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Transient receptor potential channels as predictive marker and potential indicator of chemoresistance in colon cancer

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Oncology Research 2024年第1期32卷 227-239页

作者： WEI HU THOMAS WARTMANN MARCO STRECKER ARISTOTELIS PERRAKIS ROLAND CRONER ARPAD SZALLASI wenjie shi ULF D.KAHLERT The Fourth Clinical Medical College of Yangzhou University Nantong Rich HospitalNantongChina Molecular and Experimental Surgery Clinic for General-Visceral-Vascular and Transplant SurgeryFaculty of Medicine and University Hospital MagdeburgOtto-von-Guericke UniversityMagdeburgGermany Department of Pathology and Experimental Cancer Research Semmelweis UniversityBudapestHungary

Transient receptor potential(TRP)channels are strongly associated with colon cancer development and progression.This study leveraged a multivariate Cox regression model on publicly available datasets to construct a TRP channels-associated gene signature,with further validation of signature in real world samples from our hospital treated patient samples.Kaplan-Meier(K-M)survival analysis and receiver operating characteristic(ROC)curves were employed to evaluate this gene signature’s predictive accuracy and robustness in both training and testing cohorts,respectively.Additionally,the study utilized the CIBERSORT algorithm and single-sample gene set enrichment analysis to explore the signature’s immune infiltration landscape and underlying functional implications.The support vector machine algorithm was applied to evaluate the signature’s potential in predicting chemotherapy outcomes.The findings unveiled a novel three TRP channels-related gene signature(MCOLN1,TRPM5,and TRPV4)in colon adenocarcinoma(COAD).The ROC and K-M survival curves in the training dataset(AUC=0.761;p=1.58e-05)and testing dataset(AUC=0.699;p=0.004)showed the signature’s robust predictive capability for the overall survival of COAD patients.Analysis of the immune infiltration landscape associated with the signature revealed higher immune infiltration,especially an increased presence of M2 macrophages,in high-risk group patients compared to their low-risk counterparts.High-risk score patients also exhibited potential responsiveness to immune checkpoint inhibitor therapy,evident through increased CD86 and PD-1 expression profiles.Moreover,the TRPM5 gene within the signature was highly expressed in the chemoresistance group(p=0.00095)and associated with poor prognosis(p=0.036)in COAD patients,highlighting its role as a hub gene of chemoresistance.Ultimately,this signature emerged as an independent prognosis factor for COAD patients(p=6.48e-06)and expression of model gene are validated by public data and real-world patients.Overall,this bioinformati

关键词： Colon cancer Transient receptor potential channels Prognostic signature Chemotherapy efficiency TRPM5

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MSWNet:A visual deep machine learning method adopting transfer learning based upon ResNet 50 for municipal solid waste sorting

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Frontiers of Environmental Science & Engineering 2023年第6期17卷 165-176页

作者： Kunsen Lin Youcai Zhao Lina Wang wenjie shi Feifei Cui Tao Zhou The State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention(LAP3) Department of Environmental Science and EngineeringFudan UniversityShanghai 200433China Institute of Eco-Chongming(IEC) Shanghai 202150China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China

An intelligent and efficient methodology is needed owning to the continuous increase of global municipal solid waste(MSW).This is because the common methods of manual and semi-mechanical screenings not only consume large amount of manpower and material resources but also accelerate virus community transmission.As the categories of MSW are diverse considering their compositions,chemical reactions,and processing procedures,etc.,resulting in low efficiencies in MSW sorting using the traditional methods.Deep machine learning can help MSW sorting becoming into a smarter and more efficient mode.This study for the first time applied MSWNet in MSW sorting,a ResNet-50 with transfer learning.The method of cyclical learning rate was taken to avoid blind finding,and tests were repeated until accidentally encountering a good value.Measures of visualization were also considered to make the MSWNet model more transparent and accountable.Results showed transfer learning enhanced the efficiency of training time(from 741 s to 598.5 s),and improved the accuracy of recognition performance(from 88.50%to 93.50%);MSWNet showed a better performance in MSW classsification in terms of sensitivity(93.50%),precision(93.40%),F1-score(93.40%),accuracy(93.50%)and AUC(92.00%).The findings of this study can be taken as a reference for building the model MSW classification by deep learning,quantifying a suitable learning rate,and changing the data from high dimensions to two dimensions.

