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Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第1期 249-256页

作者： Qing-Yun Fang Chengyihan gu Yinghan Chen wencheng Yan Yong Liang weipeng Li Chengjian Zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

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An Improved Formulation of Singular Boundary Method

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Advances in Applied Mathematics and Mechanics 2012年第5期4卷 543-558页

作者： wen Chen Yan gu College of Harbour Coastal and Offshore EngineeringHohai UniversityNo.1 Xikang RoadNanjingJiangsu 210098China

This study proposes a new formulation of singular boundary method(SBM)to solve the 2D potential problems,while retaining its original merits being free of integration and mesh,easy-to-program,accurate and mathematically simple without the requirement of a fictitious boundary as in the method of fundamental solutions(MFS).The key idea of the SBM is to introduce the concept of the origin intensity factor to isolate the singularity of fundamental solution so that the source points can be placed directly on the physical *** paper presents a new approach to derive the analytical solution of the origin intensity factor based on the proposed subtracting and adding-back *** the troublesome sample nodes in the ordinary SBM are avoided and the sample solution is also not necessary for the Neumann boundary *** benchmark problems are tested to demonstrate the feasibility and accuracy of the new formulation through detailed comparisons with the boundary element method(BEM),MFS,regularized meshless method(RMM)and boundary distributed source(BDS)method.

关键词： Singular boundary method fundamental solution singularity desingularization technique meshless

Improved Particle Filter for Non-Gaussian Forecasting-aided State Estimation

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Journal of Modern Power Systems and Clean Energy 2023年第4期11卷 1075-1085页

作者： Lyuzerui Yuan Jie gu Honglin wen Zhijian Jin School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Gaussian assumptions of non-Gaussian noises hinder the improvement of state estimation *** this paper,an asymmetric generalized Gaussian distribution(AGGD),as a unified representation of various unimodal distributions,is applied to formulate the non-Gaussian forecasting-aided state estimation *** address the problem,an improved particle filter is proposed,which integrates a near-optimal AGGD proposal function and an AGGD sampling method into the typical particle *** AGGD proposal function can approximate the target distribution of state variables to greatly alleviate particle degeneracy and promote precise estimation,through considering both state transitions and latest *** rapid particle generation from the AGGD proposal function,an efficient inverse cumulative distribution function(CDF)sampling method is employed based on the derived approximation of inverse CDF of *** simulations are carried out on a modified balanced IEEE 123-bus test *** results validate that the proposed method outperforms other popular state estimation methods in terms of accuracy and robustness,whether in Gaussian,non-Gaussian,or abnormal measurement errors.

关键词： State estimation particle filter asymmetric generalized Gaussian distribution non-Gaussian noise

TBL1XR1 induces cell proliferation and inhibit cell apoptosis by the PI3K/AKT pathway in pancreatic ductal adenocarcinoma

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World Journal of Gastroenterology 2020年第25期26卷 3586-3602页

作者： Jian-Feng gu wei Fu Hai-Xin Qian wen-Xiu gu Yang Zong Qian Chen Long Lu Department of General Surgery Changshu No.1 People’s Hospital Affiliated to Soochow UniversityChangshu 215500Jiangsu ProvinceChina Department of Oncology Changshu No.1 People’s Hospital Affiliated to Soochow UniversityChangshu 215500Jiangsu ProvinceChina Department of General Surgery the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC) is one of the deadliest solid tumors. Identification of diagnostic and therapeutic biomarkers for PDAC is urgently needed. Transducin(β)-like 1 X-linked receptor 1(TBL1 XR1) has been linked to the progression of various human cancers. Nevertheless, the function and role of TBL1 XR1 in pancreatic cancers are *** To elucidate the function and potential mechanism of TBL1 XR1 in the development of *** Ninety patients with histologically-confirmed PDAC were included in this study. PDAC tumor samples and cell lines were used to determine the expression of TBL1 XR1. CCK-8 assays and colony formation assays were carried out to assess PDAC cell viability. Flow cytometry was performed to measure the changes in the cell cycle and cell apoptosis. Changes in related protein expression were measured by western blot analysis. Animal analysis was conducted to confirm the impact of TBL1 XR1 in *** Patients with TBL1 XR1-positive tumors had worse overall survival than those with TBL1 XR1-negative tumors. Moreover, we found that TBL1 XR1 strongly promoted PDAC cell proliferation and inhibited PDAC cell apoptosis. Moreover, knockdown of TBL1 XR1 induced G0/G1 phase arrest. In vivo animal studies confirmed that TBL1 XR1 accelerated tumor cell growth. The results of western blot analysis showed that TBL1 XR1 might play a key role in regulating PDAC cell proliferation and apoptosis via the PI3 K/AKT *** TBL1 XR1 promoted PDAC cell progression and might be an effective diagnostic and therapeutic marker for pancreatic cancer.

