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获得性免疫在干眼的启动与维持

国际眼科杂志 2024年第4期24卷 534-538页

作者：孙文鑫郭俞利刘祖国南华大学衡阳医学院湖南省衡阳市421001 南华大学附属第一医院眼科湖南省衡阳市421001 厦门大学眼科研究所福建省眼科与视觉科学重点实验室福建省厦门市361102

干眼(dry eye,DE)是一种由多种因素介导,发病机制复杂的常见慢性眼表疾病。干眼致病因素主要包括免疫炎症,氧化应激,泪膜成分的改变,角膜神经异常和睑板腺功能障碍等。其中,免疫炎症反应是干眼发病机制中最为关键的环节,由眼表的天然免... 详细信息

干眼(dry eye,DE)是一种由多种因素介导,发病机制复杂的常见慢性眼表疾病。干眼致病因素主要包括免疫炎症,氧化应激,泪膜成分的改变,角膜神经异常和睑板腺功能障碍等。其中,免疫炎症反应是干眼发病机制中最为关键的环节,由眼表的天然免疫和获得性免疫反应共同调节。多种环境应激引发眼表天然免疫反应导致上皮细胞损伤和炎症,并激活获得性免疫参与眼表免疫炎症反应。目前已发现多种免疫细胞以及炎症因子参与了DE的发生和发展。本文就DE的免疫机制研究进展进行综述,并重点探讨获得性免疫在DE的启动与维持。通过分析最新观点和研究热点,我们对DE发病机制中的免疫调节机制进行了系统的介绍,并为DE的防治提供参考。

关键词：干眼天然免疫获得性免疫发病机制

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乙醇汽油对汽车污染物排放影响研究进展

环境科学研究 2024年第3期37卷 514-524页

作者：魏阳冰陈宏飞谢沛远孙文欣朱仁成王运静张超越郑州大学生态与环境学院河南郑州450001 中国环境科学研究院北京100012

“双碳”背景下,替代燃料乙醇汽油的推广应用在汽车减污降碳和能源安全领域受到广泛关注.为研究乙醇汽油对汽车污染物和温室气体排放的影响,本研究基于大量文献数据,统计分析了乙醇汽油的使用对汽车尾气常规气态污染物、颗粒物(PM)、温... 详细信息

“双碳”背景下,替代燃料乙醇汽油的推广应用在汽车减污降碳和能源安全领域受到广泛关注.为研究乙醇汽油对汽车污染物和温室气体排放的影响,本研究基于大量文献数据,统计分析了乙醇汽油的使用对汽车尾气常规气态污染物、颗粒物(PM)、温室气体、挥发性有机物(VOCs)以及蒸发排放的影响,并综合评估其对二氧化碳(CO_(2))、PM和VOCs的减排效果,进一步针对典型区域分析乙醇汽油推广应用带来的环境效益.结果表明:①与传统汽油相比,乙醇汽油的使用可以降低尾气中总碳氢化合物(THC)、一氧化碳(CO)、氮氧化物(NOx)、VOCs、PM及其数量的排放,其降幅分别为10.0%、22.0%、1.3%、17.7%、21.3%、14.9%,且减排率均随汽油中乙醇含量的升高而增高,但是有增加VOCs蒸发排放量的趋势.②乙醇汽油对尾气中温室气体的减排效果并不显著,但通过减少化石燃料的使用能在一定程度上减少机动车尾气中CO_(2)的排放.以2022年河南省轻型汽油车保有量为基准,评估了河南省全省推广乙醇汽油(E10汽油)后轻型汽油车CO_(2)、PM及VOCs的减排量,分别为9.1×10^(5)、92.4和1118.1 t/a.研究显示,乙醇汽油的推广使用具有一定的减污降碳协同效益,加强蒸发排放控制能够进一步降低使用乙醇汽油时的污染物排放.