关键词： Municipal solid waste sorting Deep residual network Transfer learning Cyclic learning rate Visualization

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Establishment of a developmental atlas and transgenetic tools in the ascidian Styela clava

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Marine Life Science & Technology 2023年第4期5卷 435-454页

作者： Boyan Lin wenjie shi Qiongxuan Lu Takumi Tshito Haiyan Yu Bo Dong Fang Zongxi Center College of Marine Life SciencesOcean University of ChinaQingdao 266003China Laoshan Laboratory Qingdao 266237China Department of Bioscience and Informatics Faculty of Science and TechnologyKeio UniversityYokohama 223-8522Japan MoE Key Laboratory of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China

The ascidian Styela clava is an ecologically important species that is distributed along coastal regions worldwide.It has a long history as a model animal for evolutionary and developmental biology research owing to its phylogenetic position between vertebrates and invertebrates,and its classical mosaic expression patterns.However,the standard developmental atlas and protocols and tools for molecular manipulation of this organism are inadequate.In this study,we established a standard developmental table and provided a web-based digital image resource for S.clava embryogenesis at each developmental stage from fertilized eggs to hatching larvae by utilizing confocal laser microscopy and 3D reconstruction images.It takes around 10 h for fertilized eggs to develop into swimming larvae and 20–30 min to complete the tail regression processes at the metamorphic stage.We observed that the notochord cells in S.clava embryos did not produce an extracellular lumen like Ciona robusta,but showed polarized elongation behaviors,providing us an ideal comparative model to study tissue morphogenesis.In addition,we established a chemical-washing procedure to remove the chorion easily from the fertilized eggs.Based on the dechorionation technique,we further realized transgenic manipulation by electroporation and successfully applied tissue-specific fluorescent labeling in S.clava embryos.Our work provides a standard imaging atlas and powerful genetic tools for investigating embryogenesis and evolution using S.clava as a model organism.

关键词： Ascidian Dechorionation Developmental atlas Styela clava Transgenic manipulation

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Engineering Coordination Environment of Cobalt Center in Molecular Catalysts for Improved Photocatalytic CO_(2) Reduction

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Chinese Journal of Chemistry 2023年第23期41卷 3305-3310页

作者： Yuchen Wang Jihong Zhang Wei Yang Weixue Tao Keying Tao Jihua Deng wenjie shi Dichang Zhong Tongbu Lu MOE International Joint Laboratory of Materials Microstructure Institute for New Energy Materials & Low Carbon Technologies School of Material Science & EngineeringTianjin University of TechnologyTianjin300384 China Guangdong Provincial Key Laboratory of Fuel Cell Technology GuangzhouGuangdong510641 China

The creation of effective and inexpensive catalysts is essential for photocatalytic CO_(2) reduction.Homogeneous molecular catalysts,possessing definite crystal structures,are desirable to study the relationship between catalytic performance and coordination microenvironment around catalytic center.In this report,we elaborately developed three Co(II)-based molecular catalysts with different coordination microenvironments for CO_(2) reduction,named[CoN_(3)O]ClO_(4),[CoN_(4)]ClO_(4),and[CoN_(3)S]ClO_(4),respectively.The optimal[CoN_(3)O]ClO_(4) photocatalyst has a maximum TON of 5652 in photocatalytic reduced CO_(2) reduction,which is 1.28 and 1.65 times greater than that of[CoN_(4)]ClO_(4) and[CoN_(3)S]ClO_(4),respectively.The high electronegativity of oxygen in L1(N,N-bis(2-pyridylmethyl)-N-(2-hydroxybenzyl)amine)provides the Co(II)catalytic centers with low reduction potentials and a more stable*COOH intermediate,which facilitates the CO_(2)-to-CO conversion and accounts for the high photocatalytic activity of[CoN_(3)O]ClO_(4).This work provides researchers new insights in development of catalysts for photocatalytic CO_(2) reduction.

