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The immune response to sARs-CoV-2 in people with HIV

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Cellular & Molecular Immunology 2024年第2期21卷 184-196页

作者： Maxine A.Höft wendy A.Burgers Catherine Riou Institute of Infectious Disease and Molecular Medicine University of Cape TownCape TownSouth Africa Division of Medical Virology Department of PathologyUniversity of Cape TownCape TownSouth Africa Wellcome Centre for Infectious Diseases Research in Africa University of Cape TownCape TownSouth Africa

This review examines the intersection of the HIV and sARs-CoV-2 *** with HIV(PWH)are a heterogeneous group that differ in their degree of immune suppression,immune reconstitution,and viral *** COVID-19 in those with wellcontrolled HIV infection poses no greater risk than that for HIV-uninfected individuals,people with advanced HIV disease are more vulnerable to poor COVID-19 ***-19 vaccines are effective and well tolerated in the majority of PWH,though reduced vaccine efficacy,breakthrough infections and faster waning of vaccine effectiveness have been demonstrated in *** is likely a result of suboptimal humoral and cellular immune responses after *** with advanced HIV may also experience prolonged infection that may give rise to new epidemiologically significant variants,but initiation or resumption of antiretroviral therapy(ART)can effectively clear persistent ***-19 vaccine guidelines reflect these increased risks and recommend prioritization for vaccination and additional booster doses for PWH who are moderately to severely *** recommend continued research and monitoring of PWH with sARs-CoV-2 infection,especially in areas with a high HIV burden.

关键词： sARs-CoV-2 HIV Immune dysfunction Vaccine efficacy Prolonged infection Immunogenicity

Reliability of a Multicomponent stress-strength Model Based on a Bivariate Kumaraswamy Distribution with Censored Data

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Acta Mathematicae Applicatae sinica 2024年第2期40卷 478-507页

作者： Cong-hua cheng school of Mathematics and statistics Zhaoqing UniversityZhaoqing 526061China

In this paper,we consider a system which has k statistically independent and identically distributed strength components and each component is constructed by a pair of statistically dependent elements with doubly type-II censored *** elements(X1,Y1),(X2,Y2),…,(Xk,Yk)follow a bivariate Kumaraswamy distribution and each element is exposed to a common random stress T which follows a Kumaraswamy *** system is regarded as operating only if at least s out of k(1≤s≤k)strength variables exceed the random *** multicomponent reliability of the system is given by Rs,k=P(at least s of the(Z1,…,Zk)exceed T)where Zi=min(Xi,Yi),i=1,…,*** Bayes estimates of Rs,k have been developed by using the Markov Chain Monte Carlo methods due to the lack of explicit *** uniformly minimum variance unbiased and exact Bayes estimates of Rs,k are obtained analytically when the common second shape parameter is *** asymptotic confidence interval and the highest probability density credible interval are constructed for Rs,*** reliability estimators are compared by using the estimated risks through Monte Carlo simulations.

关键词： stress-strength model bivariate Kumaraswamy distribution multicomponent reliability doubly Type-II censored scheme interval estimation

Equalizer Zero-Determinant strategy in Discounted Repeated stackelberg Asymmetric Game

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Journal of systems science & Complexity 2024年第1期37卷 184-203页

作者： cheng Zhaoyang CHEN Guanpu HONG Yiguang Key Laboratory of systems and Control Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China school of Mathematical sciences University of Chinese Academy of SciencesBeijing 100049China school of Electrical Engineering and Computer science KTH Royal Institute of Technology10044 StockholmSweden. Department of Control science and Engineering Tongji UniversityShanghai 201804China shanghai Research Institute for Intelligent Autonomous systems Tongji UniversityShanghai 210201China

This paper focuses on the performance of equalizer zero-determinant(ZD)strategies in discounted repeated stackelberg asymmetric *** the leader-follower adversarial scenario,the strong stackelberg equilibrium(ssE)deriving from the opponents’best response(BR),is technically the optimal strategy for the ***,computing an ssE strategy may be difficult since it needs to solve a mixed-integer program and has exponential complexity in the number of *** this end,the authors propose an equalizer ZD strategy,which can unilaterally restrict the opponent’s expected *** authors first study the existence of an equalizer ZD strategy with one-to-one situations,and analyze an upper bound of its performance with the baseline ssE *** the authors turn to multi-player models,where there exists one player adopting an equalizer ZD *** authors give bounds of the weighted sum of opponents’s utilities,and compare it with the ssE ***,the authors give simulations on unmanned aerial vehicles(UAVs)and the moving target defense(MTD)to verify the effectiveness of the proposed approach.