关键词：乙醇汽油尾气排放蒸发排放颗粒物(PM) 挥发性有机物(VOCs) 温室气体

Enhanced corrosion resistance,antibacterial activity and biocompatibility of gentamicin-montmorillonite coating on Mg alloy-in vitro and in vivo studies

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Journal of Materials Science & Technology 2022年第16期111卷 167-180页

作者： Lijun Fan wenxin sun Yuhong Zou Qian-qian Xu Rong-Chang Zeng Jingrui Tian Department of Bioengineering College of Chemical and Biological EngineeringShandong University of Science and TechnologyQingdao 266590China Light Alloy Corrosion Laboratory College of Materials Science and EngineeringShandong University of Science and TechnologyQingdao 266590China Hospital of Shandong University of Science and Technology Qingdao 266590China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450002China

Implant-associate infection(IAI)is a major cause of failure of bone implant materials,and one of the significant challenges in clinical managements.A synergistic coating strategy combining montmorillonite(MMT)sustained release,adsorption of bacteria and gentamicin(GS)bactericidal is proposed herein to tackle infection *** morphology,microstructure and chemical composition of the samples were investigated using SEM,XRD,FT-IR and *** experiments and immersion experiments reveal that corrosion resistance of Mg samples with GS/MMT coatings was higher than that of bare Mg alloy substrate in DMEM *** vitro studies demonstrated that the GS/MMT coating had a significant inhibitory effect on Escherichia coli(***)and Staphylococcus aureus(***).The viability of MC3T3-E1 cells was 92.7%after a co-culturing for 72 *** a subcutaneous transplantation of 90days,the survival rate was 100%for GS/MMT-coated Mg alloy specimens with no infection at the implantation sites and no toxic damage to liver,kidney and local muscles pathological *** study provides a novel method for the preparation of sustained-release antimicrobial coatings on biodegradable Mg alloys as promising candidates for orthopedic implant materials.

关键词： Magnesium alloy Montmorillonite Gentamicin Antibacterial activity Coating

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樱桃果实采后致腐病原菌鉴定及其致病性研究

扬州大学学报（农业与生命科学版） 2024年第3期45卷 120-129页

作者：孙文馨经盛红施恒松杨丽娜朱峰董京萍纪兆林扬州大学植物保护学院江苏扬州225009

为有效防止采后樱桃腐烂,减少果品损失,先后对4批次室温贮藏的我国山东和美国产地新鲜健康甜樱桃进行观察,对初现病斑和腐烂樱桃果进行病原菌分离,采用分子生物学方法对其菌株进行鉴定,并接种健康樱桃果实进行致病性测定。结果表明:4批... 详细信息

为有效防止采后樱桃腐烂,减少果品损失,先后对4批次室温贮藏的我国山东和美国产地新鲜健康甜樱桃进行观察,对初现病斑和腐烂樱桃果进行病原菌分离,采用分子生物学方法对其菌株进行鉴定,并接种健康樱桃果实进行致病性测定。结果表明:4批次从贮藏期开始腐烂的樱桃果实中共分离出12株真菌和16株细菌代表菌株,其中10株真菌具致病性,涉及6个种,分别鉴定为Alternaria sp.、Fusarium sp.、Epicoccum sorghinum、Dothiorella viticola、Nothophoma quercina和Paraconiothyrium brasiliense;8株细菌具一定的致病性但致病力较弱,涉及6个种,分别鉴定为Pantoea sp.、Bacillus sp.、Tatumella sp.、Gluconobacter sp.、Phaseolibacter sp.和Sphingomonas sp.。不同产地采后腐烂樱桃分离的真菌和细菌种类不同,其致病力也存在差异。这一研究可为樱桃采后致腐病原的进一步防治以及采后防腐保鲜技术研发提供参考。

关键词：樱桃采后腐烂病原菌分离和鉴定致病性测定

Effect of safety valve types on the gas venting behavior and thermal runaway hazard severity of large-format prismatic lithium iron phosphate batteries

