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基于WASP模型的太湖流域上游茅山地区典型乡村流域水质模拟

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湖泊科学 2017年第4期29卷 836-847页

作者：陈文君段伟利贺斌陈雯中国科学院南京地理与湖泊研究所中国科学院流域地理学重点实验室南京210008

池塘、河渠、水库是乡村流域水环境的重要组成.基于WASP模型,综合运用现场调查、GIS空间分析、污染负荷估算等方法,构建茅山地区李塔陈庄乡村流域的水质模拟模型.结果表明,主要水质指标的污染程度从高至低依次为总氮(TN)、总磷(TP)和高... 详细信息

池塘、河渠、水库是乡村流域水环境的重要组成.基于WASP模型,综合运用现场调查、GIS空间分析、污染负荷估算等方法,构建茅山地区李塔陈庄乡村流域的水质模拟模型.结果表明,主要水质指标的污染程度从高至低依次为总氮(TN)、总磷(TP)和高锰酸盐指数、氨氮.TN全年在不同水体中达到劣Ⅴ类的比例在52%~100%,而池塘、河渠的污染程度较为接近.夏、冬季,超过TP劣Ⅴ类限值的河渠占2%~6%,池塘占8%~14%,而流域中部乡村周边的池塘明显更为严重.负荷输入是模型主要不确定性因素,细化种植模式能够提高总体模拟效果,而禽畜散养与农村生活造成的污染则分别对池塘、河渠的水质影响更为明显.本研究建立了乡村流域多种水体在面源污染影响下的水质联系,能够为乡村水环境治理提供决策参考.

关键词： WASP 乡村流域茅山地区面源污染池塘河渠

Hepatitis B reactivation in cancer patients receiving immune checkpoint inhibitors:a systematic review and meta-analysis

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Infectious Diseases of Poverty 2023年第5期12卷 92-92页

作者： Zhengzheng Xia Jianyu Zhang wenjun chen Haiyan Zhou Di Du Kongcai Zhu Hui chen Jun Meng Jun Yang Department of Pharmacy National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Pharmacy National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhenChina Department of Pharmacy Hubei Cancer HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Pharmacy Beijing Youan HospitalCapital Medical UniversityBeijingChina Department of Pharmacy Tangshan Central HospitalTangshanChina

Background Immunotherapy shows promise as a treatment option for various ***,there is growing concern over potential complications from hepatitis B virus(HBV)reactivation after checkpoint blockade *** most of the previous clinical trials on immune checkpoint inhibitors(ICIs)excluded patients with HBV,a few case reports and retrospective studies of HBV reactivation have been *** aim of this study is to assess the risk of hepatitis B virus reactivation(HBVr)in patients receiving ICIs for advanced *** English and Chinese language literature published prior to April 30,2023,was searched in PubMed,EMBASE,Web of Science,Cochrane,SinoMed,CNKI and Wanfang Data for studies reporting HBVr rates in cancer patients treated with ICIs.A pooled risk estimate was calculated for HBVr rates with 95%confdence intervals(CI).Results Data from 34 studies including 7126 patients were retrieved and *** pooled HBVr rate in cancer patients treated with ICIs was 1.3%(I^(2)=90.44%,95%CI:0.2-2.9%,P<0.001).Subgroup analysis revealed that patients diagnosed with hepatocellular carcinoma(HCC),HBV carriers,and patients from Asian regions or in developing countries have a higher rate of *** Our meta-analysis demonstrated a low risk of HBVr in patients treated with ICIs for advanced *** treatment may be safely used in patients with existing HBV infection or chronic hepatitis B,accompanied by regular monitoring and appropriate antiviral prophylaxis if necessary.

关键词： Hepatitis B virus reactivation Immune checkpoint inhibitors Cancer Systematic review Meta-analysis Safety

Decoupling between Plant Productivity and Growing Season Length under a Warming Climate in Canada’s Arctic

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American Journal of Climate Change 2016年第3期5卷 334-359页

作者： wenjun chen Paul Zorn Lori White Ian Olthof Yu Zhang Robert Fraser Sylvain Leblanc Canada Centre for Remote Sensing Natural Resources Canada Ottawa Canada Parks Canada Agency Gatineau Canada Wildlife Landscape Science Directorate Environment Canada Ottawa Canada

Given the short duration of growing season in the Arctic, a strong correlation between plant productivity and growing season length (GSL) is conventionally assumed. Will this assumption hold true under a warming climate? In this study, we addressed the question by investigating the relationship between net primary productivity of leaves (NPPleaf) and GSL for various tundra ecosystems. We quantified NPPleaf and GSL using long-term satellite data and field measurements. Our results indicated that the relationship was not significant (i.e., decoupled) for 44% to 64% of tundra classes in the southern Canadian Arctic, but significant for all classes in the northern Canadian Arctic. To better understand the causes of the decoupling, we further decomposed the relationship into two components: the correspondence of interannual variations and the agreement of long- term trends. We found that the longer the mean GSL for a tundra class, the poorer the correspondence between their interannual variations. Soil moisture limitation further decoupled the relationship by deteriorating the agreement of long-term trends. Consequently, the decoupling between NPPleaf and GSL would be more likely to occur under a warming climate if the tundra class had a mean GSL > 116 (or 123) days with a dry (or moist) soil moisture regime.

