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Identification of novel drug targets for diabetic retinopathy:proteome-wide mendelian randomization and colocalization analyses

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Eye Science 2024年第1期1卷 26-44页

作者：杨少鹏朱梓瑜刘日乾黄文勇王伟 State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060China Hainan Eye Hospital and Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityHaikou 570100China

Background:Diabetic retinopathy(DR)urgently needs novel and effective therapeutic *** analyses of plasma proteomic and genetic markers can clarify the causal relevance of proteins and discover novel targets for diseases,but no systematic screening for DR has been ***:Summary statistics of plasma protein quantitative trait loci(pQTL)were derived from two extensive genome-wide analysis study(GWAS)datasets and one systematic review,with over 100 thousand participants covering thousands of plasma *** data were sourced from the largest FinnGen study,comprising 10,413 DR cases and 308,633 European *** instrumental variables were identified using multiple *** the two-sample MR analysis,Wald ratio and inverse variance-weighted(IVW)MR were utilized to investigate the causality of plasma proteins with *** MR,Bayesian Co-localization,and phenotype scanning were employed to test for potential reverse causality and confounding factors in the main MR *** systemically searching druggable gene lists,the ChEMBL database,DrugBank,and Gene Ontology database,the druggability and relevant functional pathways of the identified proteins were systematically ***:Genetically predicted levels of 24 proteins were significantly associated with DR risk at a false discovery rate<0.05 including 11 with positive associations and 13 with negative *** each standard deviation increase in plasm protein levels,the odds ratios(ORs)for DR varied from 0.51(95%CI:0.36-0.73;P=2.22×10-5)for tubulin polymerization-promoting protein family member 3(TPPP3)to 2.02(95%CI:1.44-2.83;P=5.01×10-5)for olfactomedin like 3(OLFML3).Bidirectional MR indicated there was no reverse causality that interfered with the results of the main MR *** proteins exhibited strong co-localization evidence(PH4≥0.8):cytoplasmic tRNA synthetase(WARS),acrosin binding protein(ACRBP),and intercellular adhesion molecule 1(ICAM1)wer

关键词： plasma proteome mendelian randomization therapeutic targets genome-wide analysis study colocalization analysis diabetic retinopathy

新型隔离块结构在炼钢起重机中压滑触线中的应用

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冶金标准化与质量 2024年第3期62卷 57-60页

作者：郑龙捷胡怀臣黄文永宝钢湛江钢铁有限公司炼钢厂广东湛江524000

炼钢起重机集电器滑块经过中压滑触线绝缘隔离装置时,存在绝缘块接触燃弧而烧坏。现通过一种新材料及结构隔离块解决传统3240环氧板作为隔离材料带来的绝缘、温度等缺陷。本文论述以三氧化二铝(Al2O3)为主体的陶瓷作为中压隔离材料,利... 详细信息

炼钢起重机集电器滑块经过中压滑触线绝缘隔离装置时,存在绝缘块接触燃弧而烧坏。现通过一种新材料及结构隔离块解决传统3240环氧板作为隔离材料带来的绝缘、温度等缺陷。本文论述以三氧化二铝(Al2O3)为主体的陶瓷作为中压隔离材料,利用三氧化二铝陶瓷的优良绝缘性、耐磨性、耐热性、热膨胀系数小、机械强度大等特点,设计加工成中压隔离块,满足炼钢行车中压滑触线绝缘、超高温、耐磨损、抗震动和坚固五大问题的要求。

关键词：滑触线中压绝缘隔离

Relationship between Refractive Error and Ocular Biometrics in Twin Children:the Guangzhou Twin Eye Study

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Eye Science 2014年第3期29卷 129-133页

作者： Decai Wang Bin Liu Shengsong huang wenyong huang Mingguang He Zhongshan Ophthalmic Center Sun Yat-sen University

Purpose:A cross-sectional study was conducted to explore the relationship between refractive error and ocular biometrics in children from the Guangzhou twin eye ***:.Twin participants aged 7-15 years were selected from Guangzhou Twin Eye Study..Ocular examinations included visual acuity measurement, ocular motility evaluation, autorefraction under cycloplegia, and anterior segment, media, and fundus examination...Axial length(AL),..anterior cham ber depth(ACD), and corneal curvature radius were measured using partial coherence laser interferometry. A multivariate linear regression model was used for statistical ***:.Twin children from Guangzhou city showed a decreased spherical equivalent with age,.whereas both AL and ACD were increased and corneal curvature radius remained unchanged. When adjusted by age and gender, the data from77% of twins presenting with spherical equivalent changes indicated that these were caused by predictable variables.(R2=0.77, P<0.001). Primary factors affecting children's refraction included axial length(β=-0.97,P<0.001), ACD(β=0.33,P<0.001), and curvature radius(β=2.10,P<0.001). Girls had a higher tendency for myopic status than did boys(β=-0.26,P<0.001)..Age exerted no effect upon the changes in refraction(β=-0.01, P=0.25).Conclusion:.Refraction is correlated with ocular *** status is largely determined by axial length as the major factor.

