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Infection within 2 weeks before liver transplantation closely related to prognosis of posttransplant infection:A single-center retrospective observational study in China

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Hepatobiliary & Pancreatic Diseases International 2020年第4期19卷 358-364页

作者： Yue Ying Rui-Dong Li Jing-wen Ai Yi-Min Zhu Xian Zhou Yi-Yi Qian Xin-Chang Chen Xu-Yang Wang Hao-Cheng zhang Yang Li Shan-Shan weng Yi-Qi Yu Yi-Feng Tao Yu-Xian Huang Zheng-Xin Wang wen-hong zhang Department of Infectious Diseases Huashan HospitalFudan UniversityShanghai 200040China Department of General Surgery Huashan HospitalFudan UniversityShanghai 200040China

Background:Infections still represent the main factors influencing morbidity and mortality following liver transplantation.This study aimed to evaluate the incidence and risk factors for infection and survival after liver transplantation.Methods:We retrospectively examined medical records in 210 liver recipients who underwent liver transplantation between April 2015 and October 2017 in our hospital.Clinical manifestations and results of pathogen detection test were used to define infection.We analyzed the prevalence,risk factors and prognosis of patients with infection.Results:The median follow-up was 214 days;the incidence of infection after liver transplantation was 46.7%(n=98)which included pneumonia(43.4%),biliary tract infection(21.9%),peritonitis(21.4%)and bloodstream infection(7.6%).Among the pathogens in pneumonia,the most frequently isolated was Acinetobacter baumanii(23.5%)and Klebsiella pneumoniae(21.2%).Model for end-stage liver disease(MELD)score(OR=1.083,95%CI:1.045–1.123;P<0.001),biliary complication(OR=4.725,95%CI:1.119–19.947;P=0.035)and duration of drainage tube(OR=1.040,95%CI:1.007–1.074;P=0.017)were independent risk factors for posttransplant infection.All-cause mortality was 11.0%(n=23).The prognostic factors for postoperative infection in liver recipients were prior-transplant infection,especially pneumonia within 2 weeks before transplantation.Kaplan-Meier curves of survival showed that recipients within 2 weeks prior infection had a significantly lower cumulative survival rate compared with those without infection(65.2%vs.90.0%;hazard ratio:4.480;P<0.001).Conclusions:Infection,especially pneumonia within 2 weeks before transplantation,complication with impaired renal function and MELD score after 7 days of transplantation was an independent prognostic factor for postoperative infection in liver transplant recipients.

关键词： Infection Liver transplantation Risk factors MELD score

Incidence and Potential Causes affecting Monozygotic Twin Formation Following in vitro Fertilization and Embryo Transfer

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Journal of Reproduction and Contraception 2012年第2期23卷 93-102页

作者： Li LI Xiao-lin LONG hong-zi DU wen-hong zhang Yu SHI Assisted Reproductive Department Institute of Obstetrics and Gynecology of the Third Affiliated Hospital ofGuangzhou Medical CollegeGuangzhou 510150China

Objectives To study the incidence and potential causes of monozygotic twins after in vitro fertilization and embryo transfer （IVF-ET）. Methods A retrospective study was performed on women carrying monozygotic twins （MZTs） after conventional IVF-ET treatment at the Third Affiliated Hospital of Guangzhou Medical College in China from January 2003 to May 2009. The incidence and the miscarriage rate for MZTs following IVF-ET were examined iin relation to maternal age, duration of infertility, type and dose of hormone treatment, conventional IVF-ET cycles versus intracytoplasmic sperm injection （ICSI） cycles, the use of fresh or frozen-thawed embryos, and day （post-fertilization） of embryo transfer. Results Sixteen MZT pregnancies occurred in 2 161 patients （incidence of 0.74%）, of which 5 miscarried （31.25%）. No significant difference was found between MZT and non-MZT groups in terms of maternal age, duration of infertilit）, duration of gonadotropin （Gn） administration, dosage of Gn, number of oocytes retrieved, number of oocytes fertilized, or number of embryos transferred （P〉O.05）. The incidence of MZT was not statistically different between conventional IVF-ET cycles and ICSI cycles, between fresh embryos transfer cycles and frozen-thawed embryo cycles, or between different transfer days （P〉0.05）. Conclusion The incidence of MZTs following IVF-ET treatment greatly exceeds that observed following spontaneous conception. Intracytoplasmic sperm injection, frozenthawed procedures, and embryo transfer on different days were not correlated with an increased incidence of MZT pregnancies.

