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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui liu Chao Fang Qiuxia Peng wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai liu wen-qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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NgR介导的氧化应激反应在葡萄糖诱导RGC凋亡中的作用

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国际眼科杂志 2017年第2期17卷 217-220页

作者：王玉波刘文强左中夫刘学政锦州医科大学解剖学教研室中国辽宁省锦州市121000

目的:探讨NgR介导的氧化应激在葡萄糖诱导视网膜神经节细胞(retinal ganglion cells,RGCs)凋亡中的作用。方法:RGC-5细胞株分3组培养:正常对照组(DMEM高糖培养基+100m L/L胎牛血清),高糖组(DMEM高糖培养基+100m L/L胎牛血清+30mmol/L葡... 详细信息

目的:探讨NgR介导的氧化应激在葡萄糖诱导视网膜神经节细胞(retinal ganglion cells,RGCs)凋亡中的作用。方法:RGC-5细胞株分3组培养:正常对照组(DMEM高糖培养基+100m L/L胎牛血清),高糖组(DMEM高糖培养基+100m L/L胎牛血清+30mmol/L葡萄糖)、NEP1-40组(DMEM高糖培养基+100m L/L胎牛血清+30mmol/L葡萄糖+1μmol/L NEP1-40)。各组RGC-5细胞培养3d后检测各指标:显微镜观察细胞生长状态,cell counting KIT-8(CCK-8)试剂盒检测细胞活力,Annexin V/PI双染流式细胞仪(flow cytometry,FCM)检测RGC细胞凋亡率,试剂盒检测线粒体内ROS含量的变化、胞内MDA水平及SOD活力,Western-blot检测凋亡蛋白Bcl-2和Bax的表达。结果:与正常对照组相比,高糖组细胞生长状态差、活力下降、凋亡率显著增加,ROS及MDA水平显著升高,SOD活力下降,抗凋亡蛋白Bcl-2表达降低,促凋亡蛋白Bax表达上调,Bcl-2/Bax蛋白比值降低,差异有统计学意义(P<0.05)。与高糖组相比,NEP1-40组细胞抑制NgR表达后,氧化应激反应减弱,Bcl-2/Bax提高,细胞状态改善、细胞活力提高、凋亡率降低,差异有统计学意义(P<0.05)。结论:高浓度葡萄糖能通过NgR介导氧化应激反应诱导RGC-5细胞凋亡。

关键词：视网膜神经节细胞 NgR 氧化应激反应凋亡

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期 360-368页

作者： Zheng liu Changyu Zhang Zipeng Li Wanying Ma Jia liu Xiang Xia Ning Xu wen Sun Jianjun Du Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

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Broadband and perfect terahertz absorber based on multilayer metamaterial with cross-ring patterned structures

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Optoelectronics Letters 2025年第1期21卷 1-6页

作者： wen Jin liu Zhanzhi WU Zhengwei PAN Yu ZHANG Ying School of Science Xi'an Shiyou University Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas Wells

Broadband and perfect terahertz absorber based on multilayer metamaterial using cross-ring patterned structures is proposed and investigated. The structure of the absorber is double absorption layers consisting of a chromium cross ring and eight isosceles right triangles. The unique structure of the double absorbing layers excites the electric dipole multimode resonance, giving rise to high absorption performance. Meanwhile, the influence of construal parameters on absorber behavior is also discussed. The numerical results show that the absorption achieves over 90% ranging from 2.45 THz to 6.25 THz and 99% absorption in the range of 3.7—5.3 THz. The realization of broadband and perfect absorber is described using the impedance matching principle. It is obviously found that the absorber is insensitive to the high angle of incidence for both transverse electric(TE) and transverse magnetic(TM) polarizations. Compared with the former reports, this absorber has remarkable improved absorption efficiency and smaller period. The terahertz absorber may be found applications in the fields of energy capture and thermal detection.

