检索结果-南通市图书馆

Food Science and Human Wellness 2024年第2期13卷 909-919页

作者： Xiangxin li Yijing Pu Bangdi liu Xiaoming Fang Wenjun Peng Weibo Jiang wenli Tian Institute of Apicultural Research Chinese Academy of Agricultural SciencesBeijing 100093China College of Food Science and Nutritional Engineering China Agricultural UniversityBeijing 100083China Academy of Agricultural Planning and Engineering Ministry of Agriculture and Rural AffairsBeijing 100125China

Free cholesterol has been considered to be a critical risk factor of nonalcoholic fatty liver disease(NAFLD).It remains unknown whether dietary intake of condensed tannins(CTs)have distinguishable effects to alleviate liver damage caused by a high cholesterol *** C57BL/6 mice were fed a high cholesterol diet for 6 weeks,and given CTs treatment at a dosage of 200 mg/(kg·day)at the same *** results indicated that compared with mice fed a normal diet,a high cholesterol diet group resulted in significant weight loss,dysregulation of lipid metabolism in blood and liver,and oxidative stress in the liver,but CTs treatment dramatically reversed these negative *** and eosin(H&E)staining and frozen section observation manifested that CTs treatment could effectively reduce the deposition of liver cholesterol and tissue necrosis caused by high cholesterol *** alleviated liver injury mainly by regulating the expression of related genes in cholesterol metabolism pathway and AMPK *** results confirmed that CTs have remarkable cholesterol lowering and anti-liver injury effects in vivo.

关键词： Condensed tannins High cholesterol liver injury Antioxidants Transcriptomic analysis

Research on the Innovation of Management Mode in the Construction of Safety Community

在线全文

学校读者我要写书评

暂无评论

Research on the Innovation of Management Mode in the Constru...

Effects of host identity on the gut microbiota:A comparative study on three microtinae species

2013年教育技术与管理科学国际会议

作者： li Zhixin Xu Jingzhen li wenli College of Management and Economics Tianjin University College of Economics Hebei United University Party committee Tangshan City Party School of the C.P

The purpose of this study is to explore the thinking of innovation of management mode in the construction of safe community. In this study the community safety management mode is discussed using the theory and method of synergetics. The paper puts forward that in the innovation of the management mode in the construction of safe community, the following aspects should be considered: innovation of the concept of safety management, innovation of safety management strategy, innovation of safety management mode selection basis, innovation of the system of safety management, innovation of safety management carrier, innovation of safety management means.

关键词： community safeyt safety management mode innovation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2024年第2期7卷 98-105页

作者： Zhen Yao wenli Zhao Baohong Tang Qinghua li Zhenlong Wang School of life Sciences Zhengzhou UniversityZhengzhouHenan ProvinceP.R.China

Background:Gut microbiota exert an immense effect on host health and host environmental ***,the composition and structure of gut microbiota are determined by the environment and host genetic ***,the relative contribution of the environment and host genetic factors toward shaping the structure of gut microbiota has been poorly ***:In this study,we characterized the fecal microbial communities of the closely related voles Neodon fuscus,Lasiopodomys brandtii,and *** after caged feeding in the laboratory for 6 months,through high-throughput sequencing and bioinformatics ***:The results of pairwise comparisons of *** *** and *** *** revealed significant differences in bacterial diversity and composition after *** 991 same operational taxonomic units(OTUs)were shared in three voles,there were 362,291,and 303 species-specific OTUs in ***,***,and ***,*** relative abundances of Proteobacteria and Prevotella,which are reported to be enriched in high-altitude populations,were significantly higher in high-altitude *** than in low-altitude *** after ***,which produce various digestive enzymes for energy metabolism,and Spirochaetes,which can degrade cellulose,were found in higher abundance in subterranean *** than that in *** which dwells on the earth ***:Our findings showed that some components of gut microbiota still maintained dominance even when different host species are reared under the same environmental conditions,suggesting that these bacteria are substantially influenced by host factors.

关键词： gut microbiota high-altitude Lasiopodomys brandtii Neodon fuscus

Research on comprehensive evaluation of city community safety capability based on factor analysis——Taking Tangshan City as an example

在线全文

学校读者我要写书评

暂无评论

Research on comprehensive evaluation of city community safet...