关键词： Pancreatic ductal adenocarcinoma TBL1XR1 Proliferation PI3K/AKT pathway

Inertial Proximal ADMM for Separable Multi-Block Convex Optimizations and Compressive Affine Phase Retrieval

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Acta Mathematica Sinica,English Series 2023年第8期39卷 1459-1496页

作者： Peng LI wen gu CHEN Qi Yu SUN School of Mathematics and Statistics Gansu Key Laboratory of Applied Mathematics and Complex SystemsLanzhou UniversityLanzhou 730000P.R.China Graduate School China Academy of Engineering PhysicsBeijing 100088P.R.China Institute of Applied Physics and Computational Mathematics Beijing 100088P.R.China Department of Mathematics University of Central FloridaOrlandoFL 32816USA

Separable multi-block convex optimization problem appears in many mathematical and engineering *** the first part of this paper,we propose an inertial proximal ADMM to solve a linearly constrained separable multi-block convex optimization problem,and we show that the proposed inertial proximal ADMM has global convergence under mild assumptions on the regularization *** phase retrieval arises in holography,data separation and phaseless sampling,and it is also considered as a nonhomogeneous version of phase retrieval,which has received considerable attention in recent *** by convex relaxation of vector sparsity and matrix rank in compressive sensing and by phase lifting in phase retrieval,in the second part of this paper,we introduce a compressive affine phase retrieval via lifting approach to connect affine phase retrieval with multi-block convex optimization,and then based on the proposed inertial proximal ADMM for 3-block convex optimization,we propose an algorithm to recover sparse real signals from their(noisy)affine quadratic *** numerical simulations show that the proposed algorithm has satisfactory performance for affine phase retrieval of sparse real signals.

关键词： Inertial proximal ADMM separable multi-block convex optimization affine phase retrieval

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高压泡沫涨裂破岩特性试验研究

岩土工程学报 2025年第1期47卷 125-134页

作者：刘送永崔松顾聪聪中国矿业大学机电工程学院江苏徐州221116 中国矿业大学智能采矿装备技术全国重点实验室江苏徐州221116 安徽理工大学机电工程学院安徽淮南232001

针对钻爆法和机械法在岩石破碎工程中的弊端,基于泡沫的高黏性和可压缩性,提出了高压泡沫涨裂破岩技术。首先设计高压泡沫涨裂破岩装置,理论分析高压泡沫瞬间释放冲击岩石涨裂孔过程,搭建高压泡沫涨裂力测试装置并开展涨裂力影响试验,... 详细信息

针对钻爆法和机械法在岩石破碎工程中的弊端,基于泡沫的高黏性和可压缩性,提出了高压泡沫涨裂破岩技术。首先设计高压泡沫涨裂破岩装置,理论分析高压泡沫瞬间释放冲击岩石涨裂孔过程,搭建高压泡沫涨裂力测试装置并开展涨裂力影响试验,建立高压泡沫涨裂破岩试验系统,探讨不同空气体积分数时的泡沫涨裂特性,揭示高压泡沫涨裂破岩机理。研究表明:高压泡沫释放时,能够在涨裂孔内产生比泡沫初始压力更高的涨裂力,但涨裂力随泡沫空气体积分数增加而先增大后减小,高压泡沫涨裂破岩经历了裂纹初生、裂纹扩展、涨裂抛掷、涨裂结束4个阶段,破岩重量随泡沫空气体积分数的增加而先增大后减小,当空气体积分数为60%时,由高压泡沫冲击涨裂孔产生的压应力波在岩石上表面反射形成的拉应力造成岩石破坏形式为涨裂坑,空气体积分数为70%~90%时,泡沫涨裂形式为大块岩石分离,这主要是由孔底直角处应力集中效应造成。

关键词：高压泡沫涨裂破岩裂纹扩展涨裂力

Predicting the Outcome of a Tennis Tournament:Based on Both Data and Judgments

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Journal of Systems Science and Systems Engineering 2019年第3期28卷 317-343页

作者： wei gu Thomas L.Saaty aDonlinks School of Economics and Management University of Science and Technology BeijingBeijing 100083China Distinguished University Professor University of PittsburghPittsburghPA 15260United States

This paper is about predicting the outcome of tennis matches of the Association of Tennis Professionals(ATP)and the Women's Tennis Association(WTA)using both data and *** are many factors that influence that *** important question is which factors have significant influence on the *** have identified numerous factors and systematically prioritized them subjectively and objectively,so as to improve the accuracy of the *** then used them to predict the win-lose outcome of the 2015 US OPEN tennis matches(63 men and 31 women's games)before they took *** tennis match prediction in sports literature thus far reported an accuracy rate of 70%.The accuracy of our proposed model which combines data and judgment reaches 85.1%.

