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Vitamin D-binding protein in plasma microglia-derived extracellular vesicles as a potential biomarker for major depressive disorder

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Genes & Diseases 2024年第2期11卷 1009-1021页

作者： Gaojia Zhang Ling Li Yan Kong Dandan xu Yu Bao Zhiting Zhang Zhixiang Liao Jiao Jiao Dandan Fan Xiaojing Long Ji Dai Chunming Xie Zhiqiang Meng Zhijun Zhang Department of Neurology Affiliated Zhongda HospitalResearch Institution of NeuropsychiatrySchool of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Biochemistry and Molecular Biology School of MedicineSoutheast UniversityNanjingJiangsu 210009China Shenzhen Key Laboratory of Drug Addiction Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of Sciences (CAS)ShenzhenGuangdong 518000China CAS Key Laboratory of Brain Connectome and Manipulation The Brain Cognition and Brain Disease Institute (BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China Lauterbur Research Center for Biomedical Imaging Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China Shenzhen-Hong Kong Institute of Brain Sciences-Shenzhen Fundamental Research Institutions ShenzhenGuangdong 518000China Brain Cognition and Brain Disease Institute Department of Mental Health and Public HealthFaculty of Life and Health SciencesShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China

No well-established biomarkers are available for the clinical diagnosis of major depressive disorder(MDD).Vitamin D-binding protein(VDBP)is altered in plasma and postmortem dorsolateral prefrontal cortex(DLPFC)tissues of MDD ***,the role of VDBP as a potential biomarker of MDD diagnosis was further *** extracellular vesicles(EVs)and brain cell-derived EVs(BCDEVs)were isolated from the plasma of first-episode drug-naïve or drug-free MDD patients and well-matched healthy controls(HCs)in discovery(20 MDD patients and 20 HCs)and validation cohorts(88 MDD patients and 38 HCs).VDBP level in the cerebrospinal fluid(CSF)from chronic glucocorticoid-induced depressed rhesus macaques or prelimbic cortex from lipopolysaccharide(LPS)-induced depressed mice and wild control groups was measured to evaluate its relationship with VDBP in plasma microglia-derived extracellular vesicles(MDEVs).VDBP was significantly decreased in MDD plasma MDEVs compared to HCs,and negatively correlated with HAMD-24 score with the highest diagnostic accuracy among *** in plasma MDEVs was decreased both in depressed rhesus macaques and mice.A positive correlation of VDBP in MDEVs with that in CSF was detected in depressed rhesus *** levels in prelimbic cortex microglia were negatively correlated with those in plasma MDEVs in depressed *** main results suggested that VDBP in plasma MDEVs might serve as a prospective candidate biomarker for MDD diagnosis.

关键词： Biomarker Cerebrospinal fluid Major depressive disorder Microglia derived extracellular vesicles Vitamin-D binding protein

Discovery of scheelite in the Zaozigou gold deposit of West Qinling Orogen,Northwest China and its implications for ore genesis

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China Geology 2024年第3期7卷 586-588页

作者： Meng-xu Guo Jia-jun Liu De-gao Zhai Guo-ming weng Rui Zhu State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences and ResourcesChina University of Geosciences(Beijing)Beijing 100083China Zaozigou Gold Mine Zhaojin Mining Industry Co.Ltd.Hezuo 747000China

*** The West Qinling Orogen extends east-west over 1500 km and is endowed with dozens of large-super large scale gold *** Zaozigou gold deposit has a proven reserve of 134 t with an average grade of 3.08 g/t thus is one of the largest deposits in the West Qinling ***,whether the fluid type is metamorphic or magmatichydrothermal and ore-formation processes of the Zaozigou gold deposit are *** is a ubiquitous accessory mineral in geologically diverse ore-deposit types and attested to be a strong indicator of ore-forming conditions and oredeposit genesis.

