检索结果-南通市图书馆

Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC(CTONG1804):a multicenter open-label phase II study

引用

Signal Transduction and Targeted Therapy 2024年第1期9卷 249-258页

作者： Si-Yang Liu Song Dong Xue-Ning Yang Ri-Qiang Liao Ben-Yuan Jiang Qun Wang Xiao-Song Ben Gui-Bin Qiao Jun-Tao Lin Hong-Hong Yan Li-Xu Yan Qiang Nie Hai-Yan Tu Bin-Chao Wang Jin-Ji Yang Qing Zhou Hong-Rui Li Ke Liu wendy Wu Si-Yang Maggie Liu wen-zhao zhong Yi-Long Wu Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Department of Thoracic Surgery Zhongshan HospitalFudan UniversityShanghaiChina Department of Thoracic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Department of Pathology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Fujian Key Laboratory of Advanced Technology for Cancer Screening and Early Diagnosis FuzhouChina Berry Oncology Corporation FuzhouChina Chinese Thoracic Oncology Group(CTONG) GuangzhouChina Department of Hematology The First Affiliated HospitalJinan UniversityGuangzhouChina

This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive(N)and nivolumab–chemotherapy(N/C)combinations based on PD-L1 *** patients exhibited resectable clinical stage IIA–IIIB(AJCC 8th edition)NSCLC without EGFR/ALK *** received either mono-nivolumab(N)or nivolumab+nabpaclitaxel+carboplatin(N/C)for three cycles based on PD-L1 *** primary endpoint was the major pathological response(MPR).Key secondary endpoints included the pathologic complete response(pCR),objective response rate(ORR),and event-free survival(EFS).Baseline PD-L1 expression and perioperative circulating tumor DNA(ctDNA)status were correlated with pCR and ***-two patients were enrolled,with 46 undergoing *** MPR was 50.0%(26/52),with 25.0%(13/52)achieving pCR,and 16.7%and 66.7%for patients with PD-L1≥50%in N and N/C groups,***(25.0%)patients experienced grade 3 or higher immune-related adverse events during neoadjuvant *** with post-neoadjuvant ctDNA negativity was more likely to have pCR(39.1%)compared with those remained positive(6.7%,odds ratio=6.14,95%CI 0.84-Inf,p=0.077).With a median follow-up of 25.1 months,the 18-month EFS rate was 64.8%(95%CI 51.9–81.0%).For patients with ctDNA–***+,the 18m-EFS rate was 93.8%vs 47.3%(HR,0.15;95%CI 0.04,0.94;p=0.005).Immunochemotherapy may serve as an optimal neoadjuvant treatment even for patients with PD-L1 expression≥50%.ctDNA negativity following neoadjuvant treatment and surgery could help identify superior pathological and survival benefits,which requires further confirmation in a prospective clinical trial(NCT04015778).

关键词： chemotherapy NSCLC treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neoadjuvant immunotherapy for non-small cell lung cancer:State of the art

引用

Cancer Communications 2021年第4期41卷 287-302页

作者： Jin Kang Chao Zhang wen-zhao zhong Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSchool of MedicineGuangzhouGuangdong 510080P.R.China Southern Medical University GuangzhouGuangdong 510515P.R.China

Lung cancer mortality has decreased over the past decade and can be partly attributed to advances in targeted therapy and *** checkpoint inhibitors(ICIs)have rapidly evolved from investigational drugs to standard of care for the treatment ofmetastatic non-small cell lung cancer(NSCLC).In particular,antibodies that block inhibitory immune checkpoints,such as programmed cell death protein 1(PD-1)and programmed cell death 1 ligand 1(PD-L1),have revolutionized the treatment of advanced NSCLC,when administered alone or in combination with *** is associated with higher response rates,improved overall survival(OS),and increased tolerability compared with conventional cytotoxic *** benefits may increase the utility of immunotherapy and its combinational use with chemotherapy in the neoadjuvant treatment of patients with *** findings from various ongoing clinical trials suggest that neoadjuvant ICIs alone or combined with chemotherapy may significantly reduce systemic recurrence and improve long-term OS or cure rates in resectable *** we further summarize the safety and efficacy of various neoadjuvant treatment regimens including immunotherapy from ongoing clinical trials and elaborate the role of neoadjuvant immunotherapy in patients with resectable *** addition,we discuss several unresolved challenges,including the evaluations to assess neoadjuvant immunotherapy response,the role of adjuvant treatment after neoadjuvant immunotherapy,the efficacy of treatment for oncogenic-addicted tumors,and predictive *** also provide our perspective on ways to overcome current obstacles and establish neoadjuvant immunotherapy as a standard of care.

