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Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

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World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： Ya-Xin Xu Xiao-xuan Niu wen-Chang Jia Jing wen Xue-Lin Cheng Yan Han Ming-Hui Peng Jing Zhou Yao Liu Sun-Fang Jiang Xiao-Pan Li Department of Health Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of Public Health Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region Global Burden of Disease Risk factors Disability-adjusted life years

Synthesis and Crystal Structure of a Mononuclear Zn(II) Complex with Tridentate Schiff Base,Zn(C_(12)H_(18)N_2O)(NCS)_2

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Chinese Journal of Structural Chemistry 2006年第9期25卷 1031-1034页

作者： CAI wen-xuan wen Yi-Hang SU Hong FENG Yun-long Institute of Physical Chemistry Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces Zhejiang Normal University Jinhua 321004 China

The title complex Zn（HL）（NCS）2 （C14H18N4OS2Zn, Mr = 387.81, HL = N-（3-dimethyl-aminopropyl）-salicylaldimine） has been synthesized by the reaction of ZnSO4·7H2O with the Schiff base N-（3-dimethylaminopropyl）-salicylaldimine derived from the condensation reaction of 3-dimethylamino- 1-propylamine with salicyladehyde. It crystallizes in the monoclinic system, space group P21/n with a = 9.8360（8）, b = 14.930（1）, c = 12.277（1） A, β= 101.455（2）°, V= 1767.0（3） A 3, Z = 4, F（000） = 800, Dc= 1.458 g/cm^3 and ,μ（MoKα） = 1.631 mm^-1. The structure was refined to R = 0.0463 and wR = 0.1065 for 2681 observed reflections （1 〉 2σ（I））. Crystal analyses revealed that the Zn（Ⅱ） atom is coordinated by two nitrogen atoms of two NCS^-, and an oxygen atom as well as a nitrogen atom of amine from the neutral Schiff base ligand of N-（3-dimethyl-aminopropyl）-salicylaldimine to give a distorted tetrahedral geometry.

关键词： 3-dimethylamino-1-propylamine salieylaldehyde Sehiff base,

A novel approach for radionuclide diffusion in the enclosed environment of a marine nuclear reactor during a severe accident

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Nuclear Science and Techniques 2022年第2期33卷 53-65页

作者： Fang Zhao Shu-Liang Zou Shou-long Xu xuan Wang Jun-long Wang De-wen Tang School of Resource Environment and Safety Engineering University of South ChinaHengyang 421001China Hunan Provincial Key Laboratory of Emergency Safety Technology and Equipment for Nuclear Facilities Hengyang 421001China Shanghai Nuclear Engineering Research and Design Institute Co.LTD Shanghai 200000China Science and Technology On Reactor System Design Technology Laboratory Nuclear Power Institute of ChinaChengdu 610213China

A severe accident in a marine nuclear reactor leads to radionuclide leakage,which causes hidden dangers to workers and has adverse effects of environmental *** is necessary to propose a novel approach to radionuclide diffusion in a confined environment after a severe accident in a marine nuclear ***,this study proposes a new method for the severe accident analysis program MELCOR coupled with computational fluid dynamics scSTREAM to study radioactive diffusion in severe *** radionuclide release fraction and temperature calculated by MELCOR were combined with the scSTREAM calculations to study the radionuclide diffusion behavior and the phenomenon of radionuclide diffusion in different space environments of the reactor under the conditions of varying wind velocities of the ventilation system and diffusion *** results show that the wind velocity of the ventilation system is very small or zero,and the turbulent diffusion of radionuclides is not obvious and diffuses slowly in the form of condensation sedimentation and gravity *** the wind speed of the ventilation system increases,the flow of radionuclides meets the wall and forms eddy currents,affecting the time variation of radionuclides diffusing into chamber *** wind velocity of the ventilation system and the diffusion speed has opposite effects on the time variation trend of radionuclide diffusion into the four chambers.

关键词： Radionuclide diffusion MELCOR coupled with scSTREAM Severe accident Marine nuclear reactor

Topology optimization of transient problem with maximum dynamic response constraint using SOAR scheme

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Frontiers of Mechanical Engineering 2021年第3期16卷 593-606页

作者： Kai long Xiaoyu YANG Nouman SAEED Ruohan TIAN Pin wen xuan WANG State Key Laboratory for Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China Hubei Key Laboratory of Theory and Application of Advanced Materials Mechanics School of ScienceWuhan University of TechnologyWuhan 430070China Department of Engineering Mechanics Hefei University of TechnologyHefei 230009China

This paper proposes a novel method for the continuum topology optimization of transient vibration problem with maximum dynamic response *** aggregated index in the form of an integral function is presented to cope with the maximum response constraint in the time *** density filter solid isotropic material with penalization method combined with threshold projection is *** sensitivities of the proposed index with respect to design variables are *** reduce computational cost,the second-order Amoldi reduction(SOAR)scheme is employed in transient *** of aggregate parameter,duration of loading period,interval time,and number of basis vectors in the SOAR scheme on the final designs are discussed through typical examples while unambiguous configuration can be *** comparison with the corresponding static response from the final designs,the optimized results clearly demonstrate that the transient effects cannot be ignored in structural topology optimization.

