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Host defense peptide-mimicking peptide polymer-based antibacterial hydrogel enables efficient healing of MRSA-infected wounds

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Science China Chemistry 2023年第6期66卷 1824-1833页

作者： Zhongqian Qiao wenjing zhang Yueming Wu Weinan Jiang Ning Shao Jiayang Xie Guixue Xia Qimeng Chen Zhefeng Liu Jingcheng Zou Jiawei Gu Shifang Luan Haodong Lin Runhui Liu State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic ChemistryShanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Orthopedic Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Wound infections are a compelling health issue caused by the invasion and proliferation of pathogens in wound *** hydrogels are widely used to achieve anti-infectious wound ***,due to the quick emergence of drugresistant bacteria,such as methicillin-resistant Staphylococcus aureus(MRSA),wound infection has been a formidable challenge to human *** address MRSA-infected wounds,an antibacterial peptide polymer-loaded hyaluronic acid(HA)hydrogel(Gel-HA@P)is *** peptide polymer is designed to mimic host defense peptides as the antibiotic alternative showing potent antibacterial activity,low susceptibility to drug resistance and good stability against *** is biocompatible and biodegradable hydrogel substrate as a primary constituent of the extracellular matrix and suitable for cell migration and wound ***-HA@P shows potent activity against MRSA in vitro and in vivo,low toxicity during the treatment and promotes the wound healing in *** design has proven to be an effective and antibiotic-free strategy to enable the healing of MRSA-infected wounds.

关键词： peptide polymer wound healing MRSA drug-resistance host defense peptide

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Visible-light induced photocatalyst-free difluoromethylation of quinoxalinones with difluorosulfones

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Green Synthesis and Catalysis 2024年第4期5卷 277-281页

作者： Linlin Shi Tiantian Li wenjing zhang Weinan Hu Xinju Zhu Yixin Lu Guang-Jian Mei Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhouHenan 450001China Department of Chemistry National University of Singapore3 Science Drive 3117543Singapore

Visible-light induced direct C–H difluoromethylation of quinoxalinones with 2-((difluoromethyl)sulfonyl)benzo[d]thiazole has been developed for the first time.A broad range of quinoxalinones were well tolerated and reacted with difluorosulfone smoothly to give the corresponding products in moderate to good ***,no external photocatalyst or oxidant was required,which provides a practical and green protocol to access difluoromethylated ***,the control experiments demonstrated a radical mechanism,and the density functional theory(DFT)calculations indicated the radicals were generated through the formation of an electron donoracceptor(EDA)complex.

关键词： Quinoxalinones Difluoromethylation Visible-light induced Photocatalyst-free Difluorosulfones

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SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1265-1279页

作者： Yuesheng Lv wenjing zhang Jinyao Zhao Bing Sun Yangfan Qi Haoyu Ji Chaoqun Chen Jinrui zhang Junxiu Sheng Taishu Wang Daniel Dominguez Han Liu Quentin Liu Songshu Meng Xiaoling Li Yang Wang Second Affiliated Hospital Institute of Cancer Stem CellDalian Medical UniversityDalianChina Department of Thoracic Surgery First Affiliated HospitalDalian Medical UniversityDalianChina Department of Radiation Oncology First Affiliated HospitalDalian Medical UniversityDalianChina Department of Pharmacology University of North Carolina at Chapel HillChapel HillNCUSA Signal Transduction Laboratory National Institute of Environmental Health SciencesResearch Triangle ParkNCUSA

Alternative splicing is a critical process to generate protein ***,whether and how alternative splicing regulates autophagy remains largely *** we systematically identify the splicing factor SRSF1 as an autophagy ***,SRSF1 inhibits autophagosome formation by reducing the accumulation of LC3-ⅡI and numbers of autophagosomes in different cell ***,SRSF1 promotes the splicing of the long isoform of Bcl-x that interacts with Beclinl,thereby dissociating the Beclin1-PIK3C3 *** addition,SRSF1 also directly interacts with PIK3C3 to disrupt the interaction between Beclinl and ***,the decrease of SRSF1 stabilizes the Beclinl and PIK3C3 complex and activates ***,SRSF1 can be degraded by starvation-and oxidative stresses-induced autophagy through interacting with LC3-Ⅱ,whereas reduced SRSF1 further promotes *** positive feedback is critical to inhibiting Gefitinib-resistant cancer cell progression both in vitro and in ***,the expression level of SRSF1 is inversely correlated to LC3 level in clinical cancer *** study not only provides mechanistic insights of alternative splicing in autophagy regulation but also discovers a new regulatory role of SRSF1 in tumorigenesis,thereby offering a novel avenue for potential cancer therapeutics.

