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基于模态类别的多模态信息处理与融合综述

计算机与现代化 2024年第7期 47-62页

作者：黄文栋王怡凡中国石油大学(华东)计算机科学与技术学院山东青岛266580

随着人工智能和深度学习技术的不断发展,多模态信息处理与融合领域的相关研究受到了研究者们的广泛关注。本文总结多模态信息处理的发展历史和里程碑式的工作,以及多模态融合策略和模型。根据模态类别的不同,分类整理多模态信息处理与... 详细信息

随着人工智能和深度学习技术的不断发展,多模态信息处理与融合领域的相关研究受到了研究者们的广泛关注。本文总结多模态信息处理的发展历史和里程碑式的工作,以及多模态融合策略和模型。根据模态类别的不同,分类整理多模态信息处理与融合的主流数据集。以模态类型作为分类标准,本文系统地梳理多模态信息处理与融合的研究进展,强调不同模态之间的区别,并将多模态信息处理与融合分为:视听处理与融合、声文处理与融合、视觉-文本处理与融合和视觉-音频-文本处理与融合4种类别,对不同输入模态的处理融合方法与模型进行详细的研究。最后针对多模态处理与融合领域的发展进行总结与展望。

关键词：多模态处理多模态信息处理多模态融合深度学习

Bile acid nuclear receptor FXR and digestive system diseases

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Acta Pharmaceutica Sinica B 2015年第2期5卷 135-144页

作者： Lili Ding Li Yang Zhengtao Wang wendong huang Shanghai Key Laboratory of Complex Prescriptions and MOE Key Laboratory for Standardization of Chinese Medicines Institute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine Department of Diabetes and Metabolic Diseases Research Beckman Research Institute City of Hope National Medical Center

Bile acids (BAs) are not only digestive surfactants but also important cell signaling molecules, which stimulate several signaling pathways to regulate some important biological processes. The bile-acid-activated nuclear receptor, farnesoid X receptor (FXR), plays a pivotal role in regulating bile acid, lipid and glucose homeostasis as well as in regulating the inflammatory responses, harrier function and prevention of bacterial manslocation in the intestinal tract. As expected, FXR is involved in the pathophysiology of a wide, range of diseases of gastrointestinal tract, including inflammatory bowel disease, colorectal cancer and type 2 diabetes. In this review, we discuss current knowledge of the roles of FXR in physiology of the digestive system and the related diseases. Better understanding of the roles of FXR in digestive system will accelerate the development of FXR ligands/modulators for the treatment of digestive system diseases. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. All rights reserved

关键词： Bile acids Farnesoid X receptors Gastrointestinal tract Inflammatory bowel disease Colorectal cancer Type 2 diabetes

Water Soluble C_(60)-Liposome and the Biological Effect of C_(60) to Human Cervix Cancer Cells

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Chinese Physics Letters 1994年第4期11卷 207-210页

作者： LI Wenzhu QIAN Kaixian huang wendong ZHANG Xinxin CHEN Wanxi Department of Physics Zhejiang UniversityHangzhou 310027 Department of Biology Zhejiang UniversityHangzhou 310027 Department of Chemistry Zhejiang UniversityHangzhou 310027

A preparative technique to obtain water soluble C_(60)-liposome by means of molecular package of C_(60) with lecithin has been *** concentration of C_(60) presented in liposome is 1.09 x 10-4mol/*** molecular system of C_(60)-liposome with human cervix cancer cells is irradiated with laser(570nm,800mW),there is obvious biological effect of C_(60) to huma cervix cancer cells.

关键词： cervix cancer Cancer

Bile acids and metabolic surgery

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Liver Research 2021年第3期5卷 164-170页

作者： Hui Xue Luyao huang Jui Tu Lili Ding wendong huang Shanghai Key Laboratory of Complex Prescriptions and MOE Key Laboratory for Standardization of Chinese Medicines Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghaiChina Department of Diabetes Complications and Metabolism Institute of Diabetes and Metabolism Research CenterBeckman Research InstituteCity of Hope National Medical CenterDuarteCAUSA

The epidemic of obesity and its co-mortalities has reached an alarming level ***,metabolic surgeries,especially the Roux-en-Y gastric bypass and vertical sleeve gastrectomy,are the most effective and sustainable treatments for obesity,type 2 diabetes,non-alcoholic steatohepatitis,as well as other metabolic ***,the invasive nature of the surgeries limits their broad ap-plications to the general ***,developing alternative non-invasive approaches to mimic metabolic surgery is an important direction of the *** studies have identified several potential metabolic surgery-induced downstream endocrine mediators,among which bile acids are key candidate signaling *** acids are profoundly altered by metabolic surgery,which contributes to the metabolic effects of the *** this review,we focus on the most recent studies on the roles of bile acids and bile acid receptors farnesoid X receptor and Takeda G protein-coupled receptor 5 in mediating the metabolic effects of metabolic *** conclude that targeting bile acid pathways may be a promising pharmacological approach to mimic the beneficial effects of metabolic surgery.

