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Deep decalcification of factory-provided freezing acidolysis solution to achieveα-high-strength gypsum

Chinese Journal of Chemical Engineering 2024年第5期69卷 143-151页

作者： wencai ye Yulu Li Yonggang Dong Lin Yang Yun Yi Jianxin Cao School of Chemistry and Chemical Engineering Guizhou UniversityGuiyang 550025China Engineering Research Center of Efficient Utilization for Industrial Waste Guizhou UniversityGuiyang 550025China Key Laboratory of Guizhou Province for Green Chemical Industry and Clean Energy Technology Guizhou UniversityGuiyang 550025China

The freezing acidolysis solution of the nitric acid-phosphate fertilizer process has a high calcium content,which makes it difficult to produce fine phosphate and high water-soluble phosphate fertilizer ***,based on the potential crystallization principle of calcium sulfate in NH_(4)NO_(3)-H_(3)PO_(4)-H_(2)O,the deep decalcification(*** removal)technology to achieveα-high-strength gypsum originated from freezing acidolysis-solutions has been firstly proposed and ***,calcium can be removed from the factory-provided freezing acidolysis-solution by neutralizing it with ammonia,followed by the addition of ammonium sulfate *** a result,the formation of calcium sulfate in the reaction system undergoes the nucleation and growth of CaSO_(4)·2H_(2)O(DH),as well as its dissolution and crystallization into short columnarα-CaSO_(4)·0.5H_(2)O(α-HH).Remarkably,with the molar ratio of SO_(4)^(2-)/Ca^(2+)at 1.8,the degree of neutralization(NH_(3)/HNO_(3) molar ratio)at 1.7,the reaction temperature of 94℃,and the reaction time of 300 min,the decalcification rate can reach 86.89%,of which the high-strengthα-CaSO_(4)·0.5H_(2)O(α-HH)will be ***,the deep decalcification product meets the standards for the production of fine phosphates and highly water-soluble phosphate ***,the 2 h flexural strength ofα-HH is 5.3 MPa and the dry compressive strength is 36.8 MPa,which is up to the standard of commercialα-HH.

关键词： Nitrophosphate Ammonia neutralization Deep decalcification High-strengthα-hemihydrate gypsum Controlled crystallization at atmospheric pressure

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Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba

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Acta Pharmaceutica Sinica B 2024年第1期14卷 1-19页

作者： Weile ye Jiaojiao Wang Peter JLittle Jiami Zou Zhihua Zheng Jing Lu Yanjun Yin Hao Liu Dongmei Zhang Peiqing Liu Suowen Xu wencai ye Zhiping Liu International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of China Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Pharmacy Australia Centre of Excellence School of PharmacyUniversity of QueenslandWoolloongabba QLD 4102Australia Sunshine Coast Health Institute and School of Health and Behavioural Sciences University of the Sunshine CoastBirtinya QLD 4575Australia National-Local Joint Engineering Lab of Druggability and New Drugs Evaluation Guangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510006China School of Pharmacy Bengbu Medical CollegeBengbu 233030China Institute of Endocrine and Metabolic Diseases the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China

Bioactive compounds derived from herbal medicinal plants modulate various therapeutic targets and signaling pathways associated with cardiovascular diseases(CVDs),the world’s primary cause of *** biloba,a well-known traditional Chinese medicine with notable cardiovascular actions,has been used as a cardio-and cerebrovascular therapeutic drug and nutraceutical in Asian countries for *** studies have shown that ginkgolide B,a bioactive component in Ginkgo biloba,can ameliorate atherosclerosis in cultured vascular cells and disease *** clinical relevance,several clinical trials are ongoing or being completed to examine the efficacy and safety of ginkgolide B-related drug preparations in the prevention of cerebrovascular diseases,such as ischemia ***,we present a comprehensive review of the pharmacological activities,pharmacokinetic characteristics,and mechanisms of action of ginkgolide B in atherosclerosis prevention and *** highlight new molecular targets of ginkgolide B,including nicotinamide adenine dinucleotide phosphate oxidases(NADPH oxidase),lectin-like oxidized LDL receptor-1(LOX-1),sirtuin 1(SIRT1),platelet-activating factor(PAF),proprotein convertase subtilisin/kexin type 9(PCSK9)and ***,we provide an overview and discussion of the therapeutic potential of ginkgolide B and highlight the future perspective of developing ginkgolide B as an effective therapeutic agent for treating atherosclerosis.

