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煤层群采动下围岩应力演化规律及协同控制技术研究

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煤炭科学技术 2024年第3期52卷 24-37页

作者：吴少康张俊文徐佑林宋治祥张杨范文兵董续凯张际涛陈志松中国矿业大学(北京)能源与矿业学院北京100083 贵州理工学院矿业工程学院贵州贵阳550003 贵州黔诚力锦科技有限公司贵州贵阳550081 湖南科技大学资源环境与安全工程学院湖南湘潭411201 贵州大学矿业学院贵州贵阳550003

针对煤层群开采过程中巷道支护困难问题,以贵州土城矿212回风石门为工程背景。综合采用现场调研、数值模拟、相似模拟及现场试验等手段,揭示了212回风石门应力演化规律,并提出了“卸−转−固”协同控制技术。研究结果表明:212回风石门遭... 详细信息

针对煤层群开采过程中巷道支护困难问题,以贵州土城矿212回风石门为工程背景。综合采用现场调研、数值模拟、相似模拟及现场试验等手段,揭示了212回风石门应力演化规律,并提出了“卸−转−固”协同控制技术。研究结果表明:212回风石门遭受破坏的主要原因是煤层群采动过程中存在的地质力学问题导致了围岩失稳。巷道底板及两帮在采动过程中产生不同程度的应力集中。当遭受垂直应力挤压时,巷道底部承受的挤压力较大,而顶部围岩承受的拉伸力较大,由于力学不平衡导致围岩的破坏。基于此提出了“卸−转−固”协同控制技术。通过爆破卸压的方式,利用爆破产生的冲击波引起围岩的震动和应力波动,使表层围岩中原本集中的应力分散到更深的围岩区域,降低表层围岩的应力集中程度。同时,利用爆轰和封孔工艺进一步加固卸压孔周围的围岩,形成两个承载结构。即由巷道支护体形成的内承载体和由深部围岩形成的外承载体。两者相互作用有效承受巷道浅部及深部围岩的应力,并转移到支护结构,起到保护和稳定围岩的作用。利用该技术在212回风石门现场试验,结果显示:使用该技术区域应力长期趋于稳定甚至缓慢降低,巷道顶底板及两帮移近速率分别降低了74.49%及47.67%,底鼓量降低了77.2%。而未使用该技术区域应力出现不同程度的上升,表面位移收敛严重。由此可得,围岩控制效果显著。该技术已成功推广到贵州其他不同地质环境的煤矿,均取得了显著效果。

关键词：煤层群采动应力底鼓巷道支护 “卸−转−固”协同控制技术

Phase precipitation and magnetic properties of melt-spun ternary Gd_(2)Fe_(14)B alloy and advantages of gadolinium substitution in Y_(2)Fe_(14)B alloy

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Journal of Rare Earths 2023年第7期41卷 1058-1067,I0003页

作者： Bang Zhou Yitong Liu Songmao Li wenbing fan Xuefeng Liao Jiayi He Hongya Yu Zhongwu Liu School of Materials Science and Engineering South China University of TechnologyGuangzhou 510640China

To take the advantage of gadolinium(Gd) in developing and manufacturing RE-permanent magnets,the magnetic properties and phase precipitation behavior of Gd_(2)Fe_(14)B alloys prepared by melt spinning were investigated in this *** results show that optimally direct quenched nanocrystalline Gd_(2)Fe_(14)B alloy exhibits the magnetic properties with remanence J_(r) of 0.51 T,coercivity H_(c) of 187 kA/m,and maximum energy product(BH)_(max) of 33.1 kJ/m^(3).It also shows excellent thermal stability with a small negative temperature coefficient of J_(r)(α=-0.066%/K) and a positive temperature coefficient of H_(c)(β=0.171 %/K).The phase precipitations of as spun Gd_(2)Fe_(14)B alloy during melt spinning and over-quenched amorphous Gd_(2)Fe_(14)B alloy during heat treatment were *** magnetic properties of the crystallized alloys annealed at 800℃ are close to those of the optimized directly quenched as-spun alloys,indicating good performance stability under various *** addition,the role of Gd substitution in(Y_(1-x)Gd_(x))_(2)Fe_(14)B alloys was systematically *** substitution can significantly enhance the thermal stability and decrease the irreve rsible remanence loss of Y_(2)Fe_(14)B *** increasing Gd conte nt,Gd-doped Y_(2)Fe_(14)B alloys show continuous enhancement of H_(c) at elevated *** highest β value of 0.22%/K was obtained in(Y_(0.2)Gd_(0.8))_(2)Fe_(14)B alloy at 300—400 *** substitution is not only effective in improving the exchange coupling effect and corrosion resistance of Y_(2)Fe_(14)B alloy but also superior to Nd in terms of improving the oxidation *** present work has certain instructions for designing and developing new low cost RE permanent magnets with improved thermal and environment stability.

