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Recent advances in bioinspired vision systems with curved imaging structures

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Rare Metals 2024年第4期43卷 1407-1434页

作者： Ze-Ping He Xun Han wen-qiang wu Zhang-Sheng Xu Cao-Feng Pan CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing100083China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing100049China ZJU-Hangzhou Global Scientific and Technological Innovation Center School of Micro-Nano ElectronicsZhejiang UniversityHangzhou311200China Institute of Microscale Optoelectronics Shenzhen UniversityShenzhen518060China

Limited by the planar imaging structure,the commercial camera needs to introduce additional optical elements to compensate for the curved focal plane to match the planar image *** results in a complex and bulky *** contrast,biological eyes possess a simple and compact structure due to their curved imaging structure that can directly match with the curved focal *** by the structures and functions of biological eyes,curved vision systems not only improve the image quality,but also offer a variety of advanced ***,we review the recent advances in bioinspired vision systems with curved imaging ***,we focus on their applications in implementing different functions of biological eyes,as well as the emerging curved neuromorphic imaging systems that incorporate bioinspired optical and neuromorphic processing *** addition,the challenges and opportunities of bioinspired curved imaging systems are also discussed.

关键词： Bioinspired Curved vision system Compound eye Chambered eye Neuromorphic

A Robust Self-healing Polyurethane Elastomer Enabled by Tuning the Molecular Mobility and Phase Morphology through Disulfide Bonds

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Chinese Journal of Polymer Science 2021年第10期39卷 1299-1309,I0007页

作者： Hai-Tao wu Bi-qiang Jin Hao Wang wen-qiang wu Zhen-Xing Cao Zhao-Yang Yuan Yue Huang Wei-Hang Li Guang-Su Huang Lu-Sheng Liao Jin-Rong wu State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineerngSichuan UniversityChengdu 610065China Guangdong Provincial Key Laboratory of Natural Rubber Processing Agricultural Products Processing Research Institute of Chinese Academy of Tropical Agricultural SciencesZhanjiang 524001China

Elastomers with outstanding strength,toughness and healing efficiency are highly promising for many emerging ***,it is still a challenge to integrate all these beneficial features in one ***,an asymmetric alicyclic structure adjacent to aromatic disulfide was tactfully introduced into the backbone of polyurethane(PU)***,such elastomer(PU-HPS)was fabricated by polycondensing polytetramethylene ether glycol(PTMEG),isophorone diisocyanate(IPDI)and p-hydroxydiphenyl disulfide(HPS)via one-pot *** molecular mobility and phase morphology of PU-HPS can be tuned by adjusting the HPS ***,the dynamic exchange of hydrogen and disulfide bonds in the hard segment domains can also be *** optimized sample manifests outstanding tensile strength(46.4 MPa),high toughness(109.1 MJ/m^(3)),high self-healing efficiency after fracture(90.3%),complete scratch recovery(100%)and good puncture ***,this work provides a facile strategy for developing robust self-healing polymers.

关键词： Self-healing Polyurethane Disulfide bonds Chain mobility Phase morphology

Single-molecule study reveals the folding mechanisms of DNA G-quadruplexes,and how they are regulated by specialized helicases

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Single-molecule study reveals the folding mechanisms of DNA ...

Specific CEA-producing colorectal carcinoma cell killing with recombinant adenoviral vector containing cytosine deaminase gene

第十一届全国化学生物学学术会议

作者： Xi-Miao Hou wen-qiang wu Lei Wang Xu-Guang Xi College of Life Sciences Northwest A＆F University

G-quadruplexes（G4 s） are noncanonical four-stranded DNA structures formed by Hoogsteen base paring between stacked sets of four guanines. G4 structures function in multiple cellular processes, such as DNA replication, transcription and telomere maintenance. G4 helicases play critical roles in suppressing genomic instability in cells by resolving G4 s. Until now, a bunch of helicases have been demonstrated to resolve G4 s in vivo and in vitro. First, we employed single-molecule FRET to characterize the spontaneous folding mechanism of G4 structures [1-2]. We observed that human telomeric G4 s display multiple conformations and metastable states, which are transformed into each other dynamically. In combination with molecular dynamics simulation, we proposed a multi-pathway folding mechanism for human telomeric G4. Afterwards, we carried out a systematic study on the molecular mechanisms of specialized helicases on G4 s including Pif1[3-4], BLM[5], WRN, RecQ, and DHX36. For instance, we discovered that, Pif1 unfolds G4 structures in the sequential and repetitive manner. In addition, Pif1 is sensitive to G4 stability and topology, as Pif1 preferentially unfolds antiparallel over parallel quadruplexes and cannot unfold G4 with short（single-nt） loops such as（GGGT） repeats. Taken together, those results may shed new light on our current understanding about how G4 structures are folded from ssDNA, and how they are regulated by helicases in cell.