关键词：屈光不正生物识别广州市儿童科研多元线性回归模型曲率半径 ACD

Triazatruxene-containing hyperbranched polymers:Microwave-assisted synthesis and optoelectronic properties

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Science China Chemistry 2010年第12期53卷 2472-2480页

作者： LAI wenyong,LIU Dong & huang Wei Key Laboratory for Organic Electronics & Information Displays (KLOEID) Institute of Advanced Materials (IAM),Nanjing University of Posts & Telecommunications,Nanjing 210046,China Key Laboratory for Organic Electronics & Information Displays (KLOEID) Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications Nanjing China

Hyperbranched polymer structures represent a class of high-functionality building blocks with excellent three-dimensional topology for the construction of highly substituted conjugated *** this contribution,an efficient microwave synthesis protocol toward the synthesis of conjugated hyperbranched polymers is presented.A novel series of soluble hyperbranched polyfluorenes (PTF1-PTF3) incorporating triazatruxene moiety as the branch units with various branching degrees have thus been successfully constructed with good yields and high molecular weight via a facile "A2+B2+C3" *** structures of the hyperbranched polymers were confirmed by NMR and *** thermal,optical,and electrochemical properties of the hyperbranched polymers were also *** results showed that introduction of triazatruxene units into the hyperbranched structure endowed the polymer with good thermal stability and highly amorphous *** investigation of PTFx revealed strong blue emission in both solution and solid *** polymers with higher degree of branching and proper content of linear fluorene units exhibited better photophysical properties in terms of narrow emission spectra and relatively high quantum efficiency as well as improved thermal spectral *** triazatruxene branching unit also played a role in raising the HOMO energy levels relative to those of polyfluorenes that would help to improve the charge injection and transport *** incorporation of triazatruxene unit into hyperbranched polymers has thus explored an effective avenue for constructing optoelectronic polymers with improved functional characteristics.

关键词： hyperbranched polymers microwave synthesis triazatruxene polyfluorene blue emission

Quantitative evaluation of sustainable development based on ecological footprint method: a case study of Tianjin

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Ecological Economy 2008年第2期4卷 172-179页

作者： Guo wenyong huang Qiaohua Environment Research Centel Xuzhou Normal University Xuzhou 221116 R R. China

Since the coneept of sustainable devetopment emerged in the late 1980s, more and more countries and regions have been utilizing sustainable development as their developing stratety. But decades have passed without any effective methods available to quantitatively assess sustainable development. Since the ecological footprint evaluation method initiated in 1992, it has become popular in quantitative assessment of sustainable development because of its convenience, easy-understanding, and rehability. As one of the biggest coastal cities in north China and the economic center of the Bohai Coastal Region, Tianjin＇s gross domestic product （GDP） was 369. 762 billion yuan in 2005, accounting for 2.0°of the whole nation＇s GDP. The paper analyzes Tianjin＇s development with the ecological footprint method, and the results show that Tianjin＇s ecoiogical footprint and biocapacity in 2005 were 2.507gha/cap and 0.2 76gha/cap respectively. The ecological deficit was 2.230gha/*** from 1980 to 2005,Tianjin＇s ecological deficit per 10^4 yuan GDP decreased;while per capita ecological deficit has been tending to increase rapidly in recent *** these result demonstrate that Tianjin is in a state of unsustainable development.

关键词： Ecological footprint Biocapacity Sustainable development Quantitative evaluation Tianjin

Longitudinal Relationship between Axial Length and Height in Chinese Children:Guangzhou Twin Eye Study

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Eye Science 2015年第1期30卷 1-6,12页

作者： Decai Wang Chen Zhao Shengsong huang wenyong huang Mingguang He State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University State Key Laboratory of Reproductive Medicine Department of Ophthalmology the First Affiliated Hospital of Nanjing Medical University