关键词： Co(II)-based homogeneous catalysts Coordination microenvironment Photocatalysis CO_(2)reduction Homogenous catalysis

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Epitaxially Grown Ru Clusters-Nickel Nitride Heterostructure Advances Water Electrolysis Kinetics in Alkaline and Seawater Media

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Energy & Environmental Materials 2023年第2期6卷 81-89页

作者： Jiawei Zhu Ruihu Lu wenjie shi Lei Gong Ding Chen Pengyan Wang Lei Chen Jinsong Wu shichun Mu Yan Zhao State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Xianhu Hydrogen ValleyFoshan 528200China State Key Laboratory of Silicate Materials for Architectures International School of Materials Science and EngineeringWuhan University of TechnologyWuhan 430070China NRC(Nanostructure Research Centre) Wuhan University of TechnologyWuhan 430070China

The epitaxial heterostructure can be rationally designed based on the in situ growth of two compatible phases with lattice similarity,in which the modulated electronic states and tuned adsorption behaviors are conducive to the enhancement of electrocatalytic activity.Herein,theoretical simulations first disclose the charge transfer trend and reinforced inherent electron conduction around the epitaxial heterointerface between Ru clusters and Ni_(3)N substrate(cRu-Ni_(3)N),thus leading to the optimized adsorption behaviors and reduced activation energy barriers.Subsequently,the defectrich nanosheets with the epitaxially grown cRu-Ni_(3)N heterointerface are successfully constructed.Impressively,by virtue of the superiority of intrinsic activity and reaction kinetics,such unique epitaxial heterostructure exhibits remarkable bifunctional catalytic activity toward electrocatalytic OER(226 mV@20 mA cm^(−2))and HER(32 mV@10 mA cm^(−2))in alkaline media.Furthermore,it also shows great application prospect in alkaline freshwater and seawater splitting,as well as solar-to-hydrogen integrated system.This work could provide beneficial enlightenment for the establishment of advanced electrocatalysts with epitaxial heterointerfaces.

关键词： alkaline water electrolysis bifunctional electrocatalyst epitaxial heterostructure seawater electrolysis solar-to-hydrogen integrated system

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重估传统:构建基层社会治理共同体的内生性逻辑——基于对华南村治的田野考察

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行政论坛 2024年第1期31卷 125-133页

作者：石文杰马华山西大学政治与公共管理学院山西太原030006 山西大学乡村振兴研究院山西太原030006

构建基层社会治理共同体作为当前政策话语体系的重要内容,其本身就具有独特的理论意蕴和价值内涵。基于新内生发展理论,重估以宗族为代表的传统村落可继承、可延续的基本治理要素,研究发现:其顽强的组织韧性、功能适应性和文化创造性影... 详细信息

构建基层社会治理共同体作为当前政策话语体系的重要内容,其本身就具有独特的理论意蕴和价值内涵。基于新内生发展理论,重估以宗族为代表的传统村落可继承、可延续的基本治理要素,研究发现:其顽强的组织韧性、功能适应性和文化创造性影响着基层自治模式、利益整合方式和秩序维护机制。构建基层社会治理共同体必须根植于乡村社会特殊历史演进中而具有的现代社会发展一般性规律的内生性道路,即通过激活乡村内部经济活力、扩展多元主体参与渠道和增强地域文化价值认同,以此构建起基层社会治理共同体的规范性制度内核。

关键词：基层治理社会治理共同体宗族传统村落共同体现代性价值

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Metal-organic layers as reusable solid fluorination reagents and heterogeneous catalysts for aromatic fluorination

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Nano Research 2021年第2期14卷 473-478页

作者： wenjie shi Lingzhen Zeng Lingyun Cao Ying Huang Cheng Wang Wenbin Lin State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsNational Engineering Laboratory for Green Chemical Production of AlcohobEthers and EstersDepartment of ChemistryCollege of Chemistry and Chemical EngineeringiCHEMPCOSSXiamen UniversityXiamen 361005China Department of Chemistry University of ChicagoChicagoIL 60637USA

Reusable solid fluorination reagents and heterogeneous catalysts are ideally suited for late-stage fluorination with fast and clean conversion and simplified work-up.Here we report Pd-functionalized two-dimensional metal-organic layers(MOLs)as solid reagents and heterogeneous catalysts to efficiently fluorinate a broad scope of aromatic compounds.Site isolation in the MOLs provides a unique opportunity to stabilize highly active F-containing species for the chemical conversion.A terpyridine(TPY)-based ligand on the MOL,together with a 2-chloro-1,10-phenanthroline(phenCl)as a co-ligand,chelates Pd^(Ⅱ)toform a reactive center.After treatment with Selectfluor/H_(2)0,an(N-fluoroxy)-(2-chloro)-phenanthrolinium[N-(FO)-phenCl^(+)]moiety is produced from the co-ligand on the Pd center.This active species serves as a stochiometric solid fluorination reagent,which shows different regioselectivities and reactivities as compared to homogeneous catalysts that involves Pd^(Ⅲ/Ⅳ)-F intermediates in catalytic cycles.The MOLs can also be used as heterogeneous catalysts for fluorination using Selectfluor.This work highlights opportunities in using MOLs to stabilize unique active sites for late-stage fluorination.

