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Modified Glucose-insulin-potassium Therapy for Hemorrhage-induced Traumatic Cardiac Arrest in Rabbits

Current Medical Science 2023年第6期43卷 1238-1246页

作者： Lin ZHANG wen-qiong du Zhao-wen ZONG Xin ZHONG Yi-jun JIA Ren-qing JIANG Zhao YE State Key Laboratory of Trauma Burn and Combined InjuryDepartment for Combat Casualty Care TrainingTraining Base for Army Health CareArmy Medical UniversityChongqing400038China Department of Orthopedics Xinqiao HospitalArmy Medical UniversityChongqing400037China

Objective Resuscitation with whole blood is known to be better than that with saline in attaining the return of spontaneous circulation(ROSC)and improving the short-term survival rate for hemorrhage-induced traumatic cardiac arrest(HiTCA).However,the resuscitation with whole blood alone fails to address the pathophysiological abnormalities,including hyperglycemia,hyperkalemia and coagulopathy,after *** present study aimed to determine whether the modified glucose-insulin-potassium(GIK)therapy can ameliorate the above-mentioned pathophysiological abnormalities,enhance the ROSC,improve the function of key organs,and reduce the mortality after *** HiTCA was induced in rabbits(n=36)by controlled *** arrest,the rabbits were randomly divided into three groups(n=12 each):group A(no resuscitation),group B(resuscitation with whole blood),and group C(resuscitation with whole blood plus GIK).The GIK therapy was administered based on the actual concentration of glucose and *** ROSC rate and survival rate were *** and biochemical changes were ***(TEG)was used to measure coagulation parameters,and enzyme-linked immunosorbent assay to detect parameters related to inflammation,coagulation and the function of *** All animals in groups B and C attained *** rabbits died 24–48 h after HiTCA in group B,while no rabbits died in group *** GIK therapy significantly reduced the levels of blood glucose,potassium,and biological markers for inflammatory reaction,and improved the heart,kidney,liver and brain function in group C when compared to group ***,the R values of TEG were significantly lower in group C than in group B,and the maximum amplitude of TEG was slightly lower in group B than in group C,with no significant difference *** Resuscitation with whole blood and modified GIK therapy combined can ameliorate the pathophysiological disorders,including hyperglycemi

关键词： hemorrhage-induced traumatic cardiac arrest return of spontaneous circulation glucose-insulin-potassium therapy resuscitation

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Establishment of a combat damage control surgery training platform for explosive combined thoraco-abdominal injuries

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Chinese Journal of Traumatology 2022年第4期25卷 193-200页

作者： wen-qiong du Ren-Qing Jiang Zhao-wen Zong Lin Zhang Zhao Ye Xin Zhong Yi-Jun Jia State Key Laboratory of Trauma Burn and Combined InjuryDepartment for Combat Casualty Care TrainingTraining Base for Army Health CareArmy Medical UniversityChongqing400038China Department of Orthopedics Xinqiao HospitalArmy Medical UniversityChongqing400038China

Purpose:It is challenging to prepare military surgeons with the skills of combat damage control surgery(CDCS).The current study aimed to establish a damage control surgery(DCS)training platform for explosive combined thoraco-abdominal ***:The training platform established in this study consisted of 3 main components:(1)A 50 m×50 m square yard was constructed as the explosion *** was assessed through cameras.(2)Sixteen pigs were injured by an explosion of trinitrotoluene attached with steel balls and were randomly divided into the DCS group(accepted DCS)and the control group(have not accepted DCS).The mortality rate was observed.(3)The literature was reviewed to identify the key factors for assessing CDCS,and testing standards for CDCS were then *** questionnaires were employed to evaluate the scientificity and feasibility of the testing ***,a 5-day training course with incorporated tests was used to test the efficacy of the established *** total,30 teams attended the first training *** scores that the trainees received before and after the training were *** 11.0 was employed to analyze the ***:The high-speed video playback confirmed the safety of the explosion site as no explosion fragments projected beyond the *** pig died within 24 h when DCS was performed,while 7 pigs died in the control *** a literature review,assessment criteria for CDCS were established that had a total score of 100 points and had 4 major parts:leadership and team cooperation,resuscitation,surgical procedure,and final *** questionnaire results showed that the scientific score was 8.6±1.25,and the feasibility score was 8.74±*** compared with the basic level,the trainees’score improved significantly after training.

