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中医药通过调控长链非编码RNA治疗肝癌的研究进展

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中国中医基础医学杂志 2024年第9期30卷 1614-1619页

作者：刘子铭吕建林张文富广西中医药大学南宁530200 广西中医药大学第一附属医院南宁530023 广西高发传染病中西医结合转化医学重点实验室南宁530200

长链非编码RNA(long non-coding RNA,LncRNA)是指其长度超过200个核苷酸的RNA分子。在原发性肝癌中,LncRNA的异常调控可以表现为促癌基因或抑癌基因的特性,与肝癌的发展、诊断以及治疗密切相关。越来越多的研究证实,中医药可以通过调控L... 详细信息

长链非编码RNA(long non-coding RNA,LncRNA)是指其长度超过200个核苷酸的RNA分子。在原发性肝癌中,LncRNA的异常调控可以表现为促癌基因或抑癌基因的特性,与肝癌的发展、诊断以及治疗密切相关。越来越多的研究证实,中医药可以通过调控LncRNA的表达,从而实现抑制肿瘤生长、诱导细胞凋亡、抑制血管生成、增强放射敏感性等作用。本文综述了近年来中医药通过调控LncRNA表达治疗肝癌所取得的研究进展,进一步探讨中医药治疗肝癌的优势,希望为今后肝癌的基础与临床研究提供更多思路。

关键词：长链非编码RNA 原发性肝癌中药单体研究进展

Design principles and parameters of rice ideal panicle type

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Chinese Science Bulletin 2005年第19期50卷 2253-2256页

作者： XU Zhengjin CHEN wenfu zhang Longbu YANG Shouren Rice Institute of Shenyang Agricultural University Key Laboratory ofCrop Physiology Ecology Genetics and Breeding Ministry of Agricul-ture Key Laboratory of Northern Japonica Rice Breeding of LiaoningShenyang 110161

On the basis of many years of research at the laboratory, and by making reference to the related literature published at home and abroad, in this paper the concept of rice ideal panicle type was introduced, and the principles of rice ideal panicle type design were elucidated. The parame-ters of rice ideal panicle type for Liaoning were preliminarily established as follows: Panicle length 2 mm, large vascular bundle and primary branch >15 pieces/panicle, primary branch grain >80 grains/panicle, secondary branch grains concentrating in the middle and upper parts of panicle axis, and panicle type index >0.5. In addition, the possibility of achieving unity of grain yield and quality at a still higher level by creating an ideal panicle type was explored.

关键词：水稻圆锥花序茎直径种植技术

鱼油的功效性成分、加工工艺及其在犬猫中应用的研究进展

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饲料工业 2024年第10期45卷 118-126页

作者：许佳张文府温超宇李俊姚婷兰新财余东游金华职业技术学院浙江金华321007 浙江大学动物科学学院浙江杭州310058 海特宠食科技(杭州)有限公司浙江杭州310052 中国农业科学院饲料研究所北京100081 北京市饲料监察所北京102218 浙江金大康动物保健品公司浙江金华321007

n-3多不饱和脂肪酸(n-3 polyunsaturated fatty acids,n-3 PUFA)是一类具有重要营养生理功能的脂肪酸。鱼油是n-3 PUFA的天然来源,含有丰富的二十碳五烯酸(Eicosapentaenoic acid,EPA)和二十二碳六烯酸(Docosahexaenoic acid,DHA)。鱼油的生产和精炼工艺日趋成熟,包括蒸馏、提取、酶解等过程。精炼而成的鱼油作为饲料原料已成为伴侣动物饲粮的一部分。n-3 PUFA对犬、猫疾病防治具有一定的辅助作用,可缓解心脑血管疾病、发挥抗炎作用、改善代谢性疾病等,同时也存在抗凝、不饱和脂肪酸过氧化等潜在问题。然而,当前鱼油应用于宠物方面的系统阐述鲜有报道。本文从鱼油加工工艺、功效性成分及其在犬猫上的研究进展进行综述,旨在为鱼油在宠物行业中的研究与应用提供参考依据。

关键词：鱼油 n-3多不饱和脂肪酸加工技术宠物疾病

The structure-directing role of heterologous seeds in the synthesis of zeolite

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Green Energy & Environment 2024年第5期9卷 792-801页

作者： Haoyang zhang Binyu Wang wenfu Yan State Key Laboratory of Inorganic Synthesis&Preparative Chemistry College of ChemistryJilin UniversityChangchun130012China

