检索结果-南通市图书馆

Proteome profiling of spinal cord and dorsal root ganglia in rats with trinitrobenzene sulfonic acid-induced colitis

引用

World Journal of Gastroenterology 2012年第23期18卷 2914-2928页

作者： Xiao-Jun Zhang Feung Ping Leung wendy wl hsiao Shun Tan Shao Li Hong-Xi Xu Joseph JY Sung Zhao-Xiang Bian School of Chinese Medicine HongKong Baptist University Hong Kong China Ministry of Education Key Laboratory of Bioinformat- ics and Bioinformatics Division TNLIST/Department of Auto- mation Tsinghua University Beijing 100084 China Shanghai University of Traditional Chinese Medi- cine Shanghai 200032 China Faculty of Medicine The Chinese University of Hong Kong Hong Kong China

AIM: To investigate proteomic changes in spinal cord and dorsal root ganglia (DRG) of rats with trinitrobenzene sulfonic acid (TNBS)-induced colitis. METHODS: The colonic myeloperoxidase (MPO) activity and tumor necrosis factor-(TNF- ) level were determined. A two-dimensional electrophoresis (2-DE)-based proteomic technique was used to profile the global protein expression changes in the DRG and spinal cord of the rats with acute colitis induced by intracolonic injection of TNBS. RESULTS: TNBS group showed significantly elevated colonic MPO activity and increased TNF-level. The proteins derived from lumbosacral enlargement of the spinal cord and DRG were resolved by 2-DE; and 26 and 19 proteins that displayed significantly different expression levels in the DRG and spinal cord were identified respectively. Altered proteins were found to be involved in a number of biological functions, such as inflammation/immunity, cell signaling, redox regulation, sulfate transport and cellular metabolism. The over-expression of the protein similar to potassium channel tetramerisation domain containing protein 12 (Kctd 12) and low expression of proteasome subunit type-1 (psma) were validated by Western blotting analysis. CONCLUSION: TNBS-induced colitis has a profound impact on protein profiling in the nervous system. This result helps understand the neurological pathogenesis of inflammatory bowel disease.

关键词：蛋白质组分硝基苯磺酸背根神经节结肠炎脊髓诱导大鼠蛋白质组学技术

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Prebiotic-like Effects of Herbal Saponins on Gut Microbiota in Mice

The Prebiotic-like Effects of Herbal Saponins on Gut Microbi...

引用

第十四届全国中药和天然药物学术研讨会

作者： Lei Chen William CS Tai Manreetpal S Brar Frederick CC Leung wl wendy hsiao Hong Kong Baptist University The University of Hong Kong Macau University of Science and Technology

＜正＞Herbal saponins have raised keen interest for their health-promoting effects,but have not been investigated for their potential as ***,we aim at investigating the impact of herbal saponins on gut microbiota in C57BL/6 *** of four common herbal tea,namely Gynostemma pentaphyllum（Gp）,notoginseng,ginseng and red ginseng were studied.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

A Registry-Based Observational Study on the Maternal and Fetal Outcomes of COVID-19 Patients in Hong Kong

引用

母胎医学杂志(英文) 2024年第3期6卷 156-163页

作者： Leung Hillary HY Ma Teresa wl Yu Florrie NY Kong Meliza CW Lo Tsz Kin So Pauline PL Leung Wing-Cheong Shu wendy Cheung Ka Wang Moungmaithong Sakita Wang Chi Chiu Poon Liona C. Department of Obstetrics and Gynaecology The Chinese University of Hong Kong Hong Kong China Department of Obstetrics and Gynaecology Queen Elizabeth Hospital Hong Kong China Department of Obstetrics and Gynaecology United Christian Hospital Hong Kong China Department of Obstetrics and Gynaecology Princess Margaret Hospital Hong Kong China Department of Obstetrics and Gynaecology Tuen Mun Hospital Hong Kong China Department of Obstetrics and Gynaecology Kwong Wah Hospital Hong Kong China Department of Obstetrics and Gynaecology Pamela Youde Nethersole Eastern Hospital Hong Kong China Department of Obstetrics and Gynaecology Queen Mary Hospital Hong Kong China

Objective: To report the clinical maternal and fetal outcomes of pregnant women with coronavirus disease 2019 (COVID-19), along with any associated pregnancy complications, in Hong Kong, China, and to assess the impact of COVID-19 vaccination on these ***: This prospective registry-based observational study included pregnant women who were recruited through convenient sampling and had a laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection with a cycle threshold (Ct) value result available on admission to eight local hospitals in Hong Kong, China. Data on clinical symptoms, laboratory results, medical treatments, delivery timing and mode, and pregnancy complications were extracted from the Hospital Authority’s electronic medical record system. Maternal, fetal, and pregnancy outcomes were compared between unvaccinated pregnant women with COVID-19 and those who had received at least one dose of COVID-19 vaccine before diagnosis. Nonparametric continuous variables and categorical variables were analyzed using the Mann-WhitneyU test and the Pearson’s chi-squared test respectively. AP value less than 0.05 was considered statistically ***: A total of 164 pregnant women were included, of whom 78 (47.56%) were nulliparous. COVID-19 was diagnosed before 28 weeks’ gestation in 30 (18.29%), while 134 (81.71 %) were diagnosed at or after 28 weeks’ gestation. Sixty-two (37.80%) women received at least one dose of COVID-19 vaccine. There were no significant differences between vaccinated and unvaccinated groups in the time interval between COVID-19 diagnosis and delivery, the Ct value, and the gestational age at infection onset or delivery (P > 0.05). The majority of women were symptomatic at diagnosis regardless of vaccination status (55 (88.71%) in vaccinated groupvs. 78 (76.47%) in unvaccinated group (P = 0.052). Symptoms did not significantly differ between groups except for cough (62.90%vs. 47.06%,P = 0.049). The overall

关键词： COVID-19 Maternal outcomes: Fetal outcomes Pregnancy complications Severe COVID-19

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：