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Young patient with a giant gastric bronchogenic cyst:A case report and review of literature

World Journal of Clinical Cases 2024年第13期12卷 2254-2262页

作者： Xu-Ren Lu Xu-Guang Jiao Qi-Hang Sun Bo-wen li Qing-Shun Zhu Guang-Xu Zhu Jian-Jun Qu School of Clinical Medicine Shandong Second Medical UniversityWeifang 261000Shandong ProvinceChina Department of Gastrointestinal Surgery Medical Center The First Affiliated HospitalShandong Second Medical UniversityWeifang 261000Shandong ProvinceChina

BACKGROUND Gastric bronchogenic cysts(BCs)are extremely rare cystic masses caused by abnormal development of the respiratory system during the embryonic *** bronchial cysts are rare lesions that were first reported in 1956;as of 2023,only 33 cases are available in the PubMed online *** usually have no clinical symptoms in the early stage,and imaging findings also lack ***,they are difficult to diagnose before histopathological *** SUMMARY A 34-year-old woman with respiratory distress presented at our *** ultrasound revealed an anechoic mass between the spleen,left kidney and gastric fundus,with hyperechogenic and soft elastography textures and with a size of approximately 6.5 cm×4.0 ***,a computed tomography scan demonstrated high density between the posterior stomach and the spleen and the left kidney,with uniform internal density and a small amount of *** maximum cross section was approximately 10.1 cm×6.1 cm,and the possibility of a cyst was *** the imaging findings did not suggest a malignancy and because the patient required complete resection,she underwent laparotomy ***,this cystic lesion was found to be located in the posterior wall of the large curvature of the fundus and was approximately 8 cm×6 cm in ***,the pathologists verified that the cyst in the fundus was a gastric *** patient recovered well,her symptoms of chest tightness disappeared,and the abdominal drain was removed on postoperative day 6,after which she was discharged on day 7 for 6 months of *** had no tumor recurrence or postoperative complications during the *** This is a valuable report as it describes an extremely rare case of gastric ***,this was a very young patient with a large BC in the stomach.

关键词： Bronchogenic cyst Stomach Endoscopic ultrasound-guided fine needle aspiration Endosonography Case report

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Deciphering the role of FSCN family genes in cancer:a pan-cancer bioinformatics study

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Medical Data Mining 2024年第4期7卷 10-18页

作者： wen-Shuai Zhang Dan-Yang Ren Xin li Department of Pathology Tianjin Cancer Hospital Airport HospitalTianjin 300308China National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and HospitalKey Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin 300060China

Background:The Fascin(FSCN)family,comprising actin-bundling proteins,plays vital roles in cytoskeletal reorganization and cell ***1,FSCN2,and FSCN3 are implicated in cancer progression through cell motility,invasion,and ***,their specific contributions across different cancer types remain ***:We conducted a pan-cancer bioinformatics analysis of FSCN genes using data from The Cancer Genome *** included differential expression patterns,copy number variations(CNVs),mutations,methylation status,and correlations with tumor mutational burden,microsatellite instability,and immune checkpoint molecule *** expression was analyzed using DESeq2,while CNV and mutation analyses utilized GISTIC2.0 and *** data were assessed using the Illumina Human Methylation 450K ***:FSCN1 and FSCN2 showed significant differential expression in multiple cancers,often correlating with poor ***3 exhibited less variability but a protective role in certain *** analysis indicated frequent gene gains in FSCN genes,correlating with increased ***3 had a higher mutation rate,suggesting genetic *** analysis showed hypomethylation of FSCN1 and FSCN2 in tumors compared to normal tissues,whereas FSCN3 had minor *** associations were found between FSCN gene expression and tumor mutational burden,microsatellite instability,and immune checkpoint molecules,suggesting their involvement in tumor immunogenicity and the immune ***:This pan-cancer analysis highlights the multifaceted roles of FSCN genes in cancer biology,emphasizing their potential as biomarkers and therapeutic ***1 and FSCN2 are associated with poor prognosis and aggressive phenotypes,while FSCN3 shows protective roles in specific *** findings offer new avenues for cancer diagnosis and treatment,particularly in personalized *** studie

