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Role of lysosomal trafficking regulator in autophagic lysosome reformation in neurons:a disease perspective

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Neural Regeneration Research 2024年第5期19卷 957-958页

作者： Prashant Sharma Jenny Serra-Vinardell wendy J.Introne May Christine V.Malicdan NIH Undiagnosed Diseases Program Common FundOffice of the DirectorNational Institutes of HealthBethesdaMDUSA Human Biochemical Genetics Section Medical Genetics BranchNational Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA(Serra-Vinardell JIntrone)

Lysosomes are discrete organelles that act as recycling centers for extracellular and intracellular materials,playing a pivotal role in maintaining cellular *** acidic environment,maintained by numerous hydrolytic enzymes,facilitates substrate *** in lysosomal processes can lead to abnormal substrate degradation,significantly impacting cellular *** energy-demanding cells,such as post-mitotic neurons,are especially vulnerable to these changes,often resulting in neurological ***,a conserved catabolic process,requires extensive lysosomal *** plays a key role in removing unnecessary intracellular components,ensuring cellular homeostasis,and promoting cell survival during stress conditions such as starvation,infection,or cellular damage.

关键词： homeostasis lysosomal removing

A review of public health guidelines for postpartum physical activity and sedentary behavior from around the world

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Journal of Sport and Health Science 2024年第4期13卷 472-483,F0003页

作者： Kelly R.Evenson wendy J.Brown Alison K.Brinson Emily Budzynski-Seymour Melanie Hayman Department of Epidemiology Gillings School of Global Public HealthUniversity of North Carolina at Chapel HillChapel HillNC 27599-8050USA Faculty of Health Sciences and Medicine Bond UniversityGold CoastQLD 4226Australia School of Human Movement and Nutrition Sciences The University of QueenslandBrisbaneQLD 4072Australia Department of Anthropology University of North Carolina at Chapel HillChapel HillNC 27599-3115USA Carolina Population Center University of North Carolina at Chapel HillChapel HillNC 27599-8120USA Faculty of Sport Health and Social SciencesSolent UniversitySouthamptonSO140YNUK Appleton Institute School of HealthMedical and Applied SciencesCentral Queensland UniversityRockhamptonQLD 4701Australia

Background:The period following pregnancy is a critical time window when future habits with respect to physical activity(PA) and sedentary behavior(SB) are established;therefore,it warrants *** purpose of this scoping review was to summarize public health-oriented country-specific postpartum PA and SB guidelines ***:To identity guidelines published since 2010,we performed a(a) systematic search of 4 databases(CINAHL,Global Health,PubMed,and SPORTDiscus),(b) structured repeatable web-based search separately for 194 countries,and(c) separate web-based *** the most recent guideline was included for each ***:We identified 22 countries with public health-oriented postpartum guidelines for PA and 11 countries with SB *** continents with guidelines included Europe(n=12),Asia(n=5),Oceania(n=2),Africa(n=1),North America(n=1),and South America(n=1).The most common benefits recorded for PA included weight control/management(n=10),reducing the risk of postpartum depression or depressive symptoms(n=9),and improving mood/well-being(n=8).Postpartum guidelines specified exercises to engage in,including pelvic floor exercises(n=17);muscle strengthening,weight training,or resistance exercises(n=13);aerobics/general aerobic activity(n=13);walking(n=11);cycling(n=9);and swimming(n=9).Eleven guidelines remarked on the interaction between PA and breastfeeding;several guidelines stated that PA did not impact breast milk quantity(n=7),breast milk quality(n=6),or infant growth(n=3).For SB,suggestions included limiting long-term sitting and interrupting sitting with ***:Country-specific postpartum guidelines for PA and SB can help promote healthy behaviors using a culturally appropriate context while providing specific guidance to public health practitioners.

关键词： Breastfeeding Caesarean section Guidelines Postnatal Recommendations

General practice trainee,supervisor and educator perspectives on the transitions in postgraduate training:a scoping review

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Family Medicine and Community Health 2024年第4期12卷 17-28页

作者： Michael Tran Joel Rhee wendy Hu Parker Magin Boaz Shulruf Discipline of General Practice School of Clinical MedicineUniversity of New South WalesSydneyNew South WalesAustralia School of Medicine Western Sydney UniversitySydneyNew South WalesAustralia Discipline of General Practice School of Medicine and Public HealthThe University of NewcastleNewcastleNew South WalesAustralia Office of Medical Education University of New South WalesSydneyNew South WalesAustralia

