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漯河市典型工业源挥发性有机物源成分谱特征及影响

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环境科学 2024年第8期45卷 4484-4492页

作者：杜宇彬吴丽萍牛大伟冷海斌薛爽张楠杨文中国环境科学研究院北京100012 天津城建大学环境与市政工程学院天津300384 漯河市环境监控中心漯河462000

选取漯河市10类典型工业企业开展有组织排放挥发性有机物(VOCs)样品采集,分析各行业VOCs排放特征及其影响.结果表明,包装印刷行业排放VOCs以OVOC(60.9%)为主;工业涂装行业VOCs排放以芳香烃(42.4%)和OVOC(38.9%)为主;制鞋、家具制造和造... 详细信息

选取漯河市10类典型工业企业开展有组织排放挥发性有机物(VOCs)样品采集,分析各行业VOCs排放特征及其影响.结果表明,包装印刷行业排放VOCs以OVOC(60.9%)为主;工业涂装行业VOCs排放以芳香烃(42.4%)和OVOC(38.9%)为主;制鞋、家具制造和造纸行业的VOCs排放特征相似,以OVOC(32.3%~42.6%)和芳香烃(20.7%~33.7%)为主,且卤代烃排放也不容忽视;化工和制药行业排放的VOCs中卤代烃占比最高,分别为59.3%和46.6%;砖瓦制品行业的VOCs排放以烷烃为主(62.7%);热力生产与供应行业的VOCs排放特征以OVOC(48.5%)为主,其次为卤代烃(19.7%);食品制造行业的VOCs排放则以OVOC(48.1%)和烷烃(29.4%)为主.不同行业的VOCs特征物种存在差异,但整体上,丙酮、异丙醇、苯、甲苯、间/对-二甲苯、乙烷、乙醛和二氯甲烷是漯河市多数行业VOCs排放的特征物种.漯河市典型工业有组织排放的VOCs对臭氧生成潜势贡献较大的组分以OVOC和芳香烃为主,对二次有机气溶胶生成潜势较大的组分为芳香烃.食品制造和家具制造行业排放的VOCs生成O_(3)的源活性因子[SR(O_(3))]较高,分别为3.7g·g^(-1)和3.5 g·g^(-1);工业涂装、家具制造和制鞋行业排放的VOCs生成二次有机气溶胶的源活性因子[SR(SOA)]较高,分别为0.021、0.017和0.014 g·g^(-1);基于PM_(2.5)和O_(3)协同管控视角,食品制造、工业涂装和家具制造是漯河市应当优先管控的行业,家具制造行业则是优控行业中的重中之重.

关键词：挥发性有机物(VOCs) 工业排放源成分谱臭氧生成潜势(OFP) 二次有机气溶胶生成潜势(SOAP)

Numerical Modeling of the Undertow Structure and Sandbar Migration in the Surfzone

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China Ocean Engineering 2017年第5期31卷 549-558页

作者： XIE Ming-xiao zhang Chi YANG Zhi-wen LI Shan LI Xin GUO Wei-jun ZUO Shu-hua Key Laboratory of Engineering Sediment Tianjin Research Institute for Water Transport EngineeringM.O.T. National Engineering Laboratory for Port Hydraulic Construction Technology Tianjin Research Institute for Water Transport EngineeringM.O.T. State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Nanjing Hydraulic Research Institute State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University Key Laboratory of Coastal Engineering Hydrodynamics of CCCC Tianjin Port Engineering InstituteCCCC College of Environmental Sciences and Engineering Dalian Maritime University

A process-based 3D numerical model for surfzone hydrodynamics and beach evolution was established. Comparisons between the experimental data and model results proved that the model could effectively describe the hydrodynamics, sediment transport feature and sandbar migration process in the surfzone with satisfactory precision. A series of numerical simulations on the wave breaking and shoaling up to a barred beach were carried out based on the model system. Analyzed from the model results, the wave-induced current system in the surfzone consists of two major processes, which are the phase-averaged undertow caused by wave breaking and the net drift caused by both of the nonlinear wave motion and surface roller effect. When storm waves come to the barred beach, the strong offshore undertow along the beach suppresses the onshore net drift, making the initial sandbar migrate to the seaside. Under the condition of calm wave environment, both the undertow and net drift flow to the shoreline at the offshore side of the sandbar, and then push the initial sandbar to the shoreline. The consideration of surface roller has significant impact on the modeling results of the sandbar migration. As the roller transfer rate increases, the sandbar moves onshore especially under the storm wave condition.