关键词： monozygotic twinning potential cause IVF-ET

Impact of Blood Clot in Oocyte-Corona-Cumulus Complex during in vitro Fertilization and Embryo Transfer

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Journal of Reproduction and Contraception 2012年第1期23卷 57-63页

作者： Yu-ling HUANG Xiao-ling LONG Yong FAN wen-hong zhang hong-zi DU Assisted Reproductive Center the Third Affiliated Hospital of Guangzhou Medical CollegeKey Laboratory for the Major Obstetric Disease in Guangdong ProvinceGuangzhou 510150China

Objective To study the impact of blood clots in the oocyte-corona-cumulus complexes （OCCC） during in vitro fertilization and embryo transfer （IVF-ET）.Methods The OCCCs were harvested from the patients undergoing long protocol ovarian hyperstimulation. The OCCCs with blood clots removed or not, were randomly grouped into A or B. The OCCCs without blood clots were group C （the control）.Results The patient＇s age, infertility duration, the average GN consumption, the average days of superovulation and an average number of harvested oocytes showed no significant difference in the 3 groups. The fertilization rate and 2PN rate in group A were the highest, which were 85.4% and 71.1%, respectively, followed by group C, which were 77.5% and 64.9%, respectively. The lowest fertilization rate and 2PN rate were in group B, 75.8% and 62.2%, respectively. Those in group A were significantly higher than those in groups B and C （P〈0.01）, while there was no significant difference between group B and group C. The implantation rates and pregnancy rates showed no significant difference in the 3 groups after transplantation, even if group A got the highest rate among the 3 groups. Conclusion Removing the blood clots in OCCC can improve the outcome of IVF-ET without increasing the cost and complexity of the operation.

关键词： in vitro fertilization and embryo transfer （IVF-ET） blood clot fertilization rate pregnancy

Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients

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Chinese Medical Journal 2020年第9期133卷 1039-1043页

作者： Yun Ling Shui-Bao Xu Yi-Xiao Lin Di Tian Zhao-Qin Zhu Fa-Hui Dai Fan Wu Zhi-Gang Song Wei Huang Jun Chen Bi-Jie Hu Sheng Wang En-Qiang Mao Lei Zhu wen-hong zhang hong-Zhou Lu Department of Infectious Disease Shanghai Public Health Clinical CenterShanghai 201508China Department of Infectious Disease and Immunology Shanghai Public Health Clinical CenterShanghai 201508China Department of Hepatology Shanghai Public Health Clinical CenterShanghai 201508China Department of Infectious Disease Zhongshan HospitalFudan UniversityShanghai 200032China Department of Critical Care Medicine Shanghai Tenth People’s HospitalTongji UniversityShanghai 200072China Department of Emergency Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Department of Pulmonology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Infectious Disease Huashan HospitalFudan UniversityShanghai 200041China Shanghai Medical College of Fudan University Shanghai 200032China