关键词： deposit gold Qinling

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基于混合蜜獾算法的机械臂最优运动规划方法

仪器仪表学报 2024年第4期45卷 234-247页

作者：黄成王涛许家忠哈尔滨理工大学自动化学院哈尔滨150080

针对六自由度机械臂末端执行器路径及关节空间下轨迹的规划问题,提出一种基于混合蜜獾算法和3-5-3分段多项式插值的最优运动规划方法,实现机械臂末端执行器运动路径最短及关节运动时间最优,并有效降低优化路径与规划路径的差异。首先,... 详细信息

针对六自由度机械臂末端执行器路径及关节空间下轨迹的规划问题,提出一种基于混合蜜獾算法和3-5-3分段多项式插值的最优运动规划方法,实现机械臂末端执行器运动路径最短及关节运动时间最优,并有效降低优化路径与规划路径的差异。首先,以标准蜜獾算法框架为基础,在初始化、全局寻优与局部探索中采用混沌反向学习、转移算子、正弦余弦算子以及自适应扰动系数策略,提高最优解质量与寻优能力,并据此设计机械臂末端执行器无碰撞、最短路径规划方法,引导关节轨迹规划过程;其次,在关节空间下,利用混合蜜獾算法寻找各关节最优运动时间,在此基础上,利用2次3-5-3分段多项式插值算法,在满足各关节位移、速度、加速度约束的条件下,完成机械臂关节平滑且时间最优的轨迹规划;最后,通过与其他规划方法仿真对比,验证提出的方法能够使规划路径长度缩短,关节运动时间减少,优化路径与规划路径差异较小,并以UR5机械臂抓取实验为例检验了该方法的可行性。

关键词：蜜獾算法机械臂运动规划时间最优分段多项式插值

植物病原真菌抑制几丁质触发植物免疫反应的策略

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植物病理学报 2024年第1期54卷 15-25页

作者：许铭徐婧刘慧泉西北农林科技大学植物保护学院杨凌712100

几丁质是真菌细胞壁的重要成分,其晶体结构使真菌细胞壁具有一定的强度和硬度,对植物病原真菌侵染结构和侵染菌丝的形成具有重要作用。在植物与真菌互作过程中,植物分泌的几丁质酶可以降解真菌的几丁质产生几丁质寡糖,几丁质寡糖作为一... 详细信息

几丁质是真菌细胞壁的重要成分,其晶体结构使真菌细胞壁具有一定的强度和硬度,对植物病原真菌侵染结构和侵染菌丝的形成具有重要作用。在植物与真菌互作过程中,植物分泌的几丁质酶可以降解真菌的几丁质产生几丁质寡糖,几丁质寡糖作为一种病原相关分子模式(PAMP),能够被植物细胞膜上的几丁质受体识别进而触发植物免疫反应。植物病原真菌为了成功侵染植物进化出了多种策略抑制几丁质触发的植物免疫反应,具体而言,植物病原真菌分泌大量的效应蛋白、多糖或几丁质脱乙酰化酶、几丁质酶、蛋白酶等效应子抑制植物的免疫反应。这些效应子被分泌到植物细胞质外体或细胞内部破坏植物免疫系统,促进病原真菌在植物细胞中获取营养物质以供其定殖和生长发育。本文综述了植物识别几丁质的分子机制以及植物病原真菌抑制几丁质触发植物免疫反应的主要策略,并对今后的研究前景进行了展望。

关键词：几丁质植物免疫效应蛋白几丁质脱乙酰化酶几丁质酶

Visible Light-Induced Collapse of Molecular Microcrystals into Droplets by E-to-Z Photoisomerization and Melting Phase Transition

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CCS Chemistry 2024年第4期6卷 1071-1084页

作者： Tian-Yi xu Min Cui Chengxi Zhao Shang-Wu Zhou Tian-Le Zhang Hui-Yao Lin Fei Tong Da-Hui Qu Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237

Harnessing photoresponsive behavior in organic crystals,such as shape and morphology deformation,on multiple scales is intriguing with respect to precise spatiotemporal operation,because dynamic deformations are promising in fabricating future intelligent ***,we synthesized a new photoresponsive molecular crystal composed of dimethyl(E)-2-(3-(naphthalen-1-yl)allylidene)malonate((E)-DNAM)that undergoes E-to-Z photoisomerization accompanied by photoinduced crystal-to-liquid melting phase transition when exposed to visible *** of expanding in bulk polycrystals,single-crystal(E)-DNAM rectangular microplates in an aqueous solution rapidly collapsed into liquid droplets,showing a remarkable drastic reduction in surface area of more than 97%after light *** deduce that the unique microscopic morphology of microplates with high aspect ratios of length-tothickness reaching up to 1000 is mainly responsible for the photoinduced melting leading to drastic *** addition,the cohesive forces of liquid photoproduct facilitate the overall deformations and *** have shown a facile way to achieve the remarkable collapse of molecular crystals into droplets by photochemical reaction and phase transition.