Transitions are a period and a process,through which there is a longitudinal adaptation in response to changing circumstances in clinical practice and *** the experience of the transition in medical student learning and in hospital-based specialty training programmes are well described and researched,the experience of the transition in community-based postgraduate general practitioner(GP)training has not been described *** We aimed to identify,and categorise,the formative experiences of transitions in GP training and their impacts on personal and professional *** We adopted Levac et al’s scoping review *** 1543 retrieved records,76 were selected for data *** on a combined model of the socioecological and multiple and multi-dimensional theories of transitions,data relating to the experiences of transitions were organised into contextual themes:being physical,psychosocial,organisational culture and *** criteria Empirical studies focused on general practice trainees or training,that discussed the transitions experienced in general practice training and that were published in English were *** sources PubMed,MEDLINE and Web of Science databases were searched in January 2024 with no date limits for empirical studies on the transition experiences of GP into,and through,*** Our findings describe context-dependent formative experiences which advance,or impede,learning and *** is a significant modulator of the factors contributing to more negative experiences,with some initially adverse experiences becoming more *** of the inflection point that represents a shift from initially adverse to more positive experiences of transitions may help moderate expectations for learning and performance at different stages of *** Challenges in training can either advance development and contribute positively to pr

关键词： finding initially programme

Increase in Organochlorine Contaminant Levels in Major Water Sources of the United States in Response to the Coronavirus Pandemic

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Journal of Biosciences and Medicines 2024年第5期12卷 111-143页

作者： wendy Wilburn Sujata Guha Ryan Beni Department of Biological Sciences Tennessee State University Nashville TN USA Department of Chemistry Tennessee State University Nashville TN USA

Organochlorine contaminants, such as triclosan (TCS), are present in major water sources across the United States. These antimicrobial compounds are widely used as multipurpose ingredients in everyday consumer products. They can be ingested or absorbed through the skin and are found in human blood, breast milk, and urine samples. Studies have shown that the increased use of antimicrobial agents leads to their presence and persistence in the ecosystem, particularly in soil and watersheds. Many studies have highlighted emerging concerns associated with the overuse of TCS, including dermal irritations, a higher incidence of antibacterial-related allergies, microbial resistance, disruptions in the endocrine system, altered thyroid hormone activity, metabolism, and tumor metastasis and growth. Organochlorine contaminant exposures play a role in inflammatory responsiveness, and any unwarranted innate response could lead to adverse outcomes. The capacity of TCS and other organochlorine contaminants to induce inflammation, resulting in persistent and chronic inflammation, is linked to various pathologies, such as cardiovascular disease and several types of cancers. Chronic inflammation presents a severe consequence of exposure to these antimicrobial agents, as any changes could result in the loss of immune competence. Organochlorine contaminant levels were established by the United States Environmental Protection Agency (EPA) in 2019-2020 and have consistently increased in response to the novel coronavirus (nCoV) (COVID-19) pandemic. Our previous research examined the overuse of products containing triclosan (TCS), which led to an increase in total trihalomethane (TTHM) levels affecting the quality of our water supply. We also investigated the impact of the FDA ban that now requires pre-market approval. To comprehend the consequences of excessive antimicrobial use on water quality, we conducted an analysis of the levels of total trichloromethane (chloroform), a byproduct of

关键词： Organochlorine Contaminants Triclosan Trihalomethane Chloroform Water Quality

城市蓝绿空间降温绩效评估及提升策略——以北京市为例

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地理科学 2024年第8期44卷 1376-1386页

作者：李建春 Chen Y wendy 袁文华山东师范大学商学院山东济南250358 香港大学地理系中国香港999077

绿地和水体对缓解热岛效应和改善生态环境效果显著,但因城市空间稀缺导致建设机会成本高,提升蓝绿空间绩效研究亟需深化。本文构建基于成本−收益分析的降温绩效评估模型,定量测量不同规模和类型的蓝绿空间斑块降温效果,以北京市为研究区... 详细信息

绿地和水体对缓解热岛效应和改善生态环境效果显著,但因城市空间稀缺导致建设机会成本高,提升蓝绿空间绩效研究亟需深化。本文构建基于成本−收益分析的降温绩效评估模型,定量测量不同规模和类型的蓝绿空间斑块降温效果,以北京市为研究区,利用2010—2020年3期土地利用与地表温度数据,评估大于1 hm^(2)蓝绿空间辐射范围的降温绩效。主要研究结论如下:①研究期内北京市蓝绿空间面积不断增加,呈现由小型面积(Ac)(1≤Ac<2 hm^(2))为主向中型(2≤Ac<10 hm^(2))和大型(Ac≥10 hm^(2))转变;水域持续增加,而林地、草地和混合类型减少;三环以内老城区面积基本持平,而四环减少、五环增多。②根据缓冲区降温模型,北京市蓝绿空间的降温区范围不断增加,从类型结构上看,大中型蓝绿空间形成的降温区增加,而小型蓝绿空间的降温区减少;林地面积虽然减少,但其降温区面积却在增加,而水体降温区面积增长不及自身面积增长。③不同类型蓝绿空间绩效水平呈现先上升后降低的特征,小型和中型混合类型、大型水体的降温绩效比其他同等规模的绩效更好。因此,优化蓝绿规模和类型结构、调整空间形态布局、改善生态空间质量对充分发挥蓝绿空间降温效应起到重要作用,为城市生态环境改善与可持续发展提供新思路。

