检索结果-南通市图书馆

Effectiveness and tolerability of programmed cell death protein-1 inhibitor+chemotherapy compared to chemotherapy for upper gastrointestinal tract cancers

引用

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1613-1625页

作者： Xiao-Min Zhang Ting Yang Ying-Ying Xu Bao-Zhong Li Wei Shen wen-qing hu Cai-wen Yan Liang Zong Department of Central Laboratory Changzhi People’s HospitalThe Affiliated Hospital of Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina Department of Gastrointestinal Surgery Yizheng People’s HospitalThe Affiliated Hospital of Yangzhou UniversityYangzhou 225000Jiangsu ProvinceChina Department of General Surgery Anyang Tumor HospitalAnyang 455000Henan ProvinceChina Department of General Surgery Wuxi People’s Hospital Affiliated to Nanjing Medical UniversityWuxi 214023Jiangsu ProvinceChina Department of Gastrointestinal Surgery Changzhi People’s HospitalThe Affiliated Hospital of Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina Department of Gastroenterology Changzhi People’s HospitalThe Affiliated Hospital of Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina

BACKGROUND The combination of programmed cell death protein-1(PD-1)inhibitor and che-motherapy is approved as a standard first-or second-line treatment in patients with advanced oesophageal or gastric ***,it is unclear whether this combination is superior to chemotherapy *** To assess the comparative effectiveness and tolerability of combining PD-1 inhibitors with chemotherapy vs chemotherapy alone in patients with advanced gastric cancer,gastroesophageal junction(GEJ)cancer,or oesophageal *** We searched the PubMed and Embase databases for studies that compared the efficacy and tolerance of PD-1 inhibitors in combination with chemotherapy vs chemotherapy alone in patients with advanced oesophageal or gastric *** employed either random or fixed models to analyze the outcomes of each clinical trial,en-compassing data on overall survival(OS),progression-free survival(PFS),objective response rate,and adverse events(AEs).RESULTS Nine phase 3 clinical trials(7016 advanced oesophageal and gastric cancer patients)met the inclusion *** meta-analysis demonstrated that the pooled PD-1 inhibitor+chemotherapy group had a significantly longer OS than the chemotherapy-alone group[hazard ratio(HR)=0.76,95%confidence interval(CI):0.71-0.81];the pooled PFS result was consistent with that of OS(HR=0.67,95%CI:0.61-0.74).The count of patients achieving an objective response in the PD-1 inhibitor+chemotherapy group surpassed that of the chemotherapy-alone group[odds ratio(OR)=1.86,95%CI:1.59-2.18].AE incidence was also higher in the combination-therapy group than in the chemotherapy-alone group,regardless of whether≥grade 3 only(OR=1.30,95%CI:1.07-1.57)or all AE grades(OR=1.88,95%CI:1.39-2.54)were *** performed a subgroup analysis based on the programmed death-ligand 1(PD-L1)combined positive score(CPS)and noted extended OS and PFS durations within the CPS≥1,CPS≥5,and CPS≥10 subgroups of the PD-1 inhibitor+chemotherapy ***

关键词： Programmed cell death protein-1 inhibitor Chemotherapy Oesophageal squamous cell carcinoma Gastric/gastroesophageal junction adenocarcinoma Overall survival Progression-free survival Objective response rate Adverse event

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Achyranthes bidentata polypeptides prevent apoptosis by inhibiting the glutamate current in cultured hippocampal neurons

引用

Neural Regeneration Research 2020年第6期15卷 1086-1093页

作者： Rong-Lu Pan wen-qing hu Jie Pan Li huang Cheng-Cheng Luan Hong-Mei Shen Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Institute of Nautical Medicine Co-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Neurobiology Physiology and BehaviorCollege of Biological ScienceDavisCAUSA Affiliated Mental Health Center of Nantong University Nantong Brain HospitalNantongJiangsu ProvinceChina

Glutamate-induced excitotoxicity plays a critical role in the neurological impairment caused by middle cerebral artery *** bidentata polypeptides have been shown to protect against neurological functional damage caused by middle cerebral artery occlusion,but the underlying neuroprotective mechanisms and the relationship to glutamate-induced excitotoxicity remain ***,in the current study,we investigated the protective effects of Achyranthes bidentata polypeptides against glutamate-induced excitotoxicity in cultured hippocampal *** neurons were treated with Mg^2+-free extracellular solution containing glutamate(300μM)for 3 hours as a model of glutamate-mediated excitotoxicity(glutamate group).In the normal group,hippocampal neurons were incubated in Mg^2+-free extracellular *** the Achyranthes bidentata polypeptide group,hippocampal neurons were incubated in Mg^2+-free extracellular solution containing glutamate(300μM)and Achyranthes bidentata polypeptide at different *** 24 hours after exposure to the agents,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and Hoechst 33258 staining were used to assess neuronal viability and nuclear m'orphology,***-3 expression and activity were evaluated using western blot assay and colorimetric enzymatic assay,*** various time points after glutamate treatment,reactive oxygen species in cells were detected by H2 DCF-DA,and mitochondrial membrane potential was detected by rhodamine 123 *** examine the effect of Achyranthes bidentata polypeptides on glutamate receptors,electrophysiological recording was used to measure the glutamate-induced inward current in cultured hippocampal *** bidentata polypeptide decreased the percentage of apoptotic cells and reduced the changes in caspase-3 expression and activity induced by *** addition,Achyranthes bidentata polypeptide attenuated the amplitud