关键词： Gd-Fe-B alloys Phase constitution Thermal stability Corrosion resistance Rare earths

Molecular Mechanisms of Intracellular Delivery of Nanoparticles Monitored by an Enzyme‑Induced Proximity Labeling

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Nano-Micro Letters 2024年第6期16卷 14-37页

作者： Junji Ren Zibin Zhang Shuo Geng Yuxi Cheng Huize Han Zhipu fan wenbing Dai Hua Zhang Xueqing Wang Qiang Zhang Bing He Department of Pharmaceutics School of Pharmaceutical Sciences Peking University38 Xueyuan RdHaidian DistrictBeijing 100191People’s Republic of China

Achieving increasingly finely targeted drug delivery to organs,tissues,cells,and even to intracellular biomacromolecules is one of the core goals of *** the delivery destination is refined to cellular and subcellular targets,it is essential to explore the delivery of nanomedicines at the molecular ***,due to the lack of technical methods,the molecular mechanism of the intracellular delivery of nanomedicines remains unclear to ***,we develop an enzyme-induced proximity labeling technology in nanoparticles(nano-EPL)for the real-time monitoring of proteins that interact with intracellular ***(lactic-co-glycolic acid)nanoparticles coupled with horseradish peroxidase(HRP)were fabricated as a model(HRP(+)-PNPs)to evaluate the molecular mechanism of nano delivery in *** adding the labeling probe biotin-phenol and the catalytic substrate H_(2)O_(2)at different time points in cellular delivery,nano-EPL technology was validated for the real-time in situ labeling of proteins interacting with ***-EPL achieves the dynamic molecular profiling of 740 proteins to map the intracellular delivery of HRP(+)-PNPs in macrophages over *** on dynamic clustering analysis of these proteins,we further discovered that different organelles,including endosomes,lysosomes,the endoplasmic reticulum,and the Golgi apparatus,are involved in delivery with distinct participation *** importantly,the engagement of these organelles differentially affects the drug delivery efficiency,reflecting the spatial–temporal heterogeneity of nano delivery in *** summary,these findings highlight a significant methodological advance toward understanding the molecular mechanisms involved in the intracellular delivery of nanomedicines.

关键词： Enzyme-induced proximity labeling Intracellular delivery Nano-protein interaction Dynamic molecule profiling Macrophages

Boosting synergism of chemo- and immunotherapies via switching paclitaxel-induced apoptosis to mevalonate metabolism-triggered ferroptosis by bisphosphonate coordination lipid nanogranules

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Acta Pharmaceutica Sinica B 2024年第2期14卷 836-853页

作者： Ge Song Minghui Li Shumin fan Mengmeng Qin Bin Shao wenbing Dai Hua Zhang Xueqing Wang Bing He Qiang Zhang Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Medical Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijing 100142China

Conventional chemotherapy based on cytotoxic drugs is facing tough challenges recently following the advances of monoclonal antibodies and molecularly targeted *** is critical to inspire new potential to remodel the value of this classical therapeutic ***,we fabricate bisphosphonate coordination lipid nanogranules(BC-LNPs)and load paclitaxel(PTX)to boost the chemo-and immuno-therapeutic synergism of cytotoxic *** in BC-LNPs@PTX,a bisphosphonate to block mevalonate metabolism,works as both the structure and drug constituent in nanogranules,where alendronate coordinated with calcium ions to form the particle *** synergy of alendronate enhances the efficacy of paclitaxel,suppresses tumor metastasis,and alters the cytotoxic *** from the paclitaxel-induced apoptosis,the involvement of alendronate inhibits the mevalonate metabolism,changes the mitochondrial morphology,disturbs the redox homeostasis,and causes theaccumulation of mitochondrial ROS and lethal lipid peroxides(LPO).These factors finally trigger the ferroptosis of tumor cells,an immunogenic cell death mode,which remodels the suppressive tumor immune microenvironment and synergizes with ***,by switching paclitaxel-induced apoptosis to mevalonate metabolism-triggered ferroptosis,BC-LNPs@PTX provides new insight into the development of cytotoxic drugs and highlights the potential of metabolism regulation in cancer therapy.