关键词： Fascin family pan-cancer analysis gene expression copy number variation tumor mutational burden

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N-doped hollow carbon nanospheres embedded in N-doped graphene forming a three-dimensional interconnected layered porous support loaded with palladium nanoparticles as an efficient electrocatalyst for formic acid oxidation

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新型炭材料(中英文) 2024年

作者： FANG Yue YANG Fu-kai QU Wei-li DENG Chao wang Zhen-bo Key Laboratory of Photochemical Biomaterials and Energy Storage Materials Shenzhen Key Laboratory of Special Functional Materials Shenzhen Engineering Laboratory for Advance Technology of Ceramics Guangdong Research Center for Interfacial Engineering of Functional Materials College of Materials Science and Engineering Shenzhen University MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical Engineering State Key Lab of Urban Water Resource and Environment Harbin Institute of Technology College of Chemistry and Chemical Engineering Harbin Normal University No.1 Normal University South Road

The efficient electrocatalysts with low cost, high activity and good durability plays a crucial role in the application of direct formic acid fuel cells. Herein, Pd nanoparticles supported on N-doped hollow carbon nanospheres (NHCN) embedded in Ndoped graphene (NG) with three-dimensional (3D) layered porous configuration by a simple and economical method were investigated as direct formic acid fuel cell catalysts. Owing to the unique 3D interconnected layered porous configuration doped with nitrogen atoms, Pd/NHCN@NG catalyst with smaller Pd nanoparticle size shows large catalytic active surface area, superior electrocatalyticactivity,highsteady-statecurrentdensity,strongabilitytoresistCOpoisoning,farsurpassingthoseofconventionalPd/C,Pd/NG,andPd/***/GOratio,itisfoundthatwhenthe HCN/GO mass ratio is 1∶1, Pd/NHCN@NG catalyst has the most outstanding performance in catalytic oxidation of formic acid,with an activity 4.21 times that of Pd/C. This work has developed a superior carbon-based support material for electrocatalysts, which brings broad application prospects for the development of fuel cells.

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Efficient Photolytic Halogenation and Oxidation of Unactivated Alkyl sp^(3) C—H Bonds with Iodine(III)

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Chinese Journal of Chemistry 2024年第5期42卷 505-510页

作者： Hao Jia Nan li Chunmei Tang Yajuan wang Yonghao Xi Rongbao liao Wei Xu Fufang Wu Xiaobao Shen Hongbin Zhai Biomass Oligosaccharides Engineering Technology Research Center of Anhui Province Engineering Research Center of Biomass Conversion and Pollution Prevention of Anhui Educational InstitutionsFuyang Normal UniversityFuyangAnhui236037 China Institute of Marine Biomedicine Shenzhen PolytechnicShenzhenGuangdong518055 China State Key Laboratory of Chemical Oncogenomics Shenzhen Engineering Laboratory of Nano Drug Slow-ReleasePeking University Shenzhen Graduate SchoolShenzhenGuangdong518055 China

A metal-free,green,and sustainable functionalization of unactivated alkyl sp^(3) C—H bonds is reported using iodine(III)as a feasible dehydrogenation agent under visible light or KBr,and alkyl chlorides,bromides,alcohols,and ketones could be constructed by addition of different coupling *** and safe iodobenzene diacetate was used to form a radical to activate the alkyl sp^(3) C—H bond in a highly efficient manner,which can construct different alkylation products by adding corresponding coupling reagents.

