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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang wenwu zhang Gang Li Xing Cheng Peiqiang Su Yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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Numerical Simulation Study on Cooling Characteristics of a New Type of Film Hole

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Journal of Thermal Science 2021年第1期30卷 210-219页

作者： GUO Chunhai WANG Bin KANG Zhenya zhang wenwu ZHENG Huilong Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China

A new type of film cooling hole with micro groove structure is presented in this *** on the finite volume method and the Realizable k-εmodel,the film cooling process of the hole in a flat plate structure is *** surface temperature distribution and film cooling effect of different film cooling holes were *** effects of micro-groove structure on wall attachment and cooling efficiency of jet were *** results show that under the same conditions,the transverse coverage width and overall protective area of the new micro-groove holes are larger than those of the ordinary cylindrical holes and special-shaped *** with ordinary holes,the new micro-groove holes can better form the film covering on the surface and enhance the overall film cooling efficiency of the *** example,when the blowing ratio M=1.5,the effective coverage ratio of micro-groove holes is 1.5 times the dustpan holes and is 8 times the traditional cylindrical *** provides reference data and experience rules for the optimization and selection of advanced cooling structure of high performance aero-gas engine hot-end components.

关键词： film cooling shaped hole numerical simulation optimal design cooling efficiency

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Dramatic sediment load changes and sedimentation characteristics upstream of the Three Gorges Dam due to the large reservoirs construction

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Frontiers of Earth Science 2024年第3期18卷 565-578页

作者： Jie LIU wenwu zhang Ying SHEN Xin WANG National Inland Waterway Regulation Engineering Research Center Chongqing Jiaotong UniversityChongqing 400074China State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China School of River&Ocean Engineering Chongqing Jiaotong UniversityChongqing 400074China Tianjin Research Institute for Water Transport Engineering Tianjin 300456China

After the construction of cascade reservoirs in the upper reaches of the Three Gorges Reservoir(TGR),the sediment load outflow of the upper Yangtze River Basin(YRB)has been significantly altered,decreasing from 491.8 Mt/yr(1956–2002)to 36.1 Mt/yr(2003–2017)at Yichang *** has widely affected river hydrology,suspended sediment grain size distribution,and channel *** study analyzed hydrological variations in water discharge and sediment load of the upper YRB over the past 62 years(1956–2017)by employing a double mass *** variations in the source areas of sediment yielding for the upper YRB were quantified,and field measurement data of the cross-channel profile were collected to investigate the sedimentation process in the TGR from 2003 to *** than 90%of the sediment load reduction in the upper YRB may be explained by human *** Jinshajiang River was no longer the largest sediment source area for the Zhutuo station(accounting for 5.23%)in the 2013–2017 time span,and the sediment rating rates for the inflow and outflow of the TGR shifted to negatively correlated.A longitudinal fining trend was revealed in the suspended sediment ***,the mean median grain size of suspended sediment in the TGR had an increasing trend in the 2013–2017 *** result may be closely related to sediment regulation in reservoirs and incoming sediment load *** in the TGR decreased sharply from 299.8 Mt/yr in 2003–2012 to 47.2 Mt/yr in 2013–2017,but the sedimentation rate of the TGR remained at>80%***,some cross sections in the fluctuating backwater zone experienced scouring.

关键词： cascade reservoirs sediment load sedimentation characteristics suspended sediment grain size Three Gorges Reservoir

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bcl-xl over-expression in transgenic mice reduces cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2008年第11期3卷 1237-1240页

作者： Furong Wang Yongsheng Jiang Yan Liu wenwu Xiao Suming zhang Department of Neurology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wunhan 430030Hubei Province China

BACKGROUND： Basal cell lymphoma-extra large （bcl-xl） can inhibit neuronal apoptosis by stabilizing the mitochondrial membrane and suppressing cytochrome C release into the cytoplasm. OBJECTIVE： This study aimed to further investigate the cascade reaction pathway of cellular apoptosis. We established an ischemia/repcrfusion model by middle cerebral artery occlusion （MCAO） in transgenic and wild-type mice, and observed changes in the number and distribution of apoptotic neural cells, differences in cerebral infarct volume, in neurological function score, and in cytochrome C expression in the ischemic cerebral cortex, at different time points, DESIGN AND SETTING： The present gene engineering and cell biology experiment was performed at the Laboratory of Biology, Hubei Academy of Agricultural Sciences and at the Laboratory of Immunology, Tongji Medical College, Huazhong University of Science and Technology. MATERIALS： Male bcl-xl over-expression Kunming mice aged 8 weeks and age-matched male wild-type mice were used for this study. Terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling （TUNEL） kits were purchased from Boliman, France. Cytochrome C antibody and Bcl-x immunohistochemical kit were purchased from PharMingen, USA and Santa Cruz Biotechnology, USA, respectively. METHODS： Following MCAO and reperfusion, apoptosis in the ischemic cerebral cortex was detected by the TUNEL assay. Prior to MCAO and 3 hours after reperfusion, the Bcl-xl protein level in the ischemic cerebral cortex was measured by immunohistochemistry. At 3, 6, 12 and 24 hours after reperfusion, the level of cytochrome C in the ischemic cerebral cortex was examined by western blot analysis. Subsequent to MCAO, cerebral infarct volume measurement and neurological examination were performed. MAIN OUTCOME MEASURES： Neural cell apoptosis and cytochrome C expression in the ischemic cerebral cortex; cerebral infarct volume and neurological function score. RESULTS： Twenty-four hours after rep

