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Journal of Earth Science 2024年第2期35卷 631-641页

作者： Ruilin Hao wenhui huang Jiu Bo Li Yuan Key Laboratory for Marine Reservoir Evolution and Hydrocarbon Abundance Mechanism School of Energy ResourcesChina University of GeosciencesMinistry of EducationBeijing100083China

Due to the complex conditions and strong heterogeneity of tight sandstone reservoirs,the reservoirs should be classified and the controlling factors of physical properties should be *** thin section observations,cathodoluminescence,scanning electron microscopy(SEM),X-ray diffraction(XRD),and high-pressure mercury injection(HPMI)were used to classify and optimize the *** Brooks-Corey model and stepwise regression were used to study the fractal dimension and main controlling factors of the physical properties of the high-quality *** results show that the reservoirs in the study area can be divided into four types,and the high-quality reservoir has the best physical properties and pore-throat *** the high-quality reservoir,the homogeneity of transitional pores was the best,followed by that of micropores,and the worst was *** porosity was controlled by depth and *** model with standardized coefficients is y=12.454−0.778×(Depth)+0.395×(Kaolinite).The permeability was controlled by depth,illite/montmorillonite,and siliceous cement,and the model with standardized coefficients is y=1.689−0.683×(Depth)−0.395×(Illite/Montmorillonite)−0.337×(Siliceous Cement).The pore-throat evolutionary model shows that the early-middle diagenetic period was when the reservoir physical properties were at their best,and the kaolinite intercrystalline pores and residual intergranular pores were the most important.

关键词： fractal dimension main controlling factors stepwise regression high-quality tight sandstone reservoir Ordos Basin petroleum geolgoy

Performance evaluation of the effect of humic acid on Anammox granular sludge:Apparent morphology,nitrogen removal and microbial community

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Journal of Environmental Sciences 2024年第10期144卷 148-158页

作者： wenhui huang Peiling Xu Xiang Li Yong huang Hao Sun Wei Li Mao Zhang Miao Shi Yan Yuan School of Environmental Science and Engineering Suzhou University of Science and TechnologySuzhou 215009China Suzhou Hongyu Environmental Technology Company Limited by Shares Suzhou 215011China Suzhou Tianjun Environmental Technology Limited Company Suzhou 215011China Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment Suzhou University of Science and TechnologySuzhou 215009China

Humic acid(HA)is a typical refractory organicmatter,so it is of great significance to investigate its effect on the performance of Anammox granular *** the dosage ofHA≤50 mg/L,HA promotes the total nitrogen removal rate(NRR)to 1.45 kg/(m^(3)·day).When HA was between 50 and 100 mg/L,the NRR of Anammox was *** this time,the adsorption of HA causes the sludge to gradually turn fromred to brown,but the activities of heme and enzymes showed that its capacitywas not *** HA levels reached 250 mg/L,the NRR dropped to 0.11 kg/(m3·day).Moderate HA levels promoted the release of extracellular polymeric substance(EPS),but excessive HA levels lead to a decrease in EPS *** inhibited Anammox activity,which indirectly hindered the transmission of substrate and accumulated substrate *** HA promoted the increase of heterotrophicmicrobial abundance in Anammox system,the microbial diversity decreased *** the increase of HA concentration,the abundance of Candidatus_Brocadia,the main functional microorganism of Anammox system,decreased gradually,while the abundance of Candidatus_Kuenenia increased gradually.

关键词： Anammox Landfill leachate Humic acid Heme Microbial community Enzyme activity

Toward Trustworthy Decision-Making for Autonomous Vehicles:A Robust Reinforcement Learning Approach with Safety Guarantees

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Engineering 2024年第2期33卷 77-89页

作者： Xiangkun He wenhui huang Chen Lv School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

While autonomous vehicles are vital components of intelligent transportation systems,ensuring the trustworthiness of decision-making remains a substantial challenge in realizing autonomous ***,we present a novel robust reinforcement learning approach with safety guarantees to attain trustworthy decision-making for autonomous *** proposed technique ensures decision trustworthiness in terms of policy robustness and collision ***,an adversary model is learned online to simulate the worst-case uncertainty by approximating the optimal adversarial perturbations on the observed states and environmental *** addition,an adversarial robust actor-critic algorithm is developed to enable the agent to learn robust policies against perturbations in observations and ***,we devise a safety mask to guarantee the collision safety of the autonomous driving agent during both the training and testing processes using an interpretable knowledge model known as the Responsibility-Sensitive Safety ***,the proposed approach is evaluated through both simulations and *** results indicate that the autonomous driving agent can make trustworthy decisions and drastically reduce the number of collisions through robust safety policies.