关键词： Cardiovascular disease Atherosclerosis Ginkgo biloba Ginkgolide B Endothelial dysfunction LOX-1 PCSK9 PAF-R antagonist

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Discovery of unusual phloroglucinol-triterpenoid adducts from Leptospermum scoparium and Xanthostemon chrysanthus by building blocks-based molecular networking

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Chinese Chemical Letters 2024年第6期35卷 353-357页

作者： Jinyan Zhang Fen Liu Qian Jin Xueyi Li Qiong Zhan Mu Chen Sisi Wang Zhenlong Wu wencai ye Lei Wang State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Center for Bioactive Natural Molecules and Innovative Drugs and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchJinan UniversityGuangzhou 510632China College of Pharmacy Jinan UniversityGuangzhou 510632China

The first phloroglucinol-triterpenoid hybrids,myrtphlotritins A-E(1-5),were rapidly recognized and isolated from two species of Myrtaceae by employing the building blocks-based molecular network(BBMN)*** 1-5 featured new carbon skeletons in which phloroglucinol derivatives were coupled with lupane-and dammarane-type triterpenoids through different linkage *** structures and absolute configurations were elucidated by comprehensive analysis of spectroscopic data and quantum chemical *** pathways for compounds 1-5 were proposed on the basis of the coexisting *** by the biogenetic pathways,the biomimetic synthesis of compound 1 was also ***,compounds 2,3,and 5 exhibited potent antiviral activities against herpes simplex virus type-1(HSV-1)infection,and compounds 2 and 5 displayed significant anti-inflammatory activities on RAW264.7 cells.

关键词： Phloroglucinol-triterpenoid adduct Myrtaceae Building blocks-based molecular network Biomimetic synthesis Antiviral activity Anti-inflammatory activity

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Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis

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Acta Pharmaceutica Sinica B 2024年第2期14卷 682-697页

作者： Shuran Fan Ming Qi Qi Qi Qun Miao Lijuan Deng Jinghua Pan Shenghui Qiu Jiashuai He Maohua Huang Xiaobo Li Jie Huang Jiapeng Lin Wenyu Lyu Weiqing Deng Yingyin He Xuesong Liu Lvfen Gao Dongmei Zhang wencai ye Minfeng Chen State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China School of Medicine Jinan UniversityGuangzhou 510632China School of Traditional Chinese Medicine Jinan UniversityGuangzhou 510630China The First Affiliated Hospital of Jinan University Guangzhou 510632China State Key Laboratory of Chemical Oncogenomics Guangdong Provincial Key Laboratory of Chemical BiologyTsinghua Shenzhen International Graduate SchoolShenzhen 518055China

Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases the risk of cancer recurrence and distant metastasis. The properties of the lymph node metastatic colorectal cancer(LNM-CRC) cells are poorly understood, and effective therapies are still lacking. Here, we found that hypoxia-induced fibroblast activation protein alpha(FAPα) expression in LNM-CRC cells. Gain-or loss-function experiments demonstrated that FAPα enhanced tumor cell migration, invasion, epithelial-mesenchymal transition, stemness, and lymphangiogenesis via activation of the STAT3 pathway. In addition, FAPα in tumor cells induced extracellular matrix remodeling and established an immunosuppressive environment via recruiting regulatory T cells, to promote colorectal cancer lymph node metastasis(CRCLNM). Z-GP-DAVLBH, a FAPα-activated prodrug, inhibited CRCLNM by targeting FAPα-positive LNM-CRC cells. Our study highlights the role of FAPα in tumor cells in CRCLNM and provides a potential therapeutic target and promising strategy for CRCLNM.