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Journal of Energy Chemistry 2024年第2期89卷 195-207,I0006页

作者： Zhuangzhuang Jia Yuanyuan Min Peng Qin wenxin Mei Xiangdong Meng Kaiqiang Jin Jinhua sun Qingsong Wang State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230026AnhuiChina Gotion High-Tech Co. Ltd.Hefei 230012AnhuiChina

The safety valve is an important component to ensure the safe operation of lithium-ion batteries(LIBs).However,the effect of safety valve type on the thermal runaway(TR)and gas venting behavior of LIBs,as well as the TR hazard severity of LIBs,are not *** this paper,the TR and gas venting behavior of three 100 A h lithium iron phosphate(LFP)batteries with different safety valves are investigated under *** to previous studies,the main contribution of this work is in studying and evaluating the effect of gas venting behavior and TR hazard severity of LFP batteries with three safety valve *** significant results are obtained:(Ⅰ)the safety valve type dominates over gas venting pressure of battery during safety venting,the maximum gas venting pressure of LFP batteries with a round safety valve is 3320 Pa,which is one order of magnitude higher than other batteries with oval or cavity safety valve;(Ⅱ)the LFP battery with oval safety valve has the lowest TR hazard as shown by the TR hazard assessment model based on gray-fuzzy analytic hierarchy *** study reveals the effect of safety valve type on TR and gas venting,providing a clear direction for the safety valve design.

关键词： Lithium iron phosphate battery Safety valve Thermal runaway Gas venting behavior Thermal runaway hazard severity Gray-fuzzy analytic hierarchy process

2021年学生营养健康状况监测地区中小学生维生素A水平及影响因素

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中华疾病控制杂志 2024年第5期28卷 523-529页

作者：孙文鑫徐培培甘倩许娟杨媞媞曹薇王宏亮罗瑞鹤潘慧王志芳付一萌张倩中国疾病预防控制中心营养与健康所北京100050 国家卫生健康委员会微量元素与营养重点实验室北京100050

目的分析2021年“农村义务教育学生营养改善计划”(简称“学生营养改善计划”)监测地区中小学生维生素A水平及影响因素。方法血清维生素A浓度0.2~0.3μg/mL定义为维生素A边缘性缺乏,<0.2μg/mL定义为维生素A缺乏,将维生素A边缘缺乏和... 详细信息

目的分析2021年“农村义务教育学生营养改善计划”(简称“学生营养改善计划”)监测地区中小学生维生素A水平及影响因素。方法血清维生素A浓度0.2~0.3μg/mL定义为维生素A边缘性缺乏,<0.2μg/mL定义为维生素A缺乏,将维生素A边缘缺乏和缺乏合并为维生素A不足。对“学生营养改善计划”监测地区6~17岁中小学生开展问卷调查、体格检测和实验室检查,分析其维生素A水平及影响因素。结果 45 702名中小学生维生素A的均值为0.37(0.31,0.44)μg/mL,维生素A边缘缺乏率为18.3%,缺乏率为1.0%。不同性别、年龄组、学校所在地的中小学生维生素A营养状况存在差异。多因素logistic回归分析模型分析结果显示6~<9岁年龄组(OR=3.892, 95%CI:3.303~4.587,P<0.001)、学校位于农村(OR=1.148, 95%CI:1.072~1.229,P<0.001)、父母一方及以上在外务工(OR=1.234, 95%CI:1.153~1.321,P<0.001)、母亲文化程度在高中及以下(OR=1.169,95%CI:1.046~1.306,P=0.006)、无法保证每天都喝奶(OR=1.155, 95%CI:1.075~1.240,P<0.001)、蔬菜摄入<4种/d(OR=1.081, 95%CI:1.006~1.163,P=0.034)的中小学生维生素A不足的风险增加。结论 2021年“学生营养改善计划”学生营养健康状况监测地区中小学生维生素A边缘缺乏率较高,且低年龄段儿童更易发生维生素A边缘缺乏或维生素A缺乏。母亲文化程度、奶类和蔬菜摄入情况等是维生素A缺乏的潜在影响因素,需社会予以关注和重视。

