检索结果-南通市图书馆

Relationship between abnormal vagus nerve tension and basal ganglia cerebral infarction induced paroxysmal atrial fibrillation

引用

Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 921-924页

作者： wen-bo cheng Dong Li Qin Yang Yue-Mei Hou Department of Geriatrics Shanghai Jiaotong University Affiliated Sixth People's Hospital South Campus Department of Neurology Zaozhuang Mining Group Hospitals

Objective: To investigate the relationship between basal ganglia cerebral infarction and paroxysmal atrial fibrillation(PAF) caused by abnormal vagus nerve ***: A total of 1 483 cases of elder patients with cerebral infarction who received head CT or MRI examination during the period were enrolled, including 830 male and613 female, with the average age as 78 years. These cases were divided into basal infarction ganglia group(n = 1 045) and non-basal ganglia infarction group(n = 438)according to the anatomic site of cerebral infarction. The differences of the incidence of PAF, left atrial diameter and heart rate variability were compared between the two ***: In basal ganglia infarction group, the incidence rate of PAF was significantly higher than that of non-basal ganglia infarction group(P 79 years basal ganglia cerebral infarction group, the incidence of PAF was significantly higher than that of nonbasal ganglia infarction group(P < 0.05). There was no significant difference in the left atrial diameter between the basal ganglia infarction group and non-basal ganglia infarction group. Basal ganglia cerebral infarction patients with high PAF had higher heart rate variability than non-basal ganglia infarction ***: Elderly patients with basal ganglia infarction have high incidence of *** nerve damage in cerebral basal ganglia, increased vagal tension and cardiac vagal tension are the direct causes of PAF. The results indicates that the increased central vagal nerve tension mediated PAF probably is an indication of supplying sympathetic neurotransmitter or cardiac vagal denervation treatment.

关键词： Basal ganglia Cerebral infarction Abnormal vagus nerve tension Paroxysmal atrial fibrillation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An optimized run-length based algorithm for sparse remote sensing image labeling

引用

Defence Technology（防务技术） 2022年第4期18卷 663-677页

作者： Shen-shen Luan bo-wen cheng Shuai Jiang Yu-hang Wu Zong-ling Li Ji-yang Yu Institute of Spacecraft System Engineering Haidian DistrictBeijingChina

Labeling of the connected components is the key operation of the target recognition and segmentation in remote sensing *** conventional connected-component labeling(CCL) algorithms for ordinary optical images are considered time-consuming in processing the remote sensing images because of the larger size.A dynamic run-length based CCL algorithm(Dy RLC) is proposed in this paper for the large size,big granularity sparse remote sensing image,such as space debris images and ship *** addition,the equivalence matrix method is proposed to help design the pre-processing method to accelerate the equivalence labels *** result shows our algorithm outperforms 22.86% on execution time than the other algorithms in space debris image *** proposed algorithm also can be implemented on the field programming logical array(FPGA) to enable the realization of the real-time processing on-board.

关键词： Connected-component labeling Label equivalence resolving Hardware implementation Equivalence matrix On-board processing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Danlu Tongdu tablets treat lumbar spinal stenosis through reducing reactive oxygen species and apoptosis by regulating CDK2/CDK4/CDKN1A expression

引用

Traditional Medicine Research 2023年第7期8卷 47-55页

作者： Xue Bai Ayesha Tasleem Tahir Zheng-Heng Yu wen-bo cheng bo Zhang Jun Kang School of Life Sciences Tianjin UniversityTianjin 300072China Department of Biosciences COMSATS University IslamabadIslamabad 45550Pakistan Breast Disease Center Peking University First HospitalBeijing 100034China Tianjin Key Laboratory of Medical Mass Spectrometry for Accurate Diagnosis Tianjin 300399China Institute for TCM-X MOE Key Laboratory of BioinformaticsBioinformatics DivisionBNRistDepartment of AutomationTsinghua UniversityBeijing 100084China Beijing Intelligent Medicine and Network Pharmacology Co. Ltd.Beijing 100020China

Lumbar spinal stenosis is caused by the compression of the nerve root or cauda equina nerve by stenosis of the lumbar spinal canal or intervertebral foramen,and is manifested as chronic low back and leg *** Tongdu(DLTD)tablets can relieve chronic pain caused by lumbar spinal stenosis,but the molecular mechanism remains largely *** this study,the potential molecular mechanism of DLTD tablets in the treatment of lumbar spinal stenosis was first predicted by the network pharmacology *** showed that DLTD functions in regulating anti-oxidative,apoptosis,and inflammation signaling ***,the flow cytometry results showed that DLTD tablets efficiently reduced reactive oxygen species content and inhibited rat neural stem cell apoptosis induced by hydrogen *** also inhibited the mitochondrial membrane potential damage induced by hydrogen *** analysis showed that DLTD induced cell cycle-related protein,CDK2 and CDK4,and reduced CDKN1A protein expression *** together,our study provided new insights of DLTD in treating lumbar spinal stenosis through reducing reactive oxygen species content,decreasing apoptosis by inhibiting CDKN1A and promoting CDK2 and CDK4 expression levels.