Background:A patient’s infectivity is determined by the presence of the virus in different body fluids,secretions,and excreta.The persistence and clearance of viral RNA from different specimens of patients with 2019 novel coronavirus disease(COVID-19)remain unclear.This study analyzed the clearance time and factors influencing 2019 novel coronavirus(2019-nCoV)RNA in different samples from patients with COVID-19,providing further evidence to improve the management of patients during convalescence.Methods:The clinical data and laboratory test results of convalescent patients with COVID-19 who were admitted to from January 20,2020 to February 10,2020 were collected retrospectively.The reverse transcription polymerase chain reaction(RT-PCR)results for patients’oropharyngeal swab,stool,urine,and serum samples were collected and analyzed.Convalescent patients refer to recovered non-febrile patients without respiratory symptoms who had two successive(minimum 24 h sampling interval)negative RT-PCR results for viral RNA from oropharyngeal swabs.The effects of cluster of differentiation 4(CD4)+T lymphocytes,inflammatory indicators,and glucocorticoid treatment on viral nucleic acid clearance were analyzed.Results:In the 292 confirmed cases,66 patients recovered after treatment and were included in our study.In total,28(42.4%)women and 38 men(57.6%)with a median age of 44.0(34.0-62.0)years were analyzed.After in-hospital treatment,patients’inflammatory indicators decreased with improved clinical condition.The median time from the onset of symptoms to first negative RT-PCR results for oropharyngeal swabs in convalescent patients was 9.5(6.0-11.0)days.By February 10,2020,11 convalescent patients(16.7%)still tested positive for viral RNA from stool specimens and the other 55 patients’stool specimens were negative for 2019-nCoV following a median duration of 11.0(9.0-16.0)days after symptom onset.Among these 55 patients,43 had a longer duration until stool specimens were negative for viral RNA than for throat swabs,with a median

关键词： COVID-19 2019-nCoV Nucleic acid detection Glucocorticoid

Construction of dual crosslinked network binder via sequential ionic crosslinking for high-performance silicon anodes

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Rare Metals 2023年第7期42卷 2238-2249页

作者： Ji-Na Wu hong-Xu Chen Chao Chen Hai-Dong Li hong-wen zhang Bo Wang School of Materials Science and Engineering Changzhou UniversityChangzhou213164China Nanotechnology Research Institute Jiaxing UniversityJiaxing314001China Key Laboratory of Yarn Materials Forming and Composite Processing Technology of Zhejiang Province Jiaxing UniversityJiaxing314001China School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin150080China

Nowadays,silicon has become a promising anode active material for lithium-ion batteries due to its high specific capacity.However,traditional binder materials cannot effectively restrain the volume expansion of silicon during lithiation/delithiation.Inspired by the growth process of climbing plants,we sequentially crosslink sodium alginate with calcium ions and hyperbranched polyethyleneimine to construct a dual crosslinked network binder.During the sequentially crosslinking,sodium alginate preferentially crosslinks with Ca^(2+)to form the"trellis"network,which restricts the free movement of hyperbranched polyethyleneimine and guides it,like"vine",to gradually anchor on the surrounding"trellis"through hydrogen and ionic bonding.In this dual crosslinked network,the ionic ally crosslinked sodium alginate maintains the anode structural integrity;the anchored hyperbranched polyethyleneimine forms strong multidimensional hydrogen bonds with silicon nanoparticles through its amino-rich branch chains;and the network utilizes the bonding reversibility of hydrogen and ionic bonds to repeatedly eliminate the mechanical stress and self-heal the structure damages caused by the volume change of silicon.Benefited from the multifunction of the dual crosslinked network,the silicon anode has achieved an excellent electrochemical performance with a specific capacity of 2403 mAh·g^(-1)at the current density of500 mA·g^(-1)after 100 cycles.

