检索结果-南通市图书馆

Astrocyte polarization in glaucoma: a new opportunity

Neural Regeneration Research 2022年第12期17卷 2582-2588页

作者： yi-Xin Liu Hao Sun wen-yi guo Department of Ophthalmology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology ShanghaiChina

Astrocyte polarization is a new concept which is similar to microglia polarization and in which astrocytes are classified as A1(neurotoxic)and A2(neuroprotective).Several studies on astrocyte polarization have focused mainly on neurodegenerative diseases,trauma,and ***,the role of astrocyte polarization in glaucoma,a neurodegenerative disease,has not been fully *** this review,we first describe the characteristics of astrocyte astrogliosis in glaucoma,including morphological,molecular,proliferative and functional *** then summarize understanding of astrocyte polarization in other diseases,and show that A1 astrocytes are involved in the death of retinal ganglion cells in glaucoma,and that their neurotoxins kill only damaged retinal ganglion *** on this,we propose new interesting conjecture on astrocyte polarization in glaucoma:(1)That the neurotoxin from A1 astrocytes is a product of the complement system(membrane-attacking complex),since this system is known to mediate synaptic elimination and the C3 expression is clearly increased in A1 astrocytes;(2)that reactive scar-forming astrocytes in the optic nerve head may be classified as A2 astrocytes since their ablation leads to a worse prognosis in ***,current therapeutic research progress on astrocyte polarization in other diseases is also *** of astrocyte polarization can be achieved by extracellular microglia-related and intracellular *** A1 or increased A2 astrocytes can rescue the *** example,glucagon-like peptide-1 receptor agonist rescues retinal ganglion cells by reducing A1 astrocytes via the extracellular microglia-related pathway in an ocular hypertension model,suggesting that regulation of astrocyte polarization as a therapeutic target in glaucoma is feasible.

关键词： astrocytes glaucoma heterogeneity microglia neurodegenerative disease neuroinflammation neuroprotection optic nerve retina therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interleukin-4 promotes microglial polarization toward a neuroprotective phenotype after retinal ischemia/reperfusion injury

引用

Neural Regeneration Research 2022年第12期17卷 2755-2760页

作者： Di Chen Cheng Peng Xu-Ming Ding Yue Wu Chang-Juan Zeng Li Xu wen-yi guo Department of Ophthalmology Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology ShanghaiChina

Glaucoma results from irreversible loss of retinal ganglion cells(RGCs)through an unclear *** polarization and neuroinflammation play an important role in retinal *** study aimed to explore the function of microglial polarization during glaucoma progression and identify a strategy to alleviate retinal *** ischemia/reperfusion injury was induced in C57BL/6 *** a separate cohort of animals,interleukin(IL)-4(50 ng/mL,2μL per injection)or vehicle was intravitreally injected after retinal ischemia/reperfusion *** loss was assessed by counting cells that were positive for the RGC marker RNA binding protein,mRNA processing factor in retinal flat *** expression of classically activated(M1)and alternatively activated(M2)microglial markers were assessed by quantitative reverse transcription-polymerase chain reaction,immunofluorescence,and western *** results showed that progressive RGC loss was accompanied by a continuous decrease in M2 microglia during the late phase of the 28-day period after retinal ischemia/reperfusion ***-4 was undetectable in the retina at all time points,and intravitreal IL-4 administration markedly improved M2 microglial marker expression and ameliorated RGC loss in the late phase post-retinal ischemia/reperfusion *** summary,we observed that IL-4 treatment maintained a high number of M2 microglia after RIR and promoted RGC survival.

关键词： glaucoma hyper-intraocular pressure in vivo interleukin-4 intravitreal injection M2 microglia neurodegeneration neuroprotective effect retinal ganglion cell retinal ischemia-reperfusion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In situ synthesis of porous Pt-Pd bimetallic structures for sweat glucose biosensing using dynamic hydrogen bubble template method

引用

Rare Metals 2024年第7期43卷 3408-3414页

作者： yi-wen guo Qian-Hui Wei Fei Wei Hao Liu Hong-Bin Zhao Dong Wang Hai-Ling Tu State Key Laboratory of Advanced Materials for Smart Sensing China GRINM Group Co.Ltd.Beijing 100088China Department of Advanced Electronic Materials GRIMAT Engineering Institute Co.Ltd.Beijing 101407China General Research Institute for Nonferrous Metals Beijing 100088China GRINM(Guangdong)Institute for Advanced Materials and Technology Foshan 528000China School of Chemical Engineering Northeast Electric Power UniversityJilin 132012China

For the practical application of sweat glucose biosensors,it is crucial to develop a method for modifying the working electrode with noble metals that ensures strong *** this study,we synthesized porous Pt-Pd bimetall... 详细信息