关键词： G-quardruplex folding mechanism telomere helicase single-molecule

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World Journal of Gastroenterology 2002年第2期8卷 270-275页

作者： Li-Zong Shen wen-Xi wu qiang Ding Yi-Bing Hua,Department of General Surgery,The First Affiliated Hospital of Nanjing Medical University,Nanjing,210029,Jiangsu Province,China De-Hua Xu Zhong-Cheng Zheng Xin-Yuan Liu,Shanghai Institute of Biochemistry and Cell Biology,The Chinese Academy of Sciences,Shanghai,200031,China Kun Yao,Department of Microbiology and Immunology,Nanjing Medical University,Nanjing,210029,Jiangsu Province,China Department of General Surgery The First Affiliated Hospital of Nanjing Medical University 300 Guangzhou Road Nanjing 210029 Jiangsu Province China.

AIM: To kill CEA positive colorectal carcinoma cells specifically using the E coli cytosine deaminase (CD) suicide gene, a new replication-deficient recombinant adenoviral vector was constructed in which CD gene was controlled under CEA promoter and its in vitro cytotoxic effects were evaluated. METHODS: Shuttle plasmid containing CD gene and regulatory sequence of the CEA gene was constructed and recombined with the right arm of adenovirus genome DNA in 293 cell strain. Dot blotting and PCR were used to identify positive plaques. The purification of adenovirus was performed with ultra-concentration in CsCl step gradients and the titration was measured with plaque formation assay. Cytotoxic effects were assayed with MTT method, The fifty percent inhibition concentration (IC(50)) of 5-FC was calculated using a curve-fitting parameter. The human colorectal carcinoma cell line, which was CEA-producing, and the CEA-nonproducing Hela cell line were applied in cytological tests. An established recombinant adenovirus vector AdCMVCD, in which the CD gene was controlled under CMV promoter, was used as virus control. Quantitative results were expressed as the mean +/- SD of the mean. Statistical analysis was performed using ANOVA test. RESULTS: The desired recombinant adenovirus vector was named AdCEACD. The results of dot blotting and PCR showed that the recombinant adenovirus contained CEA promoter and CD gene. Virus titer was about 5.0 X 10(14)pfu/L(-1) after purification. The CEA-producing Lovo cells were sensitive to 5-FC and had the same cytotoxic effect after infection with AdCEACD and AdCMVCD (The IC(50) values of 5-FC in parent Lovo cells, Lovo cells infected with 100 M.O.I AdCEACD and Lovo cells infected with 10 M.O.I AdCMVCD were >15000, 216.5+/-38.1 and 128.8+/-25.4 micromol.L(-1), P<0.001, respectively), and the cytotoxicity of 5-FC increased accordingly when the m.o.i of adenoviruses were enhanced (The value of IC(50) of 5-FC was reduced to 27.9+/-4.2 micr

关键词： Gene Therapy Genetic Vectors Adenoviridae Animals Antimetabolites Bystander Effect Carcinoembryonic Antigen Cell Line Colorectal Neoplasms Cytosine Deaminase Flucytosine Hela Cells Humans Nucleoside Deaminases Promoter Regions (Genetics) Research Support, Non-U.S. Gov't Tumor Cells, Cultured

2,9-二甲基菲咯啉Cu(Ⅰ)和Cu(Ⅱ)配合物的合成、晶体结构和性质（英文）

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无机化学学报 2017年第1期33卷 149-155页

作者：孙志康雷汉民文武强杜治平武汉工程大学绿色化工过程省部共建教育部重点实验室湖北省新型反应器与绿色化学工艺重点实验室武汉430073

以二水合氯化铜,2,9-二甲基菲咯啉(dmphen)和硫氰酸铵为原料,通过沉淀反应和N,N-二甲基甲酰胺(DMF)重结晶得到了2个新型配合物[Cu(Ⅰ)(dmphen)(SCN)]n(1)和[Cu(Ⅱ)(dmphen)(DMF)(NCS)2](2),并采用元素分析、红外光谱、紫外可见光谱、X... 详细信息

以二水合氯化铜,2,9-二甲基菲咯啉(dmphen)和硫氰酸铵为原料,通过沉淀反应和N,N-二甲基甲酰胺(DMF)重结晶得到了2个新型配合物[Cu(Ⅰ)(dmphen)(SCN)]n(1)和[Cu(Ⅱ)(dmphen)(DMF)(NCS)2](2),并采用元素分析、红外光谱、紫外可见光谱、X射线单晶衍射、热重分析及荧光光谱对其进行了表征。结果表明:1属单斜晶系,P21/n空间群,晶胞参数为a=1.211 1(4)nm,b=0.826 2(2)nm,c=1.367 5(4)nm,β=96.502(5)°,V=1.359 5(7)nm3,Z=4;该配合物通过硫氰酸根的桥联作用形成了一维Z链结构。2为三斜晶系,P1空间群,晶胞参数a=0.943 6(2)nm,b=1.010 9(2)nm,c=1.219 0(3)nm,α=95.628(4)°,β=103.114(4)°,γ=107.087(4)°,V=1.065 4(4)nm3,Z=2;2通过C-H…S氢键和π-π堆积构筑成一个超分子网络结构。热重和荧光分析表明:1比2具有更高的热稳定性,且1在603 nm处有最强荧光发射强度。

关键词： 2,9-二甲基菲咯啉荧光晶体结构 π-π堆积

Antiarrhythmic effects of taurine magnesium coordination on early after depolarization induced by cesium chloride

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Antiarrhythmic effects of taurine magnesium coordination on ...