关键词： Lymphaticmetastasis Colorectal cancer Fibroblastactivation proteinα FAPα-activated prodrug Epithelial-mesenchymal

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The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1288-1304页

作者： Geni ye Maohua Huang Yong Li Jie Ouyang Minfeng Chen Qing Wen Xiaobo Li Huhu Zeng Pei Long Zepei Fan Junqiang Yin wencai ye Dongmei Zhang College of Pharmacy Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research Jinan UniversityGuangzhou 510632China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhou 510632China Department of Musculoskeletal Oncology the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China

Osteosarcoma is a kind of bone tumor with highly proliferative and invasive properties,a high incidence of pulmonary metastasis and a poor *** is the mainstay of treatment for ***,there are no molecular targeted drugs approved for osteosarcoma treatment,particularly effective drugs for osteosarcoma with pulmonary *** has been reported that fibroblast activation protein alpha(FAPa)is upregulated in osteosarcoma and critically associated with osteosarcoma progression and metastasis,demonstrating that FAPa-targeted agents might be a promising therapeutic strategy for *** the present study,we reported that the FAPa-activated vinblastine prodrug Z-GP-DAVLBH exhibited potent antitumor activities against FAPa-positive osteosarcoma cells in vitro and in vivo.Z-GP-DAVLBH inhibited the growth and induced the apoptosis of osteosarcoma ***,it also decreased the migration and invasion capacities and reversed epithelial-mesenchymal transition(EMT)of osteosarcoma cells in vitro and suppressed pulmonary metastasis of osteosarcoma xenografts in ***,Z-GP-DAVLBH suppressed the AXL/AKT/GSK-3β/β-catenin pathway,leading to inhibition of the growth and metastatic spread of osteosarcoma *** findings demonstrate that Z-GP-DAVLBH is a promising agent for the treatment of FAPa-positive osteosarcoma,particularly osteosarcoma with pulmonary metastases.

关键词： Osteosarcoma Fibroblast activation protein alpha Growth Pulmonary metastasis Vinblastine prodrug AXL β-Catenin

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顶空-气相色谱法测定芍药苷-6'-O-苯磺酸酯中的残留溶剂

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广东化工 2024年第7期51卷 136-138页

作者：白柏叶文才刘菊妍许文东许一靖暨南大学广东广州510000 中药制药过程技术与新药创制国家工程研究中心广州白云山汉方现代药业有限公司广东广州510240 广州医药集团有限公司广东广州510006

目的:建立顶空-气相色谱法测定芍药苷-6’-O-苯磺酸酯中的6种残留溶剂的测定方法。方法:采用顶空-气相色谱法,HP-INNOWAX(0.530 mm×30 m,1μm)石英毛细管柱,氢火焰离子化检测器,载气为氮气,流速5 mL/min;柱温为程序升温,进样口温度为12... 详细信息

目的:建立顶空-气相色谱法测定芍药苷-6’-O-苯磺酸酯中的6种残留溶剂的测定方法。方法:采用顶空-气相色谱法,HP-INNOWAX(0.530 mm×30 m,1μm)石英毛细管柱,氢火焰离子化检测器,载气为氮气,流速5 mL/min;柱温为程序升温,进样口温度为120℃,检测器温度260℃。顶空进样条件:顶空平衡时间为30 min,平衡温度80℃,定量环温度95℃,传输线温度90℃。结果:测定的6种有机溶剂完全分离,在相应浓度范围内线性关系良好。甲醇、乙醇、丙酮、三氯甲烷、乙酸乙酯和碳酸二甲酯的定量限分别是10.0 mg/kg,5.0 mg/kg,1.0 mg/kg,1.5 mg/kg,1.0 mg/kg和5.0 mg/kg,检测限分别是3.0 mg/kg,1.5 mg/kg,0.3 mg/kg,0.45 mg/kg,0.3 mg/kg和1.5 mg/kg。加标回收率、精密度、重复性和耐用性的RSD均小于10%。结论:本方法可以较好地用于测定芍药苷-6’-O-苯磺酸酯中的残留溶剂,对芍药苷-6’-O-苯磺酸酯的质量控制提供了科学依据。

关键词：芍药苷-6’-O-苯磺酸酯气相色谱残留溶剂顶空进样

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Author correction to“The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway”[Acta Pharm Sin B 12(2022)1288–1304]

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1337-1339页

作者： Geni ye Maohua Huang Yong Li Jie Ouyang Minfeng Chen Qing Weng Xiaobo Li Huhu Zeng Pei Long Zepei Fan Junqiang Yin wencai ye Dongmei Zhang College of Pharmacy Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research Jinan UniversityGuangzhou 510632China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhou 510632China Department of Musculoskeletal Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China

We deeply regret that the representative image of invaded 143B cells treated with Z-GP-DAVLBH + AXL-KD in the lower panel of Fig. 6C was incorrect due to inadvertent mistake of copying and pasting in the process of assembling figures with Adobe Illustrator software. The image has now been corrected, and the quantification of cell invasion in Fig. 6C remains correct. The corrected version of Fig. 6C has been provided below, and the change did not affect the results and conclusions of this study. We have provided the original data of this figure to Editorial Office, and the Editorial Office or the corresponding authors can be contacted for original data access.

