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A causal multiomics study discriminates the early immune features of Ad5-vectored Ebola vaccine recipients

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The Innovation 2024年第3期5卷 77-87页

作者： Zhe Zhang wenjing Yang Zhengshan chen Haoang Chi Shipo Wu Wanru Zheng Ruochun Jin Busen Wang Yudong Wang Nan Huo Jinlong Zhang Xiaohong Song Liyang Xu Jun Zhang Lihua Hou Wei chen Institute of Biotechnology Academy of Military Medical SciencesBeijing 100071China Department of Intelligent Data Science College of Computer Science and TechnologyNational University of Defense TechnologyChangsha 410073China Intelligent Game and Decision Lab Academy of Military ScienceBeijing 100091China

The vaccine-induced innate immune response is essential for the generation of an antibody response.To date,how Ad5-vectored vaccines are influenced by preexisting anti-Ad5 antibodies during activation of the early immune response remains unclear.Here,we investigated the specific alterations in GP1,2-specific IgG-related elements of the early immune response at the genetic,molecular,and cellular levels on days 0,1,3,and 7 after Ad5-EBOV vaccination.In a causal multiomics analysis,distinct early immune responses associated with GP1,2-specific IgG were observed in Ad5-EBOV recipients with a low level of preexisting anti-Ad5 antibodies.This study revealed the correlates of the Ad5-EBOV-induced IgG response and provided mechanistic evidence for overcoming preexisting Ad5 immunity during the administration of Ad5-vectored vaccines.

关键词： vaccine immunity alterations

Tumor microenvironment-activated theranostic nanoreactor for NIR-II Photoacoustic imaging-guided tumor-specific photothermal therapy

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Fundamental Research 2024年第1期4卷 178-187页

作者： Nan Yang Hui Li Changyu Cao Lei Zhao Xuejiao Song Wenjun Wang wenjing Xu Yewei Zhang Peng chen Xiaochen Dong Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM) School of Physical and Mathematical SciencesNanjing Tech University(NanjingTech)Nanjing 211816China School of Physical Science and Information Technology Liaocheng UniversityLiaocheng 252059China Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011China School of Chemical and Biomedical Engineering Lee Kong Chian School of MedicineNanyang Technological University62 Nanyang DriveSingapore 637459Singapore

Theranostic agents that can be sensitively and specifically activated by the tumor microenvironment(TME)have recently attracted considerable attention.In this study,TME-activatable 3,3′,5,5′-tetramethylbenzidine(TMB)-copper peroxide(CuO_(2))@poly(lactic-co-glycolic acid)(PLGA)@red blood cell membrane(RBCM)(TCPR)nanoparticles(NPs)for second near-infrared photoacoustic imaging-guided tumor-specific photothermal therapy were developed by co-loading CuO_(2)NPs and TMB into PLGA camouflaged by RBCMs.As an efficient H_(2)O_(2)supplier,once exposed to a proton-rich TME,CuO_(2)NPs can generate H_(2)O_(2)and Cu^(2+),which are further reduced to Cu^(+) by endogenous glutathione.Subsequently,the Cu^(+)-mediated Fenton-like reaction produces cytotoxic·OH to kill the cancer cells and induce TMB-mediated photoacoustic and photothermal effects.Combined with the RBCM modification-prolonged blood circulation,TCPR NPs display excellent specificity and efficiency in suppressing tumor growth,paving the way for more accurate,safe,and efficient cancer theranostics.

关键词： Nanoparticles Photoacoustic imaging Second near-infrared region Tumor microenvironment Self-sufficient H_(2)O_(2)

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铁基激光熔敷层搭接与非搭接区摩擦性能

清华大学学报（自然科学版） 2022年第3期62卷 476-481页

作者：吴影刘艳陈文静陈辉西南交通大学材料科学与工程学院成都610031 清华大学机械工程系北京100084 西华大学材料科学与工程学院成都610039

多层多道激光熔敷涂层的组织呈周期性变化规律,总体分为搭接区和非搭接区。为研究涂层中不同区域的摩擦磨损性能,该文采用线性往复摩擦试验,分别设定5和25 N的压力,150和300 s的摩擦时长对铁基涂层的搭接区与非搭接区的摩擦磨损性能进... 详细信息