关键词： chemoimmunotherapy clinical trials imaging immunotherapy neoadjuvant non-small cell lung cancer perioperative radiotherapy surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Carbon efficiency modeling and optimization of solar-powered cellular networks

引用

Science China(Information Sciences) 2024年第5期67卷 228-243页

作者： Yuxi zhao Xiaohu GE wen YAN Tao HAN Yi zhong School of Electronic Information and Communications Huazhong University of Science and Technology Huawei Technology Co. Ltd.

As wireless communication traffic experiences rapid growth, the carbon emissions caused by the communication industry are also on the rise. To achieve “carbon neutrality”, researchers are considering the use of renewable energy sources to power cellular networks, thereby reducing carbon emissions. However, a challenge arises when using renewable energy, specifically owing to the unpredictable nature of both the energy consumption of the cellular network and the power generation from renewable sources. This inconsistency results in low renewable energy utilization and reduced carbon efficiency. Herein, we construct a carbon efficiency model of solar-powered cellular networks using practical data from solar radiation. We propose a mechanism that alternately optimizes the performance of the renewable energy network and the cellular network. This approach is based on convex optimization theory and the Dinkelback algorithm, and it leads to the design of a carbon efficiency optimization algorithm. This algorithm aims to improve the carbon efficiency of cellular networks and reduce their carbon emissions. Simulation results demonstrate that our optimization scheme yields a maximum improvement of 2.56 × 108bps/g in the carbon efficiency of the cellular network as compared to conventional power allocation schemes such as the traditional water filling method and heuristic energy sharing and charge/discharge algorithms.

关键词： cellular networks renewable energy carbon efficiency convex optimization theory dinkelbach

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Study of deep transportation and plugging performance of deformable gel particles in porous media

引用

Petroleum Science 2024年第2期21卷 962-973页

作者： wen-Jing zhao Jing Wang zhong-Yang Qi Hui-Qing Liu National Key Laboratory of Petroleum Resources and Engineering China University of PetroleumBeijing102249China MOE Key Laboratory of Petroleum Engineering China University of PetroleumBeijing102249China

Deformable gel particles(DGPs) possess the capability of deep profile control and flooding. However, the deep migration behavior and plugging mechanism along their path remain unclear. Breakage, an inevitable phenomenon during particle migration, significantly impacts the deep plugging effect. Due to the complexity of the process, few studies have been conducted on this subject. In this paper, we conducted DGP flow experiments using a physical model of a multi-point sandpack under various injection rates and particle sizes. Particle size and concentration tests were performed at each measurement point to investigate the transportation behavior of particles in the deep part of the reservoir. The residual resistance coefficient and concentration changes along the porous media were combined to analyze the plugging performance of DGPs. Furthermore, the particle breakage along their path was revealed by analyzing the changes in particle size along the way. A mathematical model of breakage and concentration changes along the path was established. The results showed that the passage after breakage is a significant migration behavior of particles in porous media. The particles were reduced to less than half of their initial size at the front of the porous media. Breakage is an essential reason for the continuous decreases in particle concentration, size, and residual resistance coefficient. However, the particles can remain in porous media after breakage and play a significant role in deep plugging. Higher injection rates or larger particle sizes resulted in faster breakage along the injection direction, higher degrees of breakage, and faster decreases in residual resistance coefficient along the path. These conditions also led to a weaker deep plugging ability. Smaller particles were more evenly retained along the path, but more particles flowed out of the porous media, resulting in a poor deep plugging effect. The particle size is a function of particle size before inject

关键词： Physical simulation Deformable gel particle Breakage Particle size Residual resistance coefficient

