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Knockdown of HE4 suppresses tumor growth and invasiveness in lung adenocarcinoma through regulation of EGFR signaling

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Oncology Research 2024年第6期32卷 1119-1128页

作者： YUE ZhanG wenYU YANG XIAOWANG han YUE QIAO HAITAO WANG TING CHEN TIANYING LI wen-BIN OU Department of Biopharmaceutics College of Life Sciences and MedicineZhejiang Provincial Key Laboratory of Silkworm Bioreactor and BiomedicineZhejiang Sci-Tech UniversityHangzhou310018China Department of Thoracic Surgery Zhejiang Provincial People’s HospitalHangzhou310014China

It has been shown that the high expression of human epididymis protein 4(HE4)in most lung cancers is related to the poor prognosis of patients,but the mechanism of pathological transformation of HE4 in lung cancer is still *** current study is expected to clarify the function and mechanism of HE4 in the occurrence and metastasis of lung adenocarcinoma(LUAD).Immunoblotting evaluated HE4 expression in lung cancer cell lines and biopsies,and through analysis of The Cancer Genome Atlas(TCGA)*** HE4 overexpression was demonstrated in LUAD,but not in lung squamous cell carcinoma(LUSC),indicating that HE4 can serve as a biomarker to distinguish between LUAD and ***4 knockdown significantly inhibited cell growth,colony formation,wound healing,and invasion,and blocked the G1-phase of the cell cycle in LUAD cell lines through inactivation of the EGFR signaling downstream including PI3K/AKT/mTOR and RAF/MAPK *** first-line EGFR inhibitor gefitinib and HE4 shRNA had no synergistic inhibitory effect on the growth of lung adenocarcinoma cells,while the third-line EGFR inhibitor osimertinib showed additive anti-proliferative ***,we provided evidence that HE4 regulated EGFR expression by transcription regulation and protein interaction in *** findings suggest that HE4 positively modulates the EGFR signaling pathway to promote growth and invasiveness in LUAD and highlight that targeting HE4 could be a novel strategy for LUAD treatment.

关键词： Lung adenocarcinoma Human epididymis protein 4 Epidermal growth factor receptor Biomarker Targeted therapies

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Physicochemical principles of hydrogen metallurgy in blast furnace

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Journal of Iron and Steel Research(International) 2024年第1期31卷 46-63页

作者： han-jie Guo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing100083China

Based on the stoichiometric method and the free energy minimization method,an ideal model for the reduction of iron oxides by carbon and hydrogen under blast furnace conditions was established,and the reduction efficiency and theoretical energy consumption of the all-carbon blast furnace and the hydrogen-rich blast furnace were *** results show that after the reduction reaction is completed at the bottom of the blast furnace,the gas produced by reduction at 1600℃still has a certain excessive reduction capacity,which is due to the hydrogen brought in by the hydrogen-rich blast as well as the excess carbon monoxide generated by the reaction of the coke and the oxygen brought in by the *** the process of the gas with excessive reduction capacity rising from the bottom of the blast furnace and gas reduction process,the excessive reduction capacity of the gas gradually decreases with the increase in the dydrogen content in the *** the all-carbon blast furnace,the excess gas reduction capacity is the strongest,and the total energy consumption per ton of iron reduction is the *** shows that,for the current operation mode of the blast furnace,adding hydrogen in the blast furnace cannot reduce the consumption of carbon required for reduction per ton of iron,but rather increases the consumption of carbon.

关键词： Hydrogen metallurgy Excess gas reduction capacity Theoretical energy consumption Hydrogen-rich blast furnace Thermodynamic model Gibbs minimum free energy method

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Engineered plant extracellular vesicles for autoimmune diseases therapy

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Nano Research 2024年第4期17卷 2857-2873页

作者： Ruina han Yan Wu Yafei han Xiangfei Liu han Liu Jiacan Su Institute of Translational Medicine Shanghai UniversityShanghai 200444China Organoid Research Center Shanghai UniversityShanghai 200444China National Center for Translational Medicine(Shanghai)SHU Branch Shanghai UniversityShanghai 200444China Department of Orthopedics Shanghai Zhongye HospitalShanghai 200941China Department of Orthopedics Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China

