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Lateral bearing characteristics of subsea wellhead assembly in the hydrate trial production engineering

China Geology 2023年第3期6卷 455-465页

作者： Jing Zeng wen-wei xie Bei-bei Kou Jing-an Lu Xing-chen Li De-jun Cai Hao-xian Shi Ke-wei Zhang Hua-qing Liu Jin Li Bo Li Guangzhou Marine Geological Survey China Geological SurveyMinistry of Natural ResourcesGuangzhou 510075China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China National Engineering Research Center of Gas Hydrate Exploration and Development China Geological SurveyMinistry of Natural ResourcesGuangzhou 510075China Drilling Engineering Division Offshore Engineering Company LimitedCNPCTianjin 300280China

Conductor and suction anchor are the key equipment providing bearing capacity in the field of deep-water drilling or offshore engineering,which have the advantages of high operation efficiency and short construction *** order to drill a horizontal well in the shallow hydrate reservoir in the deep water,the suction anchor wellhead assembly is employed to undertake the main vertical bearing capacity in the second round of hydrate trial production project,so as to reduce the conductor running depth and heighten the kick-off point ***,the deformation law of the deep-water suction anchor wellhead assembly under the moving load of the riser is not clear,and it is necessary to understand the lateral bearing characteristics to guide the design of its structural *** on 3D solid finite element method,the solid finite element model of the suction anchor wellhead assembly is *** the model,the seabed soil is divided into seven layers,the contact between the wellhead assembly and the soil is simulated,and the vertical load and bending moment are applied to the wellhead node to simulate the riser movement when working in the deep *** lateral bearing stability of conventional wellhead assembly and suction anchor wellhead assembly under the influence of wellhead load is *** analysis results show that the bending moment is the main factor affecting the lateral deformation of the wellhead string;the anti-bending performance from increasing the outer conductor diameter is better than that from increasing the conductor wall thickness;for the subsea wellhead,the suction anchor obviously improves the lateral bearing capacity and reduces the lateral *** conduct of the suction anchor wellhead assembly still needs to be lowered to a certain depth that below the maximum disturbed depth to ensure the lateral bearing stability,Thus,a method for the minimum conductor running depth for the suction anchor wellhead assembly is devel

关键词： Natural gas hydrate Deep-water Subsea wellhead Suction anchor Wellhead stability 3D solid finite element method Hydrate trial exploration engineering Natural gas hydrate trial production Shenhu area The South China Sea

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执行器饱和受限不确定系统的次序优化多步预测控制

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控制与决策 2017年第8期32卷 1499-1504页

作者：张浪文谢巍华南理工大学自动化科学与工程学院广州510640 华南理工大学自主系统与网络控制教育部重点实验室广州510640

设计一种次序优化机制,提出一类饱和受限不确定系统的次序优化多步预测控制方法.将系统的输入分解成多个子集合,在各采样周期仅对其中一个集合的输入进行优化,待优化的输入保持上一优化值.针对每个输入集合,确定闭环系统的不变集条件,... 详细信息

设计一种次序优化机制,提出一类饱和受限不确定系统的次序优化多步预测控制方法.将系统的输入分解成多个子集合,在各采样周期仅对其中一个集合的输入进行优化,待优化的输入保持上一优化值.针对每个输入集合,确定闭环系统的不变集条件,将次序优化预测控制器设计问题转化成"最小-最大"优化问题,通过求解一组线性矩阵不等式问题得到控制器.仿真算例表明,采用次序优化预测控制方法可以减少控制器的设计时间.

关键词：饱和受限不确定系统次序优化预测控制

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Fast multi-swarm optimization based-on Cauchy mutation and crossover operation

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黄冈师范学院学报 2008年第3期28卷 47-49,80页

作者： ZHANG Qing FENG Jie ZHANG Jun-wen xie wei College of Physical Science and Technology Huanggang Normal University Huangzhou 438000 Hubei China

The standard particle swarm optimization(PSO) algorithm is a novel evolutionary algorithm in which each particle studies its own previous best solution and the group's previous best solutions to optimization *** problem in PSO is its tendency of trapping into local *** this paper,a multi-swarm technique based on fast particle swarm optimization(FPSO) algorithm is proposed by introducing crossover *** is global search algorithm which can prevent PSO from trapping into local optima in light of Cauchy *** it can get high optimizing precision,the convergence rate is not *** can not only find satisfying solutions,but also speed up the search.