关键词： Prediction tennis data analysis judgment

Determination of the genetic diversity of vegetable soybean [Glycine max(L.) Merr.] using EST-SSR markers

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第4期14卷 279-288页

作者： gu-wen ZHANG Sheng-chun XU wei-hua MAO Qi-zan HU Ya-ming GONG Institute of Vegetable Research Zhejiang Academy of Agricultural Sciences Center of Analysis and Measurement Zhejiang University

The development of expressed sequence tag-derived simple sequence repeats(EST-SSRs) provided a useful tool for investigating plant genetic *** the present study,22 polymorphic EST-SSRs from grain soybean were identified and used to assess the genetic diversity in 48 vegetable soybean *** the 22 EST-SSR loci,tri-nucleotides were the most abundant repeats,accounting for 50.00% of the total *** was the most common motif among tri-nucleotide repeats,with a frequency of 18.18%.Polymorphic analysis identified a total of 71 alleles,with an average of 3.23 per *** polymorphism information content(PIC) values ranged from 0.144 to 0.630,with a mean of *** heterozygosity(H o) values varied from 0.0196 to 1.0000,with an average of 0.6092,while the expected heterozygosity(H e) values ranged from 0.1502 to 0.6840,with a mean value of *** coordinate analysis and phylogenetic tree analysis indicated that the accessions could be assigned to different groups based to a large extent on their geographic distribution,and most accessions from China were clustered into the same *** results suggest that Chinese vegetable soybean accessions have a narrow genetic *** results of this study indicate that EST-SSRs from grain soybean have high transferability to vegetable soybean,and that these new markers would be helpful in taxonomy,molecular breeding,and comparative mapping studies of vegetable soybean in the future.

关键词： Expressed sequence tag(EST) Simple sequence repeat(SSR) Genetic diversity Microsatellites Vegetable soybean

Composition characterization and transformation mechanism of dissolved organic phosphorus in wastewater treatment using 31P NMR spectroscopy

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Frontiers of Environmental Science & Engineering 2024年第3期18卷 103-113页

作者： Yuting Zhang wei Shang SoonThiam Khu Xingcan Zheng Yongli Sun Pengfeng Li Miao gu wen-an Zhang Huanmei Ma National Engineering Research Center For Urban Water&Wastewater North China Municipal Engineering Design&Research Institute Co.Ltd.Tianjin 300381China School of Environment Science&Engineering Tianjin UniversityTianjin 300350China

The migration and transformation of phosphorus components in wastewater treatment plants(WWTPs)play a crucial role in the convergence and circulation of ***,the composition and variation of dissolved organic phosphorus(DOP)in WWTPs were unclear because of its complex nature,hindering its efficient *** this study,the DOP species and their transformation during the treatment process in WWTP were comprehensively ***,two enrichment methods were assessed for their effectiveness at facilitating wastewater analysis:lyophilization and aluminum salt *** salt precipitation was found to be better because its application allowed 31P nuclear magnetic resonance(31P NMR)spectroscopy to identify more species in the secondary effluent:orthophosphate(Ortho-P)(81.1%–89.3%of the dissolved total phosphorus),pyrophosphates(Pyro-P)(0%–2.3%),orthophosphate monoesters(Mono-P)(7.0%–10.77%),orthophosphate diesters(Di-P)(1.0%–2.96%),and phosphonate(Phos-P)(1.7%–5.16%).Furthermore,the variation and transformation mechanism of phosphorus,particularly those of DOP,during the entire sewage-treatment process were *** the treatment steps,biological treatment combined tertiary treatment achieved better DOP removal ***,biological treatment mainly removed Mono-P and Di-P with removal efficiencies of 33.3%and 41.7%compared with the effluent of the grit ***-P has higher bioavailability and is more easily converted and utilized by microorganisms than ***,Phos-P,with low bioavailability,was hardly utilized by microorganisms,which showed only 18.4%removal efficiency in biological *** tertiary treatment,coagulation process exhibited higher removal ability of Ortho-P(69.1%)and partial removal efficiencies of DOP,resulting in an increase in the DOP proportion in *** addition,Phos-P could not be effectively removed through the biological treatment and was only partially reduced via the adsorption pro

关键词： Municipal wastewater Dissolved organic phosphorus Composition Transformation 31P nuclear magnetic resonance