关键词： Metabolic surgery Obesity Type 2 diabetes(T2D) Non-alcoholic fatty liver disease(NAFLD) Bile acid Farnesoid X receptor(FXR) Takeda G protein-coupled receptor 5(TGR5)

基于系统动力学的自动化集装箱码头作业安全风险仿真分析

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水道港口 2024年第4期45卷 648-654页

作者：卢琳琳黄文栋詹水芬胡艳华交通运输部天津水运工程科学研究所天津300456 天津港股份有限公司天津300461

采用系统动力学对自动化集装箱码头岸桥装卸作业的安全风险进行分析,利用事故树的溯源分析辅助建立了包括本质安全因素、环境因素、系统和网络因素、管理因素在内的4个方面共计19个自变量的系统动力学模型;根据实际情况识别出包括机械... 详细信息

采用系统动力学对自动化集装箱码头岸桥装卸作业的安全风险进行分析,利用事故树的溯源分析辅助建立了包括本质安全因素、环境因素、系统和网络因素、管理因素在内的4个方面共计19个自变量的系统动力学模型;根据实际情况识别出包括机械维护保养修正系数、网络安全管控措施修正系数等在内的5个辅助变量;利用模糊判断确定自变量的发生概率,根据各变量之间的逻辑关系确定系统动力学模型中的数学表达式;通过模型仿真检验当前安全策略对总体事故概率的影响性。研究成果可为自动化集装箱码头总体安全风险计算提供参考依据。

关键词：自动化集装箱码头风险评估系统动力学安全风险本质安全

Alternative approaches to target Myc for cancer treatment

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1157-1170页

作者： Chen Wang Jiawei Zhang Jie Yin Yichao Gan Senlin Xu Ying Gu wendong huang Division of Medical Genomics and Cancer Institute(Key Laboratory of Cancer Prevention and Intervention Ministry of Education)the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Institute of Genetics Zhejiang University and Department of GeneticsSchool of MedicineZhejiang UniversityHangzhouChina Zhejiang Provincial Key Lab of Genetic and Developmental Disorder HangzhouZhejiang 310058China Molecular and Cellular Biology of Cancer Program&Department of Diabetes Complications and Metabolism Beckman Research InstituteCity of HopeDuarteCAUSA Irell&Manella Graduate School of Biological Sciences Beckman Research InstituteCity of HopeDuarteCAUSA Zhejiang Laboratory for Systems&Precision Medicine Zhejiang University Medical CenterHangzhou 311121China

The Myc proto-oncogene family consists of three members,C-MYC,MYCN,and MYCL,which encodes the transcription factor c-Myc(hereafter Myc),N-Myc,and L-Myc,*** protein orchestrates diverse physiological processes,including cell proliferation,differentiation,survival,and *** modulates about 15%of the global transcriptome,and its deregulation rewires the cellular signaling modules inside tumor cells,thereby acquiring selective *** deregulation of Myc occurs in>70%of human cancers,and is related to poor prognosis;hence,hyperactivated Myc oncoprotein has been proposed as an ideal drug target for ***,no specific drug is currently available to directly target Myc,mainly because of its"undruggable"properties:lack of enzymatic pocket for conventional small molecules to bind;inaccessibility for antibody due to the predominant nucleus localization of *** the topic of targeting Myc has actively been reviewed in the past decades,exciting new progresses in this field keep *** this review,after a comprehensive summarization of valuable sources for potential druggable targets of Myc-driven cancer,we also peer into the promising future of utilizing macropinocytosis to deliver peptides like Omomyc or antibody agents to intracellular compartment for cancer treatment.