关键词： Achyranthes bidentata polypeptides apoptosis caspase-3 excitotoxicity glutamate receptors mitochondrial dysfunction mitochondrial membrane potential neuroprotection reactive oxygen species staurosporine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

One-step construction of strongly coupled Co_(3)V_(2)O_(8)/Co_(3)O_(4)/MXene heterostructure via in-situ Co-F bonds for high performance all-solid-state asymmetric supercapacitors

引用

Rare Metals 2024年第2期43卷 682-691页

作者： Ji Zhou Bin-Bin Liu hu Zheng wen-qing Ma Qian Li Cai-Xia Xu Institute for Advanced Interdisciplinary Research(iAIR) Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of ShandongSchool of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China

Co_(3)V_(2)O_(8)/Co_(3)O_(4)/Ti_(3)C_(2)T_(x) composite was easily synthesized via one-step succinct-operated hydrothermal *** interconnected Co_(3)V_(2)O_(8)/Co_(3)O_(4) nanowires network can in-situ grow and anchor on the surface of Ti_(3)C_(2)T_(x) via the strong Co-F bonds and contribute tremendously to depress Ti_(3)C_(2)T_(x) *** from the synergistically interplayed effect among the multiple interfaces and high conductivity of Ti_(3)C_(2)T_(x) as well as outstanding stability of the as-designed nanostructure,the optimum Co_(3)V_(2)O_(8)/Co_(3)O_(4)/Ti_(3)C_(2)T_(x)electrode reaches a commendable specific capacitance(up to 3800 mF·cm^(−2)),great rate capability(80%capacitance retention after 20-times current increasing),and preeminent cycling stability(95.4%/85.5%retention at 7000th/20,000th cycle).Moreover,the all-solid-state asymmetric supercapacitor based on Co_(3)V_(2)O_(8)/Co_(3)O_(4)/Ti_(3)C_(2)T_(x) and active carbon can deliver a high energy density of 84.0μWh·cm^(−2) at the power energy of 3.2 mW·cm^(−2),and excellent cycling durability with 87.0%of initial capacitance retention upon 20,000 *** work provides a practicable pathway to tailor MXene-based composites for high-performance supercapacitor.

关键词： Ti_(3)C_(2)T_(x) Co_(3)V_(2)O_(8)/Co_(3)O_(4) Heterostructure Cathode Supercapacitor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of recombinant human interleukin-11 on expressions of interleukin-11 receptorα-chain and glycoprotein 130 in intestinal epithelium cell line-6 after neutron irradiation

引用

World Journal of Gastroenterology 2006年第19期12卷 3055-3059页

作者： Rui-Juan Wang Rui-Yun Peng Kai-Fei Fu Ya-Bing Gao Rui-Gang Han wen-hua hu qing-Liang Luo Jun-Jie Ma Institute of Radiation Medicine Academy of Military Medical Sciences Beijing 100850 China

AIM： To explore the effect of recombinant human interleukin-11 （rhIL-11） on the expressions of interleukin-11 receptor α-chain （IL-11Rα） and an additional signal transducer glycoprotein 130 （gp130） in intestinal epithelium cell line-6 （IEC-6） after neutron irradiation. METHODS： Cultured IEC-6 cells were exposed to 4.0Gy neutron and treated with 100 ng/mL rhIL-11 12 h prior to or immediately after irradiation. The apoptosis and necrosis rates and expressions of IL-11Rα and gp130 were observed by flow cytometry, immunohistochemistry, Western blot and image analysis. RESULTS： The apoptosis rate of IEC-6 cells was increased by irradiation at 6 h （P 〈 0.01）, IL-11 stimulation resulted in a decreased apoptosis rate in irradiated IEC-6 cells （P 〈 0.05）. In normal control IEC-6 cells, intense immunoreactivity of IL-11Rα was located within the cell membrane and cytoplasm. The level of IL-11Rα expression significantly decreased at 6 h after irradiation （P 〈 0.01） and restored at 24 h after irradiation. In IEC-6 cells treated with both radiation and rhIL-11, the level of IL- 11Rα expression was higher than that of irradiated cells （P 〈 0.05）. When it came to gp130 protein, it was located in the cytoplasm of IEC-6 cells. After irradiation, we found a progressive decrease in the expression of gp130 protein （P 〈 0.05） in 48 hours post-radiation, while in rhIL-11-stimulated cells, it came back to normal level at 24 h after irradiation and decreased at 48 h, but was still higher than that of only irradiated cells （P 〈 0.05）. CONCLUSION： rhIL-11 can protect IEC-6 cells from neutron irradiation. The protective effect of rhIL-11 might be connected with its ability to up-regulate the expressions of specific ligand-binding subunit IL-11Rα and signal-transducing subunit gp130.