Zeolites have been widely used as catalysts,ion-exchangers,and adsorbents in chemical industries,detergent industry,steel industry,glass industry,ceramic industry,medical and healthﬁeld,and environmentalﬁeld,and recently applied in energy ***-assisted synthesis is a very effective approach in promoting the crystallization of *** some cases,the target zeolite cannot be formed in the absence of seed *** homologous seed-assisted synthesis,the structure of the seed zeolite is the same to that of the target zeolite,while the structure of the seed zeolite is different to that of the target zeolite in the heterologous seed-assisted *** this review,we brieﬂy summarized the heterologous seed-assisted syntheses of zeolites and analyzed the structure-directing effect of heterologous seeds and surveyed the“common composite building units(CBUs)hypothesis”and the“common secondary building units(SBUs)hypothesis”.However,both hypotheses cannot explain all observations on the heterologous seed-assisted ***,we proposed that the formation of the target zeolite does need nuclei with the structure of target zeolite and the formation of the nuclei of the target zeolite can be promoted by either the undissolved seed crystals with the same CBUs or SBUs to the target zeolite or by the facilitated appropriate distribution of the speciﬁc building units due to the presence of the heterologous seed that does not have any common CBUs and SBUs with the target zeolite.

关键词： Zeolite Heterologous seed Synthesis Structure-directing effect

集中荷载作用下弹性支撑矩形钢管混凝土翼缘工字形梁稳定性能研究

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河北工程大学学报（自然科学版） 2024年第2期41卷 7-15页

作者：刘迎春杨开琳计静张文福邓世林张智超东北石油大学黑龙江省高校防灾减灾工程与防护工程重点实验室黑龙江大庆163318 南京工程学院建筑工程学院江苏南京211167

为研究弹性支撑刚度对矩形钢管混凝土翼缘工字形梁稳定性能的影响,开展了集中荷载作用下3根带有不同弹性支撑刚度的矩形钢管混凝土翼缘工字形梁的稳定性能试验,研究试验梁的位移及应变的变化规律,获得梁的失稳形式和稳定承载力。试验结... 详细信息

为研究弹性支撑刚度对矩形钢管混凝土翼缘工字形梁稳定性能的影响,开展了集中荷载作用下3根带有不同弹性支撑刚度的矩形钢管混凝土翼缘工字形梁的稳定性能试验,研究试验梁的位移及应变的变化规律,获得梁的失稳形式和稳定承载力。试验结果表明,整个加载破坏过程分为三个阶段,即弹性阶段、弹塑性阶段和破坏阶段,3根试验梁均发生整体弯扭屈曲失稳。随着弹性支撑刚度增加,梁稳定承载力增大,验证了设置弹性支撑可有效地提高该梁的稳定承载力。在试验基础上,利用ANSYS有限元软件对该梁进行非线性屈曲分析,将获得的稳定承载力与试验结果进行对比,误差均小于5%,从而验证有限元分析方法的正确性。最后,研究了混凝土强度、上翼缘含钢率和腹板高厚比等参数对该类梁稳定性能的影响规律。研究表明,增大上翼缘钢管含钢率和减小腹板高厚比均可明显提高该类梁的稳定承载力,而增强混凝土强度对梁的稳定承载力提高较小。

关键词：钢管混凝土翼缘梁弹性支撑整体稳定承载力

基于CiteSpace的中医药联合TACE治疗肝癌的可视化分析

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中国现代医生 2024年第1期62卷 1-6页

作者：刘子铭戴铭黄晶晶吕建林张文富广西中医药大学研究生院广西南宁530200 广西中医基础研究重点实验室广西南宁530200 广西中医药大学第一附属医院脾胃肝病科广西南宁530023 广西高发传染病中西医结合转化医学重点实验室广西南宁530200

目的分析中医药联合经导管动脉化疗栓塞(transcatheter arterial chemoembolization,TACE)治疗肝癌研究领域的现状、热点及趋势。方法检索中国知网1994年1月至2022年12月收录的有关中医药联合TACE治疗肝癌的相关文献,利用Cite Space 6... 详细信息

目的分析中医药联合经导管动脉化疗栓塞(transcatheter arterial chemoembolization,TACE)治疗肝癌研究领域的现状、热点及趋势。方法检索中国知网1994年1月至2022年12月收录的有关中医药联合TACE治疗肝癌的相关文献,利用Cite Space 6.1.R6软件分析其发文量、作者、研究机构及关键词。结果本研究共纳入686篇文献,1994—2015年发文量呈现波动上升趋势,但自2016开始发文量有所下降,证明该领域还需要进一步突破性研究。发文作者及研究机构彼此之间的交流有待加强,跨机构、跨区域合作度较低,地域分布不均,应加强合作。高频关键词有肝癌、中药、介入治疗、治疗性等,得到9个关键词聚类标签。结论目前中医药联合TACE治疗肝癌较缺乏实验研究及相关机制的研究,未来的研究热点将更多地聚焦在中医药、介入治疗、临床观察及细胞凋亡方面,为今后开展相关研究的科研人员提供新的思路。

关键词：肝癌中医药经导管动脉化疗栓塞可视化分析

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Zeolites for the separation of ethylene,ethane,and ethyne