关键词： Discounted repeated stackelberg asymmetric game equalizer zero-determinant strategy strong stackelberg equilibrium strategy

Nutrient transport following water transfer through the world's largest water diversion channel

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Journal of Environmental sciences 2024年第1期135卷 703-714页

作者： Yuanhui cheng Hong Zhang Wei Yin state Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085 China Changjiang Water Resources Protection Institute Wuhan 430051China University of Chinese Academy of sciences Beijing 100049China

Nutrient levels in the artificial channel constructed for the Middle Route Project are significant indicators of water quality safety and aquatic ecological integrity for this large,interbasin ***,the distribution and transport of nutrients along the channel were poorly *** on a time-series dataset as well as mass balance and material flow analysis methods,the water and nutrient transport fluxes in the Middle Route of the south-to-North Water Diversion Project were identified in this *** results indicate that the nutrient concentrations varied considerably with time,but there was no significant difference among the 30 stations of the main *** temperature difference was the major factor in the large fluctuations of water quality indicators over *** nutrient loadings varied with the water volume outputs from the main channel to the waterreceiving *** deposition was an important source of nutrients in the main channel,accounting for 9.13%,20.6%,and 0.635%of the nitrogen,phosphorus,and sulfur input from the Danjiangkou Reservoir,*** 2021,a net accumulation of 988 tons of N,29 tons of P,and 2,540 tons of s,respectively,were present in the main *** increase of these external and internal nutrient loadings would cause water quality fluctuation and deterioration in some local sections of the main *** study quantified the spatial and temporal patterns of nutrient transport in the Middle Route and revealed the ecological effects on the aquatic environment,assisting authorities on the project to develop effective water conservation strategies.

关键词： Nutrient transport spatiotemporal patterns The Middle Route The south-to-North Diversion Project Hydro-ecological effects Water-receiving cities

Prediction and Output Estimation of Pattern Moving in Non-Newtonian Mechanical systems Based on Probability Density Evolution

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Computer Modeling in Engineering & sciences 2024年第4期139卷 515-536页

作者： cheng Han Zhengguang Xu school of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China Key Laboratory of Knowledge Automation for Industrial Processes University of Science and Technology BeijingBeijing100083China

A prediction framework based on the evolution of pattern motion probability density is proposed for the output prediction and estimation problem of non-Newtonian mechanical systems,assuming that the system satisfies the generalized Lipschitz *** a complex nonlinear system primarily governed by statistical laws rather than Newtonian mechanics,the output of non-Newtonian mechanics systems is difficult to describe through deterministic variables such as state variables,which poses difficulties in predicting and estimating the system’s *** this article,the temporal variation of the system is described by constructing pattern category variables,which are non-deterministic *** pattern category variables have statistical attributes but not operational attributes,operational attributes are assigned to them by posterior probability density,and a method for analyzing their motion laws using probability density evolution is ***,a data-driven form of pattern motion probabilistic density evolution prediction method is designed by combining pseudo partial derivative(PPD),achieving prediction of the probability density satisfying the system’s output *** on this,the final prediction estimation of the system’s output value is realized by minimum variance unbiased ***,a corresponding PPD estimation algorithm is designed using an extended state observer(EsO)to estimate the parameters to be estimated in the proposed prediction *** effectiveness of the parameter estimation algorithm and prediction method is demonstrated through theoretical analysis,and the accuracy of the algorithm is verified by two numerical simulation examples.

关键词： Non-newtonian mechanical systems prediction and estimation pattern moving probability density evolution pseudo partial derivative

Market Equilibrium Based on Cloud-edge Collaboration

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CsEE Journal of Power and Energy systems 2024年第1期10卷 96-104页

作者： Tong cheng Haiwang Zhong Qing Xia the state Key Laboratory of Power systems the Department of Electrical EngineeringTsinghua UniversityBeijing 100084China

Market participants can only bid with lagged information disclosure under the existing market mechanism,which can lead to information asymmetry and irrational market behavior,thus influencing market *** promote rational bidding behavior of market participants and improve market efficiency,a novel electricity market mechanism based on cloudedge collaboration is proposed in this *** market information,called residual demand curve,is published to market participants in real-time on the cloud side,while participants on the edge side are allowed to adjust their bids according to the information disclosure prior to closure *** proposed mechanism can encourage rational bids in an incentive-compatible way through the process of dynamic equilibrium while protecting participants’*** paper further formulates the mathematical model of market equilibrium to simulate the process of each market participant’s strategic bidding behavior towards equilibrium.A case study based on the IEEE 30-bus system shows the proposed market mechanism can effectively guide bidding behavior of market participants,while condensing exchanged information and protecting privacy of participants.