关键词： Alkyl sp^(3)C—H bonds Chlorination Bromination Oxidation Iodine(III) C—H activation Radical Photocatalysis

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Research on the cuttings discharge in air cushion chamber of slurry shield based on CFD-DEM coupling method Author links open overlay panel

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Particuology 2024年第8期91卷 88-105页

作者： Han wang Wantao Ding Weimin Yang Chengzhen wang wenduan Yu Zhicheng wang School of Qilu Transportation Shandong UniversityJinan250002China China Railway 14th Bureau Group Co. LtdJinan250101China

The rapid discharge of cuttings from the air cushion chamber is crucial for the construction safety and excavation efficiency of the slurry *** studies have mainly focused on the transport characteristics of cuttings in the slurry discharge pipe,while the complete process of cuttings entering the slurry discharge pipe from the air cushion chamber until they are discharged was often *** on the CFD-DEM coupling method and combined with actual engineering,this paper established a numerical model that can more completely reflect the cuttings discharge process during slurry shield tunneling,and the effects of the slurry velocity at slurry gate and scouring pipes,inclination angle of slurry discharge pipe,cuttings diameter and shape coefficient were investigated by analyzing the variation in the mass flow rate,mass of discharged cuttings,and discharged *** results revealed that increasing the slurry velocity can promote the discharge of *** keep the discharged rate at a high level,it is recommended that the slurry velocity at the slurry gate should be greater than 0.15 m/*** the inclination angle of the discharge pipe is conducive to the rapid discharge of *** with large diameter or small shape coefficient are more prone to accumulate in the air cushion chamber and cause clogging *** research results not only help to improve engineers'understanding of cuttings discharge in slurry shield,but also provide practical guidance for formulating relevant construction measures.

关键词： Slurry shield CFD-DEM coupling method Cuttings discharge Aircushion chamber Slurry discharge pipe

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The effect of intraoperative goal-directed fluid therapy in patients under anesthesia for gastrointestinal surgery

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2815-2822页

作者： Jun Zhang Xiao-wen li Bing-Feng Xie Department of Anesthesiology The Second Hospital of LongyanLongyan 364000Fujian ProvinceChina Department of Gastrointestinal Surgery Longyan First HospitalLongyan 364000Fujian ProvinceChina

BACKGROUND Intraoperative fluid management is an important aspect of anesthesia mana-gement in gastrointestinal *** goal-directed fluid therapy(GDFT)is a method for optimizing a patient's physiological state by monitoring and regulating fluid input in *** To evaluate the efficacy of intraoperative GDFT in patients under anesthesia for gastrointestinal *** This study utilized a retrospective comparative study design and included 60 patients who underwent gastrointestinal surgery at a *** experimental group(GDFT group)and the control group,each comprising 30 patients,received intraoperative GDFT and traditional fluid management strategies,*** effect of GDFT was evaluated by comparing postoperative recovery,com-plication rates,hospitalization time,and other indicators between the two patient *** Intraoperative blood loss in the experimental and control groups was 296.64±46.71 mL and 470.05±73.26 mL(Pliver,pancreas,spleen,and other internal abdominal organs[2,3].With advancements in surgical technology and anesthesia methods,the safety and success rates of surgery have significantly improved[4,5].However,intraop-erative fluid management remains a critical challenge[6].Traditional fluid management strategies often rely on experience and basic physiological parameters,which may lead to excessive or insufficient fluid input,thereby affecting p

关键词： Intraoperative goal-directed fluid therapy Gastrointestinal surgery Anesthesia management Postoperative recovery Complications Length of stay

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Inetetamab combined with sirolimus and chemotherapy for the treatment of HER2‐positive metastatic breast cancer patients with abnormal activation of the PI3K/Akt/mTOR pathway after trastuzumab treatment

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Cancer Innovation 2024年第5期3卷 102-111页

作者： Qiao li Dan Lv Xiaoying Sun Mengyuan wang li Cai Feng liu Chenghui li Jiuda Zhao Jing Sun Yehui Shi Fei Ma Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Medical Oncology Cancer Hospital of Huanxing Chaoyang DistrictBeijingChina Department of Breast Surgery Chongqing University Three Gorges HospitalChongqing UniversityWanzhouChina Department of Medical Oncology The Affiliated Tumour Hospital of Harbin Medical UniversityHarbinChina Department of Breast Surgery Fuyang Cancer HospitalFuyangChina Department of Medical Oncology Anqing Hospital Affiliated to Medical University of AnhuiAnqingChina Affiliated Hospital of Qinghai University Affiliated Cancer Hospital of Qinghai UniversityXiningChina Department of Medical Oncology Anyang Cancer HospitalAnyangChina Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerTianjinChina

Background:We explored the efficacy and safety of inetetamab combined with sirolimus and chemotherapy for the treatment of human epidermal factor receptor 2(HER2)‐positive metastatic breast cancer patients with abnormal activation of the PI3K/Akt/mTOR(PAM)pathway after trastuzumab ***:For this prospective multicenter clinical study,HER2‐positive metastatic breast cancer patients with PAM pathway mutations confirmed by histology or peripheral blood genetic testing were enrolled from July 2021 to September *** were randomly assigned to a trial or control *** patients in the trial group received inetetamab combined with sirolimus and chemotherapy,while the control group patients received pyrotinib and *** RECIST v1.1 standard was used to evaluate *** statistics were used to summarize the clinicopathological features,and the Kaplan–Meier method was used to generate survival *** log‐rank test was used to compare progression‐free survival(PFS)between the two ***:A total of 59 HER2‐positive metastatic breast cancer patients with abnormal activation of the PAM pathway were included,of which 37 received inetetamab combined with sirolimus and chemotherapy treatment and 22 received pyrotinib and chemotherapy *** median PFS was 4.64 months in the inetetamab group and 5.69 months in the pyrotinib group,with no statistically significant difference(p=0.507).The objective response rates were 27.3%for the inetetamab group and 29.4%for the pyrotinib *** safety assessment indicated that the adverse event(AE)incidences were 86.1%(31/36)in the inetetamab group and 78.9(15/19)in the pyrotinib group,with 9(25%)and four(21.1%)Grade 3/4 AEs in the inetetamab and pyrotinib groups,***:For metastatic HER2‐positive breast cancer patients with abnormal PAM pathway activation and previous trastuzumab treatment,the combination of inetetamab with sirolimus and chemotherapy is equivalen

关键词： chemotherapy inetetamab metastatic HER2‐positive breast cancer PAM pathway pyrotinib sirolimus

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A review of solid-state lithium metal batteries through in-situ solidification

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Science China Chemistry 2024年第1期67卷 67-86页

作者： Pan Xu Zong-Yao Shuang Chen-Zi Zhao Xue li li-Zhen Fan Aibing Chen Haoting Chen Elena Kuzmina Elena Karaseva Vladimir Kolosnitsyn Xiaoyuan Zeng Peng Dong Yingjie Zhang Mingpei wang Qiang Zhang Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China National and Local Joint Engineering Laboratory for lithium-ion Batteries and Materials Preparation Technology Key Laboratory of Advanced Battery Materials of Yunnan ProvinceFaculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming 650093China Institute of Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018China Ordos Carbon Neutral Research and Application Co. Ltd.Ordos City 017010China Ufa Institute of Chemistry UFRC RAS Ufa 450054Russia Institute for Carbon Neutrality Tsinghua UniversityBeijing 100084China Shanxi Research Institute for Clean Energy Tsinghua UniversityTaiyuan 030032China

High-energy-density lithium metal batteries are the next-generation battery systems of choice,and replacing the flammable liquid electrolyte with a polymer solid-state electrolyte is a prominent conduct towards realizing the goal of high-safety and high-specific-energy ***,the inherent intractable problems of poor solid-solid contacts between the electrode/electrolyte and the growth of li dendrites hinder their practical *** in-situ solidification has demonstrated a variety of advantages in the application of polymer electrolytes and artificial interphase,including the design of integrated polymer electrolytes and asymmetric polymer electrolytes to enhance the compatibility of solid–solid contact and compatibility between various electrolytes,and the construction of artificial interphase between the li anode and cathode to suppress the formation of li dendrites and to enhance the high-voltage stability of polymer *** review firstly elaborates the history of in-situ solidification for solid-state batteries,and then focuses on the synthetic methods of solidified ***,the recent progress of in-situ solidification technology from both the design of polymer electrolytes and the construction of artificial interphase is summarized,and the importance of in-situ solidification technology in enhancing safety is ***,prospects,emerging challenges,and practical applications of in-situ solidification are envisioned.