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 137-146页

作者： Binyu Wang Qiang Li Haoyang zhang Jia-Nan zhang Qinhe Pan wenfu Yan State Key Laboratory of Inorganic Synthesis&Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China Key Laboratory of Advanced Energy Catalytic and Functional Materials Preparation College of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450012China Key Laboratory of Advanced Materials of Tropical Island Resources(Ministry of Education) School of Chemistry and Chemical EngineeringHainan UniversityHaikou 570228China

The cost-effective separation of ethylene(C_(2)H_(4)),ethyne(C_(2)H_(2)),and ethane(C_(2)H_(6))poses a significant challenge in the contemporary chemical *** contrast to the energy-intensive high-pressure cryogenic distillation process,zeolite-based adsorptive separation offers a low-energy *** review provides a concise overview of recent advancements in the adsorptive separation of C_(2)H_(4),C_(2)H_(2),and C_(2)H_(6)using zeolites or zeolite-based *** commences with an examination of the industrial significance of these compounds and the associated separation ***,it systematically examines the utilization of various types of zeolites with diverse cationic species in such separation *** then it explores how different zeolitic structures impact adsorption and separation capabilities,considering principles such as cation-πinteraction,π-complexation,and steric separation concerning C_(2)H_(4),C_(2)H_(2),and C_(2)H_(6)***,it discusses methods to enhance the separation performance of zeolites and zeolite-based adsorbents,encompassing structural design,modifications,and ion exchange ***,it summarizes current research trends and future directions,highlighting the potential application value of zeolitic materials in the field of C_(2)H_(4),C_(2)H_(2),and C_(2)H_(6)separation and offering recommendations for further investigation.

关键词： zeolite ethylene ethane cation-πinteraction π-complexation

Advances in soliton microcomb generation

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Advanced Photonics 2020年第3期2卷 2-28页

作者： Weiqiang Wang Leiran Wang wenfu zhang Chinese Academy of Sciences Xi’an Institute of Optics and Precision MechanicsState Key Laboratory of Transient Optics and PhotonicsXi’anChina University of Chinese Academy of Sciences BeijingChina

Optical frequency combs,a revolutionary light source characterized by discrete and equally spaced frequencies,are usually regarded as a cornerstone for advanced frequency metrology,precision spectroscopy,high-speed communication,distance ranging,molecule detection,and many *** to the rapid development of micro/nanofabrication technology,breakthroughs in the quality factor of microresonators enable ultrahigh energy buildup inside cavities,which gives birth to microcavity-based frequency *** particular,the full coherent spectrum of the soliton microcomb(SMC)provides a route to low-noise ultrashort pulses with a repetition rate over two orders of magnitude higher than that of traditional mode-locking *** enables lower power consumption and cost for a wide range of *** review summarizes recent achievements in SMCs,including the basic theory and physical model,as well as experimental techniques for single-soliton generation and various extraordinary soliton states(soliton crystals,Stokes solitons,breathers,molecules,cavity solitons,and dark solitons),with a perspective on their potential applications and remaining challenges.

关键词： optical frequency comb soliton microcomb microcavity photonic integration Kerr effect four-wave mixing

Mechanism of interfacial effects in sodium-ion storage devices

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Nano Research 2024年第3期17卷 1313-1326页

作者： Yifan Wei Lingxing Zan Huicong Xia wenfu Yan Jia-Nan zhang College of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China Key Laboratory of Advanced Energy Catalytic and Functional Material Preparation of Zhengzhou City Zhengzhou 450001China Key Laboratory of Chemical Reaction Engineering of Shaanxi Province College of Chemistry&Chemical EngineeringYan’an UniversityYan’an 716000China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry and College of Chemistry Jilin UniversityChangchun 130012China

Rechargeable sodium-ion batteries(SIBs)are considered as the next-generation secondary *** performance of SIB is determined by the behavior of its electrode surface and the electrode–electrolyte interface during charging and ***,the characteristics of these surfaces and interfaces should be analyzed to realize large-scale energy storage systems with high energy density and long-cycle *** various studies have investigated the properties of electrode materials,few studies have focused on the construction of stable and efficient SIB interfaces,and even fewer have explored the mechanisms of interfacial effects;however,the strategies of regulating interfacial effects are yet to be completely ***,the results obtained thus far are insufficient to draw systematic *** present study reviews the literature on the mechanism of interfacial effects in Na+storage *** interfaces in a sodium-ion storage device include a heterogeneous interface between electrode materials,a solid electrolyte interphase,and a cathode electrolyte *** interfacial effects during the intercalation,transformation,and alloy reactions and the resulting overall battery performance were theoretically *** this review,we aim to provide a theoretical basis for optimizing the structures of electrode surface and electrode–electrolyte interface to optimize the performance of *** addition,the challenges of investigating interfacial effects and several possible helpful methods and opportunities for studying the mechanisms of interfacial effects in SIBs will be presented.

关键词： sodium-ion storage interfacial effects solid electrolyte interphase cathode electrolyte interphase