关键词： Autonomous vehicle Decision-making Reinforcement learning Adversarial attack Safety guarantee

Nonalcoholic Fatty Liver Disease:Changes in Gut Microbiota and Blood Lipids

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 333-345页

作者： Keen Yang Jieying Zeng Huaiyu Wu Huiyu Liu Zhimin Ding Weiyu Liang Linghu Wu Ziwei Lin wenhui huang Jinfeng Xu Fajin Dong Department of Ultrasound Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenGuangdongChina

Background and Aims:The global prevalence of nonalcoholic fatty liver disease(NAFLD)is 25%.This study aimed to explore differences in the gut microbial community and blood lipids between normal livers and those affected by NAFLD using 16S ribosomal deoxyribonucleic acid ***:Gut microbiome profiles of 40 NAFLD and 20 non-NAFLD controls were *** about four blood lipids and 13 other clinical features was *** were divided into three groups by ultrasound and FibroScan,those with a normal liver,mild FL(FL1),and moderate-to-severe FL(FL2).FL1 and FL2 patients were divided into two groups,those with either hyperlipidemia or non-hyperlipidemia based on their blood *** keystone species within the groups were identified using univariate analysis and a specificity–occupancy *** difference in biochemical parameters ion NAFLD patients and healthy individuals were identified by detrended correspondence analysis and canonical correspondence ***:Decreased gut bacterial diversity was found in patients with ***/Bacteroidetes decreased as NAFLD *** and Ruminococcus 2 were the most representative fatty-related *** pyruvic transaminase,aspartate aminotransferase,and white blood cell count were selected as the most significant biochemical *** of areas under the curve identified two microbiomes combined with the three biochemical indexes that identified normal liver and FL2 very well but performed poorly in diagnosing ***:Faecalibacterium and Ruminococcus 2,combined with glutamate pyruvic transaminase,aspartate aminotransferase,and white blood cell count distinguished *** speculate that regulating the health of gut microbiota may release NAFLD,in addition to providing new targets for clinicians to treat NAFLD.

关键词： Liver Gut microbiota Blood lipids Nonalcoholic fatty liver disease Hyperlipidemia

Mismatch analysis of all-fiber coherent beam combiners based on the self-imaging effect

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High Power Laser Science and Engineering 2024年第2期12卷 1-15页

作者： Yuefang Yan Yu Liu Haoyu Zhang Yuwei Li Chao Guo Qiang Shu wenhui huang Feng Jing Rumao Tao Laser Fusion Research Center China Academy of Engineering PhysicsMianyangChina Key Laboratory of Particle&Radiation Imaging(Tsinghua University) Ministry of EducationBeijingChina

All-fiber coherent beam combiners based on the self-imaging effect can achieve a near-perfect single laser beam,which can provide a promising way to overcome the power limitation of a single-fiber *** of the key points is combining efficiency,which is determined by various mismatches during fabrication.A theoretical model has been built,and the mismatch error is analyzed numerically for the first *** mismatch errors have been numerically studied with the beam quality and combining efficiency being chosen as the evaluation *** tolerance of each mismatch error for causing 1%loss is calculated to guide the design of the beam *** simulation results are consistent with the experimental results,which show that the mismatch error of the square-core fiber is the main cause of the efficiency *** results can provide useful guidance for the fabrication of all-fiber coherent beam combiners.

关键词： all-fiber coherent beam combination mismatch analysis self-imaging

基于端电压尖峰的无刷直流电机无位置传感器换相控制策略

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电机与控制学报 2024年第5期28卷 173-182页

作者：黄文晖闵华松武汉科技大学机器人智能系统研究院湖北武汉430081

针对现有的换相误差补偿方法需要额外滤波电路和检测电路导致无传感器换相方法变得更加复杂的问题,提出一种端电压尖峰脉冲换相误差补偿方法,实现了对无刷直流电机无传感器换相误差的准确补偿。研究了抗干扰性强的端电压尖峰脉冲信号的... 详细信息

