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Nano Research 2025年第1期18卷 315-322页

作者： Kun-Peng Yang Song Xie Zi-Meng Han Hao-Cheng liu Chong-Han Yin wen-Bin Sun Zhang-Chi ling Huai-Bin Yang De-Han Li Qing-Fang Guan Shu-Hong Yu Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

Separators play a critical role in lithium-ion ***,the restrictions of thermal stability and inferior electrical performance in commercial polyolefin separators significantly limit their applications under harsh ***,we report a cellulose-assisted self-assembly strategy to construct a cellulose-based separator massively and *** an ultrahigh ionic conductivity in electrolytes of 3.7 mS·cm^(-1) and the ability to regulate ion transport,the obtained separator is a promising alternative for high-performance lithium-ion *** addition,integrated with high thermal stability,the cellulose-based separator endows batteries with high safety at high temperatures,greatly expanding the application scenarios of energy storage devices in extreme environments.

关键词： lithium-ion batteries bio-inspired materials battery separators cellulose nanofiber ultrahigh ionic conductivity high safety

The circadian clock affects starvation resistance through the pentose phosphate pathway in silkworm,Bombyx mori

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Insect Science 2025年第1期32卷 55-68页

作者： Tai-Ming Dai Jian-Feng Qiu Cheng Luo wen-Zhao Cui Kai liu Jiang-Lan Li Ruji Peng Yang-Hu Sima Shi-Qing Xu School of Life Sciences Suzhou Medical College of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Agricultural Biotechnology&Ecology(IABE) Soochow UniversitySuzhouJiangsu ProvinceChina

Disruption of the circadian clock can affect starvation resistance,but the molecular mechanism is still ***,we found that starvation resistance was significantly reduced in the core gene BmPer deficient mutant silkworms(Per−/−),but the mutant's starvation resistance increased with larval *** natural physiological conditions,the weight of mutant 5th instar larvae was significantly increased compared to wild type,and the accumulation ability of triglycerides and glycogen in the fat bodies was ***,under starvation conditions,the weight consumption of mutant larvae was increased and cholesterol utilization was *** analysis showed that beta-oxidation was significantly upregulated under starvation conditions,fatty acid synthesis was inhibited,and the expression levels of genes related to mitochondrial function were significantly *** investigations revealed that the redox balance,which is closely related to mitochondrial metabolism,was altered in the fat bodies,the antioxidant level was increased,and the pentose phosphate pathway,the source of reducing power in cells,was *** findings suggest that one of the reasons for the increased energy burden observed in mutants is the need to maintain a more robust redox balance in metabolic *** necessitates the diversion of more glucose into the pentose phosphate pathway to ensure an adequate supply of reducing power.

关键词： Bombyx mori circadian clock oxidative stress pentose phosphate pathway starvationresistance

Effect of h-BN rods on high-temperature properties of alumina-carbon refractory

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Journal of Iron and Steel Research International 2025年第1期32卷 115-128页

作者： Ya-ge Li Shuai-bing Wu Feng Liang Zhong Huang Tu Long Long Dong Jun-yi Lv Hong-juan Duan Biao wen Yong liu Hai-jun Zhang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina Sinosteel Luoyang Institute of Refractories Research Co. Ltd.Luoyang471039HenanChina

h-BN rods modified low-carbon alumina-carbon(Al_(2)O_(3)-C)refractories were prepared,and the effect of h-BN rod addition on the high-temperature properties was investigated and compared with commercial h-BN flake,carbon black,and carbon nanotubes *** results demonstrated that Al_(2)O_(3)-C refractories containing h-BN rods exhibited optimal high-temperature service performances,including 25%higher hot modulus of rupture,21.3%higher thermal shock strength residual ratio,20.9%lower in oxidation and 44.3%less in slag corrosion,compared to the counterpart specimens without ***,benefiting from the synergistic enhancement of the rod-like h-BN and in-situ generated SiC whiskers,the high-temperature service performances of h-BN rods containing specimens outperformed counterpart specimens containing commercial h-BN flake,carbon black,and carbon nanotubes,respectively.

关键词： Al_(2)O_(3)-C refractory h-BN rod Microstructure High-temperature service performance

Effects of increased seeding density on seedling characteristics,mechanical transplantation quality,and yields of rice with crop straw boards for seedling cultivation

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Journal of Integrative Agriculture 2025年第1期24卷 101-113页

作者： Yufei ling Mengzhu liu Yuan Feng Zhipeng Xing Hui Gao Haiyan Wei Qun Hu Hongcheng Zhang Research Institute of Rice Industrial Engineering Technology Yangzhou University/Jiangsu Key Laboratory of Crop Cultivation and Physiology/Jiangsu Co-Innovation Center for Modern Production Technology of Grain CropsYangzhou 2250o0China