关键词： Sodium alginate Hyperbranched polyethyleneimine(HBPEI) Ionic crosslinking Binder Silicon anode Lithium-ion battery(LIB)

Tenofovir disoproxil fumarate in Chinese chronic hepatitis B patients:Results of a multicenter,double-blind,double-dummy,clinical trial at 96 weeks

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World Journal of Clinical Cases 2021年第18期9卷 4690-4699页

作者： Xiao-Fan Chen Ya-Nan Fan Chong-wen Si Yan-Yan Yu Jia Shang Zu-Jiang Yu Qing Mao Qing Xie Wei Zhao Jun Li Zhi-Liang Gao Shan-Ming Wu hong Tang Jun Cheng Xin-Yue Chen wen-hong zhang Hao Wang Zhong-Nan Xu Ling Wang Jun Dai Jing-Hang Xu Department of Infectious Diseases Center for Liver DiseasesPeking University First HospitalBeijing 100034China Department of Infectious Diseases Henan Provincial People's HospitalZhengzhou 450003Henan ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Infectious Diseases Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Infectious Diseases Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Department of Infectious Diseases The Second Affiliated Hospital of Southeast UniversityNanjing 210011Jiangsu ProvinceChina Department of Infectious Diseases The First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Infectious Diseases The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Infectious Diseases Shanghai Public Health Clinical CenterFudan UniversityShanghai 201052China Department of Infectious Diseases West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Center of Hepatology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of International Medical Beijing Youan HospitalCapital Medical UniversityBeijing 10069China Department of Infectious Diseases Huashan HospitalFudan UniversityShanghai 200040China Department of Infectious Diseases Peking University People's HospitalBeijing 100044China Clinical Center Jiangsu Chia-tai Tianqing Pharmaceutical Co.LtdNanjing 210000Jiangsu ProvinceChina

BACKGROUND Tenofovir disoproxil fumarate(TDF)is a prodrug of a nucleotide analogue.As an antiviral drug,TDF has been proposed in the first-line treatment of chronic hepatitis B(CHB).Qingzhong,a brand name of TDF,commercialized by Jiangsu Chia-tai Tianqing Pharmaceutical Co Ltd.,and Viread,another brand name of TDF,commercialized by GlaxoSmithKline,have both been approved by the State Food and Drug Administration,China.AIM To investigate the efficacy and safety of the two TDF agents in the treatment of Chinese CHB patients.METHODS This trial was registered at ClinicalTrials.gov with the identifier number of NCT02287857.A total of 330 Chinese CHB patients,among which 232 were hepatitis B e antigen(HBeAg)-positive,were included in this 5-year-long,multicenter,double-blinded,double-dummy,randomized-controlled,noninferiority phase III trial.The participants were initially randomized into two groups:Group A(n=161),in which the participants received 300 mg Qingzhong once a day for 48 wk;and Group B,in which the participants received 300 mg Viread once a day for 48 wk.Starting from week 49,all the participants in Groups A and B received 300 mg Qingzhong once a day until the 96th week.In this study,the primary endpoint was the decrease in plasma level of hepatitis B virus(HBV)DNA at the 96th week,while the secondary endpoints were suppression of HBV replication,alanine aminotransferase(ALT)normalization,HBeAg loss,and HBeAg seroconversion rates.RESULTS For the participants with HBeAg-positive CHB,the decrease in mean HBV DNA level relative to the baseline value was comparable between Groups A and B(5.77 vs 5.73 log10 IU/mL,P>0.05)at the 96th week.In addition,similar percentages of HBeAg-positive participants in the two groups exhibited undetectable levels of HBV DNA,HBeAg loss,and HBeAg seroconversion(71.05%vs 77.97%,31.00%vs 27.27%,and 20.22%vs 15.79%,respectively,in Group A vs Group B;P>0.05).For the participants with HBeAg-negative CHB,the decrease in mean HBV DNA level relative to the baseline value was also comparabl

关键词： Chronic hepatitis B Hepatitis B virus infection Chronic Tenofovir disoproxil

Evaluation of Endotoxin in Culture Medium for Human in vitro Fertilization

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Journal of Reproduction and Contraception 2005年第2期16卷 83-88页

作者： Jing LI Wei-jie ZHU wen-hong zhang Department of Pathophysiology Medical College Jinan University Guangzhou 510632 China Center for Reproductive Immunology Research Jinan University Guangzhou 510632 China Guangzhou No.2 Municipal People＇s Hospital Guangzhou 510150 China

