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Quantitative lithium substitution of carboxyl hydrogens in polyacrylic acid binder enables robust SiO electrodes with durable lithium storage stability

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Journal of Energy Chemistry 2024年第10期97卷 352-360,I0007页

作者： Weihua Wang wenyi Li Siyi Jing Huiping Yang Huiqun Wang Ling Huang Yuxiang Mao Xikun Pang Yudai Huang Li Zhang State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemical and Biochemical EngineeringCollege of Chemistry and Chemical EngineeringCollaborative Innovation Centre of Chemistry for Energy Materials(iChEM)Xiamen UniversityXiamen 361005FujianChina State Key Laboratory of Chemistry and Utilization of Carbon-Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830017XinjiangChina

The design of advanced binders plays a critical role in stabilizing the cycling performance of large-volume-effect silicon monoxide(SiO)*** the classic polyacrylic acid(PAA)binder,the self-association of-COOH groups in PAA leads to the formation of intramolecular and intermolecular hydrogen bonds,greatly weakening the bonding force of the binder to SiO ***,strengthening the binder-material interaction from the perspective of binder molecular regulation poses a significant ***,a modified PAA-Li_(x)(0.25≤x≤1)binder with prominent mechanical properties and adhesion strength is specifically synthesized for SiO anodes by quantitatively substituting the carboxylic hydrogen with *** appropriate lithium substitution(x=0.25)not only effectively increases the number of hydrogen bonds between the PAA binder and SiO surface owing to charge repulsion effect between ions,but also guarantees moderate entanglement between PAA-Li_x molecular chains through the ion-dipole *** such,the PAA-Li_(0.25)/SiO electrode exhibits exceptional mechanical properties and the lowest volume change,as well as the optimum cycling(1237.3 mA h g^(-1)after 100cycles at 0.1 C)and rate performance(1000.6 mA h g^(-1)at 1 C),significantly outperforming the electrode using pristine PAA *** work paves the way for quantitative regulation of binders at the molecular level.

关键词： Polyacrylic acid binder SiO anode Quantitative lithium substitution Charge repulsion effect Adhesion strength

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Human Placental Mesenchymal Stem Cells Relieve Primary Sclerosing Cholangitis via Upregulation of TGR5 in Mdr2^(-/-)Mice and Human Intrahepatic Cholangiocyte Organoid Models

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Research 2024年第2期2023卷 355-372页

作者： Qigu Yao wenyi Chen Yingduo Yu Feiqiong Gao Jiahang Zhou Jian Wu Qiaoling Pan Jinfeng Yang Lingling Zhou Jiong Yu Hongcui Cao Lanjuan Li State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases Cllaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affliated HospitalZhejang University School of Medicine79 Qingchun Rd.Hangzhou 310003China National Clinical Research Center for Infectious Diseases HangzhouChina Key Laboratory of Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province 79 Qingchun Rd.Hangzhou 310003China Jjinan Microecological Biomedicine Shandong Laboratory Jinan 250117China

Primary sclerosing cholangitis(PSC)is a biliary disease accompanied by chronic inflammation of the liver and biliary *** stem cells(MSCs)are used to treat liver diseases because of their immune regulation and regeneration-promoting *** study was performed to explore the therapeutic potential of human placental MSCs(hP-MSCs)in PSC through the Takeda G protein-coupled receptor 5(TGR5)receptor *** tissues were collected from patients with PSC and healthy donors(n=4)for RNA sequencing and intrahepatic cholangiocyte organoid ***-MSCs were injected via the tail vein into Mdr2^(-/-),bile duct ligation(BDL),and 3,5-diethoxycarbonyl-1,4-dihydrocollidine(DDC)mouse models or co-cultured with organoids to confirm their therapeutic effect on biliary *** in bile acid metabolic profile were analyzed by liquid chromatography/tandem mass spectrometry(LC-MS/MS).Compared with healthy controls,liver tissues and intrahepatic cholangiocyte organoids from PSC patients were characterized by inflammation and cholestasis,and marked downregulation of bile acid receptor TGR5 ***-MSC treatment apparently reduced the inflammation,cholestasis,and fibrosis in Mdr2^(-/-),BDL,and DDC model *** activating the phosphatidylinositol 3 kinase/extracellular signal-regulated protein kinase pathway,hP-MSC treatment promoted the proliferation of cholangiocytes,and affected the transcription of downstream nuclear factorκB through regulation of the binding of TGR5 and Pellino3,thereby affecting the cholangiocyte inflammatory phenotype.

