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Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen Luo xueran Kang Renwen Wan Fangqi Li Weiwei Lin Zhihua Han Beijie qi Jinrong Lin Yaying Sun Jiebin Huang Yuzhen xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

基于光学视频的冰区核电海面浮冰监测与分析系统设计

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海洋环境科学 2017年第5期36卷 791-795页

作者：刘雪琴袁帅史文奇王旭许宁陈元陈伟斌国家海洋环境监测中心辽宁大连116023 辽宁红沿河核电有限公司辽宁瓦房店116319

随着能源需求的不断扩大,大型核电工程已逐渐向有冰海域分布。海冰是有冰海域海洋活动的首要灾害性环境要素,冰区核电站正常运行的首要问题是如何保障冷源取水不受海冰灾害影响而失效。本文根据冰区海水直接利用工程的监测需求,分析了... 详细信息

随着能源需求的不断扩大,大型核电工程已逐渐向有冰海域分布。海冰是有冰海域海洋活动的首要灾害性环境要素,冰区核电站正常运行的首要问题是如何保障冷源取水不受海冰灾害影响而失效。本文根据冰区海水直接利用工程的监测需求,分析了光学视频在特定小区域海面浮冰监测中的优势,并基于海冰灾害风险评估的理论框架和信息处理流程,初步设计了冰区核电海面浮冰监测与分析系统。系统建成后,结合实时监测数据和风险评估数据库,可以快速提供冷源取水堵塞风险和预警信息,为企业和有关部门及时有效的采取防灾措施提供依据。

关键词：海冰灾害冰区监测风险系统设计

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病险水库除险加固设计新方法及新思路

黑龙江科学 2018年第13期9卷 92-93页

作者：温旭启杨庆华齐齐哈尔市水利勘测设计研究院有限责任公司黑龙江齐齐哈尔161006

分析了病险水库除险加固设计工作中存在的问题,提出了提升对病险水库除险加固设计重要性的认知水平,强化病险水库除险加固设计现场的管理和检查工作,强调安全鉴定报告在病险水库除险加固设计的中心作用,加强病险水库除险加固设计的外部... 详细信息

分析了病险水库除险加固设计工作中存在的问题,提出了提升对病险水库除险加固设计重要性的认知水平,强化病险水库除险加固设计现场的管理和检查工作,强调安全鉴定报告在病险水库除险加固设计的中心作用,加强病险水库除险加固设计的外部环境干预,加强病险水库除险加固设计的工作总结等措施和办法,为加强病险水库除险加固设计工作提供了新的思路和方法。

关键词：病险水库除险加固管理设计

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分布式能源站电动汽车充电站配电设计

节能 2018年第6期37卷 13-15页

作者：任其文徐从周山东电力工程咨询院有限公司山东济南250013

分布式能源站是一种分布在用户端的能源供应方式,项目建设地点多位于人员较为密集区域,人员往来及车辆进出较为频繁。随着人们环保意识的增强,电动汽车的市场占有率迅速上升。近年来,分布式能源站批量上马,配建电动汽车充电设施,呈现方... 详细信息

分布式能源站是一种分布在用户端的能源供应方式,项目建设地点多位于人员较为密集区域,人员往来及车辆进出较为频繁。随着人们环保意识的增强,电动汽车的市场占有率迅速上升。近年来,分布式能源站批量上马,配建电动汽车充电设施,呈现方兴未艾的态势。充电设施从站用电引接电源,其配电设计有别于常规电厂配套辅机。通过研究充电站配电设计的关键问题,重点推导了充电站负荷计算公式,可为类似工程的设计提供参考。

关键词：分布式能源站充电站负荷计算配电设计

金属内支架治疗胃癌术后吻合口恶性梗阻15例

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世界华人消化杂志 2009年第14期17卷 1454-1457页

作者：乞文旭马跃石喻郭启勇刘兆玉卢再鸣张军中国医科大学附属盛京医院放射科辽宁省沈阳市110004

目的:探讨金属内支架在治疗胃癌术后吻合口恶性梗阻中的作用、疗效和并发症.方法:在X光监视下或胃镜引导下,对胃癌术后吻合口狭窄15例患者置入自扩张金属支架评估其技术及临床的成功率、并发症,并通过Kaplan-Meier方法计算生存期及支架... 详细信息

目的:探讨金属内支架在治疗胃癌术后吻合口恶性梗阻中的作用、疗效和并发症.方法:在X光监视下或胃镜引导下,对胃癌术后吻合口狭窄15例患者置入自扩张金属支架评估其技术及临床的成功率、并发症,并通过Kaplan-Meier方法计算生存期及支架开通率.结果:15例患者中13例(86.7%)支架置入成功支架置入后,12例(92.3%)患者梗阻症状得到改善,在随访期(2-66wk),3例(23%)患者出现腹痛,2例(15.4%)患者支架发生迁移,1例(8%)出现肿瘤过度生长导致的支架阻塞,2例(15.4%)患者出现消化系出血.中位生存期和支架开通时间分别为87、140d.结论:介入方法放置金属内支架姑息治疗癌术后的吻合口恶性狭窄患者,可显著恢复患者经口摄食,并可提高生活质量.

关键词：支架胃癌吻合口狭窄

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu wen-qiang xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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Trichorrhexis nodosa examined by scanning electron microscopy

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International Journal of Dermatology and Venereology 2018年第4期1卷 240-242页

作者： Guan-Zhao Liang wen-qi xu Xiao-Li Zheng Jia Liu Gui-Xia Lv Yong-Nian Shen Wei-Da Liu Dong-Mei Shi Department of Mycology Hospital for Skin Diseases (Institute of Dermatology) Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing Jiangsu 210042 China Department of Dermatology The Affiliated Hospital of Qingdao University Qingdao Shandong 266000 China Department of Dermatology Jining No.1 People’s Hospital Jining Shandong 272011 China

Introduction Trichorrhexis nodosa (TN), one of the most common hair shaft anomalies, was first identified by Samuel Wilks in 1852(1)As either a congenital or acquired hair shaft disorder, TN is characterized by fragile and easily broken hair accompanied by frayed cortical fibers and loss of the cuticle(2)Complete fracture of the hair shaft subsequently occurs. Moreover, hair shaft fragility may increase the risk of developing TN. Congenital TN, including trichothiodystrophy[3], argininosuccinic aciduria[4], Menkes syndrome[5] and trichohepatoenteric syndrome[6], is rare in the clinical setting. Acquired TN, which is provoked by hair injury secondary to physical or chemical trauma (usually physical trauma), is often overlooked in daily life. We herein reported a case of TN in a woman with androgenetic alopecia.

关键词： hair TN shaft nodosa physical

A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： Quan Shi Yun-Hao xu Ming-Hui Chen Peng Zhao wen-Bo Deng Ji Xiong Kai Guo Ya-qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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