关键词：维生素A 中小学生影响因素

Application of a self adaptive method to the simulation of the tidal front in the Huanghai Sea

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Acta Oceanologica Sinica 2013年第3期32卷 34-41页

作者： WANG Hui sun wenxin ZHOU Xubo College of Physical and Environmental Oceanograph Ocean University of China College of Physics Science Qingdao University

A self adaptive three-dimensional baroclinic model is designed. A horizontal temperature gradient is used to control the grid size, which can improve computational precision in the fronts without inordinately increasing computation in the whole area. A simulation of the development and disappearance of the front in the Huanghai Sea is conducted with this model. Simulations of temperature distribution throughout the year are also conducted. The comoutational result agrees well with the observation.

关键词： self adaptive mesh temperature front baroclinic Huanghai Sea

Frequency of Food Consumption Among Students Aged 8–15 Years—China,2019 and 2021

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China CDC weekly 2023年第24期5卷 533-537页

作者： Yimeng Fu Juan Xu Qian Gan Titi Yang Peipei Xu Wei Cao Hongliang Wang Hui Pan Ruihe Luo wenxin sun Zhifang Wang Qian Zhang National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijingChina

A balanced consumption of various types of food items plays a crucial role in students’physical and intellectual development,providing the foundation for their lifelong health(1).In recent years,the living standards in China have improved,leading to a steady improvement in the intake of various foods among Chinese students(2).However,uneven socioeconomic development and differing natural environments may lead to disparities in food consumption between rural and urban students(3).The prevalence of malnutrition among rural students has decreased but remains higher than among urban students(4).Furthermore,consumption of various healthy foods increased during the coronavirus disease 2019(COVID-19)pandemic as a means to boost immunity and promote health(5).

关键词： immunity boost intake

Additive manufacturing of NiTi lightweight porous structures bio-mimicking coral skeleton with enhanced mechanical properties and shape memory functions

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Science China Technological Sciences 2024年第8期67卷 2461-2474页

作者： LIU Xin GU DongDong YUAN LuHao ZHANG Han sun JianFeng CHEN wenxin WANG Jie SHI KeYu Jiangsu Provincial Research Center for Laser Additive Manufacturing of High-Performance Components College of Materials Science and Technology Nanjing University of Aeronautics and Astronautics

Concerning the high demand for lightweight and multifunctional properties of engineering structures, the coral skeleton-inspired sheet-based（CSS） structure, which was a novel bio-mimicking coral skeleton wall-septa architecture with a unique ability to resist wave shocks was fabricated using NiTi alloy by laser powder bed fusion（LPBF） technology. The effects of laser energy density（LED） on surface morphologies, microstructures, phase transformation behavior, and mechanical properties of LPBFfabricated CSS structures were systematically investigated. The results indicated that the size deviation was predominantly governed by powder adhesion and step effect. NiTi CSS structures with LED of 71 J·mm-3possessed superior compressive modulus（～400 MPa）, ultimate strength（～13 MPa）, and energy absorption efficiency（～69%）. The compression fracture mechanism of the LPBF-fabricated NiTi CSS structures was revealed to be predominantly brittle fracture accompanied by ductile fracture. Furthermore, the Ni4Ti3nanoprecipitates induced the precipitation strengthening effect, enabling better shape memory response at LED of 71 J·mm-3, with a recoverable strain of 3.63% and recovery ratio of 90.8%, after heating under a pre-strain of 4%. This study highlights the importance of a bionic design strategy for enhancing the mechanical properties of NiTi components and offers the possibility to tailor its functional properties.

关键词： bioinspired structures laser powder bed fusion NiTi shape memory alloy mechanical performance

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