关键词： treatment utilizing thereby

Numerical simulation of the plasma acceleration process in a magnetically enhanced micro-cathode vacuum arc thruster

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Plasma Science and Technology 2020年第9期22卷 95-105页

作者： Jinyue GENG Yongcai CHEN Surong SUN wendong huang Haixing WANG Beijing Institute of Control Engineering Beijing 100094People's Republic of China School of Astronautics Beijing University of Aeronautics and AstronauticsBeijing 100191People's Republic of China

A particle-in-cell simulation is conducted to investigate the plasma acceleration process in a micro-cathode vacuum arc thruster.A coaxial electrode structure thruster with an applied magnetic field configuration is used to investigate the effects of the distribution of the magnetic field on the acceleration process and the mechanism of electrons and *** modeling results show that due to the small Larmor radius of electrons,they are magnetized and bound by the magnetic field lines to form a narrow electron *** ions with a large Larmor radius take a long time to keep up with the electron *** presence of a magnetic field strengthens the charge separation *** electric field caused by the charge separation is mainly responsible for the ion acceleration downstream of the *** impact of variations in the distribution of the magnetic field on the acceleration of the plasma is also investigated in this study,and it is found that the position of the magnetic coil relative to the thruster exit has an important impact on the acceleration of *** order to increase the axial velocity of heavy ions,the design should be considered to reduce the confinement of the magnetic field on the electrons in the downstream divergent part of the applied magnetic field.

关键词： micro-cathode vacuum arc thruster magnetic field ion acceleration

SiC逆变器供电的牵引电机匝间绝缘性能评估

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绝缘材料 2024年第4期57卷 88-99页

作者：罗英露赵安然王鹏于超凡林沐泓黄文冬彭增中车株洲电力机车研究所有限公司湖南株洲410002 四川大学电气工程学院四川成都610065

采用碳化硅(SiC)逆变器供电,虽然可以减小牵引变频电机体积、质量、温升,提高电机效率,但逆变器输出电压的高频、短上升时间等特性给牵引变频电机绝缘带来了挑战,尤其是匝间绝缘将会承受更高的电压负荷,导致绝缘过早失效。本文首先通过... 详细信息

采用碳化硅(SiC)逆变器供电,虽然可以减小牵引变频电机体积、质量、温升,提高电机效率,但逆变器输出电压的高频、短上升时间等特性给牵引变频电机绝缘带来了挑战,尤其是匝间绝缘将会承受更高的电压负荷,导致绝缘过早失效。本文首先通过模拟SiC逆变器在最大开关频率及实际电缆线长度下高压变频牵引电机匝间绝缘所承受的电压波形,在不同电压参数(频率、电压峰峰值、上升时间)、不同温度、不同匝间绝缘层厚度(0.23 mm、0.30 mm)下对高压变频电机电磁线进行局部放电起始电压测试及耐电晕寿命测试,并根据牵引电机的实际运行工况和绝缘系统的电负荷失效机理,分析PDIV、局部放电特性及寿命的变化机理。PDIV测试结果表明:频率与上升时间的变化并不会对PDIV产生影响;温度升高,PDIV呈现下降趋势,但由于制作工艺问题,在部分温度下会出现上升趋势;厚度的增加对PDIV提升较大,在考虑成本及效率可控的前提下,提高厚度能有效提高变频电机匝间绝缘能力。耐电晕测试结果表明:温度与上升时间的变化会造成绝缘寿命发生较大改变;频率及电压峰峰值对绝缘寿命的影响呈非线性关系,可用反幂模型表达,并且在工业应用上针对频率对绝缘寿命的影响可直接通过比例关系进行折算。

关键词： SiC逆变器电压参数匝间绝缘层厚度 PDIV 耐电晕寿命

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基于改进图卷积神经网络的配网线路故障诊断

计算技术与自动化 2024年第1期43卷 50-55页

作者：黄文栋张雨阮启洋许卓佳杨溢儒广东电网有限公司广州供电局广东广州510000

随着电网的不断扩容,系统结构越来越复杂,多故障频发,而多故障是故障诊断的关键和难点。为解决故障处理数据量大,需要快速、准确地诊断电网故障的问题,本文提出了一种基于模糊优化图卷积神经网络的配网故障诊断模型。首先处理采集的配... 详细信息

随着电网的不断扩容,系统结构越来越复杂,多故障频发,而多故障是故障诊断的关键和难点。为解决故障处理数据量大,需要快速、准确地诊断电网故障的问题,本文提出了一种基于模糊优化图卷积神经网络的配网故障诊断模型。首先处理采集的配网故障线路的特征数据;其次,搭建基于图卷积神经网络的故障诊断模型,利用模糊理论建立配电网故障的隶属函数;最后利用训练好的模型进行配网故障诊断。仿真结果表明,模糊优化图卷积神经网络对多故障诊断的准确率高于卷积神经网络以及其他方法,本文方法做出的诊断结果更加精确,综合诊断效果最好。

关键词：模糊优化图卷积神经网络配电网故障诊断分类器