Autoimmune diseases(AID)encompass a diverse array of conditions characterized by immune system dysregulation,resulting in aberrant responses of B cells and T cells against the body’s own healthy *** extracellular vesicles(PEVs)are nanoscale particles enclosed by phospholipid bilayers,secreted by plant cells,which facilitate intercellular communication by transporting various bioactive *** to their nanoscale structure,safety,abundant sources,low immunogenicity,high yield,biocompatibility,and effective targeting of the colon and liver,PEVs are regarded as a promising platform for the treatment of *** review provides a comprehensive summary of PEV biogenesis,physicochemical and biological properties,internalization mechanisms,isolation methods,and their applications in various diseases,with a specific focus on their potential roles in ***,we propose engineering approaches and administration methods for ***,we present an overview of the advantages and challenges associated with utilizing PEVs for the treatment of *** gaining a comprehensive understanding of PEVs,we anticipate the development of innovative therapeutic strategies for *** and engineered PEVs hold substantial promise as a valuable resource for innovative technologies in AID treatment.

关键词： autoimmune diseases plant extracellular vesicles extracellular vesicles engineering modification

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The RING zinc finger protein LbRZF1 promotes salt gland development and salt tolerance in Limonium bicolor

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Journal of Integrative Plant Biology 2024年第4期66卷 787-809页

作者： Zongran Yang Ziwei Zhang Ziqi Qiao Xueying Guo Yixuan wen Yingxue Zhou Chunliang Yao Hai Fan Baoshan Wang Guoliang han Shandong Provincial Key Laboratory of Plant Stress College of Life SciencesShandong Normal UniversityJi'nan 250014China National Center of Technology Innovation for Comprehensive Utilization of Saline-Alkali Land Agricultural High-tech Industrial Demonstration Area of the Yellow River Delta of Shandong ProvinceDongying 257000China Dongying Institute Shandong Normal UniversityDongying 257000China

The recretohalophyte Limonium bicolor thrives in high-salinity environments because salt glands on the above-ground parts of the plant help to expel excess ***,we characterize a nucleus-localized C3HC4(RING-HC)-type zinc finger protein of *** named RING ZINC FINGER PROTEIN 1(LbRZF1).LbRZF1 was expressed in salt glands and in response to NaCl ***1 showed no E3 ubiquitin ligase *** phenotypes of overexpression and knockout lines for LbRZF1 indicated that LbRZF1 positively regulated salt gland development and salt tolerance in ***1 mutants had fewer salt glands and secreted less salt than did the wild-type,whereas LbRZF1-overexpressing lines had opposite phenotypes,in keeping with the overall salt tolerance of these plants.A yeast two-hybrid screen revealed that LbRZF1 interacted with LbCATALASE2(LbCAT2)and the transcription factor LbMYB113,leading to their *** of LbCAT2 or LbMYB113 decreased salt gland density and salt *** heterologous expression of LbRZF1 in Arabidopsis thaliana conferred salt tolerance to this *** also identified the transcription factor LbMYB48 as an upstream regulator of LbRZF1 *** study of LbRZF1 in the regulation network of salt gland development also provides a good foundation for transforming crops and improving their salt resistance.

关键词： LbRZF1 Limonium bicolor molecular mechanism salt gland development salt tolerance

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A2B7-type La-Mg-Ni alloys prepared by Mg thermal diffusion for improved hydrogen storage performance

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Rare Metals 2024年第7期43卷 3260-3272页

作者： Yong-Xi Zhang Guan-Jiu Wu Jing Gu Hong-Xing Kang Yuan Li Di Zhou wen-Feng Wang Lu Zhang Shu-Min han Hebei Key Laboratory of Applied Chemistry School of Environmental and Chemical EngineeringYanshan University Department of Chemistry and Biochemistry San Diego State University State Key Laboratory of Metastable Materials Science and Technology Yanshan University

A novel approach based on thermal diffusion was used to achieve controllable Mg content in A2B7-type La-Mg-Ni-based *** formation mechanism of the A2B7-type phase as a result of the thermal diffusion process and the effect of Mg content on hydrogen storage performance were investigated.X-ray diffraction（XRD） patterns and Rietveld refinement results showed that increased Mg transformed the LaNi5phase in the La0.74Sm0.03Y0.23Ni4.32Al0.04precursor alloy into a superlattice *** electron microscopy（SEM） images showed that Mg was evenly distributed in the alloy *** in the superlattice significantly inhibited the phase decomposition of the superlattice structure during the hydrogen absorption/desorption *** A2B7-type La0.57Sm0.02Y0.18Mg0.23Ni3.38Al0.03alloy composed of Gd2Co7and Ce2Ni7phases was successfully *** pressure-composition isotherm profiles showed that the alloy had a hydrogen storage capacity as high as 1.73 wt%,with good cycling *** 50 cycles of hydrogen absorption/desorption,the alloy retained a hydrogen storage capacity of 1.45 wt%,with a capacity retention rate of up to 84.28%.The Mg thermal diffusion process thus provides a new approach for the controlled preparation of La-Mg-Ni-based alloys.