关键词： process-based numerical model undertow net driit sediment wansport sandbar migration

Evidence-based expert consensus on clinical management of safety of Bruton’s tyrosine kinase inhibitors(2024)

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Chinese Journal of Cancer Research 2024年第3期36卷 240-256页

作者： Zaiwei Song Dan Jiang Lingling Yu Yixuan Chen Daobin Zhou Yue Li Depei Wu Lingli zhang Liyan Miao jun Ma jun Zhu Hongmei Jing Rongsheng Zhao the Steering Committee,the Consensus Panel and the Evidence Synthesis Group Evidence-based Pharmacy Professional Committee of Chinese Pharmaceutical Association(CPA) Hospital Pharmacy Professional Committee of Chinese Pharmaceutical Association(CPA) Division of Therapeutic Drug Monitoring of Chinese Pharmacological Society(CPS) Expert Committee on Lymphoma of Chinese Society of Clinical Oncology(CSCO) Expert Committee on Leukemia of Chinese Society of Clinical Oncology(CSCO) Society of Integrative Cardio-Oncology of China Anti-Cancer Association(CACA) Chinese Society of Hematology of Chinese Medical Association(CMA) Hospital Pharmacy Professional Committee of Cross-Straits Medicine Exchange Association(SMEA) Department of Pharmacy Peking University Third HospitalBeijing 100191China Institute for Drug Evaluation Peking University Health Science CenterBeijing 100191China Therapeutic Drug Monitoring and Clinical Toxicology Center Peking UniversityBeijing 100191China Department of Pharmacy Administration and Clinical Pharmacy School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Hematology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Department of Cardiology the First Affiliated HospitalHarbin Medical UniversityHarbin 150001China Department of Hematology the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Pharmacy Evidence-based Pharmacy CenterWest China Second HospitalSichuan UniversityChengdu 610041China Department of Pharmacy the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Hematology and Oncology Harbin Institute of Hematology and OncologyHarbin 150010China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of LymphomaPeking University Cancer Hospital&InstituteBeijing 100142China Department of Hematology Peking University Third HospitalBeijing 100191China 不详

Bruton’s tyrosine kinase inhibitors(BTKis)have revolutionized the treatment of B-cell ***,safety issues related to the use of BTKis may hinder treatment continuity and further affect clinical efficacy.A comprehensive and systematic expert consensus from a pharmacological perspective is lacking for safety issues associated with BTKi treatment.A multidisciplinary consensus working group was established,comprising 35 members from the fields of hematology,cardiovascular disease,cardio-oncology,clinical pharmacy,and evidencebased *** evidence-based expert consensus was formulated using an evidence-based approach and the Delphi *** Joanna Briggs Institute Critical Appraisal(JBI)tool and Grading of Recommendations Assessment,Development,and Evaluation(GRADE)approach were used to rate the quality of evidence and grade the strength of recommendations,*** consensus provides practical recommendations for BTKis medication based on nine aspects within three domains,including the management of common adverse drug events such as bleeding,cardiovascular events,and hematological toxicity,as well as the management of drug-drug interactions and guidance for special *** multidisciplinary expert consensus could contribute to promoting a multi-dimensional,comprehensive and standardized management of BTKis.

关键词： Consensus BTK inhibitors safety adverse drug events drug-drug interactions

见血清提取物对LPS诱导BV-2小胶质细胞介导神经炎症的作用及成分分析

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中国中药杂志 2024年第11期49卷 3050-3060页

作者：孔帅文张源曾炼陈曦荣王海靖蔡和伦郝新才张瑜湖北医药学院药学院武当特色中药研究湖北省重点实验室湖北十堰442000 湖北省帕金森病临床医学研究中心湖北医药学院附属襄阳市第一人民医院药学部湖北襄阳441000 华中科技大学同济医学院附属同济医院麻醉科湖北武汉430000

探究见血清不同部位提取物对脂多糖(lipopolysaccharide,LPS)诱导BV-2小胶质细胞神经炎症反应的作用及潜在机制。见血清药材粉碎,提取浓缩得醇提物,经萃取得石油醚、乙酸乙酯、正丁醇和水相萃取物,进一步利用D101大孔树脂柱色谱对乙酸... 详细信息