关键词： Damage control surgery Simulation training Warfare Explosions Test

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Animal model-based simulation training for three emergent and urgent operations of penetrating thoracic injuries

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Chinese Journal of Traumatology 2023年第1期26卷 41-47页

作者： wen-qiong du Xin Zhong Ren-Qing Jjiang Zhao-wen Zong Yi-Jun Jia Zhao Ye Xiao-Lin Zhou State Key Laboratory of Trauma Burn and Combined InjuryDepartment for Combat Casualty Care TrainingTraining Base for Army Health CareArmy Medical UniversityChongqing400037China State Key Laboratory of Trauma Burn and Combined InjuryDepartment for Combat Casualty Care TrainingTraining Base for Army Health Care&Department of OrthopedicsXinqiao HospitalArmy Medical UniversityChongqing400037China

Purpose:To develop animal models of penetrating thoracic injuries and to observe the effects of the animal model-based training on improving the trainees’performance for emergent and urgent thoracic ***:With a homemade machine,animal models of lung injuries and penetrating heart injuries were produced in porcine and used for training of chest tube drainage,urgent sternotomy,and emergent *** of variation of abbreviated injury scale and blood loss was calculated to judge the reproducibility of animal *** operation teams from basic-level hospitals(group A)and five operation teams from level III hospitals(group B)were included to be trained and *** standards for the operations were established after thorough literature review,and expert questionnaires were employed to evaluate the scientificity and feasibility of the testing *** were carried out after the ***-and post-training performances were ***-training survey using 7-point Likert scale was taken to evaluate the feelings of the trainees to these training ***:Animal models of the three kinds of penetrating chest injuries were successfully established and the coefficient of variation of abbreviated injury scale and blood loss were all less than 25%.After literature review,testing standards were established,and expert questionnaire results showed that the scientific score was 7.30±1.49,and the feasibility score was 7.50±***-training performance was significantly higher in both group A and group B than pre-training ***-training survey showed that all the trainees felt confident in applying the operations and were generally agreed that the training procedure were very helpful in improving operation skills for thoracic penetrating ***:Animal model-based simulation training established in the current study could improve the trainees’performance for emergent and urgent thoracic surgeries,espec

关键词： Penetrating thoracic injuries Emergent operations Urgent operations Simulation training Animal model

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Method and Practice of Trusted Embedded Computing and Data Transmission Protection Architecture Based on Android

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Chinese Journal of Electronics 2024年第3期33卷 623-634页

作者： Yichuan WANG wen GAO Xinhong HEI Yanning du School of Computer Science and Engineering Xi'an University of Technology Shaanxi Key Laboratory for Network Computing and Security Technology

In recent years,the rapid development of Internet technology has constantly enriched people's daily life and gradually changed from the traditional computer terminal to the mobile *** with it comes the security problems brought by the mobile *** for Android system,due to its open source nature,malicious applications continue to emerge,which greatly threatens the data security of ***,this paper proposes a method of trusted embedded static measurement and data transmission protection architecture based on Android to reduce the risk of data leakage in the process of terminal storage and *** conducted detailed data and feasibility analysis of the proposed method from the aspects of time consumption,storage overhead and *** experimental results show that this method can detect Android system layer attacks such as self-booting of the malicious module and improve the security of data encryption and transmission process *** with the native system,the additional performance overhead is small.