关键词： Beclin1 Beclin thereby

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Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes

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Virologica Sinica 2021年第2期36卷 300-310页

作者： Xiaoli Wu Mingyue Li Yanfang zhang Boyun Liang Junming Shi Yaohui Fang Zhengyuan Su Mengmeng Li wenjing zhang Ling Xu Jun Wang Qiaoli Wu Shuang Tang Hualin Wang Tao zhang Cheng Peng Xin Zheng Fei Deng Shu Shen State Key Laboratory of Virology and National Virus Resource Center Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuaZhong University of Science and TechnologyWuhan 430022China

Severe fever with thrombocytopenia syndrome virus(SFTSV),the causative agent of a febrile human disease,was first identified from central and eastern provinces in China,and later in Japan and South *** Province is one of the major SFTS epidemic areas in the central part of *** study reported the isolation of 11 new SFTSV strains from patients in Hubei Province collected in *** phylogenetic analyses were conducted based on the complete coding sequences of SFTSV segments including the new *** was suggested that five different SFTSV genotypes were circulating in Hubei,and 15 reassortment patterns and migration pathways correlated with each genotype were identified,which was more than previously *** Province was more involved in the evolutionary events of SFTSV than that previously thought in which the evolutionary events of SFTSV were reported to be independent from those in other epidemic *** divergence of SFTSV strains was suggested by pairwise comparison of SFTSV sequences from each genotype and sequence identity normalized to representative strain in genotype ***,amino acid variations specific for genotype(s),strain(s),or cluster(s)were inspected,which may be related to differential biological activity of SFTSV strains/*** conclusion,we analyzed the current status of SFTSV phylogeny in Hubei Province and discussed the possible events correlated to SFTSV *** provided an in-depth insight into SFTSV evolution,raising concerns for the use of proper SFTSV strains in future studies.

关键词： Severe fever with thrombocytopenia syndrome virus(SFTSV) Genotypes Genomic reassortment Virus migration Amino acid variations

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Application Study on Visible Human Computer Interaction System of Association Rule

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通讯和计算机（中英文版） 2006年第3期3卷 100-101,113页

作者： wenjing zhang Yu Song Donglai Ma School of Computer Science and Technology North China Electric Power University Baoding 071003 China Software Engineer Department Software Institute ofHebei Baoding 071000 China College oflnformation Science and Technology Agricultural University ofHebei Baoding 071001 China

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Highly structured metal-organic framework nanofibers for methane storage

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Science China Materials 2021年第7期64卷 1742-1750页

作者： Yibo Dou Carlos Grande Andreas Kaiser wenjing zhang Department of Energy Conversion and Storage Technical University of DenmarkAnker AngelundsvejDK-2800 Kongens LyngbyDenmark Department of Environmental Engineering Technical University of DenmarkMiljøvej 113DK-2800 Kongens LyngbyDenmark SINTEF SINTEF AS.Forskningsveien 1.0373 OsloNorway

Porous materials such as metal-organic frameworks(MOFs)with high theoretical volumetric gas uptake capacity are promising materials for gas storage and separation,but the structuring for practical applications is ***,we report a general and feasible strategy to combine electrospinning with a phase conversion method to decorate polyacrylonitrile nanofibers(PAN NFs)with CuMOF(HKUST-1).The strategy is based on the combination of surface pretreatment of the NFs with Cu(OH)_(2) and a subsequent phase conversion into HKUST-1 crystals(PCHKUST-1).A significant higher loading of HKUST-1 in the PAN NF matrix was achieved by the phase conversion method compared with direct electrospinning of MOF slurries or insitu growth of MOF crystals on *** a result,the hierarchical structured PC(phase conversion)-HKUST-1 NFs revealed the highest gravimetric storage capacity of 86 cm^(3) g^(-1)(STP)at 3500 kPa and 298 K for methane(CH_(4)),which is higher than other HKUST-1 NFs reported *** improved CH_(4) uptake can be explained by the high loading of HKUST-1 due to the high availability of Cu-ions localized on the surface of the NFs during the phase conversion process,resulting in high surface area and excellent gas access of the phase converted ***,the developed strategy of structuring MOFs could be of interest for the fabrication of tailor-made MOF NF architectures for other energy and environmental applications.