关键词： method bubble porous

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The detection, extraction and parameter estimation of extreme-mass-ratio inspirals with deep learning

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 86-96页

作者： Qianyun Yun wen-Biao Han yi-Yang guo He Wang Minghui Du Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Shanghai Jiao Tong University School of Astronomy and Space Science University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Universe (Beijing/Hangzhou) University of Chinese Academy of Sciences Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Province Key Laboratory of Quantum Theory and Applications of MoE Lanzhou University Institute of Theoretical Physics & Research Center of Gravitation Lanzhou University International Centre for Theoretical Physics Asia-Pacific (ICTP-AP) University of Chinese Academy of Sciences (UCAS) Center for Gravitational Wave Experiment National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences

One of the primary goals of space-borne gravitational wave detectors is to detect and analyze extreme-mass-ratio inspirals(EMRIs). This task is particularly challenging because EMRI signals are complex, lengthy, and faint. In this work, we introduce a2-layer convolutional neural network(CNN) approach to detect EMRI signals for space-borne detectors, achieving a true positive rate(TPR) of 96.9% at a 1% false positive rate(FPR) for signal-to-noise ratio(SNR) from 50 to 100. Especially, the key intrinsic parameters of EMRIs such as the mass, spin of the supermassive black hole(SMBH) and the initial eccentricity of the orbit can also be inferred directly by employing a neural network. The mass and spin of the SMBH can be determined at 99% and 92% respectively. This will greatly reduce the parameter spaces and computing cost for the following Bayesian parameter *** model also has a low dependency on the accuracy of the waveform model. This study underscores the potential of deep learning methods in EMRI data analysis, enabling the rapid detection of EMRI signals and efficient parameter estimation.

关键词： gravitational wave EMRIs deep-learing

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Efficacy of low-energy selective laser trabeculoplasty on the treatment of primary open angle glaucoma

引用

International Journal of Ophthalmology(English edition) 2019年第9期12卷 1432-1437页

作者： Li Xu Ru-Jing Yu Xu-Ming Ding Mao Li Yue Wu Li Zhu Di Chen Cheng Peng Chang-Juan Zeng wen-yi guo Department of Ophthalmology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai 200011China

AIM: To investigate the efficacy of low-energy selective laser trabeculoplasty(SLT) on the treatment of primary open angle glaucoma(POAG) ***: Outpatients with POAG who underwent 360-degree SLT using an initial energy of 0.3 mJ(total energy of 30-40 mJ) were reviewed retrospectively from September 2011 to January ***: Eight-six eyes of 44 POAG patients underwent 360-degree SLT using initial energy of 0.3 mJ and were followed up regularly. The total energy used was 32.5±2.5 mJ(23-40 mJ, 105±6 spots). The average pretreatment intraocular pressure(IOP) was 19.8±3.9 mm Hg. At 1, 3, 6 mo, 1, and 2 y, the post-SLT IOPs(mm Hg) were 16.9±3.3, 16.5±3.3, 17.1±3.4, 16.6±3.5, 16.5±2.8, which were significantly lower than that before treatment(Pwenty-seven eyes that required reduced drugs were defined as the drug reduction group. The pre-SLT IOP was 19.2±4.4 mm Hg. At 1, 3, 6 mo, 1, and 2 y, the post-SLT IOPs(mm Hg) were 16.1±2.6, 16.5±3.1, 16.8±2.9, 16.0±2.6 and 16.3±2.4, respectively. Compared with the pretreatment IOPs, the post-SLT IOPs were significantly lower in drug retention group and drug reduction group. The patients in the drug reduction group were found to be younger than those in the drug retention ***: Low-energy SLT is safe and effective for POAG patients during a 2-year follow-up. Younger POAG patients may obtain better results after low-energy SLT treatment.

关键词： primary open angle glaucoma selective laser trabeculoplasty low energy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Glaucoma in Patients with Eyes Close to Areas Affected by Port-wine Stain has Lateral and Gender Predilection

引用

Chinese Medical Journal 2017年第24期130卷 2922-2926页

作者： Yue Wu Ru-Jing Yu Di Chen Li Xu Mao Li Li Zhu Chun-Yu guo wen-yi guo Department of Ophthalmology Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200011 China