关键词： Embedded computing Protocols Data security Computer architecture Encryption Internet Data communication

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Multi-Material Topology Optimization of 2D Structures Using Convolutional Neural Networks

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1919-1947页

作者： Jiaxiang Luo Weien Zhou Bingxiao du Daokui Li wen Yao College of Aerospace Science and Engineering National University of Defense TechnologyChangsha410073China Defense Innovation Institute Chinese Academy of Military ScienceBeijing100071China Intelligent Game and Decision Laboratory Chinese Academy of Military ScienceBeijing100071China

In recent years,there has been significant research on the application of deep learning(DL)in topology optimization(TO)to accelerate structural ***,these methods have primarily focused on solving binary TO problems,and effective solutions for multi-material topology optimization(MMTO)which requires a lot of computing resources are still ***,this paper proposes the framework of multiphase topology optimization using deep learning to accelerate MMTO *** framework employs convolutional neural network(CNN)to construct a surrogate model for solving MMTO,and the obtained surrogate model can rapidly generate multi-material structure topologies in negligible time without any *** performance evaluation results show that the proposed method not only outputs multi-material topologies with clear material boundary but also reduces the calculation cost with high prediction ***,in order to find a more reasonable modeling method for MMTO,this paper studies the characteristics of surrogate modeling as regression task and classification *** the training of 297 models,our findings show that the regression task yields slightly better results than the classification task in most ***,The results indicate that the prediction accuracy is primarily influenced by factors such as the TO problem,material category,and data ***,factors such as the domain size and the material property have minimal impact on the accuracy.

关键词： Multi-material topology optimization convolutional neural networks deep learning finite element analysis

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Network Pharmacology of Xian-Lian-Jie-du Decoction in Ameliorating Colorectal Cancer

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 83-92页

作者： Ming-Xia Zhao Cheng-Lin Song Qin-Chang Zhang Hao-Jie du Shu-qiong Zhang Yu-Xian Shen Yang Sun Hai-Bo Cheng wen Lv Department of Pharmacy School of Basic Medical SciencesAnhui Medical UniversityHefeiAnhuiChina Department of Biopharmaceutical Research Institute Anhui Medical UniversityHefeiAnhuiChina Department of Pharmaceutical Analysis State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijingChina Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor First Clinical CollegeNanjing University of Chinese MedicineNanjingJiangsuChina Deparment of Biotechnology and Pharmaceutical Sciences State Key Laboratory of Pharmaceutical BiotechnologySchool of Life SciencesNanjing UniversityNanjingJiangsuChina Deparment of Gynecology Institute of Traditional Chinese Medicine of Zhejiang ProvinceTongde Hospital of Zhejiang ProvinceHangzhouZhejiangChina

Objective:In this study,we screened for therapeutic targets of the Xian-Lian-Jie-du decoction(XLJDD)for colorectal cancer(CRC)and explored the underlying mechanisms using network pharmacology ***:Genes associated with CRC were collected from the Gene Cards *** names of the active compounds of XLJDD were used as keywords in the“chemical name”in the Traditional Chinese Medicine Systems Pharmacology(TCMSP)database to search the *** protein-protein interaction(PPI)network was constructed using Cytoscape *** Ontology functional enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were performed to identify key target ***:A total of 234 XLJDD-related targets and 250 cross-targets between XLJDD and CRC were collected based on the TCMSP and HIT 2.0 databases.A PPI network constructed based on the STRING database revealed interactions for all 250 *** network results revealed TP53,MYC,CCND1,AKT1,CASP3,and STAT3 as core potential *** pathway analysis of the 250 potential XLJDD targets for CRC in the Metascape database was performed using RStudio *** top 12 gene ratio aggregated analysis results were visualized in bubble *** interleukin(IL)-17 signaling pathway had the highest correlation with the tumor necrosis factor(TNF)signaling ***:XLJDD may be effective in ameliorating CRC by controlling inflammatory factors related to the IL-17 and TNF pathways and targeting proto-oncogenes and tumor suppressor genes,including MYC,CCND1,CTNNB1,and TP53.