关键词： Danlu Tongdu lumbar spinal stenosis reactive oxygen species cell apoptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Network pharmacology analysis combined with experimental verification of the molecular mechanism of Xihuang pill in treating liver cancer

引用

Traditional Medicine Research 2023年第6期8卷 24-32页

作者： Meng-Xin He Ayesha T.Tahir Saba Waris wen-bo cheng Jun Kang School of Life Sciences Tianjin UniversityTianjin 300072China Department of Biosciences COMSATS University IslamabadIslamabad 45550Pakistan Department of Gynacology Allama Iqbal Medical CollegeLahore 54000Pakistan Tianjin Key Laboratory of Medical Mass Spectrometry for Accurate Diagnosis Tianjin 300399China

Background:Xihuang pill is a kind of traditional Chinese medicine,which has been widely used in the treatment of kinds of ***,there is still a lack of systematic understanding of the molecular mechanism of Xihuang pill in the treatment of liver *** this work,we aim to explore the molecular mechanism of Xihuang pill in treating liver ***:The functional components in Xihuang pill were collected from Traditional Chinese Medicine Database and Analysis *** target genes of these components were also collected using Traditional Chinese Medicine Database and Analysis *** target genes of liver cancer were predicted using GeneCards *** intersecting genes were then analyzed with Venn *** Encyclopedia of Genes and Genomes and Database for Annotation,Visualization,and Integrated Discovery were used to analyze the ***,cell counting kit-8 was used to measure the half-maximal inhibitory concentration of Xihuang *** living dead cell staining method was used to observe the survival of ***2 cell apoptosis was tested by flow cytometry with fluorescein isothiocyanate/propidium iodide double staining method,and then the mitochondrial damage was also detected by flow *** expression of target genes was detected by quantitative real-time polymerase chain ***:A total of 130 compounds and 198 genes were identified as potential active ingredients and putative liver cancer‑related *** obtained 1,899 disease targets and 297 transcriptome targets from the *** drug-disease intersecting genes,CCNB1,BIRC5,TOP2A,ESR1,IGF2 and IGFBP3 were *** are enrichment in apoptosis,PI3K-AKT signaling pathway,MAPK signaling pathway,pathways in cancer and p53 signaling ***,it was found that the apoptosis rate of the HepG2 cells in Xihuang pill treated group was significantly higher than that of the control *** the apoptosis rate gradually increased in a dose depe

关键词： Xihuang pill liver cancer network pharmacology p53 signal pathway apoptosis-multiple species pathway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Glucagon-like peptide-1 protects against cardiac microvascular endothelial cells injured by high glucose

引用

Asian Pacific Journal of Tropical Medicine 2015年第1期8卷 73-78页

作者： Guang-Hao Ge Hong-Jie Dou Shuan-Suo Yang Jiang-Wei Ma wen-bo cheng Zeng-Yong Qiao Yue-Mei Hou Wei-Yi Fang Department of Cardiology Fengxian District Central Hospital Department of Cardiology Shanghai Jiaotong University Affiliated Sixth People's Hospital South campus Department of Intensive Care Unit Fengxian District Central Hospital Department of Intensive Care Unit Department of CardiologyShanghai Jiaotong University Affiliated Sixth People's Hospital South campus Department of Cardiology Shanghai Jiaotong University Affiliated Chest Hospital

Objective:To investigate the protective effect of glucagon-like peptid-1(GLP-l) against cardiac microvascular endothelial cell(GTFCs) injured by high ***:CMECs were isolated and *** assay kit and dihydroethidine(DHE) staining were used to assess oxidative *** staining and caspase 3 expression were used to assess the apoptosis of CMECs.H89 was used to inhibit eAMP/PKA pathway:fasudil was used to inhibit Rho/ROCK *** protein expressions of *** uere examined by Western blol ***:High glucose increased the production of *** activity of *** apoptosis rate and the expression level of Rho/ROCK in *** GLP- 1 decreased high glucose-induced ROS *** NADPH activity and the apoptosis rate and the expression level of Rho/ROCK in CMECs,the difference were statistically significant(P<0.05).Conclusions:GLP-1 could protect the cardiac microvessels against oxidative stress and *** protective effects of GLP-1 are dependent on downstream inhibition of Rho through a cAMP/PKA-dependent manner,resulting in a subsequent decrease in the expression of NADPH oxidase.