探究见血清不同部位提取物对脂多糖(lipopolysaccharide,LPS)诱导BV-2小胶质细胞神经炎症反应的作用及潜在机制。见血清药材粉碎,提取浓缩得醇提物,经萃取得石油醚、乙酸乙酯、正丁醇和水相萃取物,进一步利用D101大孔树脂柱色谱对乙酸乙酯萃取物进行分离得流分①~⑥。实验分为对照组、模型组、见血清提取物单独处理组及LPS联合见血清提取物干预组。采用LPS诱导BV-2建立神经炎症细胞模型,Griess法检测细胞上清中一氧化氮(nitric oxide,NO)生成;MTT法检测细胞活力;ELISA法检测细胞上清中白细胞介素(interleukin,IL)-6和肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)的释放;RT-qPCR检测促炎细胞因子诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)、环加氧酶-2(cyclooxygenase-2,COX-2)、IL-6、IL-1β和TNF-α的m RNA表达水平;Western blot检测i NOS、COX-2、核转录因子-κB p65(nuclear factor kappa-B p65,p65)、磷酸化核转录因子-κB p65(p-p65)、细胞外调节蛋白激酶(extracellular signal-regulated kinase,ERK)、磷酸化的细胞外调节蛋白激酶(p-ERK)、c-jun N末端激酶(c-jun N-terminal kinease,JNK)、磷酸化JNK(p-JNK)、p38丝裂原活化蛋白激酶(p38 mitogen activated protein kinase,p38),磷酸化p38丝裂原活化蛋白激酶(p-p38)蛋白表达;UHPLC-Q-Exactive Orbitrap技术结合文献比对解析活性部位化学成分。结果表明见血清不同部位提取物均可以显著降低LPS诱导BV-2中一氧化氮(nitric oxide,NO)的释放,其中乙酸乙酯萃取物抑制作用最显著且无细胞毒性,该部位流分⑥还可以剂量依赖性降低i NOS、COX-2、IL-6、IL-1β和TNF-α的基因及蛋白表达水平,同时对LPS诱导BV-2中p-p65、p-ERK、p-p38和p-JNK蛋白表达具有显著抑制作用;质谱分析流分⑥共鉴定到79种化合物,含12种已被证实具有抗炎活性的化合物。该研究通过体外实验证实了见血清提取物在治疗神经炎症方面具有显著效果,并揭示了其抗炎作用可能通过抑制NF-κB及MAPK信号通路实现。

关键词：见血清神经炎症小胶质细胞 NF-κB信号通路 MAPK信号通路化学成分

Dynamic evolution characteristics of the “source-reservoir” integration of gray marl and its geological significance to unconventional gas: Insights from pyrolysis experiments

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Petroleum Science 2023年第2期20卷 705-720页

作者： zhang-Hu Wang Zhong-Liang Ma Lun-Ju Zheng jun-Yu Wang Zhi-Gang wen Chen-Yang Si Cooperative Innovation Center of Unconventional Oil and Gas Yangtze UniversityWuhanHubei430100China Key Laboratory of Oil and Gas Resources and Exploration Technology Ministry of EducationCollege of Resources and EnvironmentYangtze UniversityWuhanHubei430100China Wuxi Research Institute of Petroleum Geology Sinopec Exploration and Production Research InstituteWuxiJiangsu214126China State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development WuxiJiangsu214126China School of Metallurgy and Environment Central South UniversityChangshaHunan410083China