关键词： Neutron IEC-6 Interleukin-11 IL-11Rα Gp130

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Machine learning for carbonate formation drilling: Mud loss prediction using seismic attributes and mud loss records

引用

Petroleum Science 2024年第2期21卷 1241-1256页

作者： hui-wen Pang Han-qing Wang Yi-Tian Xiao Yan Jin Yun-hu Lu Yong-Dong Fan Zhen Nie National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China College of Science China University of Petroleum-BeijingBeijing102249China Petroleum Exploration and Production Research Institute SINOPECBeijing102206China College of Petroleum Engineering China University of Petroleum-BeijingBeijing102249China Research Institute of Petroleum Exploration and Development CNPCBeijing100083China

Due to the complexity and variability of carbonate formation leakage zones, lost circulation prediction and control is one of the major challenges of carbonate drilling. It raises well-control risks and production expenses. This research utilizes the H oilfield as an example, employs seismic features to analyze mud loss prediction, and produces a complete set of pre-drilling mud loss prediction solutions. Firstly, 16seismic attributes are calculated based on the post-stack seismic data, and the mud loss rate per unit footage is specified. The sample set is constructed by extracting each attribute from the seismic trace surrounding 15 typical wells, with a ratio of 8:2 between the training set and the test set. With the calibration results for mud loss rate per unit footage, the nonlinear mapping relationship between seismic attributes and mud loss rate per unit size is established using the mixed density network ***, the influence of the number of sub-Gausses and the uncertainty coefficient on the model's prediction is evaluated. Finally, the model is used in conjunction with downhole drilling conditions to assess the risk of mud loss in various layers and along the wellbore trajectory. The study demonstrates that the mean relative errors of the model for training data and test data are 6.9% and 7.5%, respectively, and that R2is 90% and 88%, respectively, for training data and test data. The accuracy and efficacy of mud loss prediction may be greatly enhanced by combining 16 seismic attributes with the mud loss rate per unit footage and applying machine learning methods. The mud loss prediction model based on the MDN model can not only predict the mud loss rate but also objectively evaluate the prediction based on the quality of the data and the model.

关键词： Lost circulation Risk prediction Machine learning Seismic attributes Mud loss records

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The New Methods for Characterization of Molecular Weight of Supramolecular Polymers

引用

Chinese Journal of Polymer Science 2024年第10期42卷 1403-1413,I0006页

作者： hui Liu Rui hu Zi-qing hu Xiao-Fan Ji Key Laboratory of Materials Chemistry for Energy Conversion and Storage Ministry of EducationHubei Key Laboratory of Materials Chemistry and Service FailureHubei Engineering Research Center for Biomaterials and Medical Protective MaterialsSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan430074China

Supramolecular polymers,as a type of dynamic polymers,are subordinate to the interdisciplinary field of polymer chemistry and supramolecular chemistry,whose development has greatly promoted the prosperity of new ***,molecular weight is one of the most important parameters of supramolecular polymers,which affects the physical/chemical properties and processing applications of *** new methods for characterizing the molecular weight of supramolecular polymers is crucial for advancing the development of supramolecular *** this review,we elaborate and summarize three strategies for characterizing the molecular weight of supramolecular polymers that recently reported by our research group according to the characteristics of supramolecular polymers,including(1)the molecular weight distinction corresponding to variable fluorescence colors,(2)matching different molecular weights with different fluorescence lifetime,(3)transforming supramolecular polymers into mechanically interlocked polymers or covalent ***,we also discuss the limitations of current methods for characterizing supramolecular *** hope that this review can promote the development of supramolecular polymers and significantly inspire to exploit new methods to characterizing molecular weight of supramolecular polymers.