关键词： Bisphosphonate coordinationlipid nanogranules Ferroptosis Mevalonatemetabolism Mitochondrial metabolism Nano-systematic biology

Development of cost-effective nanocrystalline multi-component(Ce,La,Y)-Fe-B permanent magnetic alloys containing no critical rare earth elements of Dy,Tb,Pr and Nd

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Journal of Materials Science & Technology 2021年第17期76卷 215-221页

作者： Xuefeng Liao Jiasheng Zhang Jiayi He wenbing fan Hongya Yu Xichun Zhong Zhongwu Liu School of Materials Science and Engineering South China University of TechnologyGuangzhou 510640China

Here we first report the fully abundant rare earth(RE)-based nanocrystalline multi-component(Ce,La,Y)-Fe-B alloys containing no critical RE elements of Nd,Pr,Dy,and Tb by melt-spinning *** roles of La and Y substitutions for Ce have been fully *** plays a positive role on both thermal stability and room-temperature(RT)magnetic *** enhanced coercivity H_(cj)by partial substitution of La is attributed to the increases of anisotropy field H_A and the formation of continuously distributed grain boundaries resulting from the suppre s sion of CeFe_(2)*** Y substitution is not benefit for H_(cj),both remanent polarization J_r and thermal stability have been effectively improved since Y_(2)Fe_(14)B shows relatively high saturation magnetization M_s and a positive temperature coefficient of HA over a certain temperature *** addition,RE element segregation has been confirmed,La prefers to enter into the grain boundaries than Ce and Y prefers to remain in the 2:14:1 *** on these understanding,a series of melt-spun(Ce,La,Y)-Fe-B alloys have been designed.A relatively good combination of magnetic properties with maximum energy product(BH)_(max)=7.4 MGOe,H_(Cj)=400 kA/m,and J_r=0.63 T has been obtained in[(Ce_(0.8)La_(0.2))_(0.7)Y_(0.3)]_(17)Fe_(78)B_6 alloy,together with high Curie temperature(T_c=488 K)and low temperature coefficients of remanence(α=-0.255%/K)and coercivity(β=-0.246%/K).

关键词： Nanocrystalline(La Ce Y)-Fe-B alloys Permanent magnets RE element segregation Magnetic properties Thermal stability

COVID-19 transmission and control in land public transport:A literature review

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Fundamental Research 2024年第3期4卷 417-429页

作者： Qiqi Luo wenbing Liu Jiayuan Liao Zhongli Gu Xiaodan fan Zhiwen Luo Xuelin Zhang Jian Hang Cuiyun Ou School of Atmospheric Sciences Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong LaboratoryZhuhai 519082China Key Laboratory of Urban Meteorology China Meteorological AdministrationBeijing 100089China China Meteorological Administration Xiong'an Atmospheric Boundary Layer Key Laboratory Xiong'an 070001China Key Laboratory of Tropical Atmosphere-Ocean System(Sun Yat-sen University) Ministry of EducationZhuhai 519000China Guangdong fans-tech Agro Co. LtdYunfu 527300China Welsh School of Architecture Cardiff UniversityCardiff CF103XQUnited Kingdom

Land public transport is an important link within and between cities,and how to control the transmission of COVID-19 in land public transport is a critical issue in our daily ***,there are still many inconsistent opinions and views about the spread of SARS-CoV-2 in land public transport,which limits our ability to implement effective *** purpose of this review is to overview the literature on transmission characteristics and routes of the epidemic in land public transport,as well as to investigate factors affecting its spread and provide feasible measures to mitigate the infection risk of *** obtained 898 papers by searching the Web of Science,Pubmed,and WHO global COVID database by keywords,and finally selected 45 papers that can address the purpose of this *** public transport is a high outbreak area for COVID-19 due to characteristics like crowding,inadequate ventilation,long exposure time,and environmental *** from surface touch transmission and drop spray transmission,aerosol inhalation transmission can occur not only in short distances but also in long *** ventilation is the most important factor influencing long-distance aerosol *** transmission factors(e.g.,interpersonal distance,relative orientation,and ambient conditions)should be noticed as well,which have been summarized in this *** address various influencing factors,it is essential to suggest practical and efficient preventive *** these,increased ventilation,particularly the fresh air(i.e.,natural ventilation),has proven to effectively reduce indoor infection *** preventive measures are also effective,such as enlarging social distance,avoiding face-to-face orientation,setting up physical partitions,disinfection,avoiding talking,and so *** research on the epidemic has intensified,people have broken down many perceived barriers,but more comprehensive studies on monitoring systems and preventi

