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Piperine regulates the circadian rhythms of hepatic clock gene expressions and gut microbiota in high-fat diet-induced obese rats

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Food Science and Human Wellness 2024年第3期13卷 1617-1627页

作者： Weiyun Zhang Chi-Tang Ho wenlian Wei Jie Xiao Muwen lu Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods College of Food ScienceSouth China Agricultural UniversityGuangzhou 510642China Department of Food Science Rutgers UniversityNew Brunswick 08901USA

The interplay between the host circadian clock and microbiota has significant influences on host metabolism processes,and circadian desynchrony triggered by high-fat diet(HFD)is closely related to metabolic disorders.In this study,the modulatory effects of piperine(PIP)on lipid metabolism homeostasis,gut microbiota community and circadian rhythm of hepatic clock gene expressions in obese rats were investigated.The Sprague-Dawley(SD)rats were fed with normal diet(ND),HFD and HFD supplemented with PIP,respectively.After 9 weeks,rats were sacrificed with tissue and fecal samples collected for circadian analysis.Results showed that chronic PIP administration ameliorated the obesity-induced alterations in lipid metabolism and dysregulation of hepatic clock gene expressions in obese rats.The gut microbial communities studied through 16S rRNA sequencing showed that PIP ameliorated the imbalanced nicrobiota and recovered the circadian rhythm of Lactobacillaceae,Desulfovibrionaceae,Paraprevotellaceae,and Lachnospiraceae.The fecal metabolic profiles indicated that 3-dehydroshikimate,cytidine and lithocholyltaurine were altered,which were involved in the amino acid and fatty acid metabolism process.These findings could provide theoretical basis for PIP to work as functional food to alleviate the lipid metabolism disorder,circadian rhythm misalignment,and gut microbiota dysbiosis with wide applications in the food and pharmaceutic industries.

关键词： Piperine Circadian clock Obesity Gut microbiota

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Matrix-valued distributed stochastic optimization with constraints

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信息与电子工程前沿:英文版 2023年第9期24卷 1239-1252页

作者： Zicong XIA Yang LIU wenlian lu Weihua GUI Key Laboratory of Intelligent Education Technology and Application of Zhejiang Province Zhejiang Normal UniversityJinhua 321004China School of Mathematical Sciences Zhejiang Normal UniversityJinhua 321004China School of Mathematical Sciences Fudan UniversityShanghai 200433China School of Automation Central South UniversityChangsha 410083China

In this paper,we address matrix-valued distributed stochastic optimization with inequality and equality constraints,where the objective function is a sum of multiple matrix-valued functions with stochastic variables and the considered problems are solved in a distributed manner.A penalty method is derived to deal with the constraints,and a selection principle is proposed for choosing feasible penalty functions and penalty gains.A distributed optimization algorithm based on the gossip model is developed for solving the stochastic optimization problem,and its convergence to the optimal solution is analyzed rigorously.Two numerical examples are given to demonstrate the viability of the main results.

关键词： Distributed optimization Matrix-valued optimization Stochastic optimization Penalty method Gossip model

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Using Event-Based Method to Estimate Cybersecurity Equilibrium

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IEEE/CAA Journal of Automatica Sinica 2021年第2期8卷 455-467页

作者： Zhaofeng Liu Ren Zheng wenlian lu Shouhuai Xu the School of Mathematical Sciences Fudan UniversityShanghai 200433China the Artificial Intelligence Laboratory SAIC Motor Corporation LimitedShanghai 200041 SAIC Intelligent Technology(Shanghai)Corporation Limited Shanghai 200433China the School of Mathematical Sciences Fudan Universityand Shanghai Center for Mathematical SciencesFudan Universityand also with Shanghai Key Laboratory for Contemporary Applied MathematicsShanghai 200433China the Department of Computer Science University of Texas at San AntonioSan Antonio TX 78249 USA

Estimating the global state of a networked system is an important problem in many application domains.The classical approach to tackling this problem is the periodic(observation)method,which is inefficient because it often observes states at a very high frequency.This inefficiency has motivated the idea of event-based method,which leverages the evolution dynamics in question and makes observations only when some rules are triggered(i.e.,only when certain conditions hold).This paper initiates the investigation of using the event-based method to estimate the equilibrium in the new application domain of cybersecurity,where equilibrium is an important metric that has no closed-form solutions.More specifically,the paper presents an event-based method for estimating cybersecurity equilibrium in the preventive and reactive cyber defense dynamics,which has been proven globally convergent.The presented study proves that the estimated equilibrium from our trigger rule i)indeed converges to the equilibrium of the dynamics and ii)is Zeno-free,which assures the usefulness of the event-based method.Numerical examples show that the event-based method can reduce 98%of the observation cost incurred by the periodic method.In order to use the event-based method in practice,this paper investigates how to bridge the gap between i)the continuous state in the dynamics model,which is dubbed probability-state because it measures the probability that a node is in the secure or compromised state,and ii)the discrete state that is often encountered in practice,dubbed sample-state because it is sampled from some nodes.This bridge may be of independent value because probability-state models have been widely used to approximate exponentially-many discrete state systems.