2013年教育技术与管理科学国际会议

作者： li Zhixin Zhang lihua li wenli College of Management and Economics Tianjin University College of Economics Hebei United University Party committee Tangshan City Party School of the C.P

The purpose of this research is to comprehensively evaluate community safety capacity building of Tangshan City through extensive research, to provide basis for the future safety construction of the city. In the research, we put forward the index system of comprehensive assessment of city community safety capability, based on extensive expert investigation and questionnaire investigation, using factor analysis method, extract 4 city community safety factors, and on the basis of this, the paper evaluates the safety capacity construction situation of Tangshan City’s six area, the method can also provide reference for other city’s safety capability evaluation.

关键词： Factor analysis safety capability comprehensive evaluation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

大健康背景下对中医药食疗产业发展的思考

江西中医药大学学报 2024年第2期36卷 102-106页

作者：李文丽张高传刘红宁严小军吴志杰徐乐江西中医药大学附属洪都中医院南昌330008 江西中医药大学高等研究院南昌330004

在大健康背景下,国家高度重视中医药在建设健康中国的积极作用,中医药的养生保健作用成为研究热点,中医药食疗产业凭借中医药食疗理论优势、坚定正确的政策支持与尚未深入开发的消费市场,迎来巨大的发展机遇,同样面对许多挑战。现就中... 详细信息

在大健康背景下,国家高度重视中医药在建设健康中国的积极作用,中医药的养生保健作用成为研究热点,中医药食疗产业凭借中医药食疗理论优势、坚定正确的政策支持与尚未深入开发的消费市场,迎来巨大的发展机遇,同样面对许多挑战。现就中医药食疗产业的发展现状、相关建议和未来展望3个部分,从国家政策引导、食疗行业标准、食疗科学研发、食疗市场培育等方面探讨中医药食疗产业传承创新发展的战略方针,为中医药食疗产业发展提出建议,以期助力健康中国建设。

关键词：健康中国中医药食疗产业创新发展

真武汤对慢性心衰大鼠CaN/NFAT3信号转导通路的影响

在线全文

学校读者我要写书评

暂无评论

长治医学院学报 2024年第4期38卷 255-258,262页

作者：刘言浩刘言玉夏泽亮王莹汪晓李文丽丁峰蚌埠医科大学第一附属医院临床试验研究中心安徽蚌埠233099 蚌埠医科大学第一附属医院ICU 蚌埠医科大学第二附属医院普外科

目的:探讨真武汤对慢性心衰大鼠钙调神经磷酸酶(CaN)/T细胞活化核因子(NFAT3)信号转导通路的影响。方法:将50只SD大鼠随机分为正常组、模型组及真武汤高、中、低剂量组,皮下注射异丙肾上腺素诱导大鼠慢性心衰。连续给药4周后,观察模型... 详细信息

目的:探讨真武汤对慢性心衰大鼠钙调神经磷酸酶(CaN)/T细胞活化核因子(NFAT3)信号转导通路的影响。方法:将50只SD大鼠随机分为正常组、模型组及真武汤高、中、低剂量组,皮下注射异丙肾上腺素诱导大鼠慢性心衰。连续给药4周后,观察模型组和真武汤处理组大鼠的心肌组织病理结构变化,检测模型组和真武汤处理组大鼠的心脏质量指数、血浆BNP含量、心肌组织CaN活性和NAFT3蛋白表达情况及各组大鼠的血流动力学指标。结果:真武汤高剂量组左心室射血分数(LVEF)高于模型组(P<0.05);与模型组相比,真武汤高剂量组心脏质量指数、血浆B型利钠肽(BNP)含量、心肌组织CaN浓度、NAFT3蛋白表达水平均低于模型组(P<0.01)。结论:真武汤能改善慢性心衰大鼠心肌组织损伤,抑制心肌细胞肥大,可能与调节CaN/NFAT3信号转导通路有关。

关键词：真武汤慢性心衰 CaN/NFAT3

A MOF/poly(thioctic acid)composite for enhanced gold extraction from water matrices