关键词： mouse transgenic cerebral infarction proto-oncogene cytochrome C

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A supersaturated Cu-Ag nanoalloy joint with ultrahigh shear strength and ultrafine nanoprecipitates for power electronic packaging

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Journal of Materials Science & Technology 2023年第14期145卷 56-65页

作者： wenwu zhang Penghao zhang Dashi Lu Hao Pan Xiangli Liu Chengyan Xu Jun Wei Mingyu Li Hongjun Ji The State Key Laboratory of Advanced Welding and Joining School of Materials Science and EngineeringHarbin Institute of Technology at ShenzhenShenzhen 518055China Sauvage Laboratory for Smart Materials School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Shenzhen Key Laboratory of Flexible Printed Electronics Technology Harbin Institute of Technology(Shenzhen)Shenzhen 518055China

Ag-Cu bimetallic nanoalloy,integrating the advantages of reducing migration and cost of nano-Ag and alleviating oxidation of nano-Cu,is a prospective bonding material for power electronic *** Ag-coated Cu nanoparticles(Cu@Ag NPs)paste can execute bonding with high quality at 250℃,and the achieved supersaturated Ag-Cu nanoalloy joint with ultrahigh shear strength(152 MPa)dramatically exceeds most nano-paste *** interstitial solid solutions with atomic-level metallurgical bonds at the interface dominantly promoted the shear ***,the numerous ultrafine nanograin,high proportion of low angle grain boundaries(7.44%)without deformation,and the Cu nanoprecipitates in the joint would improve ***,the high content(16.8%)of∑3 twin boundaries would contribute to the electrical and thermal ***,the multiple strengthening mechanisms with the solid solution,the second precipitated phase,and ultrafine nanograin can dramatically enhance shear strength and electro-thermal conductivity of joints for high-temperature device packaging.

关键词： Supersaturated Ag-Cu solid solution Cu nanoparticle precipitates Ultrafine nanograin Strengthening mechanism Electronic packaging

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Improving superficial microstructure and properties of the laser-processed ultrathin kerf in Ti-6Al-4V alloy by water-jet guiding

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Journal of Materials Science & Technology 2023年第25期156卷 32-53页

作者： Yang Chao Yuezhuan Liu Zifa Xu Weixin Xie Li zhang Wentai Ouyang Haichen Wu Zebin Pan Junke Jiao Shujun Li Guangyi zhang wenwu zhang Liyuan Sheng Ningbo Institute of Materials Technology and Engineering Key Laboratory of Aero Engine Extreme Manufacturing Technology of Zhejiang ProvinceCASNingbo 315201China School of Mechanical Engineering Ningbo University of TechnologyNingbo 315336China Huizhou Port Customs Huizhou 516084China School of Mechanical Engineering Yangzhou UniversityYangzhouJiangsu 225127China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China Shenzhen Institute Peking UniversityShenzhen 518057China PKU-HKUST ShenZhen-HongKong Institution Shenzhen 518057China

In the present research,the gas-assisted laser(GAL)and water-jet guided laser(WGL)processing technologies were applied to machine the ultrathin kerf in the wrought Ti-6Al-4V *** microstructure,microhardness,and wear properties of the superficial layer were *** results reveal that the GAL processing could machine the kerf with a high depth-to-width ratio of 12–15,but the increased processing times enhance the depth *** to the oxygen entrainment and relatively low heat and mass transferring efficiency,the assisted gas promotes the formation of a scaled recast layer containingβ-Ti phase and oxides,which increases the roughness to 20μ*** WGL processed kerf has a low depth-to-width ratio with a value of 1.9–2.5 and the depth could be increased by increasing the WGL processing *** the assistance of the water jet,the remelted debris and heat could be eliminated immediately,which restrains the formation of the recast layer and heat-affected *** ultrathin oxide outer layer with hundreds of nanometers and ultrafineα-Ti grain inner layer are formed on the surface,which decreases the roughness to 12μ*** with the as-received Ti-6Al-4V alloy,the microhardness of GAL processed kerf surface is increased to 382.8 HV accompanied by residual tensile stress,while the microhardness of WGL processed kerf surface is increased to 481.6 HV accompanying with residual compressive *** addition,the GAL processing increases the wear rate at room temperature but decreases the wear rate at high ***,the WGL processing decreases the wear rate at room and high temperatures,*** wear behaviors could be ascribed to their different superficial microstructures and phase constituents.