关键词： La–Mg–Ni-based hydrogen storage alloy A 2 B 7 -type superlattice alloy Mg thermal diffusion process Phase transformation Hydrogen storage property

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New insights into the deposition of natural gas hydrate on pipeline surfaces:A molecular dynamics simulation study

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Petroleum Science 2024年第1期21卷 694-704页

作者： Jun Zhang Hai-Qiang Fu Mu-Zhi Guo Zhao Wang Li-wen Li Qi Yin You-Guo Yan Wei Wei Wei-Feng han Jie Zhong School of Materials Science and Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina School of Petroleum Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina Department of Alternative Energy PetroChina Research Institute of Petroleum Exploration&DevelopmentLangfang 065007HebeiChina

Natural gas hydrate(NGH)can cause pipeline blockages during the transportation of oil and gas under high pressures and low *** hydrate adhesion on pipelines is viewed as an efficient way to prevent NGH *** studies suggested the water film can greatly increase hydrate adhesion in gas-dominant ***,by performing the molecular dynamics simulations,we find in water-dominant system,the water film plays different roles in hydrate deposition on Fe and its corrosion ***,due to the strong affinity of water on Fe surface,the deposited hydrate cannot convert the adsorbed water into hydrate,thus,a water film *** water affinities decrease(Fe>Fe_(2)O_(3)>FeO>Fe_(3)O_(4)),adsorbed water would convert to amorphous hydrate on Fe_(2)O_(3)and form the ordered hydrate on FeO and Fe_(3)O_(4)after hydrate *** absorbed water film converts to amorphous or to hydrate,the adhesion strength of hydrate continuously increases(Fehanisms on Fe and its corrosion surfaces and suggest hydrate deposition can be adjusted by changing water affinities on pipeline surfaces.

关键词： Deposition Natural gas hydrate Pipelines Water affinity Adhesion strength

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Elucidating the cardioprotective mechanisms of sodium-glucose cotransporter-2 inhibitors beyond glycemic control

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World Journal of Diabetes 2024年第2期15卷 137-141页

作者： Ke-Xin Zhang Cheng-Xia Kan Fang han Jing-wen Zhang Xiao-Dong Sun Department of Endocrinology and Metabolism Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina

Sodium-glucose cotransporter-2(SGLT2)inhibitors have emerged as a pivotal intervention in diabetes management,offering significant cardiovascular ***,in particular,has demonstrated cardioprotective effects beyond its glucose-lowering action,reducing heart failure hospitalizations and improving cardiac *** note,the cardioprotective mechanisms appear to be independent of glucose lowering,possibly mediated through several mechanisms involving shifts in cardiac metabolism and anti-fibrotic,anti-inflammatory,and anti-oxidative *** editorial summarizes the multifaceted cardiovascular advantages of SGLT2 inhibitors,highlighting the need for further research to elucidate their full therapeutic potential in cardiac care.

关键词： Diabetes Sodium-glucose cotransporter-2 Cardiovascular diseases Empagliflozin

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Wheel-legged In-pipe Robot with a Bioinspired Hook and Dry Adhesive Attachment Device

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Journal of Bionic Engineering 2024年第3期21卷 1208-1222页

作者： Yahong Liu Yi Sun Kai Cao Shutao Wu Xiaofeng Xu Qingfei han Shikun wen Huan Shen Guangming Chen Jiajun Xu Zhiwei Yu Aihong Ji Lab of Locomotion Bioinspiration and Intelligent Robots College of Mechanical and Electrical EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

In-pipe robots have been widely used in pipes-with smooth inner ***,current in-pipe robots face challenges in terms of moving past obstacles and climbing in marine-vessel pipeline systems,which are affected by marine biofouling and electrochemical *** paper takes inspiration from the dual-hook structure of Trypoxylus dichotomus’s feet and gecko‑like dry adhesives,proposing an in-pipe robot that is capable of climbing on rough and smooth pipe *** combination of the bioinspired hook and dry adhesives allows the robot to stably attach to rough or smooth pipe inwalls,while the wheel-leg hybrid mechanism provides better conditions for obstacle *** paper explores the attachment and obstacle-surmounting mechanisms of the ***,motion strategies for the robot are devised based on different pipe structural *** experiments showed that this robot can adapt to both smooth and rough pipe environments simultaneously,and its motion performance is superior to conventional driving *** robot’s active turning actuators also enable it to navigate through horizontally or vertically oriented 90°bends.