关键词： in-situ solidification polymer electrolyte artificial solid electrolyte interphase rechargeable lithium metal batteries dendrite-free lithium metal anode

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Resist Thermal Shock Through Viscoelastic Interface Encapsulation in Perovskite Solar Cells

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Energy & Environmental Materials 2024年第6期7卷 238-245页

作者： Sai Ma Jiahong Tang Guizhou Yuan Ying Zhang Yan wang Yuetong Wu Cheng Zhu Yimiao wang Shengfang Wu Yue Lu Shumeng Chi Tinglu Song Huanping Zhou Manling Sui Yujing li Qi Chen Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications MIIT Key Laboratory for Low-dimensional Quantum Structure and DevicesExperimental Center of Advanced MaterialsSchool of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Microstructure and Properties of Solids College of Materials Science and EngineeringBeijing University of TechnologyBeijing 100124China Analysis and Testing Center Jiangnan UniversityWuxi 214122China School of Materials Science and Engineering Peking UniversityBeijing 100871China

Enhancing the lifetime of perovskite solar cells(PSCs)is one of the essential challenges for their *** the external encapsulation protects the perovskite device from the erosion of moisture and oxygen under various harsh ***,the perovskite devices still undergo static and dynamic thermal stress during thermal and thermal cycling aging,respectively,resulting in irreversible damage to the morphology,component,and phase of stacked ***,the viscoelastic polymer polyvinyl butyral(PVB)material is designed onto the surface of perovskite films to form flexible interface *** PVB interface encapsulation,the surface modulus of perovskite films decreases by nearly 50%,and the interface stress range under the dynamic temperature field(−40 to 85°C)drops from−42.5 to 64.8 MPa to−14.8 to 5.0 ***,PVB forms chemical interactions with FA+cations and Pb^(2+),and the macroscopic residual stress is regulated and defects are reduced of the PVB encapsulated perovskite *** a result,the optimized device's efficiency increases from 22.21%to 23.11%.Additionally,after 1500 h of thermal treatment(85°C),1000 h of damp heat test(85°C&85%RH),and 250 cycles of thermal cycling test(−40 to 85°C),the devices maintain 92.6%,85.8%,and 96.1%of their initial efficiencies,respectively.

关键词： device stability perovskite solar cells stress field surface modulus thermal shock

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A novel micro-rolling&incremental sheet forming hybrid process:Deformation behavior and microstructure evolution

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Chinese Journal of Aeronautics 2024年第5期37卷 603-622页

作者： Yanle li Feifei liU Hao YUAN Xiaoqiang li Jianfeng li Guoqun ZHAO Key Laboratory of High Efficiency and Clean Mechanical Manufacture Ministry of EducationShandong UniversityJi'nan 250061China School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Key Laboratory for liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong UniversityJi'nan 250061China

Thin-walled metal parts with functional micro-featured surface have broad application prospects in the fields of resistance reduction,noise reduction,*** this study,a novel micro-rolling&incremental sheet forming hybrid process(μR-ISF)is proposed to fabricate thin-walled metal parts with microgroove *** analytical model which relates the rolling force and microgroove depth in the micro-rolling stage was first ***,the formation mechanism of microgroove morphology during both micro-rolling stage and macro-shape forming stage are *** the micro-grooved sheet being incrementally formed,a significant reduction(between 21%to nearly 60%)is occurred in the depth of both transverse and longitudinal grooves compared to the flat ***,the width of transverse grooves decreases slightly by about 10%on average,while the width of longitudinal microgrooves increases significantly by more than 30%on *** micro-rolling,85°{102}tensile twins appear on the micro-grooved sheet and the percentage of 65°{112}compressive twins *** incremental forming,the percentage of low-angle grain boundaries and the density of geometrically necessary dislocations in the formed part increase significantly,and the grain size distribution becomes more *** present work provides a new strategy for the fabrication of 3D metal thin-walled components with surface micro-features.

关键词： Incremental sheet forming Microgrooves rolling Surface micromachining Groove size Microstructural evolution

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