To determine whether the presence of bacterial endotoxin in the commercial culture media utilized for human in vitro fertilization （IVF）, and evaluate the difference in detecting endotoxin in culture medium between the human sperm motility assay and the 2-cell mouse embryo assay. Methods Thirty-six batches of culture media commonly used in IVF laboratories from 3 manufacturers were determined for thepresence ofendotoxin before using the medium for the assisted reproductive programs （group A）. After being used, 25 specimens among above media were also tested （group B）. The chromogenic limulus amoebocyte lysate （LAL） test was used for quantification the content of endotoxin. In addition, the human sperm motility assay was compared with the 2-cell mouse embryo assay to evaluate the difference in detecting endotoxin in culture medium. Results Endotoxin was not detected in group A. However, 2 samples were positive in group B, Sperm did not show significant change in motility in group A during 24 h of incubation when compared with the control （P〉0. 05）. However, in group A the 2-cell embryo development to blastocyst was suppressed in 3 batches of media. Conclusions Regular screening of each batch of culture medium should be performed if possible although there was no evidence of endotoxin contamination in commercially prepared pre-tested media. Culture environment should be stringently controlled in case the medium is polluted. The sensitivity of the sperm motility assay was lower than that of the mouse embryo assay for detecting low levels of endotoxin or toxic compounds in the medium.

关键词： endotoxin culture medium human sperm mouse embryo

The role of prophylactic antibiotics in hepatitis B virus-related acute-on-chronic liver failure patients at risk of bacterial infection: a retrospective study

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Infectious Diseases of Poverty 2021年第2期10卷 84-84页

作者： Xiao-Qin Liu Xue-Yun zhang YueYing Jian-Ming Zheng Jian Sun wen-hong zhang Ji-Ming zhang Yu-Xian Huang Departm ent of Infectious Diseases Huashan HospitalFudan University12 Middle Urumqi RoadShanghai 200040China 不详

Background:Acute-on-chronic liver failure(ACLF)is characterized by an excessive systemic inflammatory response and organ failure and has high mortality.Bacterial infections(Bis)worsen the clinical course of ACLF and carry a poor prognosis in ACLF patients.The efficacy of third-generation cephalosporins has been challenged in recent years.The aim of this study was to characterize the difference between ACLF patients with and without Bis and to provide a reference for medical intervention.

关键词： Acute-on-chronic liver failure Hepatitis B virus Infection Prophylactic antibiotics

A Review on Engineering Design for Enhancing Interfacial Contact in Solid-State Lithium–Sulfur Batteries

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Nano-Micro Letters 2024年第4期16卷 219-252页

作者： Bingxin Qi Xinyue hong Ying Jiang Jing Shi Mingrui zhang wen Yan Chao Lai School of Chemistry and Materials Science Jiangsu Normal UniversityXuzhou 221116JiangsuPeople’s Republic of China

The utilization of solid-state electrolytes(SSEs)presents a promising solution to the issues of safety concern and shuttle effect in Li–S batteries,which has garnered significant interest recently.However,the high interfacial impedances existing between the SSEs and the electrodes(both lithium anodes and sulfur cathodes)hinder the charge transfer and intensify the uneven deposition of lithium,which ultimately result in insufficient capacity utilization and poor cycling stability.Hence,the reduction of interfacial resistance between SSEs and electrodes is of paramount importance in the pursuit of efficacious solid-state batteries.In this review,we focus on the experimental strategies employed to enhance the interfacial contact between SSEs and electrodes,and summarize recent progresses of their applications in solidstate Li–S batteries.Moreover,the challenges and perspectives of rational interfacial design in practical solid-state Li–S batteries are outlined as well.We expect that this review will provide new insights into the further technique development and practical applications of solid-state lithium batteries.

关键词： Solid-state lithium–sulfur batteries Solid-state electrolytes Electrode/electrolyte interface Interfacial engineering Enhancing interfacial contact