关键词： Colorectal cancer network pharmacology Xian-Lian-Jie-du decoction

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Thermal-force control ability under variation of electromagnetic stick structure parameters in RPECT

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Journal of Iron and Steel Research(International) 2024年第1期31卷 224-236页

作者： Ting-song Yang wen-quan Sun Feng-shan du An-rui He Quan Yang National Engineering Research Center of Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing100083China Institute of Engineering and Technology University of Science and Technology BeijingBeijing100083China College of Mechanical Engineering Yanshan UniversityQinhuangdao066004HebeiChina

Thermal-force driving of roll profile electromagnetic control technology(RPECT),which can be used to adjust the roll profile,can be affected by the sequential temperature rise between the electromagnetic stick(ES)and electromagnetic control *** to the limited space of ES and induction coil,the cross-sectional area of induction coil can be inevitably affected by changing the size of the ES induction zone,which can further change the energy input under the same electromagnetic parameters,the temperature rising effect and the bulging *** investigate this phenomenon,the effects of the radius of the induction zone on the thermal-force contribution ratio,the heating ability of ES and the temperature distribution were analyzed through an electromagnetic-thermal-structural finite element *** ensure that the results are applicable to RPECT,the thermal energy conversion ability and thermal-force roll crown control ability under different lengths of the induction zone were *** was found that whether the current density regulation mode or the current frequency regulation mode is adopted,the cases with 20 or 25 mm radius of the induction zone have the great thermal energy conversion ability and the good thermal-force roll crown control *** reasonable adjustment of the length of the induction zone can reduce the radius required for the maximum energy efficiency *** with the results of the simulation analysis,the optimization of ES based on the control ability maximization requirement is achieved,which provides the base for the design and configuration of ES in RPECT.

关键词： Roll profile electromagnetic control technology Electromagnetic stick Electromagnetic control roll Induction area Thermal-force driving

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Bioinspired zinc-mediated umpolung thiolation of alkyl electrophiles: reaction development, scope and mechanism

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Science China Chemistry 2024年第3期67卷 898-907页

作者： Yuenian Xu Yan Zhang Yong Liu wen-Wu Sun Jie Huang Hui He Yingjie Wu wen Liu Shao-Fei Ni Xu-qiong Xiao Xinxin Shao College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material Technology of Ministry of EducationHangzhou Normal UniversityHangzhou 311121China School of Pharmaceutical Sciences South-Central Minzu UniversityWuhan 430074China Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guang-dong Province Shantou UniversityShantou 515063China

Zinc-promoted umpolung thiolation of alkyl electrophiles with masked sulfur transfer reagents in the absence of nickel or copper catalysis is described. This protocol proceeds via a SET process of Zn to electrophilic sulfur reagent followed by insertion of Zn into disulfide and nucleophilic thiolation, providing straightforward access to a wide range of alkyl sulfides with broad substrate scope. A neutral TMEDA-ligated four-coordinated zinc thiolate with tetrahedra geometry was synthesized, isolated and fully characterized by NMR, IR and X-ray analysis. More importantly, the chemical reactivity of this active intermediate has been investigated, enabling the construction of C-Se, C-Te, Sb-S and Bi-S bonds to prepare valuable sulfur-containing molecules and beyond.