关键词：蓝绿空间成本−收益分析降温绩效生态福祉

The roles of polysaccharides in tilapia farming:A review

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Aquaculture and Fisheries 2024年第1期9卷 20-27页

作者： Zulhisyam Abdul Kari wendy Wee Noor Khalidah Abdul Hamid Mahmoud A.O.Dawood Nik Nur Azwanida Binti Zakaria Lee Seong Wei Department of Agricultural Sciences Faculty of Agro-Based IndustryUniversiti Malaysia KelantanJeli CampusJeliKelantan17600Malaysia Advanced Livestock and Aquaculture Research Group Faculty of Agro-Based IndustryUniversiti Malaysia KelantanJeli CampusJeliKelantan17600Malaysia Center of Fundamental and Continuing Education Universiti Malaysia TerengganuKuala NerusTerengganu21030Malaysia School of Biological Sciences Universiti Sains MalaysiaMindenPulau Pinang11800Malaysia Animal Production Department Faculty of AgricultureKafrelsheikh UniversityKafr El-Sheikh33516Egypt The Center for Applied Research on the Environment and Sustainability The American University in Cairo11835CairoEgypt

Impairment of fish growth and immune system due to stress and disease are major constraints in aquaculture ***,antibiotic was used as prophylactic agent in the health management of aquaculture ***,antibiotic only provide a temporary solution to the problem of disease ***-reliance on antibiotic also has led to the increasing cases of antibiotic resistance among pathogenic bacteria from aquaculture sites and contamination of antibiotic residues into human food ***,prebiotic and symbiotic are therefore suggested as alternatives to prophylactic antibiotic to be used in the aquaculture industry.A potential prophylactic agent is polysaccharide that could be developed into an alternative antibiotic for aquatic *** this review paper,definition,sources,and mode of action of polysaccharide are *** roles of polysaccharides in fish farming with emphasis on growth improvement,immune system enhancement,disease resistance stimulation in tilapia farming,and the effects of polysaccharides on abiotic stressors are summarized and discussed.

关键词： Aquaculture Growth performance Immune response Disease resistance Abiotic stressor Synergistic Polysaccharide

Highly enhanced UV absorption and light emission of monolayer WS_(2)through hybridization with Ti_(2)N MXene quantum dots and g-C_(3)N_(4)quantum dots

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Opto-Electronic Advances 2024年第6期7卷 31-39页

作者： Anir S.Sharbirin Rebekah E.Kong wendy B.Mato Trang Thu Tran Eunji Lee Jolene W.P.Khor Afrizal L.Fadli Jeongyong Kim Department of Energy Science Sungkyunkwan UniversitySuwon 16419Republic of Korea

Two-dimensional(2D)transition metal dichalcogenides(TMD)are atomically thin semiconductors with promising optoelectronic applications across the visible ***,their intrinsically weak light absorption and the low photoluminescence quantum yield(PLQY)restrict their performance and potential use,especially in ultraviolet(UV)wavelength light *** dots(QD)derived from 2D materials(2D/QD)provide efficient light absorption and emission of which energy can be tuned for desirable light *** this study,we greatly enhanced the photon absorption and PLQY of monolayer(1L)tungsten disulfide(WS_(2))in the UV range via hybridization with 2D/QD,particularly titanium nitride MXene QD(Ti_(2)N MQD)and graphitic carbon nitride QD(GCNQD).With the hybridization of MQD or GCNQD,1LWS_(2)showed a maximum PL enhancement by 15 times with 300 nm wavelength excitation,while no noticeable enhancement was observed when the excitation photon energy was less than the bandgap of the QD,indicating that UV absorption by the QD played a crucial role in enhancing the light emission of 1L-WS_(2)in our 0D/2D hybrid *** findings present a convenient method for enhancing the photo-response of 1L-WS_(2)to UV light and offer exciting possibilities for harvesting UV energy using 1L-TMD.

关键词： monolayer TMD WS_(2) 2D-derived quantum dots UV absorption energy transfer

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Publisher's Note

Genes & Diseases 2024年第3期11卷 1-1页

作者： wendy Ye 不详

Introducing article numbering to Genes&Diseases Within the publishing industry,article numbering has emerged as an easy and efficient way to cite journal *** numbering has already been successfully rolled out to Elsevier's multidisciplinary open access journal Heliyon,as well as more than 1600 other journals,and has been well received by the academic *** on that positive feedback,we are now pleased to introduce article numbering to Genes&Diseases from 3rd issue of 2024.

关键词： journal Elsevier academic