关键词： Net Primary Productivity Growing Season Length Arctic Tundra Decoupling Remote Sensing Soil Moisture Regime

Tumor microenvironment-activated theranostic nanoreactor for NIR-II Photoacoustic imaging-guided tumor-specific photothermal therapy

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Fundamental Research 2024年第1期4卷 178-187页

作者： Nan Yang Hui Li Changyu Cao Lei Zhao Xuejiao Song wenjun Wang Wenjing Xu Yewei Zhang Peng chen Xiaochen Dong Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM) School of Physical and Mathematical SciencesNanjing Tech University(NanjingTech)Nanjing 211816China School of Physical Science and Information Technology Liaocheng UniversityLiaocheng 252059China Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011China School of Chemical and Biomedical Engineering Lee Kong Chian School of MedicineNanyang Technological University62 Nanyang DriveSingapore 637459Singapore

Theranostic agents that can be sensitively and specifically activated by the tumor microenvironment(TME)have recently attracted considerable *** this study,TME-activatable 3,3′,5,5′-tetramethylbenzidine(TMB)-copper peroxide(CuO_(2))@poly(lactic-co-glycolic acid)(PLGA)@red blood cell membrane(RBCM)(TCPR)nanoparticles(NPs)for second near-infrared photoacoustic imaging-guided tumor-specific photothermal therapy were developed by co-loading CuO_(2)NPs and TMB into PLGA camouflaged by *** an efficient H_(2)O_(2)supplier,once exposed to a proton-rich TME,CuO_(2)NPs can generate H_(2)O_(2)and Cu^(2+),which are further reduced to Cu^(+) by endogenous ***,the Cu^(+)-mediated Fenton-like reaction produces cytotoxic·OH to kill the cancer cells and induce TMB-mediated photoacoustic and photothermal *** with the RBCM modification-prolonged blood circulation,TCPR NPs display excellent specificity and efficiency in suppressing tumor growth,paving the way for more accurate,safe,and efficient cancer theranostics.

关键词： Nanoparticles Photoacoustic imaging Second near-infrared region Tumor microenvironment Self-sufficient H_(2)O_(2)

Hydroxylated metal–organic-layer nanocages anchoring single atomic cobalt sites for robust photocatalytic CO_(2) reduction

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Nano Research 2024年第4期17卷 2410-2419页

作者： Weiyi Pan Zhihe Wei Yanhui Su Yuebin Lian Zhangyi Zheng Huihong Yuan Yongze Qin Xulan Xie Qianqian Bai Zhenyang Jiao Wei Hua Jinzhou chen wenjun Yang Zhao Deng Yang Peng Soochow Institute for Energy and Materials Innovations College of EnergySoochow UniversitySuzhou 215006China Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province Soochow UniversitySuzhou 215006China School of Photoelectric Engineering Changzhou institute of technologyChangzhou 213032China Jiangsu Key Laboratory for Advanced Negative Carbon Technologies Soochow UniversitySuzhou 215123China

Assembly of two-dimensional(2D)metal–organic layers(MOLs)based on the hard and soft acid–base theorem represents an exquisite strategy for the construction of photocatalytic platforms in virtue of the highly exposed active sites,much improved mass transport,and greatly elevated ***,nanocages composed of MOLs are produced for the first time through a cosolvent approach utilizing zirconium-based UiO-66-(OH)2 as the structural *** endow the catalytic activity for CO_(2) conversion,single atomic Co^(2+)sites are appended to the Zr-oxo nodes of the MOL cages,demonstrating a remarkable CO yield of 7.74 mmol·g^(-1)·h^(-1) and operational stability of 97.1%product retention after five repeated *** an outstanding photocatalytic performance is mainly attributed to the unique nanocage morphology comprising enormous 2D nanosheets for augmented Co^(2+)exposure and the abundant surface hydroxyl groups for local CO_(2) *** work underlines the tailoring of both metal–organic framework(MOF)morphology and functionality to boost the turnover rate of photocatalytic CO_(2) reduction reaction(CO_(2)RR).