针对现有的换相误差补偿方法需要额外滤波电路和检测电路导致无传感器换相方法变得更加复杂的问题,提出一种端电压尖峰脉冲换相误差补偿方法,实现了对无刷直流电机无传感器换相误差的准确补偿。研究了抗干扰性强的端电压尖峰脉冲信号的变化特性,得出了端电压尖峰脉冲持续时间是随着换相误差单调变化的结论,并利用端电压尖峰脉冲设计了换相误差闭环控制方法。该方法无需额外的滤波电路和检测电路,简化了换相误差补偿方法的电路设计,并且具备良好的鲁棒性和准确性。搭建了仿真和实际实验平台,对比了补偿前后的换相误差,实验结果表明,所提出方法能够实现准确的换相误差补偿。仿真实验和实际实验中,换相误差分别被控制在了1.1个电角度范围内和4个电角度范围内。在速度调控实验中,补偿后的无传感器方法表现出了和霍尔传感器相似的动态特性。相比于现有方法,提出方法更适合无刷直流电机无传感器方法在高性能电机控制场景的应用。

关键词：无刷直流电机六步换相法无传感器控制换相误差补偿端电压尖峰脉冲闭环控制

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Unveiling the nexus:Decoding interactions between regulated cell death and systemic lupus erythematosus pathogenesis for innovative therapeutic avenues

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Rheumatology & Autoimmunity 2024年第1期4卷 1-10页

作者： Qing Tan wenhui huang Yu Zheng Mingyan Li Yi Tao Shuilian Yu Department of Rheumatology The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangdongGuangzhouChina Department of Urology The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangdongGuangzhouChina Department of Cardiology The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangdongGuangzhouChina

Systemic lupus erythematosus(SLE)is characterized by disruptions in cell death pathways and impaired clearance of apoptotic cells,resulting in immune dysregulation and tissue *** review explores the complex interplay of regulated cell death(RCD)mechanisms,including apoptosis,necroptosis,pyroptosis,NETosis,autophagy,and ferroptosis,in the pathogenesis of *** pathways release autoantigens and danger signals,triggering autoimmune reactions and *** various RCDs have mutual associates to support immune dysregulation and are associated with *** intrinsically induces immune tolerance by packaging dying cells into immunologically inert *** in apoptotic clearance will result in impaired ***,pyroptosis,NETosis,and ferroptosis lead to cell membrane destruction,production of intracellular immunostimulatory components,and triggering a strong inflammatory immune *** autophagic activity affects the development,differentiation,function,and metabolism of many immune cell *** the interconnections between cell death pathways and SLE sheds light on the disease's underlying mechanisms and provides opportunities for novel therapeutic *** convergence of precision medicine and innovative strategies targeting these intricate pathways holds promise for expanding the landscape of SLE treatment.

关键词： autoimmunity immune dysregulation innovative therapies regulated cell death systemic lupus erythematosus therapeutic targets

维持性血液透析患者合并导管相关性血流感染预后的危险因素分析

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中华危重病急救医学 2024年第2期36卷 183-188页

作者：陈彩合马淑燕黄文辉甘肃中医药大学第一临床医学院兰州730000 甘肃省人民医院肾病科兰州730000

目的分析维持性血液透析(MHD)患者非住院期间发生导管相关性血流感染(CRBSI)的病原菌分布特征及影响预后的危险因素。方法采用回顾性对照研究,选择2020年1月至2023年5月在甘肃省人民医院肾病科因非住院期间发生CRBSI收治的34例以半永久... 详细信息