关键词： Land transportation Infection risk Transmission route Mitigation measures COVID-19

采用云和PUF的轻量级RFID双标签认证协议

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西安电子科技大学学报 2023年第1期50卷 177-191页

作者：艾璐琳常正泰范文兵孔德涵郑州大学电气与信息工程学院河南郑州450001

针对医药系统中药品和说明书同时认证的应用需求,提出一种快速双标签身份认证方案。该方案引入云服务器和物理不可克隆函数,确保了射频识别系统的可扩展性和标签的不可克隆性。针对传统射频识别系统逐一认证双标签效率较低的问题,提出... 详细信息

针对医药系统中药品和说明书同时认证的应用需求,提出一种快速双标签身份认证方案。该方案引入云服务器和物理不可克隆函数,确保了射频识别系统的可扩展性和标签的不可克隆性。针对传统射频识别系统逐一认证双标签效率较低的问题,提出一种双标签响应合并流程;针对物理不可克隆函数引发的系统错误认证问题,计算了物理不可克隆函数响应的最佳认证阈值,以降低系统的认证错误率;针对云服务器的不可信问题,提出3种超轻量级位流函数以实现两种加密机制,从而保护前向信道免受云服务器隐私泄露的威胁。安全分析表明,快速双标签身份认证协议可满足标签匿名性和不可追踪性,并能有效地抵抗克隆攻击、去同步化攻击、重放攻击等恶意攻击。此外,使用BAN逻辑分析和AVISPA工具,进一步验证了协议的安全性。与近期的认证协议相比,快速双标签身份认证协议的服务器搜索耗时最短,在满足各项安全属性的同时,以近似单标签的资源开销实现了对双标签的快速认证,适用于资源受限的大规模双标签认证场景。

关键词：射频识别双标签云服务器物理不可克隆函数 BAN逻辑分析 AVISPA工具

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当代中国“高品质建筑作品”实现困境研究与对策探讨——以让·努维尔设计的浦东美术馆为例

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艺术管理（中英文） 2023年第1期 115-125页

作者：范文兵上海交通大学设计学院上海200030

本文通过实地体验与文献阅读,以“建筑作品”概念为视角,结合对法国建筑大师让·努维尔(Jean Nouvel)的研究,分析其在设计上海浦东美术馆(MAP)的过程中,如何主动或被动降低“建筑作品的主体创造性”,揭示在当今中国建设现实中,实现“高... 详细信息

本文通过实地体验与文献阅读,以“建筑作品”概念为视角,结合对法国建筑大师让·努维尔(Jean Nouvel)的研究,分析其在设计上海浦东美术馆(MAP)的过程中,如何主动或被动降低“建筑作品的主体创造性”,揭示在当今中国建设现实中,实现“高品质建筑作品”可能遇到的多重困境。

关键词：主体创造性建筑作品浦东美术馆让·努维尔中国建设现实

从定海桥开始在认识"上海的B面"中塑造"建筑教育的具体地域性"

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时代建筑 2022年第6期 60-65页

作者：范文兵上海交通大学设计学院

通过分析作者主持的一系列围绕以定海桥为代表的"上海B面城市现象"的教学实践,文章探讨了如何在建筑教育中培养学生以复杂性视角理解上海,主要叙述了教育如何介入社会现实,如何针对性开展国际合作教学,学术研究如何与教学互动等议题.最... 详细信息

通过分析作者主持的一系列围绕以定海桥为代表的"上海B面城市现象"的教学实践,文章探讨了如何在建筑教育中培养学生以复杂性视角理解上海,主要叙述了教育如何介入社会现实,如何针对性开展国际合作教学,学术研究如何与教学互动等议题.最终目标,是塑造一种带有"具体地域性"的建筑教育,做出基于中国现实的学术贡献.

关键词：定海桥上海B面城市现象建筑教育的具体地域性