关键词： inflammation TGR5 Human

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A Hierarchical Method for Locating the Interferometric Fringes of Celestial Sources in the Visibility Data

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Research in Astronomy and Astrophysics 2024年第3期24卷 110-128页

作者： Rong Ma Ruiqing Yan Hanshuai Cui Xiaochun Cheng Jixia Li Fengquan Wu Zongyao Yin Hao Wang wenyi Zeng Xianchuan Yu School of Artificial Intelligence Beijing Normal UniversityBeijing 100875China Department of Computer Science Swansea UniversitySwanseaSA18ENUK National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China

In source detection in the Tianlai project,locating the interferometric fringe in visibility data accurately will influence downstream tasks drastically,such as physical parameter estimation and weak source *** that traditional locating methods are time-consuming and supervised methods require a great quantity of expensive labeled data,in this paper,we first investigate characteristics of interferometric fringes in the simulation and real scenario separately,and integrate an almost parameter-free unsupervised clustering method and seeding filling or eraser algorithm to propose a hierarchical plug and play method to improve location ***,we apply our method to locate single and multiple sources’interferometric fringes in simulation ***,we apply our method to real data taken from the Tianlai radio telescope ***,we compare with unsupervised methods that are state of the *** results show that our method has robustness in different scenarios and can improve location measurement accuracy effectively.

关键词： methods data analysis-techniques image processing-techniques interferometric

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二维机器视觉测量中的图元识别

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计算机工程与应用 2006年第3期42卷 217-218页

作者：朱宏德娄小平邓文怡吕乃光北京机械工业学院北京100085

采用视觉测量方法对工件的各种断面尺寸参数进行测量时,需要在采集到的图像中找到被测量对象。文章给出了一种识别测量对象的图像匹配方法。该方法首先采用Canny方法从工件图像中提取出宽度为单像素的连续边缘图像,并根据工件的原理图... 详细信息

采用视觉测量方法对工件的各种断面尺寸参数进行测量时,需要在采集到的图像中找到被测量对象。文章给出了一种识别测量对象的图像匹配方法。该方法首先采用Canny方法从工件图像中提取出宽度为单像素的连续边缘图像,并根据工件的原理图纸生成待匹配的模板图像;对模板图像进行缩放和旋转,使之能在匹配率的约束下和边缘图像实现匹配;原理模板中包含图元的编码信息,据此可以在边缘图像中识别出工件的图元信息。实验结果表明,文中提出的方法能适用于一般工件的断面图元识别。

关键词：图元识别断面测量二维机器视觉测量

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Ultra-high spatio-temporal resolution imaging with parallel acquisition-readout structured illumination microscopy(PAR-SIM)

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Light(Science & Applications) 2024年第6期13卷 1140-1158页

作者： Xinzhu Xu wenyi Wang Liang Qiao Yunzhe Fu Xichuan Ge Kun Zhao Karl Zhanghao Meiling Guan Xin Chen Meiqi Li Dayong Jin Peng Xi Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing100871China Wallace H.Coulter Dept.of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlanta30332GAUSA National Biomedical Imaging Center Peking UniversityBeijing100871China Department of Biomedical Engineering College of EngineeringSouthern University of Science and TechnologyShenzhen518055GuangdongChina Airy Technologies Co. Ltd.Beijing100086China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingboZhejiang315200China School of Life Science Peking UniversityBeijing100871China Institute for Biomedical Materials and Devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW2007Australia