关键词： photocatalytic CO_(2) reduction metal–organic layer nanocage single-atom catalyst co-catalyst

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3D概念对新疆城市化发展模式的政策启示

开发研究 2009年第3期 134-137页

作者：陈闻君中央财经大学北京100081

3D即经济地理变迁的三大特征:密度、距离和分割,3D的概念有助于确定地方、国家和国际等所有地理标度的主要市场力量和切实可行的反应政策,对于选择城市化发展模式与政策选择有很重要的理论启发。本文从3D概念视角对新疆城市化发展的困... 详细信息

3D即经济地理变迁的三大特征:密度、距离和分割,3D的概念有助于确定地方、国家和国际等所有地理标度的主要市场力量和切实可行的反应政策,对于选择城市化发展模式与政策选择有很重要的理论启发。本文从3D概念视角对新疆城市化发展的困境与模式进行研究,提出改变交通格局,增加城市经济密度,打破地理分割;强化城市区域分工合作,打造特色产业与特色城市,打破经济分割;提高绿洲城市整体布局和规划能力,实施非均衡城市发展战略等基于3D的地理空间特性和符合新疆绿洲经济体系特殊性的政策框架。

关键词： 3D 城市化模式政策框架新疆

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FPGA在隧道窑炉温度模糊控制中的应用

电气传动 2004年第Z1期34卷 190-193页

作者：陈文军武汉理工大学自动化学院

利用FPGA来实现隧道窑炉温度模糊控制的软件实现,在高温接近理想值情况下,采用PID控制来消除静差.将主控制逻辑电路集成于一片FPGA之中,以便缩小印制板的面积同时提高系统可靠性,在很大程度上切断了EMI的途径;同时在软件方面,FPGA的现... 详细信息

利用FPGA来实现隧道窑炉温度模糊控制的软件实现,在高温接近理想值情况下,采用PID控制来消除静差.将主控制逻辑电路集成于一片FPGA之中,以便缩小印制板的面积同时提高系统可靠性,在很大程度上切断了EMI的途径;同时在软件方面,FPGA的现场可编程特点使得软件编程可以像PLC编程一样简单,构成的系统在灵活性、二次开发上具有明显的柔软性.最主要的是利用FPGA来实现一种模糊控制的新思想,并应用于隧道窑炉温度控制系统之中.

关键词： FPGA 模糊控制可重构 PCM PFM

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新农村建设中农村剩余劳动力转移就业的路径

改革与战略 2009年第6期25卷 100-103页

作者：陈闻君中央财经大学北京100081 新疆财经大学经济学院新疆乌鲁木齐830012

农村剩余劳动力转移基于就业机会带来的收入增长,但目前面临的困境制约着转移大军就业机会的获得。农村剩余劳动力和就业机会之间的均衡应是工业化与第三产业的发展,包括大力建设新农村,发展农村现代化,而不是一味地向城市转移或者表面... 详细信息

农村剩余劳动力转移基于就业机会带来的收入增长,但目前面临的困境制约着转移大军就业机会的获得。农村剩余劳动力和就业机会之间的均衡应是工业化与第三产业的发展,包括大力建设新农村,发展农村现代化,而不是一味地向城市转移或者表面城镇化。当务之急是发展农村教育,提高农民素质,提高人力资本含量,增强就业机会的主动创造能力,实现农民从贫困落后向现代生活方式与观念转变的文明转型。

关键词：城市化剩余劳动力转移就业机会

肺隐球菌性肺热病CT征象与中医辨证分型的相关性研究

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中华中医药学刊 2016年第2期34卷 490-493页

作者：程文君台州市立医院放射科浙江台州318000

目的:探讨肺隐球菌性肺热病患者的中医病症分型与CT征象的相关性,为中医治疗肺隐球菌性肺热病提供影像学依据。方法:分析过去5年间医院60例经手术切除病理或者体外穿刺活检证实属于肺隐球菌性肺热病的患者,按照中医辨证分型标准、中医... 详细信息

目的:探讨肺隐球菌性肺热病患者的中医病症分型与CT征象的相关性,为中医治疗肺隐球菌性肺热病提供影像学依据。方法:分析过去5年间医院60例经手术切除病理或者体外穿刺活检证实属于肺隐球菌性肺热病的患者,按照中医辨证分型标准、中医症侯分型标准分为风热犯肺型、痰热雍肺、邪热内结、脾肾阳虚,所有研究对象均进行CT扫描,结合患者的临床症状,采用双盲法对其CT表现与各证型之间的关系进行分析。结果:CT主要表现为浸润实变型、网织结节型、肿块型、混合型,分别为28例、15例、11例、6例;以风热犯肺型、痰热雍肺多见,分别为32例和17例,其中浸润实变型在风热犯肺中多见,网织结节型在风热犯肺型中明显多于其他症型(P<0.01),肿块型在痰热雍肺中明显多于其它证型(P<0.01)。结论:在肺隐球菌性肺热病的中医病症的诊断中,CT扫描具有较好的辅助作用,其中医分型与CT征象有一定的相关性,可以作为临床辨证论治及判断预后的一个依据。

关键词：肺隐球菌性肺热病病症 CT 中医辨证分型相关性