关键词： metal-organic layers solid reagent heterogeneous catalyst fluorination

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数字乡村建设影响农户创业吗?

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中国软科学 2024年第2期 201-211页

作者：邹美凤高云凤马华石文杰太原科技大学经济与管理学院山西太原030024 山西大学政治与公共管理学院山西太原030006

数字乡村建设不仅重塑了农户的生产生活方式,而且催生了如电商、直播等全新的商业模式和创业形态,展现出对农户创业的深刻影响。基于社会认知理论,采用县域数字乡村指数和中国家庭追踪调查数据(CFPS)研究数字乡村建设对农户创业的影响... 详细信息

数字乡村建设不仅重塑了农户的生产生活方式,而且催生了如电商、直播等全新的商业模式和创业形态,展现出对农户创业的深刻影响。基于社会认知理论,采用县域数字乡村指数和中国家庭追踪调查数据(CFPS)研究数字乡村建设对农户创业的影响及作用机制。研究发现:数字乡村建设能够促进农户创业;东部地区、男性、中青年和低数字素养群体促进作用更加显著;西部地区阻碍作用更显著。机制分析发现,数字乡村建设通过资源效应和信息效应提高农户创业。研究结论为大力推进数字乡村战略对农户创业带来的具体影响提供了经验证据,为农村地区贯彻“大众创业、万众创新”激活农民创新创业找到了新动力源泉,也启示决策部门应因人施策、因地制宜推进数字乡村建设,以避免“运动式”“一刀切式”数字乡村建设对农户创业的不利影响。

关键词：数字乡村建设农户创业资源效应信息效应

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高原桥墩混凝土抗裂技术研究

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四川建材 2024年第6期50卷 25-27页

作者：史文杰中铁二十四局集团南昌铁路工程有限公司江西南昌330000

高原、高寒、高海拔地区复杂的环境特点,使得桥墩大体积混凝土施工面临巨大的挑战,混凝土配合比设计、施工工艺、养护工艺及智能监测的全过程精细化控制是防止混凝土开裂的重要措施。通过混凝土配合比的优化、施工和养护方法的提升、施... 详细信息

高原、高寒、高海拔地区复杂的环境特点,使得桥墩大体积混凝土施工面临巨大的挑战,混凝土配合比设计、施工工艺、养护工艺及智能监测的全过程精细化控制是防止混凝土开裂的重要措施。通过混凝土配合比的优化、施工和养护方法的提升、施工装备的改进,有效克服大温差、低湿度、强风速等恶劣环境下混凝土的开裂难题,为高原、高寒地区桥墩大体积混凝土施工提供可靠的技术和装备保障,创造更大的经济和社会效益。

关键词：高原环境桥墩混凝土高海拔大温差全过程控制

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立柱式SCARA型码垛机器人设计与分析

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机械工程师 2024年第3期 6-9页

作者：史文杰常州大学机械与轨道交通学院江苏常州213164

针对中小型货物搬运,设计了一种立柱式SCARA型码垛机器人,可实现一转动、三平移的4自由度运动。设计了SCARA码垛机器人的结构模型,采用D-H矩阵理论推导了其运动学正解模型。机器人的可达工作空间为以臂长和为半径、以移动行程为高度的... 详细信息

针对中小型货物搬运,设计了一种立柱式SCARA型码垛机器人,可实现一转动、三平移的4自由度运动。设计了SCARA码垛机器人的结构模型,采用D-H矩阵理论推导了其运动学正解模型。机器人的可达工作空间为以臂长和为半径、以移动行程为高度的圆柱体,以工作空间要求为目标,确定了机器人机构的相关几何参数。采用UG对码垛机器人进行三维实体建模,采用ANSYS Workbench软件对其进行静态分析,得到大臂、小臂的应变图。结果表明该机器人的结构强度和应变量满足使用要求,为整体结构的优化设计提供了依据。

关键词：码垛机器人工作空间运动学静态分析

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