The high labor demand during rice seedling cultivation and transplantation poses a significant challenge in advancing machine-transplanted rice *** problem may be solved by increasing the seeding rate during seedling production while reducing the number of seedling *** study conducted field experiments from 2021 to 2022,using transplanting seedling ages of 10 and 15 days to explore the effects of 250,300,and 350 g/tray on the seedling quality,mechanical transplantation quality,yields,and economic benefits of *** commonly used combination of 150 g/tray with a 20-day seedling age in rice production was used as *** cultivation of seedlings under a high seeding rate and short seedling age significantly affected seedling characteristics,but there was no significant difference in seedling vitality compared to *** minimum number of rice trays used in the experiment was observed in the treatment of 350-10(300 g/tray and 10-day seedling age),only 152-155 trays ha^(-1),resulting in a 62%reduction in the number of trays *** increasing the seeding rate of rice,missed holes during mechanical transplantation decreased by 2.8 to 4%.The treatment of 300-15(300 g/tray and 15-day seedling age)achieved the highest yields and economic *** results indicated that using crop straw boards can reduce the application of seedling *** that basis,rice yields can be increased by raising the seeding rate and shortening the seedling age of rice without compromising seedling quality.

关键词： machine-transplanted rice crop straw board seedling rate seedling quality mechanical transplanta quality yield

Carboniferous-Early Permian heterogeneous distribution of porous carbonate reservoirs in the Central Uplift of the South Yellow Sea Basin and its hydrocarbon potential analysis

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China Geology 2025年第1期8卷 58-76页

作者： Shu-yu Wu Jun liu Jian-wen Chen Qi-liang Sun Yin-guo Zhang Jie Liang Yong-cai Feng School of Engineering China University of GeoscienceWuhan 430074China Yantai Center of Coastal Zone Geological Survey China Geological SurveyMinistry of Natural ResourcesYantai 264001China Key Laboratory of Submarine Geosicences Ministry of Natural ResourcesHangzhou 310012China Chinese Academy of Geological Sciences China Geological SurveyMinistry of Natural ResourcesBeijing 100037China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266061China The Key Laboratory of Gas Hydrate Ministry of Natural ResourcesQingdao Institute of Marine GeologyChina Geological SurveyMinistry of Natural ResourcesQingdao 266071China College of Marine Science and Technology China University of GeoscienceWuhan 430074China

Mesozoic-Palaeozoic marine carbonate rocks are crucial hydrocarbon reservoirs in the Central Uplift area of the South Yellow Sea Basin(SYSB).Due to the scarcity of boreholes and the significant heterogeneity of carbonate reservoirs,the distribution of porous carbonate reservoirs and their related key controlling factors remain *** this study,factors affecting the distribution of porous Carboniferous-Early Permian carbonate reservoirs in the SYSB were investigated through seismic inversion and isotope *** log-seismic characteristics of porous carbonate reservoirs,sensitive lithology parameters,and physical property parameters were extracted and *** pre-stack simultaneous inversion technique was applied to predict the lithology and physical properties of porous carbonate ***,the sedimentary of carbonate was analyzed using isotopes of carbon,oxygen,and *** results show that porous carbonate reservoirs are mainly developed in the open platform sediments with porosities of 3%-5%and are mainly distributed in the paleo-highland(Huanglong Formation and Chuanshan Formation)and the slope of paleo-highland(Hezhou Formation).The porous carbonate reservoirs of the Qixia Formation are only locally *** addition,the negativeδ13C excursions indicate a warm and humid tropical climate with three sea-level fluctuations in the study area from the Carboniferous to Early *** favorable conditions for developing porous carbonate rocks include the sedimentary environment and diagenetic *** primary pore tends to form in high-energy environments of the paleo-highland,and the secondary pore is increased by dissolution during the syngenetic or quasi-syngenetic *** to the hydrocarbon potential analysis,the Late Ordovician Wufeng Formation and Lower Silurian Gaojiabian Formation are the source rocks in the high-maturity-over-maturity stage,the Carboniferous-Lower Permian carbonate is the good reservoirs,and th

关键词： Sedimentary Heterogeneous porous carbonate reservoirs C-H-Sr isotope analysis Carboniferous-Early Permian Chuanshan Formation Huanglong Formation Pre-stack simultaneous inversion technique Oil-gas exploration engineering Hydrocarbon accumulation Hydrocarbon potential Central Uplift of the South Yellow Sea Basin

Aerodynamic Performance Analysis on Blade Snubber with Bionic Structure

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Journal of Thermal Science 2025年第02期 579-589页

作者： liu Yunfeng YAN Han DU Wei ZHANG Hongtao LI Yufeng wen Fengbo ZHOU Xun School of Energy Science and Engineering Harbin Institute of Technology Harbin Turbine Company Limited

The utilization of a part-span connector(PSC) has the potential to enhance the blade frequency,but with the penalty of aerodynamic *** this study,we numerically investigate the aerodynamic performance of two types of bionic structure snubbers:(1) Harbor seal whisker(HSW) and (2) Atropus' s body shape(ABS).The investigation is conducted by solving the three-dimensional Reynolds-Averaged Navier-Stokes(RANS) equations and utilizing the SST turbulent *** this study,the performance impact of classical snubbers on a cascade blade has been examined by modeling it with and without an ellipse-shaped *** vortex induced by the snubber predominantly manifests on the suction side and can be categorized into three primary vortices:upper,lower,and *** upper and lower vortices serve as the primary contributors to *** to the conventional ellipse snubber,the ABS snubber exhibits a reduction in the total pressure loss coefficient by 0.11% and an increase in the mass flow rate by 0.41%.On the contrary,the implementation of the HSW snubber has the potential to mitigate parameter ***,it is important to note that this comes at the cost of a 0.10% increase in the total pressure loss coefficient and a 0.20% decrease in mass flow *** article further examines the factors contributing to these disparities.