关键词： Ti-6Al-4V alloy Water-jet guided laser processing Superficial layer Microstructure Wear properties

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Ring finger protein 157 is a prognostic biomarker and is associated with immune infiltrates in human breast cancer

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BIOCELL 2023年第10期47卷 2265-2281页

作者： XIN ZHU BIN XIAO wenwu zhang XIAOYU SONG WEI GONG LINHAI LI XINPING CHEN School of Life Sciences Hainan UniversityHaikou570228China Department of Medical Laboratory Hainan Cancer HospitalAffiliated Cancer Hospital of Hainan Medical UniversityHainan Tropical Cancer Research InstituteHaikou570312China Department of Laboratory Medicine The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuan511518China Graduate School Guangzhou University of Chinese MedicineGuangzhou510006China School of Pharmaceutical Sciences Hainan UniversityHaikou570228China

Background: The protein encoded by ring finger protein 157 (RNF157) is known to function as an E3 ubiquitinligase. However, whether the level of RNF157 expression in breast cancer correlates with prognosis and immune cellinfiltration among breast cancer patients remains to be further explored. Methods: In this study, publicly availabledatasets were used for evaluating RNF157 expression in different tumors compared with normal samples. Severalindependent datasets were screened for investigating the relationship between RNF157 and breast cancer survival,different mutation profiles, and tumor immune cell infiltration. We conducted a pathway enrichment analysis toidentify signaling pathways associated with RNF157. Results: Analysis of public and online databases revealed thatRNF157 expression markedly decreased in breast cancer tissue samples compared to non-carcinoma ***, immunohistochemistry assays also demonstrated this RNF157 down-regulation in breast cancer ***157 up-regulation could predict the improved survival of breast cancer cases. Further, different RNF157expression level groups exhibited different mutational profiles. Pathway enrichment profiling of RNF157-related genessuggested its possible involvement in regulating breast cancer via the mitogen-activated protein kinase (MAPK)pathway. RNA sequencing (RNA-seq) data and genomic enrichment analysis showed that RNF157 downregulatedseveral genes positively associated with the MAPK signaling pathway. We also explored RNF157 expression andimmune cell infiltration in breast cancer and found that RNF157 mRNA levels were negatively related to non-Timmune cell infiltration. Conclusion: According to our work, RNF157 may be a promising diagnostic biomarker andtherapeutic target for breast cancer.

关键词： RNF157 Prognosis Immune infiltrate MAPK signal pathway Breast cancer

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Optimal flexibility dispatch of demand side resources with high penetration of renewables:a Stackelberg game method

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Global Energy Interconnection 2021年第1期4卷 28-38页

作者： Peng Lu Hao Lv Nian Liu Tieqiang Wang Jianpei Han wenwu zhang Li Ma State Grid Hebei Electric Power Company Shijiazhuang 050011Hebei ProvinceP.R.China North China Electric Power University Beijing 102206P.R.China Tellhow Software Co.Ltd. Nanchang 330096Jiangxi ProvinceP.R.China Stevens Institute of Technology HobokenNJ 07030USA

To promote the utilization of renewable energy,such as photovoltaics,this paper proposes an optimal flexibility dispatch method for demand-side resources(DSR)based on the Stackelberg game ***,the concept of the generalized DSR is analyzed and flexibility models for various DSR are ***,owing to the characteristics of small capacity but large-scale,an outer approximation is proposed to describe the aggregate flexibility of ***,the optimal flexibility dispatch model of DSR based on the Stackelberg game is established and a decentralized solution algorithm is designed to obtain the Stackelberg ***,the actual data are utilized for the case study and the results show that,compared to the traditional centralized optimization method,the proposed optimal flexibility dispatch method can not only reduce the net load variability of the DSR aggregator but is beneficial for all DSR owners,which is more suitable for practical applications.

关键词： Demand side resource Optimal dispatch Aggregate flexibility Stackelberg game Decentralized solution

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Design of Damping Damping Design of New Boring Head Drive Structure

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Mechanical Engineering Science 2023年第1期5卷 4-6,I0006,I0007页

作者： Haoyang LIU Zhaowei MENG Liang HAN wenwu zhang Yingkou Institute of Technology YingkouLiaoning115004China

This paper takes the boring head of 20 roll mill as the research object,optimizes the vibration inside the boring head through a differential damping structure,and then conducts the 3 d model inside the boring head through SolidWorks,and checks the interference of the boring head ***,Ansys workbench finite element analysis software is used to analyze and verify the vibration damping characteristics of the differential damping structure.

关键词： Gear drive Damping Vibration Reduction

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Design of High Precision CNC Vertical Lathe Turning Tool Holder

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Mechanical Engineering Science 2023年第1期5卷 22-26,I0005页

作者： wenwu zhang Guangchen XU Lin QIAN Mantong WANG Jiayu LI Yingkou Institute of Technology YingkouLiaoning115000China 不详

A large aspect ratio vibration reducing tool holder based on passive damping vibration reduction technology is designed to solve the vibration problem that occurs in deep hole machining of vertical lathes.A dynamic model of passive damping vibration reduction tool holder was established,and the optimal damping ratio,optimal frequency ratio,and maximum relative amplitude were *** analysis of the passive damping vibrationreduction tool holder was conducted using *** results showed that the maximum response amplitude of the passive damping vibration reduction tool holder decreased significantly compared to the original one.

关键词： CNC vertical lathe Cutting chatter Cutting tool holder

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