Purpose:.To understand the growth model of axial length(AL) and height, and to explore the relationship between the two with the passage of ***:.We followed twins in the Guangzhou Twin Eye Study for five years..The AL of both eyes was measured by partial coherence interferometry, and height was measured by a standard scale during each visit..A multivariate multilevel mixed model was adopted for data ***:.A total of 1217 children were included in the *** AL and height increased, but the rate of growth slowed down with age..The mitigation rate of height growth was-0.34 cm / year;.while that of AL growth was-0.01 mm / *** was positively related to height,.with a relevant coefficient of R=0.22(Cov [height intercept, AL intercept] =1.56, 95%CI=1.14 to 1.99). The growth rates of AL and height were also positively related, with a relevant coefficient of R =0.18(Cov [height slope, AL slope] =0.03, 95%CI=0.01 to 0.05).However, taller children had slower rates of height increases,with a relevant coefficient of R=-0.12(Cov[height intercept,height slope]=-1.33,95%CI=-2.25 to-0.42); but had faster AL growth,.with a relevant coefficient of R =(Cov [height intercept, AL slope] =0.02, 95%CI=-0.05 to 0.08, R=0.02).AL and its growth rate were positively related to each other,with a relevant coefficient of R=(Cov [AL intercept,.AL slope]=0.04, 95%CI=0.03 to 0.05, R=0.3); while the growth rates of AL and height were negatively related to each other, with a relevant coefficient of R=(Cov [AL intercept, height slope]=--0.03 95%CI=-0.16 to 0.1, R=-0.02).Conclusion:.The increase in children's AL is relevant to their height increases..The faster their height increases,.the faster their AL increases.

关键词：轴向长度儿童科研广州相关系数冠状病毒拦截高度中国

Systematic Elastostatic Stiffness Model of Over-Constrained Parallel Manipulators Without Additional Constraint Equations

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Chinese Journal of Mechanical Engineering 2024年第4期 271-289页

作者： Chao Yang wenyong Yu Wei Ye Qiaohong Chen Fengli huang College of Mechanical and Electrical Engineering Jiaxing University Zhejiang Siekon Transmission Technology Co. Ltd. National and Local Joint Engineering Research Center of Reliability Analysis and Testing for Mechanical and Electrical Products Zhejiang Sci-Tech University School of Computer Science and Technology Zhejiang Sci-Tech University

The establishment of an elastostatic stiffness model for over constrained parallel manipulators(PMs), particularly those with over constrained subclosed loops, poses a challenge while ensuring numerical stability. This study addresses this issue by proposing a systematic elastostatic stiffness model based on matrix structural analysis(MSA)and independent displacement coordinates(IDCs) extraction techniques. To begin, the closed-loop PM is transformed into an open-loop PM by eliminating constraints. A subassembly element is then introduced, which considers the flexibility of both rods and joints. This approach helps circumvent the numerical instability typically encountered with traditional constraint equations. The IDCs and analytical constraint equations of nodes constrained by various joints are summarized in the appendix, utilizing multipoint constraint theory and singularity analysis, all unified within a single coordinate frame. Subsequently, the open-loop mechanism is efficiently closed by referencing the constraint equations presented in the appendix, alongside its elastostatic model. The proposed method proves to be both modeling and computationally efficient due to the comprehensive summary of the constraint equations in the Appendix, eliminating the need for additional equations. An example utilizing an over constrained subclosed loops demonstrate the application of the proposed method. In conclusion, the model proposed in this study enriches the theory of elastostatic stiffness modeling of PMs and provides an effective solution for stiffness modeling challenges they present.

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Five-year outcome of correctable visual impairment:the Liwan Eye Study

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Five-year outcome of correctable visual impairment:the Liwan...

江西省第十三次中西医结合中医眼科学术交流会暨赣州市医学会眼科学会第八次学术会议

作者： Yanzhi Zhao Lanhua Wang wenyong huang Mingguang He Third Affiliated Hospital of Nanchang University State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University University College London Institute of Ophthalmology ORBIS International

Purpose:To assess the visual outcome of subjects with correctable visual(VI)over a 5-year period and its ***:A comprehensive eye examination was performed at baseline and 5 years later on subjects participating in a population-based *** impairment was defined as visual acuity<0.5 in better eye by criteria of united *** visual impairment was defined as subjects with visual impairment improved to no impairment after correction.

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预拌混凝土供需双方质量责任评析

混凝土 2014年第2期 102-105,113页

作者：黄文咏黄有龄厦门美益集团有限公司福建厦门361027 厦门市建设工程材料设备协会福建厦门361004

混凝土结构工程质量与预拌混凝土的生产方和使用方都有密切关系,然而由于历史的原因和一些人的偏见,当混凝土结构构件出现质量问题时,大都责备混凝土生产企业,而对施工单位批评甚少。从实际出发评析现状以求分清预拌混凝土供需双方的质... 详细信息

混凝土结构工程质量与预拌混凝土的生产方和使用方都有密切关系,然而由于历史的原因和一些人的偏见,当混凝土结构构件出现质量问题时,大都责备混凝土生产企业,而对施工单位批评甚少。从实际出发评析现状以求分清预拌混凝土供需双方的质量责任。

关键词：预拌混凝土供需双方质量责任评论分析