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

树脂基复合材料无损检测及损伤修复技术研究

引用

航空精密制造技术 2024年第1期60卷 62-64,67页

作者：薛旋赵文忠许培伦李建伟孙坤中国电子科技集团公司第二十研究所西安710068

介绍了树脂基复合材料热压罐成型过程及服役过程中的各类缺陷,分析了缺陷产生的原因。针对各类缺陷,阐述了当前复合材料常用的无损检测技术以无损检测技术发展趋势。最后,针对复合材料的损伤修复,本文进一步论述了几种常见的损伤修复技... 详细信息

介绍了树脂基复合材料热压罐成型过程及服役过程中的各类缺陷,分析了缺陷产生的原因。针对各类缺陷,阐述了当前复合材料常用的无损检测技术以无损检测技术发展趋势。最后,针对复合材料的损伤修复,本文进一步论述了几种常见的损伤修复技术及当前新兴的外场原位修复技术。

关键词：复合材料热压罐成型无损检测损伤修复

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Topology optimization of chiral metamaterials with application to underwater sound insulation

引用

Applied Mathematics and Mechanics(English Edition) 2024年第7期45卷 1119-1138页

作者： Chao WANG Honggang zhao Yang WANG Jie zhong Dianlong YU Jihong wen Laboratory of Science and Technology on Integrated Logistics Support National University of Defense TechnologyChangsha410073China

Chiral metamaterials have been proven to possess many appealing mechanical phenomena,such as negative Poisson's ratio,high-impact resistance,and energy *** work extends the applications of chiral metamaterials to underwater sound *** chiral metamaterials with low acoustic impedance and proper stiffness are inversely designed using the topology optimization *** acoustic impedance enables the metamaterials to have a high and broadband sound transmission loss(STL),while proper stiffness guarantees its robust acoustic performance under a hydrostatic *** proof-of-concept demonstrations,two specimens are fabricated and tested in a water-filled impedance *** results show that,on average,over 95%incident sound energy can be isolated by the specimens in a broad frequency range from 1 k Hz to 5 k Hz,while the sound insulation performance keeps stable under a certain hydrostatic *** work may provide new insights for chiral metamaterials into the underwater applications with sound insulation.

关键词： chiral metamaterial topology optimization underwater sound insulation low acoustic impedance sound transmission loss(STL)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

First Fatal Infection and Phylodynamic Analysis of Severe Fever with Thrombocytopenia Syndrome Virus in Jilin Province,Northeastern China

引用

Virologica Sinica 2021年第2期36卷 329-332页

作者： Xu Zhang Nina Wang Zedong Wang Lihe Che Chen Chen wen-zhong zhao Quan Liu School of Life Sciences and Engineering Foshan UniversityFoshan 528225China The First Hospital of Jilin University Changchun 130021China Key Laboratory of National Health and Family Planning Commission of China for Male Reproduction and Genetics Family Planning Research Institute of Guangdong ProvinceGuangzhou 510600China

Dear Editor,Severe fever with thrombocytopenia syndrome(SFTS),caused by SFTS virus(SFTSV)in the genus Banyangvirus of the family Phenuiviridae,is an emerging tick-borne viral zoonosis(Liu et al.2014).Typical clinical symptoms of SFTS include fever,headache,thrombocytopenia,and leukocytopenia(Yu et al.2011).Since SFTSV was identified in 2009,it has been found in more than 20 provinces in China and is closely related to strains from Japan and South Korea(Kim et al.2013;Takahashi et al.2014).

关键词： eastern dynamic Jilin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Artificial intelligence-assisted repair of peripheral nerve injury: a new research hotspot and associated challenges

引用

Neural Regeneration Research 2024年第3期19卷 663-670页

作者： Yang Guo Liying Sun wenyao zhong Nan Zhang Zongxuan zhao wen Tian Department of Hand Surgery Beijing Jishuitan HospitalBeijingChina

