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World Journal of Clinical Cases 2024年第2期12卷 285-292页

作者： Sha-Sha Sun Xiao-Di Guo wen-dong li Jing-Long Chen Department of Oncology Capital Medical University Affiliated Beijing Ditan HospitalBeijing 100015China

BACKGROUND Recently,combination therapy has shown a better trend towards improved tumour response and survival outcomes than monotherapy in patients with hepatocellular carcinoma(HCC).However,research on triple therapy[lenvatinib+sintilimab+transarterial chemoembolization(TACE)]as a first-line treatment for advanced HCC is *** To evaluate the safety and efficacy of triple therapy as a first-line treatment for advanced *** HCC patients with Barcelona Clinic liver Cancer stage C treated with triple therapy were *** patients were treated with lenvatinib every day and sintilimab once every 3 ***,TACE was performed every 4-6 wk if *** primary outcome of the study was overall survival(OS).The secondary outcomes were the objective response rate(ORR),disease control rate(DCR),and incidence of adverse *** Forty HCC patients who underwent triple therapy were retrospectively analysed from January 2019 to January *** a median follow-up of 8.5 months,the 3-,6-,and 12-mo OS rates were 100%,88.5%,and 22.5%,*** ORR and DCR were 45%and 90%,*** median progressive free survival and median OS were not *** complications were observed in 76%of the patients(grade 3,15%;grade 4,2.5%).CONCLUSION Combination therapy comprising lenvatinib,sintilimab and TACE achieved promising outcomes in advanced HCC patients and had manageable effects.

关键词： Lenvatinib Sintilimab Advanced hepatocellular carcinoma Combination therapy Tumor response

A New Nonmonotone Trust Region Barzilai-Borwein Method for Unconstrained Optimization Problems

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Acta Mathematicae Applicatae Sinica 2021年第1期37卷 166-175页

作者： Xing li wen-li dong Zheng PENG College of Mathematics and Computer Science Fuzhou UniversityFuzhou 350108China School of Mathematics and Computational Science Xiangtan UniversityXiangtan 411105China

In this paper,we propose a new nonmonotone trust region Barzilai-Borwein(BB for short)method for solving unconstrained optimization *** proposed method is given by a novel combination of a modified Metropolis criterion,BB-stepsize and trust region *** new method uses the reciprocal of BB-stepsize to approximate the Hessian matrix of the objective function in the trust region subproblems,and accepts some bad solutions according to the modified Metropolis criterion based on simulated annealing *** some suitable assumptions,the global convergence of the new method is *** preliminary numerical results indicate that,the new method is more efficient compared with the existing trust region BB method.

关键词： Barzilai-Borwein method trust region method nonmonotone technique Metropolis criterion global convergence

Cross-layer scheduling with fairness for multi-user OFDM system:a restless bandit approach

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The Journal of China Universities of Posts and Telecommunications 2011年第4期18卷 25-30页

作者： GE wen-dong JI Hong li Xi Key Laboratory of Universal Wireless Communications Ministry of Education Beijing University of Posts and Telecommunications Beijing 100876 China

In OFDM-based System such as long term evolution （LTE）, the scheduling scheme plays an essential role in not only improving the capacity of system, but also guarantee the fairness among the user equipments （UEs）. However, most existing work about scheduling only considers the current throughput in physical layer. Thus in this paper, a cross-layer scheduling with fairness based on restless bandit （CSFRB） scheme with the ＇indexability＇ property is proposed for the multi-user orthogonal frequency-division multiplexing （OFDM） system to minimize the distortion in the application layer, to maximize the throughput and to minimize the energy consumption in the physical layer. The scheduling problem is firstly established as a restless bandit problem, which is solved by the primal-dual index heuristic algorithm based on the first order relaxation with low complexity, to yield the CSFRB scheme. AdditionaUy, this scheme is divided into offiine computation and online selection, where main work will be finished in former one so as to decrease the complexity further. Finally, extensive simulation results illustrate the significant performance improvement of the proposed CSFRB scheme compared to the existing one in different scenarios.