关键词：最佳化设计苛西定理操作性能计算方法

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Experimental Study on Geometry Characteristics of Turbulent Premixed Flames for Natural Gas/Air Mixtures

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Journal of Thermal Science 2025年第1期34卷 268-282页

作者： ZHENG weilin WANG Qijiao XIAO Huahua CHEN Xiaoxiao xie Fan ZENG wen Liaoning Key Lab of Advanced Test Technology for Aerospace Propulsion System Shenyang Aerospace University State Key Laboratory of Fire Science University of science and Technology of China AVIC Shenyang Aircraft Design and Research Institute

In this study,focusing on the geometry characteristics of spherical expanding flame,the turbulent premixed flames of natural gas/air mixtures were investigated in a fan-stirred turbulent *** effects of initial temperature（T=300-400 K）,initial pressure（P=0.1-0.3 MPa）,turbulence intensity（u'=1.0-2.7 m/s）,oxygen volumetric percentage(φ（O2）=15%-21%) and carbon dioxide volumetric percentage(φ（CO2）=0-20%)were delved *** flame profile under the Cartesian coordinate system was derived from the schlieren images taken by the high-speed ***,from both macroscopic and microscopic perspectives,the influence of experimental conditions on the flame geometry characteristics was explored through flame front extraction,wavelet decomposition and network *** results demonstrate that for significant flame wrinkling,changes in species concentrations and turbulence intensity have more pronounced effects on the flame wrinkling *** wrinkling of the flame front maintains a certain degree of similarity,as evidenced by the locally concentrated distribution of the angles of the maximum fluctuation *** disturbance energy under large-scale（D6-D8） disturbances exhibits relatively high values with a similar trend,exerting a significant impact on the geometry characteristics of the flame *** peaks of correlation degree are scattered either with the decomposition scale or the development of flame radius,indicating no linear correlation between different detail ***,the probability distribution of node degrees in key wrinkled regions exhibits different trends with that of large-scale wrinkling and disturbance energy,especially with changes in initial *** occurs because the number of key wrinkles varies based on the perturbation's strength or the region's ***,an increase in the fluctuation frequency of the flame's local radius may not necessarily lead to an increase in the number of key folded regions.

关键词： fan-stirred turbulent combustor geometry characteristics large-scale wrinkling network topology wavelet decomposition

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The anti-endotoxic effect of o-aminobenzoic acid from Radix Isatidis

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Acta Pharmacologica Sinica 2005年第5期26卷 593-597页

作者： Jian-guo FANG~2,Yun-hai LIU,wen-qing WANG,wei xie,Shu-xian FANG,Hong-gang HANDepartment of Pharmacy,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China Department of Pharmacy Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China

Aim:To study the anti-endotoxic effect of o-aminobenzoic acid(OABA)isolatedfrom Banlangen(BLG).Methods:OABA was extracted and isolated from BLG anddiluted into 0.5% *** concentration of endotoxin(ET)pretreated withOABA was quantitatively detected using Limulus *** inhibition of ET-induced fever by OABA was measured in *** rates of lipopolysaccha-rides(LPS)-induced death in mice pretreated with or without OABA were *** influence of OABA on the release of TNF-α and NO from mac-rophages induced by LPS was examined in ***:After pretreatment withOABA,84.4% of ET was *** ET-induced fever in rabbits decreasedsignificantly and the rate of LPS-induced death in mice dropped from 70% to 20%.The release of TNF-α and NO induced by LPS in mice was inhibited dose-depen-dently when the concentration of OABA was between 0.125% and 0.5%.Conclusion:OABA isolated from BLG has an anti-endotoxic effect.

关键词： Radix Isatidis(Banlangen) o-aminobenzoic acid endotoxin lipopolysaccharides Tachypleus Amebocyte Lysale tumor necrosis factor-α nitric oxide

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The first offshore natural gas hydrate production test in South China Sea

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China Geology 2018年第1期1卷 5-16页

作者： Jin-fa Li Jian-liang Ye Xu-wen Qin Hai-jun Qiu Neng-you Wu Hai-long Lu wen-wei xie Jing-an Lu Fei Peng Zhen-qiang Xu Cheng Lu Zeng-gui Kuang Jian-gong wei Qian-yong Liang Hong-feng Lu Bei-bei Kou China Geological Survey Beijing 100037China Guangzhou Marine Geologtcal Survey China Geologtcal SurveyGuangzhou 510075China Qingdao Institute of Marine Geology China Geological SurveyQingdao 266071China Peking University Beijing 100871China Institute of Exploration Techmques China Academy of Geological SciencesLangfang 065000China CNPC Offshore Engineering Company Ltd Beijing 100102China Center of Oil & Natural Gas Resource Exploration China Geological SurveyBeijing 100083China

Natural gas hydrates (NGH)is one of key future clean energy *** industrialized development will help remit the huge demand of global natural gas,relieve the increasing pressure of the environment, and play a vital role in the green sustainable growth of human *** on nearly two decades' studying on the reservoir characteristics in the South China Sea (SCS)and the knowledge of reservoir system,the China Geological Survey (CGS)conducted the first production test on an optimal target selected in Shenhu area SCS in *** by the "three-phase control"exploitation theory which focused on formation stabilization,technologies such as formation fluid extraction,well drilling and completing, reservoir stimulating,sand controlling,environmental monitoring,monitoring and preventing of secondary formation of hydrates were *** test lasted for 60 days from May 10^th when starting to pump, drop pressure and ignite to well killing on July 9^th,with gas production of 3.09×10^5 m^3 in total,which is a world record with the longest continuous duration of gas production and maximal gas *** successful test brings a significant breakthrough on safety control of NGH production.