多层多道激光熔敷涂层的组织呈周期性变化规律,总体分为搭接区和非搭接区。为研究涂层中不同区域的摩擦磨损性能,该文采用线性往复摩擦试验,分别设定5和25 N的压力,150和300 s的摩擦时长对铁基涂层的搭接区与非搭接区的摩擦磨损性能进行研究,并结合不同区域的组织和物相的分析,讨论了摩擦性能与组织之间的关系,及摩擦过程中组织的演变规律。研究结果表明:在低压力下,抗磨损性能受组织影响较大,搭接区由于组织粗大、α-Fe含量较少,其抗磨损性能较差;而非搭接区组织细密、α-Fe含量较多,其抗磨损性能较好。在高压力下,抗磨损性能受组织影响较小,搭接区与非搭接区的抗磨损性能相似。在摩擦试验过程中,磨痕浅表层产生剪切变形层,其厚度、硬度及等效应变量随压力和摩擦时长的增加而增加,其中搭接区硬度增加速率高于非搭接区。

关键词：多道激光熔敷搭接区与非搭接区组织摩擦性能

Hetero-phase zirconia encapsulated with Au nanoparticles for boosting electrocatalytic nitrogen reduction

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Chinese Chemical Letters 2024年第5期35卷 509-513页

作者： Xue Xin Qiming Qu Islam E.Khalil Yuting Huang Mo Wei Jie chen Weina Zhang Fengwei Huo wenjing Liu Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing 211816China

Electrocatalytic nitrogen reduction reaction(NRR)is considered as an attractive approach for ammonia synthesis under mild conditions.A bottleneck of NRR is the exploration of efficient catalysts for accelerating reaction kinetics,among which heterogeneous structures possessing distinct atomic arrangement could modify electronic structure,and therefore altering their NRR activity.Here,we report a facile strategy for fabricating hetero-phase metal oxides derived from metal organic framework that are further integrated with Au nanoparticles as NRR catalysts.The phase composition of zirconia can be easily adjusted by simply changing the reaction temperature,where the monoclinic and tetragonal phases with the roughly close proportions have a distinct interface,leading to a strong interaction between Au and ZrO_(2).The enhanced interaction renders Au to be more electropositive and facilitates stronger binding to N_(2).As a result,a remarkable ammonia yield of 22.32μg h^(-1)mg_(cat.)^(-1) and a Faradaic efficiency of 31.92%can be achieved at low overpotential.This work is expected to pave the way for the design of heterogeneous structures and the exploration of hetero-phase nanostructures in boosting the electrocatalytic NRR.

关键词： Hetero-phase Metal-organic framework derivatives Zirconia Nitrogen reduction reaction Electrochemistry

科技期刊知识服务的演进分析:阶段特征、动力因素和驱动机制

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中国科技期刊研究 2022年第5期33卷 573-581页

作者：陈文静福建省农业科学院农业经济与科技信息研究所福建省福州市350003 《台湾农业探索》编辑部福建省福州市350003

【目的】探究科技期刊知识服务的演进规律,为我国科技期刊更好地参与知识服务进程提供参考。【方法】依据产业发展的基本规律,采用文献研究和案例分析相结合的方法,总结科技期刊知识服务的发展阶段及特征、动力因素的来源及层次、驱动... 详细信息

【目的】探究科技期刊知识服务的演进规律,为我国科技期刊更好地参与知识服务进程提供参考。【方法】依据产业发展的基本规律,采用文献研究和案例分析相结合的方法,总结科技期刊知识服务的发展阶段及特征、动力因素的来源及层次、驱动机制及其与知识服务发展阶段的关系。【结果】科技期刊知识服务在技术进步、个刊发展、产业升级等内部因素,用户需求、政策导向、知识付费经济等外部因素的共同作用下,通过“延伸拓展—重组推进—多元协同—创新融合”四重作用机制,逐步实现由单刊发展阶段、集群发展阶段、共同体发展阶段向智能体发展阶段迈进。【结论】基于科技期刊知识服务的发展规律,我国科技期刊应强化典型引领,加速知识服务布局;引导生态竞合,深化产业融合发展;培育创新能力,活化知识服务资源;优化运营策略,增强产业造血功能,以提供更好的知识服务。

