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中华实验外科杂志 2003年第5期20卷 427-428页

作者：张建国杨维良沈滨秦华东邹小明 wennberg l 哈尔滨医科大学附属第二医院普外科 150086 瑞典卡洛林斯卡医学院呼丁医院移植外科

目的　研究FTY72 0单独用药和联合应用FTY72 0及环孢素A (CsA)在抑制猪大鼠异种胰岛移植排斥反应中的作用。方法　大鼠肾被膜下移植成年猪胰岛 (APIs) 2 μl,单独应用FTY72 0 ( 1.0mg/kg·d和 3 .0mg/kg·d)和联合应用FTY 72 0及CsA(F... 详细信息

目的　研究FTY72 0单独用药和联合应用FTY72 0及环孢素A (CsA)在抑制猪大鼠异种胰岛移植排斥反应中的作用。方法　大鼠肾被膜下移植成年猪胰岛 (APIs) 2 μl,单独应用FTY72 0 ( 1.0mg/kg·d和 3 .0mg/kg·d)和联合应用FTY 72 0及CsA(FTY 72 0 1.0mg/kg·d +CsA15mg/d和FTY72 0 3 .0mg/kg·d +CsA15mg/kg·d)。移植后 12d应用免疫组织化学染色方法来观察移植物内细胞浸润情况。结果　单独应用FTY72 0不能抑制API异种移植排斥反应的发生 ;在FTY72 0 +CsA组 ,排斥反应过程被明显抑制。在移植后第 12天 ,可以见到大量完整的API ,仅偶尔有细胞浸润。内分泌组织完整。结论　在猪大鼠异种胰岛细胞模型中 ,联合应用FTY72 0及CsA可有效抑制排斥反应直到移植后第 12天 ,且未出现任何明显毒性作用。

关键词： FTY720 异种胰岛移植排斥反应环孢素A

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维普期刊数据库

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对1962年金属加工文献的评论——金属切削的分析部分

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工具技术 1964年第11期 45-47页

作者： J.l.wennberg ,B.F.von Turkovich ,潘敏元

切屑形成的理论在1962年期间,有几篇重要的文章发展了金属切创过程的理论。***继续发展了他的关于加工硬化材料的理论。提出了改进的角度系关式,比Merchant,lee和Shaffer等人的理论更能符合实验数据。他的

关键词：金属切削切创文章耐用度切削力刀具切削速度切削用量测力仪测力计切屑形成

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急性心肌梗死的医保患者的介入与药物治疗强度存在地区差别的长期结果

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世界核心医学期刊文摘（心脏病学分册） 2005年第9期1卷 17-18页

作者： Stukel T.A. lucas F.l. wennberg D.E. 任付先 Dr. Inst. for Clin. Evaluative Sciences G106-2075 Bayview Ave Toronto Ont. M4N 3M5 Canada

Context: The health and policy implications of the marked regional variations in intensity of invasive compared with medical management of patients with acute myocardial infarction(AMI) are unknown. Objectives: To evaluate patient clinical characteristics associated with receiving more intensive treatment; and to assess whether AMI patients residing in regions with more intensive invasive treatment and management strategies have better longterm survival than those residing in regions with more intensive medical management strategies. Design, Setting, and Patients: National cohort study of 158831 elderly Medicare patients hospitalized with first episode of confirmed AMI in 1994-1995, followed up for 7 years(mean, 3.6 years), according to the intensity of invasive management(perfor-mance of cardiac catheterization within 30 days) and medical management(prescription of βblockers to appropriate patients at discharge) in their region of residence. Baseline chart reviews were drawn from the Cooperative Cardiovascular Project and linked to Medicare health administrative data. Main Outcome Measure: long-term survival over 7 years of followup. Results: Patient baseline AMI severity was similar across regions. In all regions, younger and healthier patients were more likely than older high-risk patients to receive invasive treatment and medical therapy. Regions with more invasive treatment practice styles had more cardiac catheterization laboratory capacity; patients in these regions were more likely to receive interventional treatment, regardless of age, clinical indication, or risk profile. The absolute unadjusted difference in 7-year survival between regions providing the highest rates of both invasive and medical management strategies and those providing the lowest rates of both was 6.2%. For both ST-and non-ST-segment elevation AMI patients, survival improved with regional intensity of both invasive and medical management. In areas with higher rates of medical management,

关键词：治疗强度急性心肌梗死医保患者药物治疗地区差别 β受体阻断剂远期生存率介入治疗队列研究心导管室

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维普期刊数据库

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在有和无现场冠状动脉旁路移植外科的治疗中心分别进行经皮冠状动脉介入治疗的结果

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世界核心医学期刊文摘（心脏病学分册） 2005年第3期1卷 6-7页

作者： wennberg D.E. lucas F.l. Siewers A.E. 任付先 Ctr. for Outcomes Res. and Eval. 139 Forest Ave Portland ME 04101 United States Dr.

Context: An ongoing debate focuses on whether institutions should perform percutaneous coronary interventions (PCIs) without an onsite coronary artery bypass graft(CABG) surgery program. Objective: To compare patient outcomes following PCI at US institutions performing this procedure without and with onsite cardiac surgery. Design, Setting, and Patients: Medicare hospital(part A) data were used to identify PCIs performed on fee-for-service Medicare enrollees(n=625 854) aged at least 65 years at acute care facilities between January 1, 1999, and December 1, 2001. Hospitals without and with onsite cardiac surgery were identified based on the presence of claims for CABG surgery. Patients were characterized as undergoing primary/rescue PCI, defined as an emergency procedure performed on the same day of admission for an acute myocardial infarction(MI), vs all other PCIs. Main Outcome Measures: Post-PCI CABG surgery and combined in-hospi-tal and 30-day mortality. Results: A total of 178 hospitals performed PCIs without onsite cardiac surgery and 943 hospitals performed PCIs with onsite cardiac surgery. Patients undergoing PCIs in hospitals without onsite cardiac surgery were similar to those with onsite cardiac surgery with respect to age, sex, race, and measurable comorbidities; however, patients undergoing PCIs in hospitals without onsite cardiac surgery were more likely to have a primary/rescue PCI(22.0%vs 5.6%, Pls without cardiac surgery were more likely to die(6.0%vs 3.3%; adjusted odds ratio, 1.29; 95%confi-dence interval, 1.14-1.47; P line differences, mortality for patients with primary/ rescue PCI was similar in institutions without and with cardiac surgery (adjusted OR, 0.93; 95%CI, 0.80-1.08; P=.34). However, for the larger non-primary/rescue PCI population, mortality was higher in hospitals without onsite cardiac surgery(adjusted OR, 1.38; 95%CI, 1.14-1.67; P=.001). This increase in

关键词：旁路移植治疗中心介入治疗急诊手术免费医疗急性心肌梗死急诊治疗医疗保健医疗机构保健性

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维普期刊数据库

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