Background：The location of facial port-wine stain （PWS） may be helpful for predicting some associated anomalies;high glaucoma incidence is found in patients with eyes close to PWS-affected areas （V1,ophthalmic branch area of the trigeminal nerve）.This study aimed to investigate the characteristics of glaucoma in V1-affected ***：A total of 569 patients with V1 area-affected PWS were reviewed in the *** large series was based on the referral system between the Department of Plastic and Reconstructive Surgery and the Department of *** patients were screened for glaucoma with assessments of intraocular pressure,cup-to-disc ratio,comeal diameter （only for infants）,and axial ***：Of the 569 patients,110 （19.3%） patients had *** the patients,18.1% （76/420） had early-onset glaucoma （under 4-year-old group）.In the 4 to 18-year-old age group,29.3% （29/99） of the patients had *** with right lateral and bilateral PWS,left-sided PWS had a lower risk of glaucoma in this study （odds ratio =0.432 [95% confidence interval,0.264-0.706],P =0.01）.The under 4-year-old group showed a slight predominance of males （61.8%） in ***：High glaucoma incidence was observed in patients with eyes close to *** attention should be paid to glaucoma screening for right lateral and bilateral PWS *** predominance of males in Sturge-Weber syndrome （SWS） early-onset glaucoma patients might be due to the limitation of the case number;however,it might also provide us a new clue of potential relationship between SWS and PCG.

关键词： Birthmark Glaucoma Port-wine Stain Sturge-Weber Syndrome

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

咖啡因预处理解冻精液对牛体外受精的影响

引用

西南农业学报 2000年第2期13卷 95-98页

作者：文国艺广西大学动物科技学院中国南宁530005

用２．５ｍＭ咖啡因处理解冻牛精液１０ｍｉｎ．或５．０ｍＭ咖啡因处理３０ｍｉｎ，精子经离心后加入到不含咖啡因的受精液中进行体外受精，均获得较高卵裂率（分别为８９．１％、８９．９％）及囊胚率（分别为４４．４％... 详细信息

用２．５ｍＭ咖啡因处理解冻牛精液１０ｍｉｎ．或５．０ｍＭ咖啡因处理３０ｍｉｎ，精子经离心后加入到不含咖啡因的受精液中进行体外受精，均获得较高卵裂率（分别为８９．１％、８９．９％）及囊胚率（分别为４４．４％、４５．９％），并且第７天一级囊胚数较多。

关键词：牛卵母细胞体外受精咖啡因受精液卵裂率

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

血清甘氨酰脯氨酸二肽氨基肽酶活力测定在消化系肿瘤中的诊断价值

引用

中华消化杂志 1990年第2期10卷 84-86页

作者：文国义任成山第三军医大学新桥医院

对167例消化系疾病和60例正常人作血清甘氨酰脯氨酸二肽氨基肽酶（SGPDA）活力测定。测定结果表明胃癌组SGPDA活力明显降低，而肝癌组明显升高。如以正常人SGPDA活力均值加减2SD（33~77u/L）为鉴别良、恶性病变的界限，则胃癌组酶活力在... 详细信息

对167例消化系疾病和60例正常人作血清甘氨酰脯氨酸二肽氨基肽酶（SGPDA）活力测定。测定结果表明胃癌组SGPDA活力明显降低，而肝癌组明显升高。如以正常人SGPDA活力均值加减2SD（33~77u/L）为鉴别良、恶性病变的界限，则胃癌组酶活力在33u/L以下者占75%胃肠良性病变占17.39%；肝癌组酶活力在77u/L以上者占66.7%，而肝硬化组仅占3%，胆囊炎、胆石症组占15.38%。良恶性病变组间差异均有非常显著性。说明SGPDA活力测定对胃癌及肝癌具有一定的诊断价值。

关键词：活力测定消化系肿瘤诊断 SGPDA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exosomes:the next-generation therapeutic platform for ischemic stroke

引用

Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： wenjing yin Hongyin Ma Yang Qu Jiaxin Ren yingying Sun Zhen-Ni guo yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

碳酸饮料企业应用热回收型冷水机组的节能经济分析

引用

食品与机械 2016年第10期32卷 101-104页

作者：陈树文郭怡婷湖南城建职业技术学院湖南湘潭411101

文章介绍中国碳酸饮料企业制取生产工艺用热水的现状,结合传统的制冷机组冷凝热回收方法,提出采用回收制冷机组的冷凝热预热制取蒸气用水、制取工艺用低温热水以减少锅炉耗能的新方法,为碳酸饮料企业节能降耗提供了可以参考和借鉴的新... 详细信息

文章介绍中国碳酸饮料企业制取生产工艺用热水的现状,结合传统的制冷机组冷凝热回收方法,提出采用回收制冷机组的冷凝热预热制取蒸气用水、制取工艺用低温热水以减少锅炉耗能的新方法,为碳酸饮料企业节能降耗提供了可以参考和借鉴的新方法。

关键词：碳酸饮料冷凝热回收节能降耗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：