关键词：科技期刊知识服务阶段特征动力因素驱动机制发展对策

Coupling Au with BO_(x) matrix induced by Closo-boron cluster for electrochemical synthesis of ammonia

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Journal of Energy Chemistry 2024年第6期93卷 471-477,I0012页

作者： wenjing Liu Nan Yang Yuao Wei Yingjie Yu Jie chen Mo Wei Yuting Huang Xiaohan Li Linghai Zhang Faisal Saleem Weina Zhang Haibo Zhang Fengwei Huo Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) School of Flexible Electronics(Future Technologies)Nanjing Tech UniversityNanjing 211816JiangsuChina College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072HubeiChina

Au is considered as one of the most promising catalysts for nitrogen reduction reaction(NRR),however maximizing the activity utilization rate of Au and understanding the synergistic effects between Au and carriers pose ongoing challenges.Herein,we systematically explore the synergistic catalytic effect of incorporating Au with boron clusters for accelerating NRR kinetics.An in-situ abinitio strategy is employed to construct B-doped Au nanoparticles(2-6 nm in diameter)loaded on BO_(x) substrates(AuBO_(x)),in which B not only modulates the surface electronic structure of Au but also forms strong coupling interactions to stabilize the nanoparticles.The electrochemical results show that Au-BO_(x) possesses excellent NRR activity(NH_(3) yield of 48.52μg h^(-1)mg_(cat)^(-1),Faraday efficiency of 56.18%),and exhibits high stability and reproducibility throughout the electrocatalytic NRR process.Theoretical calculations reveal that the introduction of B induces the formation of both Au dangling bond and Au-B coupling bond.which considerably facilitates the hydrogenation of~*N_(2)^(-)~*NH_(3).The present work provides a new avenue for the preparation of metal-boron materials achieved by one-step reduction and doping process,utilizing boron clusters as reducing and stabilizing agents.

关键词： Boron clusters Nitrogen reduction reaction Au–B coupling

Lead-free hybrid two-dimensional double perovskite with switchable dielectric phase transition

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Chinese Chemical Letters 2024年第6期35卷 176-179页

作者： Tian Yang Yi Liu Lina Hua Yaoyao chen Wuqian Guo Haojie Xu Xi Zeng Changhao Gao wenjing Li Junhua Luo Zhihua Sun College of Chemistry Fuzhou UniversityFuzhou 350108China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Molecular dielectric switches constitute a type of intelligent materials that are highly coveted for their distinctive advantages of switchable dielectric responses,lightweight,and mechanical flexibility.Twodimensional(2D)hybrid perovskites have demonstrated excellent promise for assembling dielectric switches,in which the dynamic motions of organic moieties afford driving force to trigger switchable dielectric phase transition.Here,we successfully assembled a new lead-free hybrid double perovskite,(CHA)4Cu Bi Br8(1,CHA=cyclohexylammonium),adopting a typical 2D structural motif,which shows dielectric anisotropy and bistable behaviors during the reversible phase transition near T_(c)=378 K(the Curie temperature).That is,its dielectric constants could be switched and tuned between high-dielectric and low-dielectric states.Structure analyses reveal that the ordered-disordered transformation of the organic CHA+moiety and distortion of inorganic framework account for its phase transition.This result will stimulate further exploration of molecular dielectric switches in this 2D environmentally friendly family.

关键词： Dielectric switch Lead-free Double perovskite Phase transition Symmetry breaking

不同触发阈值对肺动脉CTA图像质量影响的研究

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CT理论与应用研究（中英文） 2024年第2期33卷 175-181页

作者：王永胜杨磊清杨怡帆裴青霞王晨思鲁梦云何俊林陈文静田香宝上海市金山区亭林医院放射科上海201505

目的:研究不同触发阈值对肺动脉CTA图像质量的影响。资料与方法:前瞻性纳入上海市金山区亭林医院2021年12月至2023年4月临床怀疑肺动脉栓塞的患者112例作为研究对象,其中男性49例,女性63例,年龄在37~93岁,平均年龄为64.28岁。根据触发... 详细信息