关键词： Supramolecular polymers Molecular weight Self-assembly Mechanically interlocked polymers Dynamic polymers

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Approaching the theoretical capacity of TiO_(2) anode in a photorechargeable lithium-ion battery

引用

Nano Research 2024年第4期17卷 2655-2662页

作者： wen Yan Jie Wang qing hu Jingjing Fu Mohamed K.Albolkany Tian Zhang Xiao Lu Fei Ye Bo Liu School of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230026China

New generation of lithium-ion batteries(LIBs)integrating solar energy conversion and storage is emerging,as they could solve the fluctuation problem in the utilization of solar ***-rechargeable lithium-ion batteries(PR-LIBs)are ideal devices for such target,in which solar energy is converted into electricity and stored in *** order to achieve the high performance of PR-LIB,it is crucial to develop dual-function electrode materials that can synergistically capture solar energy and store ***,we present photo-rechargeable lithium-ion batteries using defective black TiO_(2) as photoanode prepared by lithium *** photoanode exhibits excellent photo response in full solar spectrum with a capacity enhancement of 46.4%under illumination,corresponding to the energy conversion efficiency of 4.4%at the current density of 1 A·g^(-1).When illumination is applied at 20 mA·g^(-1),the battery capacity increases from~230 in dark to~349 mAh·g^(-1) at the first cycle,and then stabilizes at 310 mAh·g^(-1),approaching the theoretical value of 335 mAh·g^(-1) of TiO_(2) electrode *** finding provides thoughts for breaking the capacity limitations in TiO_(2) and paves the way for powering LIBs by solar illumination.

关键词： photo-rechargeable lithium-ion batteries photoanode defective TiO_(2)(D-TiO_(2))

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Artificial neural network-based method for discriminating Compton scattering events in high-purity germaniumγ-ray spectrometer

引用

Nuclear Science and Techniques 2024年第2期35卷 64-84页

作者： Chun-Di Fan Guo-Qiang Zeng Hao-wen Deng Lei Yan Jian Yang Chuan-Hao hu Song qing Yang Hou College of Nuclear Technology and Automation Engineering Chengdu University of TechnologyChengdu 610059China

To detect radioactive substances with low activity levels,an anticoincidence detector and a high-purity germanium(HPGe)detector are typically used simultaneously to suppress Compton scattering background,thereby resulting in an extremely low detection limit and improving the measurement ***,the complex and expensive hardware required does not facilitate the application or promotion of this ***,a method is proposed in this study to discriminate the digital waveform of pulse signals output using an HPGe detector,whereby Compton scattering background is suppressed and a low minimum detectable activity(MDA)is achieved without using an expensive and complex anticoincidence detector and *** electric-field-strength and energy-deposition distributions of the detector are simulated to determine the relationship between pulse shape and energy-deposition location,as well as the characteristics of energy-deposition distributions for fulland partial-energy deposition *** relationship is used to develop a pulse-shape-discrimination algorithm based on an artificial neural network for pulse-feature *** accurately determine the relationship between the deposited energy of gamma(γ)rays in the detector and the deposition location,we extract four shape parameters from the pulse signals output by the *** learning is used to input the four shape parameters into the ***,the pulse signals are identified and classified to discriminate between partial-and full-energy deposition *** partial-energy deposition events are removed to suppress Compton *** proposed method effectively decreases the MDA of an HPGeγ-energy dispersive *** results show that the Compton suppression factors for energy spectra obtained from measurements on ^(152)Eu,^(137)Cs,and ^(60)Co radioactive sources are 1.13(344 keV),1.11(662 keV),and 1.08(1332 keV),respectively,and that the corresponding MDAs are 1.4%,5.

关键词： High-purity germaniumγ-ray spectrometer Pulse-shape discrimination Compton scattering Artificial neural network Minimum detectable activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

All types of base conversions allowed by base editors

引用

Science China(Life Sciences) 2024年第2期67卷 431-433页

作者： Shun-qing Liang wen Xue RNA Therapeutics Institute UMass Chan Medical SchoolWorcester 01655USA Department of Molecular Cell and Cancer BiologyUMass Chan Medical SchoolWorcester 01655USA Department of Molecular Medicine UMass Chan Medical SchoolWorcester 01655USA Li Weibo Institute for Rare Diseases Research UMass Chan Medical SchoolWorcester 01655USA

Base editors(BEs) hold great promise as tools for introducing single-base-pair changes in both basic research and therapeutic applications(Rees and Liu,2018).Base editors are composed of a Cas9 nickase fused to a DNA-modifying enzyme,which chemically modifies nucleobases within a specific targeting window near the Cas9-binding site.

关键词： base bases allowed

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cascade electrolysis and thermocatalysis: a reliable system for upgrading C1 to C4 hydrocarbons

引用

Rare Metals 2024年第1期43卷 410-412页

作者： Chao-Yue Sun wen Li Hai-qing Wang Institute for Advanced Interdisciplinary Research(iAIR) College of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China

The carbon cycle is important for maintaining a stable climate and carbon balance on Earth. Renewable-electricitydriven upcycling of carbon dioxide (CO_(2)) into value-added multi-carbon molecules is a potentially sus... 详细信息

关键词： cycling hydrocarbons enable

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：