The marl–limestone rhythmic strata of the Permian Maokou Formation have been identified as hosts of unconventional gas reservoirs with “source–reservoir” integration. The lack of research on the pore structure evolution of organic-rich carbonate rock restricts gas exploration of these strata. Here, pyrolysis experiments were performed on the Mao-1 carbonate to simulate hydrocarbon generation, expulsion and diagenesis in gray marl from low maturity to overmaturity. The pore structure of this marl is dominated by mesopores and macropores, and the proportion of macropores increases gradually with temperature. The macropores are mainly pores in the organic matter and shrinkage microcracks. Additionally, micropores and mesopores, dominated by clay mineral interlayer pores and pyrite intergranular pores, are developed in the high mature stage and subsequently compressed in the overmature stage. The main contributors to the specific surface area are micropores and mesopores, which are conducive to natural gas adsorption. After the same pyrolysis treatment, the available porosity of grey marl is higher than that of marine/lacustrine shales, and exhibits an obvious decrease in the low mature–mature stage. These suggest that the abundant residual oil generated blocked the organic and inorganic pores in the gray marl, providing a pivotal material foundation for the gas generation. Micropores and mesopores developed during the high mature stage ensure the gas accumulation and preservation. The above indicate the organic-rich carbonate at the high mature–overmature stage (Ro = 1.7%–2.5%) in the Sichuan Basin may be a favorable exploration horizon for unconventional oil and gas.

关键词： Residual oil Organic pores Porosity Sepiolite Hydrocarbon generation

X射线自由电子激光与金属钌相互作用双温模型的数值分析

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核技术 2024年第7期47卷 15-24页

作者：海雪张斐斐温阿利殷亚茹任翠兰怀平中国科学院上海应用物理研究所上海201800 中国科学院大学北京100049 上海科技大学大科学中心上海201210 上海科技大学硬X射线自由电子激光装置(SHINE) 上海201210 中国科学院上海高等研究院上海光源科学中心上海201204

金属钌(Ru)具有优异的力学性能和化学稳定性,同时具有高反射率、较大临界角等优异性能,是自由电子激光装置中光学元件的候选镀层材料之一。本文对X射线自由电子激光(X-ray Free-electron Lasers,XFEL)脉冲与金属钌薄膜相互作用过程进行... 详细信息

金属钌(Ru)具有优异的力学性能和化学稳定性,同时具有高反射率、较大临界角等优异性能,是自由电子激光装置中光学元件的候选镀层材料之一。本文对X射线自由电子激光(X-ray Free-electron Lasers,XFEL)脉冲与金属钌薄膜相互作用过程进行了模拟,采用数值方法求解双温模型(Two-temperature Model,TTM),得到了电子和晶格温度随时间的演化规律。获得激光的脉冲宽度、能量密度、穿透深度、材料的电声子耦合系数等对激光与金属钌相互作用过程中热效应的影响规律。通过对X射线自由电子激光脉冲与金属相互作用过程的双温模型数值解,可以获得材料中电子和晶格温度随时间的演化规律,并探究光源的参数对其热传输过程的影响。研究发现,金属钌晶格平衡温度与能量密度呈正相关;金属钌电子最高温度随脉冲宽度的增加而降低;金属钌的晶格平衡温度随穿透深度的减小而增加,最终趋于稳定;电子-声子平衡时间与电声子耦合系数呈负相关。本文获得X射线自由电子激光脉冲与金属钌相互作用的相关数据及基本演化规律,有助于进一步理解金属钌在激光辐照作用下材料的热效应演化机制,为自由电子激光装置光学元件薄膜材料的选取及辐照性能分析提供理论依据。

关键词： X射线自由电子激光金属钌薄膜双温模型数值分析

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鲜食嫩果辣椒‘樟树港’果实品质特性研究

园艺学报 2024年第3期51卷 616-630页

作者：付稳朱程红兰嘉仪李诗张正刘峰戴雄泽湖南农业大学园艺学院长沙410128 园艺作物种质创新与新品种选育教育部工程研究中心蔬菜生物学湖南省重点实验室长沙410128

以适合鲜食嫩果的‘樟树港’辣椒为试验材料,研究其果实发育过程中果实形状、硬度、组织结构、主要营养成分及细胞壁物质、风味物质的变化,并对品质指标进行相关性分析和主成分分析,以明确影响其品质的关键因素。结果表明:从坐果到转色... 详细信息