关键词： Cloud-edge collaboration market mechanism residual demand curve strategic bidding

Machine learning and numerical investigation on drag coefficient of arbitrary polygonal particles

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International Journal of Mechanical system Dynamics 2024年第3期4卷 317-330页

作者： Haonan Xiang cheng cheng Pei Zhang Genghui Jiang school of Energy and Power Engineering Nanjing University of Science and TechnologyNanjingChina school of Engineering Westlake UniversityHangzhouChina

The drag coefficient,as the most important parameter that characterizes particle dynamics in flows,has been the focus of a large number of *** good predictability is achieved for simple shapes,it is still challenging to accurately predict drag coefficient of complex-shaped particles even under moderate Reynolds number(Re).The problem is that the small-scale shape details of particles can still have considerable impact on the drag coefficient,but these geometrical details cannot be described by single shape *** address this challenge,we leverage modern deep-learning method's ability for pattern recognition,take multiple shape factors as input to better characterize particle-shape details,and use the drag coefficient as *** obtain a high-precision data set,the discrete element method coupled with an improved velocity interpolation scheme of the lattice Boltzmann method is used to simulate and analyze the sedimentation dynamics of polygonal *** different machine-learning models for predicting the drag coefficient are developed and *** results show that our model can well predict the drag coefficient with an average error of less than 5%for *** findings suggest that data-driven models can be an attractive option for the drag-coefficient prediction for particles with complex shapes.

关键词： drag coefficient arbitrary polygonal particle shape factor DEM–LBM machine Learning

Model-driven path planning for robotic plasma cutting of branch pipe with single Y-groove based on pipe-rotating scheme

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Advances in Manufacturing 2024年第1期12卷 94-107页

作者： Yan Liu Qiu Tang Xin-cheng Tian school of Control science and Engineering Shandong UniversityJinan250061People’s Republic of China Engineering Research Center of Intelligent Unmanned system Ministry of EducationJinan250061People’s Republic of China school of Mechanical and Electronic Engineering Shandong Jianzhu UniversityJinan250101People’s Republic of China

The automatic cutting of intersecting pipes is a challenging task in *** improved automation and accuracy,this paper proposes a model-driven path planning approach for the robotic plasma cutting of a branch pipe with a single ***,it summarizes the intersection forms and introduces a dual-pipe intersection *** on this model,the moving three-plane structure(a description unit of the geometric characteristics of the intersecting curve)is constructed,and a geometric model of the branch pipe with a single Y-groove is ***,a novel mathematical model for plasma radius and taper compensation is ***,the compensation model and groove model are integrated by establishing movable ***,to prevent collisions between the plasma torch and workpiece,the torch height is planned and a branch pipe-rotating scheme is *** the established models and moving frames,the planned path description of cutting robot is provided in this novel *** accuracy of the proposed method is verified by simulations and robotic cutting experiments.

关键词： Automatic groove cutting of intersecting pipes Model-driven robot path planning Plasma beam radius and taper compensation

Evaluating quality of motion for unsupervised video object segmentation

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Optoelectronics Letters 2024年第6期20卷 379-384页

作者： cheng Guanjun sONG Huihui Jiangsu Key Laboratory of Big Data Analysis Technology Jiangsu Collaborative Innovation Center on Atmospheric Environment and Equipment TechnologyNanjing University of Information Science&TechnologyNanjing 210044China12

Current mainstream unsupervised video object segmentation(UVOs) approaches typically incorporate optical flow as motion information to locate the primary objects in coherent video frames. However, they fuse appearance and motion information without evaluating the quality of the optical flow. When poor-quality optical flow is used for the interaction with the appearance information, it introduces significant noise and leads to a decline in overall performance. To alleviate this issue, we first employ a quality evaluation module(QEM) to evaluate the optical flow. Then, we select high-quality optical flow as motion cues to fuse with the appearance information, which can prevent poor-quality optical flow from diverting the network's attention. Moreover, we design an appearance-guided fusion module(AGFM) to better integrate appearance and motion information. Extensive experiments on several widely utilized datasets, including DAVIs-16, FBMs-59, and You Tube-Objects, demonstrate that the proposed method outperforms existing methods.

关键词： Evaluating quality of motion for unsupervised video object segmentation