关键词： molecular crystals crystal-to-liquid transition extreme deformations photochemistry crystal engineering flexible crystals

Highly robust zinc metal anode directed by organic–inorganic synergistic interfaces for wearable aqueous zinc battery

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SmartMat 2024年第1期5卷 135-146页

作者： Xixi Zhang Chuanlin Li Guangmeng Qu Chenggang Wang Shunshun Zhao Tongkai Wang Na Li Xiaojuan Li Xijin xu School of Physics and Technology University of JinanJinanChina School of Chemistry and Chemical Engineering Shandong UniversityJinanChina State Key Laboratory of Chemical Resource Engineering Beijing Key Laboratory of Electrochemical Process and Technology of MaterialsBeijing University of Chemical TechnologyBeijingChina

Flexible aqueous zinc batteries(FAZBs)with high safety and environmental friendliness are promising smart power sources for smart wearable ***,the bare zinc anode usually suffers from damnable dendrite growth and rampant side reaction on the surface,greatly impeding practical applications in ***,a composite polymer interface layer is artificially self‐assembled on the surface of the zinc anode by graft‐modified fluorinated monomer(polyacrylic acid‐2‐(Trifluoromethyl)propenoic acid,PAA‐TFPA),on which an organic–inorganic hybrid(PAA‐Zn/ZnF2)solid electrolyte interface(SEI)with excellent ionic conductivity is formed by interacting with Zn2+.Both the pouch cell and fiber zinc anode exhibit excellent plating/stripping reversibility after protecting by this organic–inorganic SEI,which can be stably cycled more than 3000 h in symmetric Zn||Zn cells or 550 h in fiber Zn||Zn ***,this interface layer preserves zinc anode with excellent mechanical durability under various mechanical deformation(stably working for another 1200 h after bending 100 h).The corresponding PAA‐Zn/ZnF2@Zn||MnO2 full cell displays an ultra‐long life span(79%capacity retention after 3000 cycles)and mechanical robustness(85%of the initial capacity for another 3000 cycles after bending 100 times).More importantly,the as‐assembled cells can easily power smart wearable devices to monitor the user's health condition.

关键词： hybrid SEI mechanical durability wearable zinc battery zinc anode

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基于各向异性注意力的双分支血管分割模型

计算机工程 2024年第1期50卷 348-356页

作者：徐晓峰黄韫栀徐军南京信息工程大学人工智能学院智慧医疗研究院江苏南京210044

血管分割对于血管疾病的诊断和治疗具有重要意义,但由于血管边界模糊、病变血管的形状多变且不同样本之间的差异性较大,因此要求分割模型能够准确地挖掘血管与背景类间的差异性以及血管内部的连通性。提出一种基于中心线约束与各向异性... 详细信息

血管分割对于血管疾病的诊断和治疗具有重要意义,但由于血管边界模糊、病变血管的形状多变且不同样本之间的差异性较大,因此要求分割模型能够准确地挖掘血管与背景类间的差异性以及血管内部的连通性。提出一种基于中心线约束与各向异性注意力的新型三维血管分割网络CAU-Net。针对血管分割的难点,对基础网络结构ResU-Net进行改进,构建各向异性注意力模块,该模块根据管腔结构特有的空间各向异性,从3个方向提取血管空间各向异性特征,并对特征通道间的相关性进行建模,学习血管的三维空间信息。采用主-辅双分支模型,b-Net对血管进行语义分割,a-Net学习血管中心线的连续性特征,约束b-Net的血管分割结果,保证血管分割结果的完整性。在公开数据集3D-IRCADb-01上的实验结果表明,对于门静脉及肝静脉的分割,CAU-Net分别取得(74.80±8.05)%和(76.14±6.89)%的Dice系数、(54.80±8.09)%和(50.40±5.22)%的NSD系数、(72.43±8.26)%和(70.84±6.05)%的clDice系数、(46.47±12.89)%和(39.19±7.97)%的分支检测率以及(67.08±15.59)%和(61.47±9.32)%的树长检测率。在公开脑血管数据集IXI上进行组件消融实验,模型在验证集上的平均Dice、NSD、clDice、BD和TD分别为(94.11±0.39)%、(96.53±0.37)%、(95.83±0.59)%、(98.64±1.63)%和(95.44±1.22)%,相比于Baseline分别提升了0.92%、0.82%、0.92%、1.11%和1.60%。CAU-Net血管分割模型能够显著提升血管分割的精度和完整度。