关键词： multi-user OFDM scheduling cross-layer design restless bandits

Chemically exfoliated WS2 nanosheets efficiently inhibit amyloid β-peptide aggregation and can be used for photothermal treatment of Alzheimer＇s disease

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Nano Research 2015年第10期8卷 3216-3227页

作者： Meng li Andong Zhao Kai dong wen li Jinsong Ren Xiaogang Qu LaboratoryofChemicalBiologyandStateKeyLaboratoryofRareEarthResourceUtilization ChangchunInstituteofAppliedChemistryUniversityofChineseAcademyofSciencesChineseAcademyofSciencesChangchun130022China

Polymerization of amyloid-β peptide （Aβ） into amyloid fibrils is a critical step in the pathogenesis of Alzheimer＇s disease （AD）. Inhibition of Aβ aggregation and destabilization of preformed Aβ fibrils have promising effects against AD and have been used in clinic trials. Herein, we demonstrate, for the first time, the application of WS2 nanosheets, to not only effectively inhibit Aβ aggregation, but also dissociate preformed Aβ aggregates upon near infrared （NIR） irradiation. Additionally, the biocompatible WS2 nanosheets possess the ability to cross the blood-brain barrier （BBB） to overcome the limitations of most previously reported Aβ inhibitors. Through van der Waals and electrostatic interactions between Aβ40 and WS2, Aβ40 monomers can be selectively adsorbed on the surface of the nanosheet to inhibit the Aβ40 aggregation process. Intriguingly, the unique high NIR absorption property of WS2 enables amyloid aggregates to be dissolved upon NIR irradiation. These results will promote biological applications of WS2 and provide new insight into the design of multifunctional nanomaterials for AD treatment.

关键词： Alzheimer disease WS2 nanosheets Aβ inhibitors photothermal treatment Aβ aggregation near infrared (NIR)

Transarterial chemoembolization combined with radiofrequency ablation in the treatment of large hepatocellular carcinoma with stage C

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World Journal of Clinical Cases 2022年第33期10卷 12156-12163页

作者： Sha-Sha Sun wen-dong li Jing-Long Chen Department of Oncology Capital Medical University Affiliated Beijing Ditan HospitalBeijing 100015China

BACKGROUND The combination therapy of transarterial chemoembolization and radiofrequency ablation(TACE-RFA)shows promising efficacy in large hepatocellular carcinoma(HCC).Data on the clinical efficacy and safety of TACE-RFA for large HCC with barcelona clinic liver cancer(BCLC)stage C are lacking in *** To determine the safety and efficacy of TACE-RFA for large,advanced *** Patients of HCC with BCLC stage C who were treated with TACE-RFA or TACE alone at our institute from August 2008 to January 2017 were retrospectively *** complications were *** associations between overall survival(OS)and treatment method were *** Data were collected from 102 HCC *** them,64 underwent TACERFA and 38 underwent *** combination of TACE and RFA was *** complications were *** median OS in the TACE-RFA group was significantly longer than that in the TACE group(8.0 mo vs 4.0 mo,P=0.000).The 6-,12-and 24-mo survival rates of the combination group were 68.8%,34.4%,and 10.9%,respectively,while those of the TACE group were 36.8%,7.9%,and 0%(P<0.05).CONCLUSION TACE-RFA has an advantage over TACE alone in improving OS in large HCC patients with BCLC stage C.

关键词： Large advanced hepatocellular carcinoma Transarterial chemoembolization Radiofrequency ablation Overall survival Combination therapy

Synthesis of Novel 1-Arylsulfonyl-4-(1′-N-2′, 3′, 4′, 6′-tetra- O-acetyl-β-D-glucopyranosyl)thiosemicarbazides

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Chinese Chemical Letters 2006年第2期17卷 153-155页

作者： Yu Xin li Zheng Ming li Wei Guang ZHAO wen li dong Su Hua WANG State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071

The synthesis of novel 1-arylsulfonyl -4- （1＇-N -2＇, 3＇, 4＇, 6＇-tetra-O-acetyl-β-D-gluco- pyranosyl） thiosemicarbazides via condensation of 2, 3, 4, 6-tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate with substituted phenylsulfonyl hydrazines was described. Their structures and physical properties were confirmed by ^1H NMR, ^13C NMR spectra, elemental analysis and MS.