关键词： topology optimization solid isotropic material with penalization transient response aggregation function second-order Amoldi reduction

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

Low lighting image enhancement using local maximum color value prior

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Frontiers of Computer Science 2016年第1期10卷 147-156页

作者： xuan DONG Jiangtao wen Department of Computer Science and Technology Tsinghua University Beijing 100084 China

We study the problem of low lighting image en- hancement. Previous enhancement methods for images un- der low lighting conditions usually fail to consider the factor of image degradation during image formation. As a result, the lost contrast could not be recovered after enhancement. This paper will adaptively recover the contrast and adjust the exposure for low lighting images. Our first contribution is the modeling of image degradation in low lighting con- ditions. Then, the local maximum color value prior is pro- posed, i.e., in most regions of well exposed images, the lo- cal maximum color value of a pixel will be very high. By combining the image degradation model and local maximum color value prior, we propose to recover the un-degraded im- ages under low lighting conditions. Last, an adaptive expo- sure adjustment module is proposed to obtain the final result. We show that our approach enables better enhancement com- paring with popular image editing tools and academic algo- rithms.

关键词： low lighting enhancement image degradationmodel

A pixel-based outlier-free motion estimation algorithm for scalable video quality enhancement

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Frontiers of Computer Science 2015年第5期9卷 729-740页

作者： xuan DONG Jiangtao wen Department of Computer Science and Technology Tsinghua University Beijing 100084 China

Scalable video quality enhancement refers to the process of enhancing low quality frames using high quality ones in scalable video bitstreams with time-varying qualities. A key problem in the enhancement is how to search for correspondence between high quality and low quality frames. Previous algorithms usually use block-based motion estimation to search for correspondences. Such an approach can hardly estimate scale and rotation transforms and always in- troduces outliers to the motion estimation results. In this paper, we propose a pixel-based outlier-free motion estimation algorithm to solve this problem. In our algorithm, the motion vector for each pixel is calculated with respect to estimate translation, scale, and rotation transforms. The motion relationships between neighboring pixels are considered via the Markov random field model to improve the motion estimation accuracy. Outliers are detected and avoided by taking both blocking effects and matching percentage in scale- invariant feature transform field into consideration. Experiments are conducted in two scenarios that exhibit spatial scalability and quality scalability, respectively. Experimental results demonstrate that, in comparison with previous algorithms, the proposed algorithm achieves better correspondence and avoids the simultaneous introduction of outliers, especially for videos with scale and rotation transforms.

关键词： motion estimation scalable video coding videosuper resolution.

Concurrent topology optimization for minimization of total mass considering load-carrying capabilities and thermal insulation simultaneously

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Acta Mechanica Sinica 2018年第2期34卷 315-326页

作者： Kai long xuan Wang Xianguang Gu Beijing Key Laboratory of Energy Safety and Clean Utilization North China Electric Power University State Key Laboratory for Alternate Electrical Power System with Renewable Energy Sources North China Electric Power University State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering Mechanics Dalian University of Technology School of Automobile and Traffic Engineering Hefei University of Technology

The present work introduces a novel concurrent optimization formulation to meet the requirements of lightweight design and various constraints *** displacement of macrostructure and effective thermal conductivity of microstructure are regarded as the constraint functions, which means taking into account both the loadcarrying capabilities and the thermal insulation *** effective properties of porous material derived from numerical homogenization are used for macrostructural analysis. Meanwhile, displacement vectors of macrostructures from original and adjoint load cases are used for sensitivity analysis of the microstructure. Design variables in the form of reciprocal functions of relative densities are introduced and used for linearization of the constraint function. The objective function of total mass is approximately expressed by the second order Taylor series expansion. Then, the proposed concurrent optimization problem is solved using a sequential quadratic programming algorithm, by splitting into a series of sub-problems in the form of the quadratic program. Finally, several numerical examples are presented to validate the effectiveness of the proposed optimization method. The various effects including initial designs, prescribed limits of nodal displacement, and effective thermal conductivity on optimized designs are also investigated. An amount of optimized macrostructures and their corresponding microstructures are achieved.

关键词： Concurrent design Topology optimization Homogenization Thermal insulation Nodal displacement Independent continuous mapping method

In situ growth of NiSe@Co_(0.85)Se heterointerface structure with electronic modulation on nickel foam for overall water splitting

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Rare Metals 2021年第6期40卷 1373-1382页

作者： wen-long Ding Yan-Hui Cao Hui Liu Ao-xuan Wang Cui-Juan Zhang Xue-Rong Zheng Key Laboratory for Green Chemical Technology of Ministry of Education State Key Laboratory of Chemical EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China School of Materials Science and Engineering Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of EducationTianjin UniversityTianjin 300072China Department of Physics and Astronomy University of CaliforniaIrvineCA 92697USA Tianjin Kaben New Materials Technology Co. Ltd.Tianjin 300350China

Constructing heterointerface engineering has becoming an effective and general strategy for developing highly efficient and durable nonnoble electrocatalysts for catalyzing both hydrogen evolution reaction(HER)and oxygen evolution reaction(OER).In this work,we synthesized a self-supporting heterogeneous NiSe@Co_(0.85)Se/NF electrocatalyst using a facile in situ selenization of transition metal precursors that coated on the nickel foam(NF)in polyol *** NF was used as both conductive substrate and nickel source,ensuring superior electronic conductivity for *** NiSe@-Co_(0.85)Se/NF exhibited remarkable bifunctional electrocatalytic activities with HER overpotential of 168 mV and OER overpotential of 258 mV to achieve 10 mA·*** water splitting system using NiSe@Co_(0.85)Se/NF as both anode and cathode electrodes achieved a current density of 10 mA·cm^(-2) at 1.61 V with nearly 100% faradaic efficiency and impressively long-term *** efficient bifunctional catalytic performance of NiSe@-Co_(0.85)Se/NF should be attributed to the electronic modulation and synergistic effect between NiSe and Co_(0.85)Se,the intrinsic metallic conductivity and the enlarged active sites *** work provides a facile method for developing heterogeneous bifunctional catalysts for advanced electrochemical energy conversion technologies.

关键词： NiSe@Co_(0.85)Se/NF Heterointerface structure Electronic modulation Bifunctional electrocatalyst Overall water splitting