目的分析维持性血液透析(MHD)患者非住院期间发生导管相关性血流感染(CRBSI)的病原菌分布特征及影响预后的危险因素。方法采用回顾性对照研究,选择2020年1月至2023年5月在甘肃省人民医院肾病科因非住院期间发生CRBSI收治的34例以半永久导管为通路进行MHD的病例为研究对象。分析MHD患者非住院期间发生CRBSI的病原菌分布特点;所有患者入院后积极给予抗感染治疗,通过电子病历系统收集患者的一般资料、实验室检查指标及住院期间预后情况。根据住院期间的治疗结果将患者分为预后不良组(14例)和预后良好组(20例),采用单因素和多因素Logistic回归分析影响患者预后的危险因素,并绘制受试者工作特征曲线(ROC曲线)评估其对预后的预测价值。结果34例患者中共分离出28株病原菌,其中革兰阳性菌25株,葡萄球菌属为最多见病原菌,占总数的82.15%,金黄色葡萄球菌16株(57.15%),包括耐甲氧西林金黄色葡萄球菌(MRSA)6株(21.43%),表皮葡萄球菌7株(25.00%),包括耐甲氧西林表皮葡萄球菌(MRSE)3株(10.71%);革兰阴性菌3株,铜绿假单胞菌、大肠埃希菌、鲍曼不动杆菌各1株。单因素分析显示,MHD合并CRBSI患者预后不良组发热时间比预后良好组明显延长〔d:8.50(3.75,45.00)比2.50(1.00,4.75),P<0.01〕,血清红细胞沉降率(ESR)、C-反应蛋白(CRP)、随机血糖(GLU)均明显高于预后良好组〔ESR(mm/1 h):82.36±24.98比56.95±35.65,CRP(mg/L):123.45±74.10比67.35±55.22,GLU(mmol/L):8.74±3.66比6.42±1.95,均P<0.05〕。多因素Logistic回归分析显示,血清CRP为MHD合并CRBSI患者预后不良的独立危险因素〔优势比(OR)=1.020,95%可信区间(95%CI)为1.002~1.038,P=0.025〕。ROC曲线分析显示,血清CRP预测MHD合并CRBSI患者预后不良的曲线下面积(AUC)为0.711;最佳截断值为104.65 mg/L时,敏感度64.3%,特异度为85.0%,说明其具有较好的预测价值。结论MHD患者非住院期间发生CRBSI时,主要以革兰阳性菌感染为主;且其预后不良主要与较高的血清CRP水平有关;血清CRP水平能有效筛选MHD合并CRBSI患者预后不良的高危人群。

关键词：维持性血液透析导管相关性血流感染预后危险因素

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连续激光载波同步系统的慢漂抑制

强激光与粒子束 2024年第6期36卷 97-102页

作者：贾燕庆杜应超黄文会清华大学工程物理系北京100084

高精度同步系统是加速器产生高品质束流的关键因素之一,基于清华大学已有的连续激光载波同步系统,对不同接收端之间参考微波信号相位差的长时漂移,即同步系统慢漂进行了研究,提出了一种基于接收端参考微波信号幅值的电光调制器(EOM)偏... 详细信息

高精度同步系统是加速器产生高品质束流的关键因素之一,基于清华大学已有的连续激光载波同步系统,对不同接收端之间参考微波信号相位差的长时漂移,即同步系统慢漂进行了研究,提出了一种基于接收端参考微波信号幅值的电光调制器(EOM)偏置电压控制方法抑制慢漂。采用该方法后,清华大学甚高频光阴极电子枪测试平台L波段(1300 MHz)同步系统慢漂被抑制到10.45 fs@24 h,清华大学汤姆逊散射装置(TTX)S波段(2856 MHz)同步系统慢漂被抑制到10.53 fs@24 h,并且该方法可以使整套同步系统工作于室温环境,有效地提高了同步系统对工作环境温度的适应性。

关键词：同步系统加速器连续激光载波慢漂

“三创”产教融合背景下高职院校大学生创业孵化基地机制构建研究

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安徽职业技术学院学报 2024年第1期23卷 81-85页

作者：黄文汇芜湖职业技术学院公共管理学院安徽芜湖241003

本文通过访谈调研,使用关键词编码得出“三创”(创新、创业、创造)产教融合背景下,高职院校大学生创业孵化基地机制的构建,受到政策资源、人才培养、导师团队、企业合作、文化环境五大方面影响。研究分析后提出了加大政策支持力度,完善... 详细信息

本文通过访谈调研,使用关键词编码得出“三创”(创新、创业、创造)产教融合背景下,高职院校大学生创业孵化基地机制的构建,受到政策资源、人才培养、导师团队、企业合作、文化环境五大方面影响。研究分析后提出了加大政策支持力度,完善管理机制;推进创业课程改革,构建创新创业培训教育体系;建立导师创业专项辅导制度,打造创业服务团队;强化校企合作,搭建资源对接平台等相关构建策略,高职院校大学生创业孵化基地机制的构建系“三创”产教融合的重要途径,有助于培养创新型人才,且满足社会和经济发展的需求。

关键词：三创产教融合创业孵化