中国药理学会第十一次全国学术会议

作者： LOU Jian-shi,YIN Yong-qiang,wen Ke,wu Yan-na,KANG Yi (Department of Pharmacology,Tianjin Medical University,Tianjin 300070,China)

OBJECTIVE To study the effects of taurine magnesium coordination compound(TMC) against cesium chloride-in- duced arrhythmia in the rabbit heart to discern the mechanism of TMC antiarrhythmic *** Early afterdepolarization (EAD) was induced by 1.5 mmol·L cesium chloride(1 ml·kg) through intravenous administration in *** monophasic action potentials(MAP) and electrocardiograms(ECGs) were simultaneously *** effects of TMC on functional refractory periods(FRPs) and excitability in the left atrium were also observed in *** Arrhythmias onset was significantly retarded by *** number of ventricular premature contractions(VPCs) and incidence of monophasic ventricular tachycardia(MVT) and polyphasic ventricular tachycardia(PVT) in 10 min was decreased by *** amplitudes(EADA) were decreased by TMC (P<0.01 VS control).MAP durations at 90%repolarization(MAPD) were significantly prolonged by *** vitro experiments showed that FRPs were prolonged by TMC but that excitability remained *** The data indicate that TMC has an antiarrhythmic *** of triggered activity and prolongation of refractory periods underlie the antiarrhythmic effects of TMC.

关键词： taurine magnesium coordination compound cesium chloride antiarrhythmic effect electrophysiology

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非甾体抗炎药中间体甲酯化反应的热力学分析

化学工程 2018年第2期46卷 29-34页

作者：文武强来家威李亮杜治平武汉工程大学化工与制药学院湖北省新型反应器与绿色化学工艺重点实验室绿色化工过程教育部重点实验室湖北武汉430074 湖北省迅达药业股份有限公司湖北武穴435400

以丙酸和含不同对位取代基的非甾体抗炎药中间体2-苯丙酸为模型化合物,以其与甲醇的酯化反应为探针反应,采用Joback和Benson基团贡献法计算了模型化合物的基础热力学数据和探针反应的标准摩尔反应焓、标准摩尔反应熵、标准摩尔反应Gibb... 详细信息

以丙酸和含不同对位取代基的非甾体抗炎药中间体2-苯丙酸为模型化合物,以其与甲醇的酯化反应为探针反应,采用Joback和Benson基团贡献法计算了模型化合物的基础热力学数据和探针反应的标准摩尔反应焓、标准摩尔反应熵、标准摩尔反应Gibbs函数、标准平衡常数以及平衡转化率,并依此分析了温度、压力、醇酸比以及模型化合物的结构对热力学数据的影响。结果表明:探针反应均为自发过程;升温不利于反应的正向进行,而增压有利于增大反应的平衡常数和转化率;增大醇酸比可以提高反应的转化率;水分对酯化反应平衡转化率的影响较小,而邻近羧基的基团效应则对酯化反应的影响较大;对于含有结构繁杂或基团贡献值缺失的对位取代基的2-苯丙酸类化合物,均可用2-苯丙酸的热力学数据代替进行甲酯化反应的热力学分析。

关键词：基团贡献法苯丙酸类非甾体抗炎药 2-苯丙酸酯化反应热力学

Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian Yin Fan wen Zhigang Tao Hai Pu Tianci Deng Yaoyao Meng Qingbin Meng Hongwen Jing Bo Meng Jiangyu wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

基于InfiniBand集群并行全景图拼接系统设计

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四川大学学报（自然科学版） 2016年第6期53卷 1247-1254页

作者：陆应通李文强吴志红四川大学计算机学院视觉合成图形图像国防重点学科实验室成都610065

全景图拼接是通过对序列图像进行拼接,从而实现对场景全方位环视的技术,是计算机视觉和图像处理的研究热点.针对大规模高分辨率的序列图像拼接,单计算机的拼接效率已经难以满足实际应用需求的问题,提出了一种基于InfiniBand高速网络通... 详细信息

全景图拼接是通过对序列图像进行拼接,从而实现对场景全方位环视的技术,是计算机视觉和图像处理的研究热点.针对大规模高分辨率的序列图像拼接,单计算机的拼接效率已经难以满足实际应用需求的问题,提出了一种基于InfiniBand高速网络通信的多机并行架构实现全景图并行拼接的解决方案.首先,对全景图拼接的关键步骤进行并行性分析,将全景图拼接尽可能划分成细粒度和高并行度的子任务;然后,通过并行架构中的控制节点和计算节点进行任务的分配和执行;最后,针对随着图像数据量增大,采用传统的TCP/IP网络传输,计算节点间的数据传输速率低下的问题,设计了基于InfiniBand与TCP/IP结合的高速网络传输模块,有效地提高节点间的传输速率.实验结果表明,在此并行架构上实现的分布式计算,能够有效地提升全景图拼接效率,有明显的实际应用价值.

关键词：全景图拼接并行架构并行性分析 InfiniBand