Structured illumination microscopy(SIM)has emerged as a promising super-resolution fluorescence imaging technique,offering diverse configurations and computational strategies to mitigate phototoxicity during real-time imaging of biological *** efforts to enhance system frame rates have concentrated on processing algorithms,like rolling reconstruction or reduced frame reconstruction,or on investments in costly sCMOS cameras with accelerated row readout *** this article,we introduce an approach to elevate SIM frame rates and region of interest(ROI)coverage at the hardware level,without necessitating an upsurge in camera expenses or intricate ***,parallel acquisition-readout SIM(PAR-SIM)achieves the highest imaging speed for fluorescence imaging at currently available detector *** using the full frame-width of the detector through synchronizing the pattern generation and image exposure-readout process,we have achieved a fundamentally stupendous information spatial-temporal flux of 132.9 MPixels·s^(−1),9.6-fold that of the latest techniques,with the lowest SNR of−2.11 dB and 100 nm ***-SIM demonstrates its proficiency in successfully reconstructing diverse cellular organelles in dual excitations,even under conditions of low signal due to ultra-short exposure ***,mitochondrial dynamic tubulation and ongoing membrane fusion processes have been captured in live COS-7 cell,recorded with PAR-SIM at an impressive 408 *** posit that this novel parallel exposure-readout mode not only augments SIM pattern modulation for superior frame rates but also holds the potential to benefit other complex imaging systems with a strategic controlling approach.

关键词： hardware illumination resolution

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Design,synthesis and biological evaluation of fluorescent derivatives of ursolic acid in living cells

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Chinese Chemical Letters 2024年第5期35卷 287-289页

作者： wenyi Mei Lijuan Xie Xiaodong Zhang Cunjian Shi Fengzhi Wang Qiqi Fu Zhenjiang Zhao Honglin Li Yufang Xu Zhuo Chen Shanghai Key Laboratory of New Drug Design State Key Laboratory of Bioreactor EngineeringSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China Innovation Center for AI and Drug Discovery East China Normal UniversityShanghai 200062China Lingang Laboratory Shanghai 200031China

Ursolic acid(UA)is a naturally occurring ursane triterpenoid,which exhibits a wide range of unique biological *** clarify its mechanism of action(MOA),a series of fluorescent derivatives of UA(5a-c)were designed and synthesized by conjugation with 7-nitrobenzo-2-oxa-1,3-diazole(NBD)*** them,5c exhibited similar anti-proliferative activity with UA against HCT116 cells(half maximal inhibitory concentration(IC_(50))=9.21±0.50μmol/L).Cell imaging experiment indicated that 5c was rapidly taken up in HCT116 cells in a dose and time-dependent ***,5c was found to localize in endoplasmic reticulum(ER),lysosomes,and mitochondria,but not in nucleus of HCT116 cells by confocal microscopy *** MOA proved that UA induced autophagy with a unique intracellular distribution mechanism involving ER and *** all,our work provides new clues for revealing the molecular mechanism of UA as an antitumor agent.

关键词： Pentacyclic triterpenoid Ursolic acid Fluorescent derivatives Autophagy Apoptosis

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金属氧化物类催化剂上HC-SCR研究进展

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环境科学与技术 2016年第1期39卷 93-100页

作者：周皞苏亚欣邓文义钟方川东华大学环境科学与工程学院上海201620 常州工程职业技术学院江苏常州213164

烃类化合物选择性催化还原氮氧化物(HC-SCR)是一种极具应用前景的烟气脱硝技术,金属氧化物类催化剂因水热稳定性好、中高温催化活性较高而在HC-SCR领域得到广泛研究。该文系统介绍了载体类型、负载金属、制备方式、还原剂、H2O和SO2对... 详细信息

烃类化合物选择性催化还原氮氧化物(HC-SCR)是一种极具应用前景的烟气脱硝技术,金属氧化物类催化剂因水热稳定性好、中高温催化活性较高而在HC-SCR领域得到广泛研究。该文系统介绍了载体类型、负载金属、制备方式、还原剂、H2O和SO2对金属氧化物类催化剂活性的影响,总结了其HC-SCR反应机理,对金属氧化物类催化剂在HC-SCR技术进一步应用研究进行了展望。

关键词：氮氧化物烃类 SCR 脱硝金属氧化物

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负载金属分子筛类催化剂上HC-SCR研究进展

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环境科学与技术 2015年第10期38卷 64-73页

作者：周皞苏亚欣邓文义钟方川东华大学环境科学与工程学院上海201620 常州工程职业技术学院江苏常州213164

烃类化合物选择性催化还原氮氧化物(HC-SCR)是一种极具应用前景的烟气脱硝技术,负载金属分子筛类催化剂因催化活性高而在HC-SCR领域得到广泛研究。该文简要总结了分子筛催化剂HC-SCR反应的机理,介绍了载体类型、负载金属、制备方式、还... 详细信息