关键词： electrospinning phase conversion metal-organic frameworks(MOFs) methane storage

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Function Characteristics of Language related brain regions in patients with NSCL/P based on fMRI Dataset

Function Characteristics of Language related brain regions i...

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第十四次中国口腔颌面外科学术会议

作者： wenjing zhang Renji Chen Dept.of Oral and Maxillofacial Plastic and trauma Surgery Beijing Stomatological Hospital

Objective: This study aimed to explore the function changes of related brain region in adults with nonsyndrome cleft lip and palate(NSCL/P), by using task-based fMRI,which help to select effective rehabilitation treatments. Methods:Two groups, 24 adults after palatoplasty with speech training and 24 healthy young volunteers as age-matched and sex-matched *** activation during speech task and behavioral data were recorded by using functional MRI, which was scanned from cranial vault to foramina magnum. High resolution 3 DT1,3 DT2, DKI, and speech task based fMRI weighted images were acquired. Blocks design was used to objective brain activation linked to the speech ***, all these data were processed with VBM,DPARSF software. in statistical parametric mapping software(SPM12). These results in conjuction with images from each group were put into second-level one-sample t-tests to yield group-level activation Results:Patients with NSCL/P responded to the target significantly more slowly compared with the controls, whereas no significant difference in accuracy was found between the groups. Brain activation had similar patterns between groups. Broca’s area, Wernicke’s area, motor areas, somatosensory areas, and insula in both hemispheres,the dorso lateral prefrontal cortex and the ventrolateral prefrontal cortex in the right hemisphere were activated in both groups, with no statistically significant difference. Furthermore, the two sample t-test showed that the hippocampus in the left hemisphere was activated significantly in patients with NSCL/P compared with the controls. Conclusion:Adults with NSCL/P have abnormal brain structure, potentially due to abnormal language development caused by structural articulation disorder. the hippocampus might be involved in the language-related neural circuit in patients with NSCL/P and play a role on pronunciation retrieval to help patients with NSCL/P to complete the pronunciation effectively.

关键词： non-syndromic cleft of lip with or without palate functional magnetic resonance imaging speech disorder task-based fMRI

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RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2363-2383页

作者： Lei Chen wenjing zhang Dan Chen Quan Yang Siwen Sun Zhenwei Dai Zhengzheng Li Xuemei Liang Chaoqun Chen Yuexia Jiao Lili Zhi Lianmei Zhao Jinrui zhang Xuefeng Liu Jinyao Zhao Man Li Yang Wang Yangfan Qi Institute of Cancer Stem Cells and the Second Affiliated Hospital of Dalian Medical University Dalian Medical UniversityDalian116044China Department of Pathology the First Affiliated Hospital of Dalian Medical UniversityDalian116011China Department of Oncology the Second Affiliated Hospital of Dalian Medical UniversityDalian116023China Department of Thoracic Surgery the First Affiliated Hospital of Dalian Medical UniversityDalian116011China Research Center the Fourth Hospital of Hebei Medical UniversityShijiazhuang050011China