关键词： Illustrator correction image

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芍药苷-6'-O-苯磺酸酯在甲醇中降解杂质结构解析和降解机制研究

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广东化工 2024年第6期51卷 1-3,28页

作者：白柏叶文才刘菊妍袁诚唐顺之彭万才许文东暨南大学广东广州510000 中药制药过程技术与新药创制国家工程研究中心广州白云山汉方现代药业有限公司广东广州510240 广州医药集团有限公司广东广州510006

目的:探究芍药苷-6’-O-苯磺酸酯在甲醇中的降解杂质,确证其结构,阐明降解机理。方法:将芍药苷-6’-O-苯磺酸酯溶于甲醇中,在加热的条件下生成降解杂质,通过硅胶柱层析和制备液相分离得到2个降解杂质,采用核磁共振、红外、质谱等技术确... 详细信息

目的:探究芍药苷-6’-O-苯磺酸酯在甲醇中的降解杂质,确证其结构,阐明降解机理。方法:将芍药苷-6’-O-苯磺酸酯溶于甲醇中,在加热的条件下生成降解杂质,通过硅胶柱层析和制备液相分离得到2个降解杂质,采用核磁共振、红外、质谱等技术确证杂质的结构,并对其降解机理进行推理。结果:鉴定了2个降解杂质结构,推测出芍药苷-6’-O-苯磺酸酯在甲醇中的降解机理。结论:为芍药苷-6’-O-苯磺酸酯的杂质研究提供了物质基础,同时也为其工艺路线的选择、分析方法开发以及质量研究与控制提供较为科学的依据。

关键词：芍药苷-6’-O-苯磺酸酯降解杂质结构解析机理研究

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Fusagerins A–F,New Alkaloids from the Fungus Fusarium sp.

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Natural Products and Bioprospecting 2015年第4期5卷 195-203页

作者： Hao Wen Yan Li Xingzhong Liu wencai ye Xinsheng Yao Yongsheng Che Institute of Traditional Chinese Medicine&Natural Products College of PharmacyJinan UniversityGuangzhou 510632People’s Republic of China State Key Laboratory of Toxicology&Medical Countermeasures Beijing Institute of Pharmacology&ToxicologyBeijing 100850People’s Republic of China

Fusagerins A–F(1–6),six new alkaloids including a unique one with the rare a-(N-formyl)carboxamide moiety(1),a hydantoin(imidazolidin-2,4-dione)derivative(2),and four fungerin analogues(3–6),were isolated from the crude extract of the fungus Fusarium sp.,together with the known compound fungerin(7).Compound 2 was isolated as a racemate and further separated into two enantiomers on a chiral HPLC *** structures of 1–6 were determined mainly by NMR experiments,and the absolute configuration of 1 and 2 was assigned by electronic circular dichroism(ECD)*** 7 showed antibacterial activity against Staphylococcus aureus and Streptococcus pneumoniae,and weak cytotoxicity against the T24 cells.

关键词： Fusarium sp. Alkaloids Structure elucidation Configuration determination

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Genetic Identification of Lycium barbarum *** Two Localities

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第十四届全国中药和天然药物学术研讨会

作者： Hui Cao Ying Zhang wencai ye Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences National Engineering Research Center for Modernization of traditional Chinese Medicine College of Pharmacy Jinan University

Objective To investigate the relationship between the variation of chloroplast matK gene sequence and the geographical origin of Lycium barbarum *** PCR direct sequencing was applied to detect two iocalities（Ningxia and Xinjiang）.Result The matK gene sequences are identical in samples tested,there is only one SNP in the mafK gene sequences,*** 1099 nt "A" in GenBank（AB036630） and "G" in *** *** from two different *** result revealed the intraspecific stability of matK gene of L barbarum *** There is no intraspecific heterogeneity in matK gene sequence of Lycium barbarum *** Ningxia and Xinjiang.

关键词： Genetic identification PCR matK Lycium barbarum L.

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