关键词： Metamaterials

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论大学学术的公共性与学术生产力的提升

科技与管理 2017年第4期19卷 116-120页

作者：王文强刘剑虹宁波大学教师教育学院浙江宁波315211 湖州师范学院党委办公室浙江湖州313000

公共性是大学学术研究的根本属性,它决定着学术生产力的发展。学术生产力主要由教学生产力、科研生产力和社会服务生产力组成,代表着大学的学术实力和学术资本。在公共性与大学学术生产力之间存在着彼此影响的关系,学术生产力决定了公... 详细信息

公共性是大学学术研究的根本属性,它决定着学术生产力的发展。学术生产力主要由教学生产力、科研生产力和社会服务生产力组成,代表着大学的学术实力和学术资本。在公共性与大学学术生产力之间存在着彼此影响的关系,学术生产力决定了公共性的形成与状态,而公共性又反作用于学术生产力的发展。因此,要提升大学学术生产力,就必须在彰显公共性价值的前提下,着力推动学术生产力的提升与融合。

关键词：大学学术公共性学术生产力

湿法脱硫浆液中Hg^(2+)的还原机制研究

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燃料化学学报 2017年第6期45卷 755-760页

作者：赵莉何青松刘宇吴洋文陆强刘松涛董长青华北电力大学生物质发电成套设备国家工程实验室北京102206 华北电力大学环境科学与工程学院河北保定071003

针对燃煤电厂湿法脱硫浆液中Hg^(2+)易被还原的特性,研究Hg^(2+)在模拟湿法脱硫系统中的迁移机制,考察了浆液温度、pH值以及SO_3^(2-)、Cl^-、Ca^(2+)、Mg^(2+)浓度等因素对Hg^(2+)还原性能的影响。结果表明,Hg^(2+)还原率随着浆液中SO_... 详细信息

针对燃煤电厂湿法脱硫浆液中Hg^(2+)易被还原的特性,研究Hg^(2+)在模拟湿法脱硫系统中的迁移机制,考察了浆液温度、pH值以及SO_3^(2-)、Cl^-、Ca^(2+)、Mg^(2+)浓度等因素对Hg^(2+)还原性能的影响。结果表明,Hg^(2+)还原率随着浆液中SO_3^(2-)浓度的增大而降低;pH值对Hg^(2+)的还原呈先增加后降低的趋势,在pH值为5.5时还原率最高;温度的升高不利于浆液中稳定的二价汞盐络合物存在,导致Hg^(2+)还原率增加;Ca^(2+)、Mg^(2+)以及Cl^-浓度的增加有利于形成稳定化合物,从而抑制Hg^(2+)的还原。

关键词： Hg^2+还原 pH值浆液温度离子浓度湿法脱硫

候选药物T-VA的质谱裂解规律及其在大鼠体内的代谢产物研究

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质谱学报 2017年第1期38卷 67-74页

作者：张晨泽闫萌萌徐冰林宏英闫文强刘帅陈静刘永刚王鹏龙雷海民北京中医药大学中药学院北京100102 西藏藏医学院教务处西藏拉萨850000

采用液相色谱-线性离子阱-静电场轨道阱高分辨质谱(LC/LTQ-Orbitrap MS)技术研究候选药物T-VA的裂解规律及体内代谢,建立了大鼠体内T-VA及其代谢产物的LC/MSn分析方法,分析讨论了各自的主要碎片离子峰、质谱特征与结构信息,发现了血浆... 详细信息

采用液相色谱-线性离子阱-静电场轨道阱高分辨质谱(LC/LTQ-Orbitrap MS)技术研究候选药物T-VA的裂解规律及体内代谢,建立了大鼠体内T-VA及其代谢产物的LC/MSn分析方法,分析讨论了各自的主要碎片离子峰、质谱特征与结构信息,发现了血浆中主要代谢物M1。借鉴药物化学的方法,合成得到了代谢产物实体M1-1,经1 HNMR、13 CNMR、HRMS确认其结构,根据其色谱、质谱特征进行验证,结果表明,合成得到的M1-1即为血浆主要代谢物M1。借助PC12细胞模型验证了代谢产物M1的神经保护活性,该结果可为进一步研究其生物转化过程与前药修饰提供重要信息。

关键词：液相色谱-线性离子阱-静电场轨道阱高分辨质谱(LC/LTQ-Orbitrap MS) 候选药物T-VA 裂解规律代谢产物化学合成神经保护活性

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong qiang liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K