关键词： Glucagon-like peptid-1 Cardiac microvascular endothelial cell ROS Rho/ROCK

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cooperative HARQ protocol and diversity analysis of systems with multiple incremental relays

引用

The Journal of China Universities of Posts and Telecommunications 2009年第5期16卷 8-13页

作者： FAN Bin , WANG wen-bo, LIN Yi-cheng, ZHENG Kan Wireless Signal Processing and Network Lab, Key Laboratory of Universal Wireless Communication, Ministry of Education, Beijing University of Posts and Telecommunications, Beijing 100876, China [a]Wireless Signal Processing and Network Lab Key Laboratory of Universal Wireless Communication Ministry of Education Beijing University of Posts and Telecommunications Beijing 100876 China

Wireless networks contain an inherent distributed spatial diversity that can be exploited by relays. Relay networks can take advantage of the broadcast-oriented nature of wireless transmission, but require more radio resource to transmit data for their multi-hop traits. Fortunately, incremental relaying technique, which can choose direct or multi-hop transmission adaptively, can efficiently utilize resource. In this article, the incremental transmission with amplify-and-forward （AF） relays is focused on. A practical hybrid-automatic retransmission request （HARQ） protocol is designed, and the related optimal relay selection strategy is proposed. To analyze the cooperative diversity of system with the proposed protocol, the capacity lower bound is deduced. Simulation and analytical results indicate that by adopting the optimal relay selection strategy, the system with the proposed HARQ protocol can achieve an order of cooperative diversity that equals the aggregated number of the relay and source nodes.

关键词： cooperative HARQ AF incremental relay diversity gain

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

引用

Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-Jun Zhang wen-Wei Wang Jing-Shui Zhen bo-cheng Li De-cheng Cai Yang-Yang Du Hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prediction and validation of molecular biological mechanism of Fuzheng Huayu capsule in the treatment of liver cancer

引用

Cancer Advances 2023年第7期6卷 1-9页

作者： Zi-Ning Wang Ayesha T.Tahir Saba Waris wen-bo cheng Jun Kang School of Life Sciences Tianjin UniversityTianjin 300072China Department of Biosciences COMSATS University IslamabadIslamabad 45550Pakistan Department of Gynacology Allama Lqbal Medical CollegeLahore 54000Pakistan Tianjin Key Laboratory of Medical Mass Spectrometry for Accurate Diagnosis Tianjin 300399China

Background:Fuzheng Huayu capsule(FZHY)combined with antiviral treatment has been shown to significantly reduce the risk of liver cancer in patients with hepatitis B ***,the potential of FZHY to directly treat liver cancer remains largely *** study aims to investigate the molecular mechanism underlying the potential of FZHY in treating liver ***:A network pharmacological analysis was performed using the Traditional Chinese Medicine Systems Pharmacology database to identify FZHY compounds and *** targets were searched using the Genecards database,and transcriptome data was downloaded from the NCBI *** Ontology analysis was conducted using the DAVID database,and Kyoto Encyclopedia of Genes and Genomes analysis was based on KOBAS and bioinformatics *** Swissdock database was used for molecular *** cell experiments,the half inhibitory concentration(IC50)of FZHY was determined using the CCK8 *** effects of FZHY on cell viability,apoptosis,and mitochondrial membrane potential were evaluated using a fluorescence microscope and flow *** molecular mechanism of FZHY in treating liver cancer was verified using quantitative polymerase chain ***:A total of 127 compounds and 184 proteins were identified as potential active ingredients and putative liver cancer-related ***,1,899 liver cancer targets,279 transcriptome targets,and 3 pathways(p53 signaling pathway,apoptosis and PI3K-Akt pathway)were *** FZHY-targets-liver cancer interaction network was ***50 of FZHY lyophilized powder solution to liver cancer was 5.13 mg/mL(IC50=5.13 mg/mL).FZHY treatment led to an increase in the ratio of cell apoptosis and induced mitochondrial membrane potential damage,resulting in an increase in the number of dead *** expression levels of CCNB1 and BIRC5 were induced with FZHY treatment,while the expression levels of AKR1C3 and IGF2 were ***

关键词： liver cancer Fuzheng Huayu capsule traditional Chinese medicine CCNB1 BIRC5 AKR1C3 IGF2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

引用

Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen wen bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Improving postoperative outcomes in patients with pancreatic cancer:Inflammatory and nutritional biomarkers

引用

World Journal of Clinical Oncology 2025年第1期16卷 59-64页

作者： Chun-Han cheng wen-Rui Hao Tzu-Hurng cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305Taiwan Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561Taiwan Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328Taiwan

This editorial assesses the prognostic value of preoperative inflammatory and nutritional biomarkers in patients undergoing surgical resection for pancreatic *** et al evaluated the ability of seven biomarkers to predict postoperative recovery and long-term *** biomarkers were albumin-to-globulin ratio,prognostic nutritional index(PNI),systemic immune-inflammation index,neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,nutritional risk index,and geriatric nutritional risk *** PNI was found to be a strong predictor of both overall and recurrence-free survival,underscoring its clinical relevance in managing patients with pancreatic cancer.

关键词： Pancreatic cancer Prognostic nutritional index Systemic immune-inflammation index Postoperative recovery Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：