关键词： Cybersecurity dynamics cybersecurity equilibrium event-based method global state estimation preventive and reactive cyber defense dynamics

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分段线性神经网络的逼近理论

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数学年刊（A辑） 2024年第1期45卷 53-70页

作者：吴心宇陈天平卢文联复旦大学数学科学学院上海200433 上海数学中心上海200438 上海市现代应用数学重点实验室上海200433

随着分段线性函数的广泛应用,本文尝试研究浅层和深层的分段线性神经网络的逼近理论.作者将应用于三层感知机模型的万能逼近定理拓展到分段线性神经网络中,并给出与隐藏神经元个数相关的逼近误差估计.利用分段线性函数构造锯齿函数的显... 详细信息

随着分段线性函数的广泛应用,本文尝试研究浅层和深层的分段线性神经网络的逼近理论.作者将应用于三层感知机模型的万能逼近定理拓展到分段线性神经网络中,并给出与隐藏神经元个数相关的逼近误差估计.利用分段线性函数构造锯齿函数的显式方法,证明解析函数可以通过分段线性神经网络的深度堆叠以指数速率逼近,并辅以相应的数值实验.

关键词：分段线性神经网络逼近理论

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Dynamical behaviors of recurrently connected neural networks and linearly coupled networks with discontinuous right-hand sides

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Frontiers of Electrical and Electronic Engineering in China 2012年第1期7卷 32-48页

作者： wenlian lu Tianping CHEN Bo LIU Xiangnan HE School of Mathematical Sciences Fudan UniversityShanghai 200433China

The aim of this paper is to provide a sys- tematic review on the framework to analyze dynamics in recurrently connected neural networks with discontinu- ous right-hand sides with a focus on the authors＇ works in the past three years. The concept of the Filippov so- lution is employed to define the solution of the neural network systems by transforming them to differential in- clusions. The theory of viability provides a tool to study the existence and uniqueness of the solution and the Lya- punov function （functional） approach is used to investi- gate the global stability and synchronization. More pre- cisely, we prove that the diagonal-dominant conditions guarantee the existence, uniqueness, and stability of a general class of integro-differential equations with （al- most） periodic self-inhibitions, interconnection weights, inputs, and delays. This model is rather general and in- cludes the well-known Hopfield neural networks, Cohen- Grossberg neural networks, and cellular neural networks as special cases. We extend the absolute stability anal- ysis of gradient-like neural network model by relaxing the analytic constraints so that they can be employed to solve optimization problem with non-smooth cost func- tions. Furthermore, we study the global synchronization problem of a class of linearly coupled neural network with discontinuous right-hand sides.

关键词： delayed integro-differential system discontinuous activation ahnost periodic function nonsmooth cost function complete synchronization

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面向学生成长与就业的高校劳动教育改革与创新

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吉林省教育学院学报 2024年第6期40卷 7-12页

作者：李文莲王粲青岛理工大学

时代发展对高校劳动育人的使命提出新要求，当代大学生成长与就业中呈现出的一些现实问题使得改革与创新劳动教育更加紧迫。文章基于面向学生的问卷调查数据，揭示了当代大学生对劳动及劳动教育的认识、态度、偏好、评价及诉求；针对学... 详细信息

时代发展对高校劳动育人的使命提出新要求，当代大学生成长与就业中呈现出的一些现实问题使得改革与创新劳动教育更加紧迫。文章基于面向学生的问卷调查数据，揭示了当代大学生对劳动及劳动教育的认识、态度、偏好、评价及诉求；针对学生中存在的不想劳动（劳动观念和意识）、不会劳动（劳动技能）、不珍惜劳动（劳动价值观）等现实问题，论述重视劳动教育对学生职业成熟度的提升效果，提出高校加强和创新劳动教育的建议。

关键词：劳动教育高校改革创新就业

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Nanopores/Nanochannels Based on Electrical and Optical Dual Signal Response for Application in Biological Detection

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Chinese Journal of Chemistry 2023年第11期41卷 1374-1384页

作者： Guangwen lu Niya Lin Zhaojun Chen wenlian Jiang Jing-Jing Hu Fan Xia Xiaoding Lou State Key Laboratory of Biogeology and Environmental Geology Faculty of Materials Science and ChemistryChina University of GeosciencesWuhanHubei430078 China