以适合鲜食嫩果的‘樟树港’辣椒为试验材料,研究其果实发育过程中果实形状、硬度、组织结构、主要营养成分及细胞壁物质、风味物质的变化,并对品质指标进行相关性分析和主成分分析,以明确影响其品质的关键因素。结果表明:从坐果到转色期,果实纵径、横径、单果质量、果肉厚度、硬度和角质层厚度呈上升趋势;果肉细胞层数基本稳定,薄壁细胞体积增大导致果肉增厚;可溶性蛋白含量随果实发育呈“U”形变化,可溶性糖和维生素C含量整体呈上升趋势,总果胶含量呈先增加后下降的变化趋势,纤维素和半纤维素含量呈下降—上升—下降—上升的变化趋势,开花后15d含量最低;辣椒素含量在发育前期增加迅速。果实发育过程中共检测出158种挥发性成分,以萜类、酯类、杂环化合物、烃类、酮类、醇类、醛类为主,开花后10~25 d萜类、酯类、烃类、酮类、醛类化合物增加。嫩果期果实口感优良的原因主要为果实硬度小、角质层薄、辣度适中、纤维素和总果胶含量低,挥发性成分相对较多。此外,主成分分析结果表明,可溶性蛋白含量也是影响‘樟树港’辣椒品质的重要因素之一。

关键词：辣椒生长发育口感风味物质

心电图aVR导联及血NT-proBNP、MHR与非ST段抬高型心肌梗死患者冠脉病变相关性研究

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中华灾害救援医学 2024年第4期11卷 389-392页

作者：李坤志张军邹平市中心医院急诊科山东邹平256212 邹平市中心医院ICU 山东邹平256212

目的分析心电图aVR导联及血氨基酸末端B型脑钠素原(NT-proBNP)、外周血单核细胞/高密度脂蛋白胆固醇比值(MHR)与非ST段抬高型心肌梗死患者冠脉病变(NSTEMI)的相关性。方法回顾性分析2020年1月至2022年12月在邹平市中心医院就诊的NSTEMI... 详细信息

目的分析心电图aVR导联及血氨基酸末端B型脑钠素原(NT-proBNP)、外周血单核细胞/高密度脂蛋白胆固醇比值(MHR)与非ST段抬高型心肌梗死患者冠脉病变(NSTEMI)的相关性。方法回顾性分析2020年1月至2022年12月在邹平市中心医院就诊的NSTEMI患者72例,依据患者冠脉病变支数给予分组,20例患者纳入单支病变组,27例患者纳入双支病变组,25例患者纳入三支病变组,比较各组患者心电图aVR导联及血NT-proBNP、MHR与NSTEMI的差异,并分析相关性。结果双支病变组、三支病变组血NT-proBNP、MHR高于单支病变组,三支病变组血NT-proBNP、MHR高于双支病变组,差异均有统计学意义(P0.05);血NT-proBNP、MHR与NSTEMI患者冠脉病变支数呈正相关(P<0.05)。结论QRS、ST段下移程度及血NT-proBNP、MHR与NSTEMI患者冠脉病变支数呈正相关。

关键词：心肌梗死心电描记术冠状动脉狭窄

Suppression of self-sustained oscillations of incompressible flow over aperture-cavities and its mechanisms

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Journal of Hydrodynamics 2022年第5期34卷 876-892页

作者： wen-wen zhang Rong-wu Xu Lin He Jia Duan Institute of Vibration and Sound Naval University of EngineeringWuhan430033China National Key Laboratory on Ship Vibration and Noise Naval University of EngineeringWuhan430033China

Experiments and large-eddy simulations(LESs)are conducted to study the effectiveness and the underlying physical mechanisms of a passive control technique for suppressing the self-sustained oscillations of incompressible flow over *** control technique is implemented by installing a wedge block above the chamfered *** experiments are carried out in a low-speed water tunnel with the freestream velocity ranging from 0.4 m/s to 4.4 m/s,while the large-eddy simulations are carried out corresponding to the experiment at a velocity of 4.0 m/*** wall pressure fluctuations measured along the cavity floor show that a significant suppression of the self-sustained oscillations of the shear layers can be achieved by the control ***,the suppression performance is improved as the freestream velocity increases,not limited to the design point of the control *** analysis of numerical simulation results focuses on three aspects,the vorticity fields,the velocity fields and the pressure fields,and the physical effects of the control device on the incompressible aperture-cavity flow are *** mechanisms of suppressing the cavity oscillations are identified from the numerical results,which are the destruction of the large vortex structures by the high frequency vortical excitations,the inhabitation of the intracavity recirculation feedback by introducing the lower shunt flow,and the attenuation of the trailing-edge impingement by thickening the shear layer.

关键词： Cavity oscillations flow control flow-induced noise numerical simulations hydrodynamic noise