Cellular senescence provides a protective barrier against tumorigenesis in precancerous or normal tissues upon distinct ***,the detailed mechanisms by which tumor cells evade premature senescence to malignant progression remain largely *** we reported that RBM4 adversely impacted cellular senescence to favor glutamine-dependent survival of esophageal squamous cell carcinoma(ESCC)cells by dictating the activity of LKB1,a critical governor of cancer *** level of RBM4 was specifically elevated in ESCC compared to normal tissues,and RBM4 overexpression promoted the malignant ***4 contributed to overcome H-RAS-or doxorubicin-induced senescence,while its depletion caused P27-dependent senescence and proliferation arrest by activating LKB1-AMPK-mTOR ***,RBM4 competitively bound LKB1 to disrupt the LKB1/STRAD/MO25 heterotrimeric complex,subsequently recruiting the E3 ligase TRIM26 to LKB1,promoting LKB1 ubiquitination and degradation in ***,such molecular process leads to bypassing senescence and sustaining cell proliferation through the activation of glutamine ***,the ESCC patients with high RBM4 and low LKB1 have significantly worse overall survival than those with low RBM4 and high *** RBM4 high/LKB1 low expression confers increased sensitivity of ESCC cells to glutaminase inhibitor CB-839,providing a novel insight into mechanisms underlying the glutamine-dependency to improve the efficacy of glutamine inhibitors in ESCC therapeutics.

关键词： LKB1 ESCC protective

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一种有限脉冲响应滤波器格型结构优化方法及灵敏度分析

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电子与信息学报 2022年第2期44卷 686-693页

作者：庄陵张文静重庆邮电大学通信与信息工程学院重庆400065 移动通信教育部工程研究中心重庆400065 移动通信技术重庆市重点实验室重庆400065

有限脉冲响应(FIR)滤波器是无线通信研究中多载波调制系统的主要组成单元。针对有限字长效应导致FIR滤波器性能下降问题,该文提出一种FIR滤波器格型结构改善因量化导致的滤波器系数误差,即降低系数灵敏度,利用状态空间结构表示相应改进... 详细信息

有限脉冲响应(FIR)滤波器是无线通信研究中多载波调制系统的主要组成单元。针对有限字长效应导致FIR滤波器性能下降问题,该文提出一种FIR滤波器格型结构改善因量化导致的滤波器系数误差,即降低系数灵敏度,利用状态空间结构表示相应改进格型结构系数,并推导分析其系数灵敏度表达式。仿真实例验证理论推导结果,即改进格型结构系数灵敏度与采样周期相关。与传统格型结构相比,在量化字长和采样周期约束下,改进格型结构频响特性曲线更接近理想频响特性曲线,系数灵敏度更小,抗有限字长效应能力更好。

关键词：有限脉冲响应滤波器有限字长格型结构状态空间系数灵敏度

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Fabrication and research of bi-functional CuNi_(2)S_(4) nanosheets decorated TiO_(2)/CuNi_(2)S_(4) heterojunction photoanode for photoelectrochemical water splitting

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Chinese Physics B 2023年第11期32卷 124-133页

作者：金伟张立媛张文静孙倩张德恺苗慧胡晓云 School of Physics Northwest UniversityXi’an 710127China

As a traditional n-type semiconductor, TiO_(2)has good UV absorption ability and stable physical and chemical properties. However, its wide band gap and low oxygen evolution reaction(OER) activity limit its application in the field of photoelectrochemical(PEC) water splitting. In this work, a type-Ⅱ TiO2/CuNi2S4heterojunction photoanode is successfully constructed, which expanded the light absorption range to visible and enhanced the OER activity. Firstly, TiO2nanotubes(NTs) thin films are prepared on Ti substrates by two-step anodization, and then the bi-functional electrocatalytic material CuNi2S4is grown on TiO2NTs in the shape of nanosheets(NSs) in situ by solvothermal method. As a bi-functional electrocatalytic material, CuNi2S4has good visible light absorption property as well as OER catalytic activity. Compared with TiO_(2), the IPCE value of TiO_(2)/CuNi_(2)S_(4)is 2.59% at 635 nm, and that of TiO2is a mere 0.002%.The separation efficiency and injection efficiency increase from 2.49% and 31.52% to 3.61% and 87.77%, respectively. At 1.23 V vs. RHE, the maximum photocurrent density is 0.26 m A/cm^(2), which is 2.6 times than that of TiO2(0.11 m A/cm^(2)),and can be maintained at 0.25 m A/cm^(2)for at least 2 h under light illumination. Moreover, a hydrogen production rate of 4.21 μmol·cm^(-2)·h^(-1)is achieved within 2 h. This work provides a new idea for the application of TiO_(2)in the field of PEC water splitting and the construction of efficient and stable photoelectronic devices.

关键词： TiO_(2) CuNi2S4 high stability photoelectrochemical properties

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