关键词： umpolung thiolation C(sp^(3))-S bond formation masked sulfur reagents reductive coupling

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Tuning heterogeneous microstructures to enhance mechanical properties of nano-TiN particle reinforced Haynes 230 composites by laser powder bed fusion

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Rare Metals 2024年第9期43卷 4548-4565页

作者： wen-Jie Liu Hui Li Qian-Xing Yin He-Jun du School of Power and Mechanical Engineering Wuhan University The Institute of Technological Sciences Wuhan University School of Mechanical&Aerospace Engineering Nanyang Technological University

Laser powder bed fusion(LPBF) is considered to be one of the most promising additive manufacturing technologies for producing components with geometries and high geometrical precision that are unattainable by traditional technologies. The superalloy exhibits exceptional mechanical and high-temperature performances,rendering it a prime candidate for advanced aero-engine applications. Despite the high demand for LPBF-manufactured superalloys, the superalloy is one of the materials manufactured difficultly by LPBF due to their large laser absorptivity fluctuation, poor molten pool stability and sharp temperature gradient. Hence, superalloys are characterized by severe pores, undesirable coarse columnar grains and poor mechanical properties. In this work, the effect of nano-Ti N particles on defects, molten pool characteristics and microstructure and performance of the composites were investigated. The 4.5 wt% Ti N/Haynes230 samples exhibited exceptional nanohardness and elastic modulus with maximum values reaching 5.53 GPa and 240.03 GPa, respectively. These superior mechanical properties were attributed to the combined effects of spatter and gas pore inhibition, grain refinement and duplex nanophases strengthening. Moreover, the stability of molten pool was enhanced, and spatter was effectively suppressed by adding nano-Ti N particles, while grain refinement and columnar to equiaxed transitions were promoted. Furthermore, the matrix exhibited a high dislocation density due to a significant hindrance of dislocation movement caused by massive nano-phases(e.g., Ti N and M23C6), resulting in the formation of extensive dislocation tangles and *** work offers novel insights into the role of nanoparticles reinforced superalloy composites by LPBF.

关键词： Composites Laser powder bed fusion Molten pool characteristics Microstructure Mechanical properties PERFORMANCE EVOLUTION ALLOYS

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Bimetallic NiCoP catalysts anchored on phosphorus-doped lignin-based carbon for robust oxygen evolution performance

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Rare Metals 2024年第7期43卷 3084-3095页

作者： Ling-Ying-Zi Xiong Bo-wen Liu Lei du Yue-Kuan Zhou Xu-Liang Lin Huan Wang Guangdong Engineering Technology Research Center for Sensing Materials&Devices Guangzhou Key Laboratory of Sensing Materials&DevicesSchool of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhou 510006China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Jieyang 515200China Sustainable Energy and Environment Thrust Function HubThe Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Division of Emerging Interdisciplinary Areas Department of Mechanical and Aerospace EngineeringThe Hong Kong University of Science and TechnologyHong Kong 999077China State Key Lab of Pulp and Paper Engineering South China University of TechnologyGuangzhou 510640China

Oxygen evolution reaction(OER)catalysts are the key core materials that determine the performance of fuel cells,metal-air batteries,electrolytic water decomposition,and other *** this work,a green lignin-based non-precious metal OER catalyst was prepared by a simple ***,c arboxylated lignin was used to complex Ni and Co in situ,and then they were placed with sodium hypophosphite in the same tube furnace for upstream and downstream high-temperature calcination to construct a lignin carbon-based Ni-Co bimetallic OER catalyst(NiCoP@C).The synthesized catalyst is a porous bimetallic phosphide with a three-dimensional network structure and high-density electrochemical active ***@C exhibited favorable catalytic activity for the oxygen evolution reaction(OER)with overpotential of 280 mV at 10 mA·cm~(-2)and a Tafel slope of 77 mV·dec~(-1).Additionally,it exhibited remarkable durability during *** functional theory(DFT)calculations revealed that by leveraging the distinctive structure of transition metal phosphide nanoparticles incorporated into a reticulated substrate,the NiCoP@C catalyst offered an increased number of active sites for OER catalysis,significantly enhancing its stability during practical *** present study broadens the utilization pathways of biomass to"turn waste into treasure,"aligning the development concept of green sustainable development.

关键词： Oxygen evolution reaction Lignin Carbon-based catalyst Nickel-cobalt bimetal Metal phosphide

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