关键词：血管分割中心线约束各向异性注意力机制双分支模型

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白细胞酯酶诊断关节假体感染的意义

中国矫形外科杂志 2024年第1期32卷 44-49页

作者：张苍旭杜文豪张大海谢士成济宁医学院临床医学院山东济宁272067 济宁医学院附属医院关节外科山东济宁272007

关节假体周围感染(periprosthetic joint infection,PJI)是关节置换术后灾难性的并发症,一旦发生,会给患者带来很大的心理和经济负担。所以及时且正确的诊断很重要。目前常用的诊断方法根据临床表现、影像学表现、血清与滑液标记物等制... 详细信息

关节假体周围感染(periprosthetic joint infection,PJI)是关节置换术后灾难性的并发症,一旦发生,会给患者带来很大的心理和经济负担。所以及时且正确的诊断很重要。目前常用的诊断方法根据临床表现、影像学表现、血清与滑液标记物等制定,随着更多的血清与滑液标记物的发现与实验,生化指标检查日益重要,有些滑液标记物易受到炎症的影响。近年来白细胞酯酶(leukocyte esterase,LE)逐渐被重视,LE有较高的敏感性和特异性。因此,应结合其他临床评价和辅助检查来诊断。LE水平的影响需要进一步研究。本文综合分析目前有关滑液LE的临床研究,对其在PJI诊断中的研究现状和临床价值进行综述。

关键词：关节假体周围感染生物标志物滑液白细胞酯酶

2020年版《中国药典》儿童禁忌相关药品研究

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中国临床药理学杂志 2024年第9期40卷 1355-1359页

作者：杨钰赵瑞玲许馨文赵志刚山西省儿童医院临床试验机构办公室山西太原030013 中国医药新闻信息协会儿童安全用药分会北京100044 首都医科大学附属北京天坛医院药学部北京100070

目的分析2020年版《中国药典》收载化学药品中儿童禁忌相关品种,为根据中国儿童发展纲要(2021年至2030年)要求制定儿童禁用药品目录提供技术基础。方法通过“药智网”等网站收集药品说明书,从中提取儿童禁用相关信息,对不同生产企业说... 详细信息

目的分析2020年版《中国药典》收载化学药品中儿童禁忌相关品种,为根据中国儿童发展纲要(2021年至2030年)要求制定儿童禁用药品目录提供技术基础。方法通过“药智网”等网站收集药品说明书,从中提取儿童禁用相关信息,对不同生产企业说明书标注儿童禁用相关信息一致的药品进行分析。结果1741种化学药品中不同生产企业说明书标注儿童禁用相关信息一致的药品共计240种,其中标注“禁用”于不同年龄段儿童113种,“不宜”用于不同年龄段儿童53种,“不推荐”用于不同年龄段儿童38种,标注其他儿童禁用相关信息的36种。依据中国药典《临床用药须知》(2020年版)分类,涉及21个药物类别,包含抗感染药物(77个),解热、镇痛、抗炎与抗风湿药以及抗痛风药(28个),神经系统用药(20个),精神药物(16个),消化系统用药(16个),内分泌系统用药(16个)等。结论儿童生长发育处在特殊阶段,药物在儿童体内的药理毒理特征与成人存在差异,药品用于儿童的风险获益比需要不断研究以提供更详实的用药依据,保障儿童用药安全。

关键词：儿童禁忌药品说明书用药安全