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第1期17卷 382-389页

作者： Ruiqing li Sen Yan Tianwei Xue Rongxing Qiu Yin li wenli Hao Guangkuo Xu Yanliang Wang Yanzhen Hong Yuzhong Su Hongtao Wang Shuliang Yang li Peng Jun li College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005China Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China College of Energy Xiamen UniversityXiamen 361005China National Engineering Laboratory for Green Chemical Productions of Alcohols Ethers and EstersXiamen UniversityXiamen 361005China Collaborative Innovation Center of Chemistry for Energy Materials Xiamen UniversityXiamen 361005China

With the fast generation of electronic waste(e-waste)and the increasing depletion of metal resources,“urban mining”that can selectively recover gold from secondary resources has attracted great *** of materials with high extraction capacity and satisfying selectivity in complex aqueous-based matrices still remains ***,a novel metal-organic framework/polymer composite(Fe-BTC/poly(thioctic acid),denoted as Fe-BTC/pTA)has been newly synthesized and applied for selective gold recovery in different matrices(river water,seawater,and leaching solution of e-waste).Benefiting from the high specific surface area and suitable pore sizes as well as the rational design of active sites,the composite exhibits high adsorption capacity(920 mg/g),high removal efficiency(>99%),fast kinetics(below 0.1 ppb within 10 min),and good applicability in complex matrices,which are better than those of most reported sulfur-containing ***-state metallic gold with high purity can be effectively enriched due to the high recyclability and long-term stability of the *** material after adsorption can be further applied as a heterogeneous catalyst for water remediation due to the in situ generated gold nanoparticles by the redox reaction between Au(III)ions and the S-containing groups in the composites.

关键词： metal-organic frameworks(MOFs) poly(thioctic acid)(pTA) polymer composites gold recovery urban mining

Inhibitory effect of procyanidin B2 and tannin acid on cholesterol esterase and their synergistic effect with orlistat

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第1期13卷 360-369页

作者： Xiangxin li Yijing Pu Haitao Jiang Wenxiao Jiao Wenjun Peng wenli Tian Weibo Jiang Xiaoming Fang Institute of Apicultural Research Chinese Academy of Agricultural SciencesBeijing 100093China College of Food Science and Nutritional Engineering China Agricultural UniversityBeijing 100083China College of Food Science and Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China

This study was aimed to analyze the effect of procyanidin B2(PC)and tannin acid(TA)on the activities of cholesterol esterase(CEase)and the inhibitory mechanisms of enzymatic *** interaction mechanisms were investigated by enzymatic kinetics,multi-spectroscopy methods,thermodynamics analysis,molecular docking,and dynamic *** and TA could bind with CEase and inhibit the activity of enzyme in a mixed-competitive manner and non-competitive manner,which was verified by molecular docking simulations and dynamics ***,PC and TA showed the synergistic inhibition with ***,UVvis and the thermodynamic analysis revealed that the complexes were formed from CEase and inhibitors by noncovalent *** revealed by the circular dichroism results,both PC and TA decreased enzymatic activities by altering the conformations of *** inhibition of PC and TA on CEase might be one mechanism for its cholesterol-lowering effect.

关键词： Cholesterol esterase Polyphenols Interaction mechanisms Molecular dynamic simulation Synergistic effect

超高效液相色谱串联质谱法测定复方胃痛胶囊中马兜铃酸Ⅰ、马兜铃酸Ⅱ的含量

在线全文

学校读者我要写书评

暂无评论

药品评价 2024年第1期21卷 15-19页

作者：彭玲娜梁晟孙辉丁野李文莉刘静戴忠马双成湖南省药品检验检测研究院湖南省药品质量评价工程技术中心湖南长沙410001 中国食品药品检定研究院北京100050

目的建立UPLC-MS/MS同时测定复方胃痛胶囊中马兜铃酸Ⅰ和马兜铃酸Ⅱ含量的方法。方法采用Agilent Poroshell SB-C18色谱柱(100 mm×2.1 mm,2.7μm);流动相为乙腈和含5 mmol/L甲酸铵的0.1%甲酸溶液,梯度洗脱,流速为0.3 mL/min,柱温为30℃... 详细信息