关键词： In-pipe robot Bioinspired attachment device Wheel-legged robot Mechanical design

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Random Raman Fiber Laser as a Liquid Refractive Index Sensor

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Photonic Sensors 2024年第1期14卷 13-22页

作者： Bing han Yuxi MA han WU Yong ZHAO College of Information Science and Engineering Northeastern UniversityShenyang 110819China Hebei Key Laboratory of Micro-Nano Precision Optical Sensing and Measurement Technology Qinhuangdao 066004China College of Electronics and Information Engineering Sichuan UniversityChengdu 610064China

In this paper,a new concept of forward-pumped random Raman fiber laser(RRFL)-based liquid refractive index sensing is proposed for the first *** liquid refractive index sensing,the flat fiber end immersed in the liquid can act as the point reflector for generating random fiber lasing and also as the sensing *** to the high sensitivity of the output power of the RRFL to the reflectivity provided by the point reflector in the ultralow reflectivity regime,the proposed RRFL is capable of achieving liquid refractive index sensing by measuring the random lasing output *** theoretically investigate the effects of the operating pump power and fiber length on the refractive index sensitivity for the proposed *** a proof-of-concept demonstration,we experimentally realize high-sensitivity half-open short-cavity RRFL-based liquid refractive index sensing with the maximum sensitivity and the sensing resolution of-39.88W/RIU and 2.5075×10^(-5) RIU,*** also experimentally verify that the refractive index sensitivity can be enhanced with the shorter fiber length of the *** work extends the application of the random fiber laser as a new platform for highly-sensitive refractive index sensing in chemical,biomedical,and environmental monitoring applications,etc.

关键词： Fiber optic sensors refractive index measurements fiber lasers Rayleigh scattering stimulated Raman scattering

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Discontinuity development patterns and the challenges for 3D discrete fracture network modeling on complicated exposed rock surfaces

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2154-2171页

作者： wen Zhang Ming Wei Ying Zhang Tengyue Li Qing Wang Chen Cao Chun Zhu Zhengwei Li Zhenbang Nie Shuonan Wang han Yin College of Construction Engineering Jilin UniversityChangchun130026China Liaoning Nonferrous Geological Exploration and Research Institute Co. Shenyang110013China School of Earth Sciences and Engineering Hohai UniversityNanjing210098China Northeastern University Shenyang110819China

Natural slopes usually display complicated exposed rock surfaces that are characterized by complex and substantial terrain undulation and ubiquitous undesirable phenomena such as vegetation cover and *** study presents a systematic outcrop research of fracture pattern variations in a complicated rock slope,and the qualitative and quantitative study of the complex phenomena impact on threedimensional(3D)discrete fracture network(DFN)*** the studies of the outcrop fracture pattern have been so far focused on local variations,thus,we put forward a statistical analysis of global *** entire outcrop is partitioned into several subzones,and the subzone-scale variability of fracture geometric properties is analyzed(including the orientation,the density,and the trace length).The results reveal significant variations in fracture characteristics(such as the concentrative degree,the average orientation,the density,and the trace length)among different ***,the density of fracture sets,which is approximately parallel to the slope surface,exhibits a notably higher value compared to other fracture sets across all *** improve the accuracy of the DFN modeling,the effects of three common phenomena resulting from vegetation and rockfalls are qualitatively analyzed and the corresponding quantitative data processing solutions are ***,the 3D fracture geometric parameters are determined for different areas of the high-steep rock slope in terms of the subzone *** results show significant variations in the same set of 3D fracture parameters across different regions with density differing by up to tenfold and mean trace length exhibiting differences of 3e4 *** study results present precise geological structural information,improve modeling accuracy,and provide practical solutions for addressing complex outcrop issues.

关键词： Complicated exposed rock surfaces Discontinuity characteristic variation Three-dimensional discrete fracture network modeling Outcrop study Vegetation cover and rockfalls

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