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai liu wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines(Chinese Academy of Sciences) Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical OncogenomicsPeking University Shenzhen Graduate SchoolShenzhen 518055China Shenzhen Bay Laboratory Shenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Microbial Metabolism School of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201China Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical SciencesBeijing 100730China

In the intricate process of natural product biosynthesis,a metabolon can enhance metabolic flux by associating sequential enzymes.A fungal metabolon,comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G,is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide *** notoamide E as a substance,Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation,followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium ***,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol *** provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

Failure mechanisms of AlGaN/GaN HEMTs irradiated by high-energy heavy ions with and without bias

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Nuclear Science and Techniques 2025年第1期36卷 49-58页

作者： Pei-Pei Hu Li-Jun Xu Sheng-Xia Zhang Peng-Fei Zhai ling Lv Xiao-Yu Yan Zong-Zhen Li Yan-Rong Cao Xue-Feng Zheng Jian Zeng Yuan He Jie liu Institute of Modern Physics Chinese Academy of Sciences(CAS)Lanzhou 730000China Key Laboratory of Wide Band‑gap Semiconductor Materials Ministry of EducationXidian UniversityXi’an 710071China University of Chinese Academy of Sciences(UCAS) Beijing 100049China

Gallium nitride(GaN)-based devices have significant potential for space ***,the mechanisms of radiation damage to the device,particularly from strong ionizing radiation,remains *** study investigates the effects of radiation on p-gate AlGaN/GaN high-electron-mobility transistors(HEMTs).Under a high voltage,the HEMT leakage current increased sharply and was accompanied by a rapid increase in power density that caused"thermal burnout"of the *** addition,a burnout signature appeared on the surface of the burned devices,proving that a single-event burnout effect ***,degradation,including an increase in the on-resistance and a decrease in the breakdown voltage,was observed in devices irradiated with high-energy heavy ions and without *** latent tracks induced by heavy ions penetrated the heterojunction interface and extended into the GaN ***,a new type of N_(2)bubble defect was discovered inside the tracks using Fresnel *** accumulation of N_(2)bubbles in the heterojunction and buffer layers is more likely to cause leakage and *** study indicates that electrical stress accelerates the failure rate and that improving heat dissipation is an effective reinforcement method for GaN-based devices.

关键词： GaN HEMTs Heavy ions Single-event burnout Latent tracks Degradation

Anti-programmed death-1 immunotherapy-promising treatment for metastatic colorectal cancer:A case report

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 291-298页

作者： Tian-Hao Guo Sheng-Wei Hong wen-Jian Zhu Yi-Fan Hui wen-Li Qiu Yan Wu Xuan Li Fei Ke liu Li Hai-Bo Cheng Institute of Health and Regimen Jiangsu Open UniversityNanjing 210036Jiangsu ProvinceChina The First Clinical Medical College Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Radiology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Oncology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Pathology Jiangsu Provincial Hospital of Traditional Chinese Medicine(Affiliated Hospital of Nanjing University of Chinese Medicine)Nanjing 210029Jiangsu ProvinceChina

BACKGROUND Colorectal cancer(CRC)is the third most prevalent form of cancer *** patients with CRC,colorectal liver metastasis(CRLM)is the foremost direct contributor to *** recent years,immunotherapy has swiftly risen to prominence as a vital approach for treating a range of solid tumors,including *** present a unique case of a patient suffering from CRLM,with the goal of offering an insightful example and relevant references for the treatment of *** SUMMARY We report a patient who experienced liver metastasis after undergoing successful surgical removal of CRC,with the postoperative pathological stage identified as *** patient has been receiving a combination treatment of Western and Traditional Chinese *** assessments of the patient’s condition have been conducted,encompassing evaluations of serum carcinoembryonic antigen levels,carbohydrate antigen 199,and observations of the tongue complexion and its *** patient achieved clinical remission after anti-programmed death-1 immunotherapy when various systemic therapies *** the diagnosis of CRLM,the patient has survived for more than 6 years,surpassing the expected survival time for those with advanced *** This case illustrates the considerable promise of anti-programmed death-1 immunotherapy in managing CRLM,especially in scenarios of drug resistance and disease progression.

关键词： Colorectal cancer Colorectal liver metastasis Drug resistance Immunotherapy Anti-programmed death-1 Case report

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui liu Chao Fang Qiuxia Peng wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway