,the strong binding energy of negatively charged suspended S and O sites for H+,as well as the weak adsorption of positively charged unsaturated heterometal atoms for H*,reduces the energy barrier of the hydrogen evolution reaction proved by theoretical ***,the electrocatalytic hydrogen evolution performance is markedly improved by the ensemble effect of unsaturated heterometal atoms and highlighted with an overpotential of 84 mV and Tafel slope of 68.5 mV dec^(−1).In brief,this metal vacancy-induced valence state regulation of heterometal can manipulate the coordination structure and catalytic activity of heterometal atoms doped in the 2D atomic lattice but not limited to 2D nanomaterials.

关键词： clusters hydrogen evolution reaction metal vacancy MoS2 unsaturated heterometal

我院108例化疗致Ⅳ度骨髓抑制的晚期乳腺癌患者用药合理性分析

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中国药房 2016年第20期27卷 2756-2758页

作者：杜娟赵秀莉张文周王毅刚郑州大学附属肿瘤医院药学部郑州450003 陕西省核工业二一五医院药学部陕西咸阳712000

目的:为化疗致Ⅳ度骨髓抑制的晚期乳腺癌患者临床合理用药提供参考。方法:采用回顾性分析方法,对某院2014年7月-2015年6月108例化疗致Ⅳ度骨髓抑制的晚期乳腺癌患者的骨髓抑制特点、化疗方案及骨髓抑制对症用药的合理性进行分析。结果:... 详细信息

目的:为化疗致Ⅳ度骨髓抑制的晚期乳腺癌患者临床合理用药提供参考。方法:采用回顾性分析方法,对某院2014年7月-2015年6月108例化疗致Ⅳ度骨髓抑制的晚期乳腺癌患者的骨髓抑制特点、化疗方案及骨髓抑制对症用药的合理性进行分析。结果:该院晚期乳腺癌患者化疗致Ⅳ度骨髓抑制的发生率为8.3%,主要表现为Ⅳ度粒细胞减少(占94.4%);发生Ⅳ度骨髓抑制的化疗方案主要为多西他赛+表柔比星、多西他赛、长春瑞滨+洛铂方案。化疗方案不合理主要表现在化疗药物预处理不当(32例,91.4%);Ⅳ度骨髓抑制处理不合理主要表现在无指征预防使用抗菌药物和抗菌药物选择不当(各29例,各占36.2%)。结论:该院化疗致Ⅳ度骨髓抑制的晚期乳腺癌患者临床用药基本合理,但在化疗药物预处理和Ⅳ度骨髓抑制处理上仍存在部分不合理之处,需进一步改进。

关键词：化疗乳腺癌晚期 Ⅳ度骨髓抑制合理用药

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冷却壁水压试验的压力波动分析

冶金设备 2005年第1期 66-68页

作者：张文周谭承峰济南钢铁集团机械设备制造厂山东济南250101

根据高炉冷却壁水压试验时出现的压力波动现象,分析了压力变化产生的原因,提出了合理的水压试验工艺方法,并设计了一种结构新颖的快速水管接头,提高了压力试验效率,对冷却壁制造厂家和炼铁企业具有一定的参考价值。

关键词：冷却壁炼铁高炉工艺方法水压试验快速企业制造厂家效率参考价值

聊城市人民医院呼吸内科住院患者抗菌药物应用分析

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中国医院用药评价与分析 2015年第9期15卷 1221-1223页

作者：郑艳张文洲张宏伟聊城市人民医院药学部山东聊城252000

目的:了解聊城市人民医院(以下简称"我院")呼吸内科抗菌药物使用情况,促进抗菌药物的合理应用。方法:回顾性分析2013年3月—8月呼吸内科的200份病历资料。结果:社区获得性肺炎、慢性阻塞性肺疾病急性加重为主要病种,使用抗菌药物的患者... 详细信息

目的:了解聊城市人民医院(以下简称"我院")呼吸内科抗菌药物使用情况,促进抗菌药物的合理应用。方法:回顾性分析2013年3月—8月呼吸内科的200份病历资料。结果:社区获得性肺炎、慢性阻塞性肺疾病急性加重为主要病种,使用抗菌药物的患者所占比例为83.00%(166/200),特殊使用级抗菌药物使用率为15.32%,抗菌药物使用强度为105.87 DDDs/(100人·d)。结论:我院抗菌药物的应用比较合理,但仍有些地方应进一步改进。

关键词：呼吸内科抗菌药物合理应用

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厚朴提取物对大鼠CYP2D6亚型酶的影响

实用临床医药杂志 2013年第21期17卷 1-3页

作者：于卫江张斌张文周郑州大学附属肿瘤医院河南省肿瘤医院药学部河南郑州450008

目的观察厚朴提取物对大鼠CYP2D6亚型酶的影响。方法将16只成年雄性Wistar大鼠随机分为对照组和实验组,2组分别经口给予生理盐水和厚朴提取物1周,采用高效液相色谱法(HPLC)测定大鼠尿样及肝微粒体中CYP2D6的探针药物右美沙芬(DM)的代谢... 详细信息

目的观察厚朴提取物对大鼠CYP2D6亚型酶的影响。方法将16只成年雄性Wistar大鼠随机分为对照组和实验组,2组分别经口给予生理盐水和厚朴提取物1周,采用高效液相色谱法(HPLC)测定大鼠尿样及肝微粒体中CYP2D6的探针药物右美沙芬(DM)的代谢率,观察厚朴提取物对CYP2D6亚型酶活性的影响,并通过特异性抑制剂确定肝微粒体重组系统中厚朴提取物对CYP2D6亚型酶活性的影响。结果实验组大鼠尿样及体外肝微粒体中DM代谢率均明显低于对照组,差异有统计学意义;厚朴提取物组肝微粒体中DM代谢率显著低于西咪替丁组和对照组,差异有统计学意义,而西咪替丁组和对照组比较,差异无统计学意义。结论厚朴提取物可有效抑制CYP2D6亚型酶的活性,且抑制能力优于西咪替丁。

关键词：厚朴提取物 CYP2D6 肝微粒体右美沙芬高效液相色谱法

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建筑环境调控话语的四个象限

新建筑 2024年第5期 97-102页

作者：仲文洲张彤东南大学建筑学院南京210096

回溯现代主义以来建筑环境调控的话语和实践,以“自然、建筑、人”组成的系统结构为纬线,以机械论和有机论两个向度为经线,构建定位范式类型、价值观念与技术方法的坐标模型。划分出不同逻辑驱动的四个象限,以此作为辨析历史视野中建筑... 详细信息

回溯现代主义以来建筑环境调控的话语和实践,以“自然、建筑、人”组成的系统结构为纬线,以机械论和有机论两个向度为经线,构建定位范式类型、价值观念与技术方法的坐标模型。划分出不同逻辑驱动的四个象限,以此作为辨析历史视野中建筑环境调控范式分野及转变的理论框架,揭示其与当代环境议题之间的承袭与差异。同时塑造建筑环境调控话语体系的基底结构,发掘其在凝聚建筑学本体问题中所显示的潜力与可能。

关键词：环境调控医学身体能源控制气候适应感知身体

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类风湿关节炎的诊断及其药物治疗研究进展

中国医药导报 2016年第30期13卷 56-59页

作者：许相洋张文州泉州医学高等专科学校基础医学部福建泉州362000

类风湿关节炎(RA)是一种慢性的炎性难治性自身免疫性关节病,其发病机制尚未清楚,可能与环境、遗传、免疫因素等息息相关,目前仍无法完全治愈,仍以控制为主。本文综述了RA临床常见的诊断方法和治疗RA的化学类药物(改变病情抗风湿药、糖... 详细信息

类风湿关节炎(RA)是一种慢性的炎性难治性自身免疫性关节病,其发病机制尚未清楚,可能与环境、遗传、免疫因素等息息相关,目前仍无法完全治愈,仍以控制为主。本文综述了RA临床常见的诊断方法和治疗RA的化学类药物(改变病情抗风湿药、糖皮质激素、非甾体抗炎药)、中药类药物(单味中药、复方中药等)以及生物类药物,以期为今后RA的诊疗提供参考和依据。

关键词：类风湿关节炎临床诊断化学类药物中药类药物生物类药物

Regulating the intrinsic electronic structure of carbon nanofibers with high-spin state Ni for sodium storage with high-power density

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Journal of Materials Science & Technology 2024年第4期171卷 16-23页

作者： Zhijia zhang Gang Xie Yuefang Chen Yanhao Wei Mengmeng zhang Shulei Chou Yunxiao Wang Yifang zhang Yong Jiang School of Materials Science and Engineering Institute of Quantum Materials and DevicesState Key Laboratory of Separation Membrane and Membrane ProcessesTiangong UniversityTianjin 300387China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China Institute for Superconducting and Electronic Materials University of WollongongWollongongNSW 2522Australia

Carbon nanofibers(CNFs)with high specific surface area show great potential for sodium storage as a hard carbon ***,CNFs anchored with Ni nanoparticles(CNFs/Ni)were prepared through chemical vapor deposition and impregnation reduction methods,in situ growing on the three-dimensional porous copper current collector(3DP-Cu).The coupling effect of high-spin state Ni nanopar-ticles leads to the increase of defect density and the expansion of lattice spacing of ***,the 3DP-Cu ensures a high loading capacity of CNFs and short ion/electron transport *** an integral binder-free anode,the 3DP-Cu/CNFs/Ni exhibits excellent electrochemical performance,which demon-strates a high specific capacity with 298.5 mAh g^(-1)at 1000 mA g^(-1)after 1500 cycles,and a high power density with 200 mAh g^(-1)over 1000 cycles at 5000 mA g^(-1).Density functional theory calculation re-sults show that the high-spin state Ni regulates the electronic structure of CNFs,which significantly reduces the adsorption energy for Na^(+)(-2.7 Ev)and thus enables high-rate *** regulation of the electronic structure of carbon materials by high-spin state metal provides a new strategy for developing high-power carbonaceous anode materials for sodium-ion batteries.

关键词： Carbon nanofibers Ni nanoparticles High-spin state Sodium-ion batteries Anode materials Density functional theory calculation

Effects of pyraclostrobin on growth,oxidative stress,and gene expression in relation to stress and ATP-binding cassette transporters in Tetrahymena thermophila

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Journal of Oceanology and Limnology 2024年第1期42卷 150-162页

作者： Yang LIU Jiale zhang Peng XIAO Xin LIU Yisifu MA Jing zhang Bangjun zhang Henan International Joint Laboratory of Aquatic Ecotoxicology and Health Protection Xinxiang 453007China College of Life Sciences Henan Normal UniversityXinxiang 453007China Journal of Henan Normal University Xinxiang 453007China College of Life and Environmental Science Wenzhou UniversityWenzhou 325035China Department of Ecosystem Studies School of Environmental ScienceUniversity of Shiga PrefectureShiga 522-8533Japan

Pyraclostrobin(PYR),a widely used fungicide,has negative effects on fish and algae,but its toxicity in protozoa remains *** this study,the effects of PYR on the growth,oxidative stress,and gene expression related to stress and ATP-binding cassette(ABC)transporters in Tetrahymena thermophila were *** result showed that the 96-h IC_(50)of PYR against *** was 17.2 mg/***,PYR inhibited the growth of *** in concentration-or time-dependent manner.A morphological study revealed that the shape and size of *** changed,and damage of cell membrane surface was observed by scanning electron microscopy after 96 h of PYR *** activities of superoxide dismutase(SOD)and catalase(CAT)increased throughout the *** contrast,the glutathione(GSH)content was increased at 24 h and 48 h of exposure and decreased at 96 ***,a significant increase in malondialdehyde(MDA)level was observed in *** after96 h of ***,PYR upregulated the HSP703,HSP705,GPx2,and ABAC15 gene expression in the 0.1–5-mg/L groups and downregulated the HSP704,HSP90,TGR,and ABCC52 mRNA levels at 96 h of *** results suggest that PYR may exert adverse effects on *** by inducing oxidative stress and changing the gene expression related to ABC transporters and stress,which may enrich the understanding of the toxicity mechanism of PYR in aquatic organisms and provide reference data for aquatic ecological risk assessments.

关键词： pyraclostrobin Tetrahymena thermophila growth oxidative stress gene expression