Artificial intelligence can be indirectly applied to the repair of peripheral nerve ***,it can be used to analyze and process data regarding peripheral nerve injury and repair,while study findings on peripheral nerve injury and repair can provide valuable data to enrich artificial intelligence *** investigate advances in the use of artificial intelligence in the diagnosis,rehabilitation,and scientific examination of peripheral nerve injury,we used CiteSpace and VOSviewer software to analyze the relevant literature included in the Web of Science from 1994–*** identified the following research hotspots in peripheral nerve injury and repair:(1)diagnosis,classification,and prognostic assessment of peripheral nerve injury using neuroimaging and artificial intelligence techniques,such as corneal confocal microscopy and coherent anti-Stokes Raman spectroscopy;(2)motion control and rehabilitation following peripheral nerve injury using artificial neural networks and machine learning algorithms,such as wearable devices and assisted wheelchair systems;(3)improving the accuracy and effectiveness of peripheral nerve electrical stimulation therapy using artificial intelligence techniques combined with deep learning,such as implantable peripheral nerve interfaces;(4)the application of artificial intelligence technology to brain-machine interfaces for disabled patients and those with reduced mobility,enabling them to control devices such as networked hand prostheses;(5)artificial intelligence robots that can replace doctors in certain procedures during surgery or rehabilitation,thereby reducing surgical risk and complications,and facilitating postoperative *** artificial intelligence has shown many benefits and potential applications in peripheral nerve injury and repair,there are some limitations to this technology,such as the consequences of missing or imbalanced data,low data accuracy and reproducibility,and ethical issues(e.g.,privac

关键词： artificial intelligence artificial prosthesis medical-industrial integration brain-machine interface deep learning machine learning networked hand prosthesis neural interface neural network neural regeneration peripheral nerve

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genomic Evolution of Lung Cancer Metastasis:Current Status and Perspectives

引用

Cancer Communications 2021年第12期41卷 1252-1256页

作者： wen-Fang Tang Rui Fu Yi Liang Jie-Shan Lin Zhen-Bin Qiu Yi-Long Wu wen-zhao zhong Department of Cardiothoracic Surgery Zhongshan City People’s HospitalZhongshanGuangdong 528403P.R.China Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s Hospital&Guangdong Academy of Medical SciencesGuangzhouGuangdong 510080P.R.China Department of Nephrology Blood Purification CenterZhongshan City People’s HospitalZhongshanGuangdong 528403P.R.China Southern Medical University GuangzhouGuangdong 510515P.R.China

INTRODUCTION Lung cancer is one of the cancers with the highest morbidity and mortality *** the two past decades,although the treatment of non-small cell lung cancer(NSCLC)has been revolutionized by the use of tyrosine kinase inhibitor(TKI)and immune treatments,metastatic disease remains largely incurable and presents a 5-year survival rate of approximately 10%[1].

关键词： Lung mortality lung

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Magnetic-field-assisted triboelectric nanogenerator for harvesting multi-directional wave energy

引用

Nano Research 2024年第8期17卷 7144-7152页

作者： Mengru Ding Jianlong Wang Da zhao Hengyu Li Xiaojun Cheng Jianming wen zhong Lin Wang Tinghai Cheng Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049China Guangzhou Institute of Blue Energy Guangzhou 510555China College of Engineering Zhejiang Normal UniversityJinhua 321004China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332-0245USA

Ocean wave energy is a significant and promising source of renewable ***,the energy harvesting is challenging due to the multi-directional nature of *** paper proposes a magnetic-field-assisted triboelectric nanogenerator(MFATENG)for harvesting multi-directional wave *** incorporating a magnetic field,the planar motion of the pendulum is converted into spatial motion,increasing the triggering of multilayered TENG(M-TENG)and enhancing the output energy of the *** results demonstrate that the output energy of the MFA-TENG is increased by 73%by utilizing the magnetic ***,a spring model based on the origami-structured M-TENG is established to analyze the effect of different equivalent stiffnesses on the performance of the M-TENG,aiming to obtain optimal output *** results showcase the impressive output performance of the M-TENG,generating outputs of 250 V,18μA,and 255 ***,the proposed MFA-TENG effectively harvests multi-directional wave energy under water-wave driven *** study significantly enhances the ability of the MFA-TENG to harvest multi-directional wave energy and presents a promising approach for self-powered marine monitoring in the future.

关键词： triboelectric nanogenerator magnetic-field-assisted spring model multi-directional wave energy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：