关键词： Phenylfulfonyl hydrazine thiosemicatbazide condensation.

芳纶增强MXene-聚丙烯酸-无定型碳酸钙复合水凝胶的制备及性能

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高分子通报 2024年第2期37卷 257-262页

作者：左红梅闻立冬郭锦涛董功明郑皓月王洪杰王赫阮芳涛邹梨花徐珍珍安徽工程大学纺织服装学院芜湖241000

传统水凝胶存在机械性能和可加工性差的缺点,本研究制备了芳纶增强MXene-聚丙烯酸-无定型碳酸钙(ANF/MXene-PAA-ACC)复合水凝胶,并研究了其相关力学与物理性能。首先,通过氟化锂和盐酸刻蚀法,结合超声剥离工艺制备了二维MXene单层纳米片... 详细信息

传统水凝胶存在机械性能和可加工性差的缺点,本研究制备了芳纶增强MXene-聚丙烯酸-无定型碳酸钙(ANF/MXene-PAA-ACC)复合水凝胶,并研究了其相关力学与物理性能。首先,通过氟化锂和盐酸刻蚀法,结合超声剥离工艺制备了二维MXene单层纳米片,将其应用到PAA-ACC复合水凝胶中。为了提高MXene-PAA-ACC的力学性能,进一步通过加入芳纶,制备了ANF/MXene-PAA-ACC复合水凝胶。采用扫描电镜和万能力学试验机对复合水凝胶的表观形貌、力学性能、自修复和粘附性等物理性能进行了表征和测试。结果表明:与PAA-ACC水凝胶相比,ANF/MXene-PAA-ACC水凝胶的可加工性、力学性能、粘附性、自修复性都得到了提高。

关键词： MXene 聚丙烯酸-无定型碳酸钙水凝胶芳纶

Dynamic lithium-compensation mechanism for densification of garnet-type li_(7)La_(3)Zr_(2)O_(12)electrolyte by li_(2)O atmosphere buffer pair

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Nano Research 2024年第7期17卷 6184-6191页

作者： Chujun Zheng Ya Chen Haoxin dong Yan Lu Jun Jin Zhaoyin wen CAS Key Laboratory of Materials for Energy Conversion Shanghai Institute of CeramicsChinese Academy of ScienceShanghai 200050China State Key Lab High Performance Ceram and Superfine Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Solid-state lithium metal batteries are one of the most promising options for next-generation batteries pursuing high-energy density and ***,the inevitable volatilization of lithium compounds during sintering leads to low relative density and low ionic conductivity of solid-state ***,the dynamic lithium-compensation mechanism is proposed to facilitate the densification of Ta-substituted garnet-type electrolyte(li_(6.5)La_(3)Zr_(1.5)Ta_(0.5)O_(12)(LLZT))through the reversible manipulating of li_(2)O ***_(2)ZrO_(3)is used as mother powder additive,which reacts with li_(2)O in sintering atmosphere and forms li_(6)Zr_(2)O_(7).li_(2)ZrO_(3)/li_(6)Zr_(2)O_(7)buffer pair manipulates the sintering li_(2)O atmosphere,which is vital for LLZT,within the li_(2)O partial pressure range corresponding to li_(2)ZrO_(3)and li_(6)Zr_(2)O_(7).Furthermore,the reversibility mechanism of buffer pair for li_(2)O absorption and release is *** obtained LLZT exhibits a relative density of over 96%and an ionic conductivity exceeding 7×10^(−4)S·cm^(−1)with no abnormal grain *** symmetric cell demonstrates an excellent lithium dendrite suppressing ability(stable cycling at a current density of 0.3 mA·cm^(−2)for over 1000 h).Such dynamic lithium-compensation strategy has been successfully applied in atmosphere manipulation of LLZT sintering process,which reduces the dependence of LLZT on the li_(2)O atmosphere,making it conducive to large-scale preparation of electrolyte ceramics.