目的:研究不同触发阈值对肺动脉CTA图像质量的影响。资料与方法:前瞻性纳入上海市金山区亭林医院2021年12月至2023年4月临床怀疑肺动脉栓塞的患者112例作为研究对象,其中男性49例,女性63例,年龄在37~93岁,平均年龄为64.28岁。根据触发阈值不同分成3组,将患者分配到A、B、C3组,A组触发阈值为120 HU共38例、B组触发阈值为200 HU共37例、C组触发阈值为250 HU共37例,3组间性别、年龄、身高、体重差异无统计学意义。采用单因素ANOVA检验,比较3组间的上腔静脉、肺动脉主干及左右肺动脉、右肺静脉的CT值以及图像质量主观评分。结果:3组间肺动脉主干及左右肺动脉CT值无统计学差异,上腔静脉、右肺静脉CT值有统计学差异;3组间的图像质量主观评分有统计学差异;两名医师间对所得图像质量主观评价的一致性结果为高度一致,Kappa=0.78。结论:肺动脉CTA触发阈值在200 HU,2 s后启动扫描时,既能保证肺动脉主干CT值的浓度,满足临床诊断,又保证对比剂充分的灌注到5~6级分支,上腔静脉潴留少,肺静脉显影淡,肺动脉CTA的图像质量最佳。

关键词：肺动脉CTA 触发阈值图像质量

Integrative analysis of metabolome and transcriptome provides new insights into functional components of Lilii Bulbus

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Chinese Herbal Medicines 2024年第3期16卷 435-448页

作者： Wenjun Wei Tao Guo Wenguang Fan Mengshan Ji Yu Fu Conglong Lian Suiqing chen wenjing Ma Wenfang Ma Shuying Feng School of Pharmacy Henan University of Chinese Medicine Henan Engineering Research Center of Medicinal and Edible Chinese Medicine Technology School of Life Science and Engineering Lanzhou University of Technology Lanzhou Shibai Agricultural Biotechnology Co. Ltd. Medical College Henan University of Chinese Medicine

Objective:Lilium brownii var.viridulum(LB) and L.lancifolium(LL) are the main sources of medicinal lily(Lilii Bulbus,Baihe in Chinese) in China.However,the functional components of these two species responsible for the treatment efficacy are yet not clear.In order to explore the therapeutic material basis of Lilii Bulbus,we selected L.davidii var.willmottiae(LD) only used for food as the control group to analyze the differences between LD and the other two(LB and LL).Methods:Metabolome and transcriptome were carried out to investigate the differences of active components in LD vs LB and LD vs LL,Data of metabolome and transcriptome was analysed using various analysis methods,such as principal component analysis(PCA),hierarchical cluster analysis(HCA),and so on.Differentially expressed genes(DEGs) were enriched through KEGG and GO enrichment analysis.Results:The PCA and HCA of the metabolome indicated the metabolites were clearly separated and varied greatly in LL and LB contrasted with LD.There were 318 significantly differential metabolites(SDMs) in LD vs LB group and 298 SDMs in LD vs LL group.Compared with LD group,the significant up-regulation of steroidal saponins and steroidal alkaloids were detected both in LB and LL groups,especially in LB group.The HCA of transcriptome indicated that there was significant difference in LB vs LD group,while the difference between LL and LD varied slightly.Additionally,47 540 DEGs in LD vs LB group and 18 958 DEGs in LD vs LL group were identified.Notably,CYP450s involving in the biosynthesis of steroidal saponins and steroidal alkaloids were detected,and comparing with LD,CYP724,CYP710A,and CYP734A1 in LB and CYP90B in LL were all up-regulated.Conclusion:This study suggested that steroidal saponins and steroidal alkaloids maybe the representative functional components of Lilii Bulbus,which can provide new insights for Lilii Bulbus used in the research and development of classic famous formula.

关键词： Lilium brownii F. E. Brown var. viridulum Baker Lilium davidii var. willmottiae (E. H. Wilson) Raffill Lilium lancifolium Thunb. metabolome transcriptome