关键词： Natural gas hydrate (NGH) Production test Shenhu area South Chma Sea (SCS)

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Structural engineering of high-entropy alloys for advanced electrocatalytic reactions

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Tungsten 2025年第1期7卷 1-31页

作者： Qiao xie Ying-Jie Yu Hai-Jun Zhang Ya-Ping Deng wen Lei The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and Technology Department of Chemical Engineering Waterloo Institute for Sustainable Energy Waterloo Institute for Nanotechnology University of Waterloo

High-entropy alloys(HEAs) have emerged as promising candidates to replace traditional precious metal catalysts,owing to their unique chemical and physical *** review commences by revisiting the fundamental concepts of HEAs,including their synthesis methods and structural control strategies in *** underscores the critical role of meticulously manipulating both macroscopic and microscopic structures of the HEAs to optimize their catalytic performance.A deep understanding of the structure-activity relationship in HEAs across various configurations is pivotal in developing more effective *** review methodically encapsulates the research progress of structural control strategies for HEAs in achieving efficient energy conversion,with the aim of gaining a better understanding of the relationship between structure and *** review concludes by summarizing the current achievements and challenges,and suggestions for potential future directions of HEAs in the fields of energy conversion and environmental purification.

关键词： Electrocatalytic Energy conversion High-entropy alloys Structural modulation

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Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin Luo Caiyan wei Yaru Qiao Jiming xie Xianchao Pan Juan Xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

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Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

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Oncology Research 2025年第1期33卷 67-81页

作者： XIANG LI wenKE JIN LIFENG WU HUAN WANG XIN xie wei HUANG BO LIU State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical TechnologyChengdu University of Traditional Chinese MedicineChengdu611137China Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China

Background:Triple-negative breast cancer(TNBC),characterized by its lack of traditional hormone receptors and HER2,presents a significant challenge in oncology due to its poor response to conventional *** is an important process for maintaining cellular homeostasis,and there are currently autophagy biomarkers that play an effective role in the clinical treatment of *** contrast to targeting protein activity,intervention with proteinprotein interaction(PPI)can avoid unrelated crosstalk and regulate the autophagy process with minimal interference ***:Here,we employed Naive Bayes,Decision Tree,and k-Nearest Neighbors to elucidate the complex PPI network associated with autophagy in TNBC,aiming to uncover novel therapeutic ***,the candidate proteins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay,and the interaction relationship was verified by molecular docking and CO-IP experiments after *** formation,cellular immunofluorescence,cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)tests were used to predict the clinical therapeutic effects of manipulating candidate ***:By developing three PPI classification models and analyzing over 13,000 datasets,we identified 3733 previously unknown autophagy-related *** network analysis revealed the central role of Beclin 2 in autophagy regulation,uncovering its interactions with 39 newly identified ***,the CO-IP studies identified the substantial interaction between Beclin 2 and Ubiquilin 1,which was anticipated by our model and discovered in immunoprecipitation-mass spectrometry assay ***,in vitro investigations showed that overexpressing Beclin 2 increased Ubiquilin 1,promoted autophagy-dependent cell death,and inhibited proliferation and metastasis in MDA-MB-231 ***:This study not

关键词： Triple-negative breast cancer(TNBC) Autophagy Protein-protein interactions(PPI) Artificial intelligence(AI) Beclin 2 Ubiquilin 1

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Optimizing electronic structure through point defect engineering for enhanced electrocatalytic energy conversion

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Green Energy & Environment 2025年第1期10卷 109-131页

作者： wei Ma Jiahao Yao Fang xie Xinqi Wang Hao Wan Xiangjian Shen Lili Zhang Menggai Jiao Zhen Zhou Interdisciplinary Research Center for Sustainable Energy Science and Engineering(IRC4SE2) School of Chemical EngineeringZhengzhou UniversityHenan450001China

Point defect engineering endows catalysts with novel physical and chemical properties,elevating their electrocatalytic *** introduction of defects emerges as a promising strategy,effectively modifying the electronic structure of active *** optimization influences the adsorption energy of intermediates,thereby mitigating reaction energy barriers,altering paths,enhancing selectivity,and ultimately improving the catalytic efficiency of *** elucidate the impact of defects on the electrocatalytic process,we comprehensively outline the roles of various point defects,their synthetic methodologies,and characterization ***,we consolidate insights into the relationship between point defects and catalytic activity for hydrogen/oxygen evolution and CO_(2)/O_(2)/N_(2) reduction reactions by integrating mechanisms from diverse *** underscores the pivotal role of point defects in enhancing catalytic *** last,the principal challenges and prospects associated with point defects in current electrocatalysts are proposed,emphasizing their role in advancing the efficiency of electrochemical energy storage and conversion materials.

关键词： Point defect engineering Doping Vacancy Electrocatalysis Electronic structure

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