目的建立UPLC-MS/MS同时测定复方胃痛胶囊中马兜铃酸Ⅰ和马兜铃酸Ⅱ含量的方法。方法采用Agilent Poroshell SB-C18色谱柱(100 mm×2.1 mm,2.7μm);流动相为乙腈和含5 mmol/L甲酸铵的0.1%甲酸溶液,梯度洗脱,流速为0.3 mL/min,柱温为30℃;采用三重四级杆质谱检测器,电喷雾离子源(ESI)正离子模式下多反应监测(MRM)模式进行质谱检测。结果马兜铃酸Ⅰ和马兜铃酸Ⅱ分别在1.05~210 ng/mL(r=0.9996)和1.00~200 ng/mL(r=0.9998)有良好的线性关系。马兜铃酸Ⅰ的回收率为95.90%,RSD为2.11%;马兜铃酸Ⅱ的回收率为93.22%,RSD为1.17%。马兜铃酸Ⅰ的定量限为0.3 pg、检出限为0.1 pg;马兜铃酸Ⅱ的定量限为0.7 pg、检出限为0.2 pg。结论该方法专属性好,灵敏度高,准确可靠,能够用于测定复方胃痛胶囊中马兜铃酸Ⅰ和马兜铃酸Ⅱ的含量。

关键词：复方胃痛胶囊马兜铃酸超高效液相色谱串联质谱法

miR-498过表达对鼻咽癌细胞增殖、侵袭、迁移和上皮间质转化的影响及其机制

在线全文

学校读者我要写书评

暂无评论

山东医药 2024年第1期64卷 25-29页

作者：袁洛花李文丽刘海兵范嘉佳彭中华邹剑四川大学华西医院耳鼻咽喉头颈外科成都610041 四川省妇幼保健院耳鼻喉科

目的探讨微小RNA-498(miR-498)过表达对鼻咽癌细胞增殖、侵袭、迁移和上皮间质转化(EMT)的影响及其机制。方法体外传代培养人永生化鼻咽上皮细胞系NP69及人鼻咽癌细胞系CNE-2Z、CNE-1、HNE-1、SUNE-1,采用RT-qPCR法检测各细胞miR-498表... 详细信息

目的探讨微小RNA-498(miR-498)过表达对鼻咽癌细胞增殖、侵袭、迁移和上皮间质转化(EMT)的影响及其机制。方法体外传代培养人永生化鼻咽上皮细胞系NP69及人鼻咽癌细胞系CNE-2Z、CNE-1、HNE-1、SUNE-1,采用RT-qPCR法检测各细胞miR-498表达,选择miR-498表达最低的鼻咽癌细胞进行后续实验。取传3代、对数生长期、生长状态良好的鼻咽癌细胞,随机分为miR-498 mimics组和NC mimics组,分别转染miR-498 mimics、NC mimics。转染6 h更换新鲜培养基继续培养24 h,收集细胞。采用CCK-8法检测细胞增殖活性,采用平板克隆形成实验检测集落形成能力,采用Transwell小室法检测细胞侵袭和迁移能力,采用Western blotting法检测EMT相关上皮型钙黏素(E-cadherin)、波形蛋白(Vimentin)、纤连蛋白(Fibronectin)以及高迁移率族蛋白A2(HMGA2)表达。结果CNE-1、HNE-1、CNE-2Z、SUNE-1细胞miR-498相对表达量均低于NP69细胞(P均<0.05)。以CNE-2Z细胞miR-498相对表达量最低,故选择该细胞系进行后续实验。经验证,miR-498 mimics组miR-498相对表达量高于NC mimics组(P<0.05)。miR-498 mimics组培养0、24、48、72 h细胞增殖活性均低于NC mimics组(P均<0.05);miR-498 mimics组集落形成能力以及细胞侵袭和迁移能力均低于NC mimics组(P均<0.05);miR-498 mimics组Vimentin、Fibronectin、HMGA2蛋白相对表达量均低于NC mimics组,E-cadherin蛋白相对表达量高于NC mimics组(P均<0.05)。结论鼻咽癌细胞miR-498低表达;miR-498过表达则能抑制鼻咽癌细胞的增殖、侵袭、迁移以及EMT,其机制可能与靶向调控HMGA2表达有关。

关键词：鼻咽癌微小RNA-498 细胞增殖细胞侵袭细胞迁移上皮间质转化

维普期刊数据库博看期刊