烃类化合物选择性催化还原氮氧化物(HC-SCR)是一种极具应用前景的烟气脱硝技术,负载金属分子筛类催化剂因催化活性高而在HC-SCR领域得到广泛研究。该文简要总结了分子筛催化剂HC-SCR反应的机理,介绍了载体类型、负载金属、制备方式、还原剂、H_2O和SO_2对催化剂活性的影响。最后对负载金属分子筛催化剂在HC-SCR技术应用研究进行了展望。

关键词：氮氧化物烃类 SCR 脱硝负载金属分子筛

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SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4164-4173页

作者： Kaixiang Zhu Lili Song Linyue Wang Lei Hua Ziyu Luo Tongyun Wang Bo Qin Shuofeng Yuan Xiaopan Gao wenyi Mi Sheng Cui NHC Key Laboratory of Systems Biology of Pathogens National Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Key Laboratory of Pathogen Infection Prevention and Control(Peking Union Medical College) Ministry of EducationBeijing 100730China The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease(Ministry of Education)Tianjin Medical University General HospitalDepartment of ImmunologyTianjin Medical UniversityTianjin 300070China Medical School Yan’an UniversityShaanxi ProvinceYan’an 716000China State Key Laboratory of Emerging Infectious Diseases Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SARChina Department of Microbiology Li Ka ShingFaculty of Medicinethe University of Hong KongPokfulamHong Kong SARChina

Viruses often manipulate ubiquitination pathways to facilitate their replication and ***2ZYG11B known as the substrate receptor of cullin-2 RING E3 ligase,is bound by SARS-CoV-2 ORF10 to increase its E3 ligase activity,leading to degradation of IFT46,a protein component of the intraflagellar transport(IFT)complex *** results in dysfunctional cilia,which explains certain symptoms that are specific to ***,the precise molecular mechanism of how ORF10 recognizes CUL2ZYG11B remains ***,we determined the crystal structure of CUL2ZYG11B complexed with the N-terminal extension(NTE)of SARS-CoV-2 ORF10(2.9 A°).The structure reveals that the ORF10 N-terminal heptapeptide(NTH)mimics the Gly/N-degron to bind *** studies identified key residues within ORF10 that are key players in its interaction with CUL2ZYG11B both in ITC assay and in vivo *** addition,we prove that enhancement of CUL2ZYG11B activity for IFT46 degradation by which ORF10-mediated correlates with the binding affinity between ORF10 and ***,we used a Global Protein Stability system to show that the NTH of ORF10 mimics the Gly/N-degron motif,thereby binding competitively to CUL2ZYG11B and inhibiting the degradation of target substrates bearing the Gly/N-degron ***,this study sheds light on how SARS-CoV-2 ORF10 exploits the ubiquitination machinery for proteasomal degradation,and offers valuable insights for optimizing PROTAC-based drug design based on NTH CUL2ZYG11B interaction,while pinpointing a promising target for the development of treatments for COVID-19.

关键词： SARS-CoV-2 ORF10 Crystal structure cullin-2 RING E3 ligase Drug design

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基于FPGA的图像增强处理系统的设计与实现

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微计算机信息 2007年第26期23卷 229-230,122页

作者：韩娟娟邓文怡娄小平北京机械工业学院北京硕士研究生100085

FPGA(现场可编程门阵列)可以灵活地实现并行、实时处理图像数据。正是利用这一特点,提出了一种基于FPGA的SOPC(片上可编程系统),该SOPC完成图像增强处理。本文阐述了图像对比度增强算法原理,提出了系统设计思路,并分析了该系统的结构及... 详细信息

FPGA(现场可编程门阵列)可以灵活地实现并行、实时处理图像数据。正是利用这一特点,提出了一种基于FPGA的SOPC(片上可编程系统),该SOPC完成图像增强处理。本文阐述了图像对比度增强算法原理,提出了系统设计思路,并分析了该系统的结构及功能实现,说明了系统实现过程,最后,给出了测试结果,并和软件处理的结果进行了对比。证明该方案的正确性与应用的可行性。

关键词： FPGA VHDL(超高速集成电路硬件描述语言) SOPC 图像对比度增强

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