关键词： solid-state batteries garnet-type electrolyte high-density electrolyte dynamic lithium-compensation buffer pair

Corrosion behavior and protection mechanism of carbon steel coated with ethylene chlorotrifluoroethylene(ECTFE)

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第6期25卷 502-515页

作者： Peihu SHEN Jun wen Biqin dong Hedong li Minjia WANG School of Civil Engineering and Architecture Zhejiang Sci-Tech UniversityHangzhou310018China College of Civil and Transportation Engineering Shenzhen UniversityShenzhen518061China Zhejiang Research Institute of Chemical Industry Co. Ltd.Hangzhou310023China

Ethylene chlorotrifluoroethylene(ECTFE)coating was applied to the surface of carbon steel through electrostatic spraying and low-temperature heat *** morphology and structure of the coating were analyzed using various characterization *** electrochemical data of the coated steel soaked in 3.5%(mass fraction)NaCl solution for 90 d at different periods were also *** findings indicate that the outer surface of the coating remains structurally stable before and after soaking.F can diffuse into the steel substrate,facilitating the bonding between the coating and the steel substrate,but the free F also induces a weakening effect on the crystalline *** to the thickness of the coating edge and the susceptibility to infiltration of the corrosive medium,under-film micro-zone corrosion occurs at a slow *** soaking for 90 d,the impedance modulus measures approximately 10^(4)Ω·cm^(2),and the open circuit potential(OCP)is−0.61 *** self-corrosion current density is 1.13×10^(−6)A/cm^(2),resulting in a calculated coating protection rate of 99.29%.In summary,despite edge corrosion occurring,the ECTFE coating provides excellent corrosion protection.

关键词： Coating Fluorine resin Edge corrosion Corrosive behavior Electrochemical performance

Ultrahigh strength and uniform corrosion in Zn-li alloys through ultrahigh pressure supersaturated solid solution treatment for biodegradable orthopedic applications

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Rare Metals 2024年第10期43卷 5284-5304页

作者： Wan-Ying li Yi-Long Dai wen-Hao Cai Si-Han lin lin Guo De-Chuang Zhang Yuncang li Cuie wen School of Materials Science and Engineering Xiangtan University Department of Prosthodontics Shanghai Ninth People′s HospitalShanghai Jiao Tong University Key Laboratory of Low Dimensional Materials&Application Technology Ministry of EducationXiangtan University School of Engineering RMIT UniversityMelbourne

Zn-li alloys are considered promising candidate materials for biodegradable orthopedic implant applications due to their high mechanical performance and good ***,the presence of a large number of second-phase particles in this class of Zn alloys can lead to severe localized degradation due to micro-galvanic corrosion,which is detrimental to the mechanical integrity of the alloys during tissue healing in the human *** this study we report ultrahigh strength,uniform corrosion,good cytocompatibility,and effective antibacterial ability in Zn-x li（x=0.3,0.5,0.7;wt%） alloys achieved through supersaturated solid solution treatment （SSST） at 375℃ under ultrahigh pressure of 3 GPa.A high concentration of β-liZn4phases coexisted with the-Zn matrix in the as-cast Zn-x li alloys,whereas almost all the li dissolved into the-Zn matrix of SSST *** yield strength was 437 MPa for SSST Zn-0.3li,592 MPa for SSST Zn-0.5 li and 686 MPa for SSST *** SSST Zn-li alloys showed uniform degradation with remarkably reduced degradation rates compared to their as-cast *** 25% concentration extracts of the Zn-x li alloys demonstrated no cytotoxicity toward MC3T3-E1 cells,and the alloys exhibited effective antibacterial ability agains methicillin-resistant staphylococcus aureus.

关键词： Corrosion behavior Mechanical property Supersaturated solid solution treatment (SSST) Ultrahigh pressure Zn-li alloy