Cancers and chronic diseases have always been global health problems. The occurrence and development of such diseases are closely related to the abnormalities of proteins, nucleic acids, ions or small molecules in the body. Nowadays, nanopores/nanochannels have emerged as a powerful platform for detecting these biomolecules based on the electrical signal variation caused by biomolecules passing. However, detection relied on the electrical signal easily suffered from the clogging defects, low throughput, and strong background signals. Fortunately, the emergence of designing nanopores/nanochannels based on electrical and optical dual signal response has brought innovative impetus to biological detection, which can also identify the chemical compositions and conformations of the biomolecules. In this review, we summarize the reasonable preparation of nanopores/nanochannels with electrical and optical dual signal response and their application in biological detection. According to different biomolecules, we divide the targets into four types, including nucleic acids, small molecules, ions and proteins. In each section, the design of representative examples and the principle of dual signal generation are introduced and discussed. Finally, the prospects and challenges of nanopores/nanochannels based on electrical and optical dual signal response are also discussed.

关键词： Biomolecules Nanopores nanochannels Electrical and optical Fluorescence lon current

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数智时代高校劳动教育改革的守正与创新

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高教论坛 2024年第4期 115-119页

作者：李文莲王粲青岛理工大学山东青岛266520

当前高校劳动教育存在的问题呈现多面性与多层次性。其中,价值认知问题和教育成效问题相互交织,是隐含于诸多显性问题背后的深层核心问题。数智时代劳动形态多元化、人才需求高阶化、教育受众网生化、技术支持数智化是劳动教育改革要面... 详细信息

当前高校劳动教育存在的问题呈现多面性与多层次性。其中,价值认知问题和教育成效问题相互交织,是隐含于诸多显性问题背后的深层核心问题。数智时代劳动形态多元化、人才需求高阶化、教育受众网生化、技术支持数智化是劳动教育改革要面对的客观实际。高校劳动教育改革要做到“守正+创新”,需要坚守马克思主义劳动观和价值论,坚守数字人文主义;以数智思维和技术融合创新教育理念、教育目标、教育内容与模式,构建“三位一体、三课堂互动”的数智化劳动教育新生态。

关键词：数智时代劳动教育守正创新教育协同平台

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破片防护结构对冲击波测试影响的数值分析

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兵工自动化 2024年第5期43卷 66-70页

作者：郭庆王文廉郭科科江虹颖中北大学仪器科学与动态测试教育部重点实验室太原030051

针对防护结构对冲击波特征的影响,利用AUTODYN对防护结构条件下冲击波信号传播进行数值模拟。采用2D-Euler Multi-material算法进行仿真计算,将防护区域不同位置冲击波压力曲线、特征参数与空旷环境进行对比,分析防护结构与测点的距离... 详细信息

针对防护结构对冲击波特征的影响,利用AUTODYN对防护结构条件下冲击波信号传播进行数值模拟。采用2D-Euler Multi-material算法进行仿真计算,将防护区域不同位置冲击波压力曲线、特征参数与空旷环境进行对比,分析防护结构与测点的距离及防护结构偏离冲击波传播方向的角度α对冲击波测试的影响。结果表明:在单向防护时,若达到正向防护(α=0)且防护结构与测点距离等于10倍圆柱直径时,压力峰值、正压作用时间和比冲量误差分别为0.51%、4.36%和1.91%;在多向防护时,以10倍直径距离分析,α=0时,压力峰值误差最小,为-0.43%;α=30°时,正压作用时间和比冲量误差更小,为-2.91%和0.66%。

关键词：冲击波测试防护结构数值模拟特征参数

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曲面工件超声自适应检测方法研究

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传感器与微系统 2024年第5期43卷 51-54页

作者：黄江茵潘文联龙晋桓付磊韩军厦门理工学院电气工程与自动化学院福建厦门361024 中国科学院海西研究院泉州装备制造研究中心福建泉州362000

对曲面工件进行超声检测时,受工件曲率影响,超声波在曲界面处反射偏转特性不规律,造成回波接收困难,增加了检测的实现难度。针对以上问题,结合超声测距和幅值最大原理,阐述了以机械臂为运动机构的曲面工件点云建模方法,分析点位间角度关... 详细信息

对曲面工件进行超声检测时,受工件曲率影响,超声波在曲界面处反射偏转特性不规律,造成回波接收困难,增加了检测的实现难度。针对以上问题,结合超声测距和幅值最大原理,阐述了以机械臂为运动机构的曲面工件点云建模方法,分析点位间角度关系,提出了一种基于分段三次Hermite函数的声束姿态调整算法,并通过C扫结果验证了算法有效性。以曲面轴承试块为例,进行了缺陷定量实验,试块缺陷检出率100%,缺陷尺寸误差不大于5.86%。实验结果表明:该方法能够实现曲面工件高精度扫查,为实现曲面工件超声自动化检测提供了一种便捷有效的途径。

关键词：曲面工件机械臂超声检测 C扫成像

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